Requirement for tyrosine residues 315 and 319 within ζ chain-associated protein 70 for T cell development

Journal of Experimental Medicine

Volumn 194, Issue 4, 2001, Pages 507-518

  Gong, Q ^a   Jin, X ^a   Akk, A M ^a   Foger, N ^a   White, M ^a   Gong, G ^a   Wardenburg, J B ^a   Chan, A C ^a  

^a Box 8022 ^*  (United States)

Author keywords

Lymphocyte development; Protein tyrosine kinases; Signal transduction; T cell activation; T cell selection

Indexed keywords

PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; THYMUS;

ANIMALS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TYROSINE;

EID: 0035920572     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.4.507     Document Type: Article

References (41)

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7. + thymic selection in humans lacking ZAP-70 kinase
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20. Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70
21. The cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr 292 negative regulatory phosphorylation site of ZAP-70
22. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
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28. Phosphorylation of Tyr 319 in ZAP-70 is required for T-cell antigen receptor phospholipase C-γ1 and ras activation
29. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
30. Tyrosine 319 in the Interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
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32. Functional dissection of the lck proximal promoter
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35. + thymocytes
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