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Volumn 42, Issue 6, 2007, Pages 589-594

Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method

Author keywords

Cytochrome P 450; LC MS MS; Liver microsomes

Indexed keywords

CYTOCHROME P450; ENZYME INHIBITOR;

EID: 34547452296     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (19)
  • 1
    • 9644262514 scopus 로고    scopus 로고
    • Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: Application to cytochrome P450 phenotyping studies [J]
    • Yin OQ, Lam SS, Lo CM, et al. Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies [J]. Rapid Commun Mass Spectrom, 2004,18: 2921-2933.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 2921-2933
    • Yin, O.Q.1    Lam, S.S.2    Lo, C.M.3
  • 2
    • 27644596457 scopus 로고    scopus 로고
    • Predicting in vivo drug interactions from in vitro drug discovery data [J]
    • Wienkers LC, Heath TG. Predicting in vivo drug interactions from in vitro drug discovery data [J]. Nat Rev Drug Discov, 2005,4:825-833.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 825-833
    • Wienkers, L.C.1    Heath, T.G.2
  • 3
    • 0033997634 scopus 로고    scopus 로고
    • Automated high throughput human CYP isoform activity assay using SPE-LC/MS method; application in CYP inhibition evaluation [J]
    • Yin H, Racha J, Li SY, et al. Automated high throughput human CYP isoform activity assay using SPE-LC/MS method; application in CYP inhibition evaluation [J]. Xenobiotica, 2000,30:141-154.
    • (2000) Xenobiotica , vol.30 , pp. 141-154
    • Yin, H.1    Racha, J.2    Li, S.Y.3
  • 4
    • 0033811314 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/ on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites [J]
    • Bu HZ, Magis L, Knuth K, et al. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/ on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites [J]. Rapid Commun Mass Spectrom, 2000,14:1619-1624.
    • (2000) Rapid Commun Mass Spectrom , vol.14 , pp. 1619-1624
    • Bu, H.Z.1    Magis, L.2    Knuth, K.3
  • 5
    • 0035157254 scopus 로고    scopus 로고
    • A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry [J]
    • Dierks EA, Stams KR, Lim HK, et al. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry [J]. Drug Metab Dispos, 2001,29:23-29.
    • (2001) Drug Metab Dispos , vol.29 , pp. 23-29
    • Dierks, E.A.1    Stams, K.R.2    Lim, H.K.3
  • 6
    • 0037175449 scopus 로고    scopus 로고
    • Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry [J]
    • Zhang T, Zhu Y, Gunaratna C. Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry [J]. J Chromatogr B, 2002,780:371-379.
    • (2002) J Chromatogr B , vol.780 , pp. 371-379
    • Zhang, T.1    Zhu, Y.2    Gunaratna, C.3
  • 7
    • 0037212558 scopus 로고    scopus 로고
    • High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry [J]
    • Testino SA, Patonay G. High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry [J]. J Pharm Biomed Anal, 2003, 30:1459-1467.
    • (2003) J Pharm Biomed Anal , vol.30 , pp. 1459-1467
    • Testino, S.A.1    Patonay, G.2
  • 8
    • 4644223218 scopus 로고    scopus 로고
    • Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction [J]
    • Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction [J]. Rapid Commun Mass Spectrom, 2004, 18:2273-2281.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 2273-2281
    • Unger, M.1    Frank, A.2
  • 9
    • 11144242471 scopus 로고    scopus 로고
    • Multiple P450 substrates in a single run: Rapid and comprehensive in vitro interaction assay [J]
    • Turpeinen M, Uusitalo J, Jalonen J, et al. Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay [J]. Eur J Pharm Sci, 2005,24: 123-132.
    • (2005) Eur J Pharm Sci , vol.24 , pp. 123-132
    • Turpeinen, M.1    Uusitalo, J.2    Jalonen, J.3
  • 11
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding [J]
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding [J]. Anal Biochem, 1976,2:248-254.
    • (1976) Anal Biochem , vol.2 , pp. 248-254
    • Bradford, M.M.1
  • 12
    • 2442690439 scopus 로고    scopus 로고
    • Validated assays for human cytochrome P450 activities [J]
    • Walsky RL, Obach RS. Validated assays for human cytochrome P450 activities [J]. Drug Metab Dispos, 2004,32:647-660.
    • (2004) Drug Metab Dispos , vol.32 , pp. 647-660
    • Walsky, R.L.1    Obach, R.S.2
  • 13
    • 3042641177 scopus 로고    scopus 로고
    • An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates [J]
    • Andersson TB, Bredberg E, Ericsson H, et al. An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates [J]. Drug Metab Dispos, 2004,32: 715-721.
    • (2004) Drug Metab Dispos , vol.32 , pp. 715-721
    • Andersson, T.B.1    Bredberg, E.2    Ericsson, H.3
  • 14
    • 0035108902 scopus 로고    scopus 로고
    • High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP1A2 inhibition assessment [J]
    • Bu HZ, Knuth K, Magis L, et al. High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP1A2 inhibition assessment [J]. Eur J Pharm Sci, 2001,12:447-452.
    • (2001) Eur J Pharm Sci , vol.12 , pp. 447-452
    • Bu, H.Z.1    Knuth, K.2    Magis, L.3
  • 15
    • 0032711206 scopus 로고    scopus 로고
    • Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry [J]
    • Scott RJ, Palmer J, Lewis IA, et al. Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry [J]. Rapid Commun Mass Spectrom, 1999,13:2305-2319.
    • (1999) Rapid Commun Mass Spectrom , vol.13 , pp. 2305-2319
    • Scott, R.J.1    Palmer, J.2    Lewis, I.A.3
  • 16
    • 0142131213 scopus 로고    scopus 로고
    • The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective [J]
    • Bjornsson TD, Callaghan JT, Einolf HJ, et al. The conduct of in vitro and in vivo drug-drug interaction studies: a PhRMA perspective [J]. J Clin Pharmcol, 2003,43:443-469.
    • (2003) J Clin Pharmcol , vol.43 , pp. 443-469
    • Bjornsson, T.D.1    Callaghan, J.T.2    Einolf, H.J.3
  • 17
    • 0037403747 scopus 로고    scopus 로고
    • Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6; implications for relating in vitro inhibition data to in vivo drug interactions [J]
    • Margolis JM, Obach RS. Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6; implications for relating in vitro inhibition data to in vivo drug interactions [J]. Drug Metab Dispos, 2003,31:606-611.
    • (2003) Drug Metab Dispos , vol.31 , pp. 606-611
    • Margolis, J.M.1    Obach, R.S.2
  • 18
    • 0036891924 scopus 로고    scopus 로고
    • Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors [J]
    • Tran TH, Von Moltke LL, Venkatakrishnan K, et al. Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors [J]. Drug Metab Dispos, 2002,30:1441-1445.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1441-1445
    • Tran, T.H.1    Von Moltke, L.L.2    Venkatakrishnan, K.3
  • 19
    • 26844546679 scopus 로고    scopus 로고
    • Influence of cytochrom P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide metabolism using oligonucleotide genotyping microarray [J]
    • Li J, Wen SY, Wang R, et al. Influence of cytochrom P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide metabolism using oligonucleotide genotyping microarray [J]. Acta Pharm Sin, 2005, 40:695-699.
    • (2005) Acta Pharm Sin , vol.40 , pp. 695-699
    • Li, J.1    Wen, S.Y.2    Wang, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.