Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70

Molecular and Cellular Biology

Volumn 16, Issue 12, 1996, Pages 6765-6774

  Zhao, Qihong ^a,b,c   Weiss, Arthur ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0029968995     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.12.6765     Document Type: Article

References (53)

1. Abraham, N., M. C. Miceli, J. R. Parnes, and A. Veillette. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p561ck. Nature (London) 350:62-66.
2. + thymic selection in humans lacking ZAP-70 kinase. Cell 76:947-958.
3. Bolen, J. B. 1995. Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Opin. Immunol. 7:306-331.
4. Cambier, J. C., C. M. Pleiman, and M. R. Clark. 1994. Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rev. Immunol. 12:457-486.
5. Chan, A. C., M. Dalton, R. Johnson, G. Kong, T. Wang, R. Thomas, and T. Kurosaki. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14:2499-2508.
6. Chan, A. C., B. A. Irving, J. D. Fraser, and A. Weiss. 1991. The ζ-chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70, a 70 kilodalton tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 88:9166-9170.
7. Chan, A. C., M. Iwashima, C. W. Turk, and A. Weiss. 1992. ZAP-70, a 70KD protein tyrosine kinase that associates with the TCR ζ chain. Cell 71:649-662.
8. Chan, A. C., T. A. Kadlecek, M. E. Elder, A. H. Filipovich, W. L. Kuo, M. Iwashima, T. G. Parslow, and A. Weiss. 1994. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264:1599-1601.
9. Cheng, A. M., B. Rowley, W. Pao, A. Hayday, J. B. Bolen, and T. Pawson. 1995. Syk tyrosine kinase required for mouse viability and B-cell development. Nature (London) 378:303-306.
10. Choi, M. S., R. D. Brines, M. J. Holman, and G. G. Klaus. 1994. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1:179-187.
11. Clipstone, N. A., and G. R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (London) 357:695-697.
12. DeFranco, A. L. 1995. Transmembrane signaling by antigen receptors of B and T lymphocytes. Curr. Opin. Cell Biol. 7:163-175.
13. Duplay, P., M. Thome, R. Herve, and O. Acuto. 1994. p56lck interacts via its SH2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163-1172.
14. Durand, D. B., J. P. Shaw, M. R. Bush, R. E. Replogle, R. Gelagaje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol. 8:1715-1724.
15. Elder, M. E., D. Lin, J. Clever, A. C. Chan, T. J. Hope, A. Weiss, and T. Parslow. 1994. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264:1596-1599.
16. Fischer, K. D., A. Zmuldzinas, S. Gardner, M. Barbacid, M. Bernstein, and C. Guidos. 1995. Defective T-cell receptor signaling and positive selection of vav-dch'cient CD4+ CD8+ thymocytes. Nature (London) 374:474-477.
17. syk. J. Biol. Chem. 269:955-959.
18. Hatada, M. H., X. Lu, E. R. Laird, J. Green, J. P. Morgenstern, M. Lou, C. S. Marr, T. B. Phillips, M. K. Ram, K. Theriault, et al. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature (London) 376:32-38.
19. Iwashima, M., B. A. Irving, N. S. C. van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136-1139.
20. ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J. Exp. Med. 178:1199-1208.
21. Katzav, S., M. Sutherland, G. Packham, T. Yi, and A. Weiss. 1994. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of protovav. J. Biol. Chem. 269:32579-32585.
22. Kong, G., J. Y. Bu, T. Kurosaki, A. S. Shaw, and A. C. Chan. 1995. Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. Immunity 2:485-492.
23. Kong, G., M. Dalton, J. B. Wardenburg, D. Straus, T. Kurosaki, and A. C. Chan. 1996. Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell. Biol. 16:5026-5035.
24. Luo, K., and B. M. Sefton. 1992. Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells. Mol. Cell. Biol. 12:4724-4732.
25. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation by TCR antagonists or partial agonists. Science 267:515-518.
26. Negishi, I., N. Motoyama, K. Nakayama, K. Nakayama, S. Senju, S. Hatakeyama, Q. Zhang, A. C. Chan, and D. Y. Loh. 1995. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature (London) 376:435-438.
27. Neumeister, E. N., Y. Zhu, S. Richard, C. Terhorst, A. C, Chan, and A. S. Shaw. 1995. Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15:3171-3178.
28. Owaki, H., R. Varma, B. Gillis, J. T. Bruder. U. R. Rapp, L. S. Davis, and T. D. Geppert. 1993. Raf-1 is required for T cell IL2 production. EMBO J. 12:4367-4373.
29. Perlmutter, R. M., S. D. Levin, M. W. Appleby, S. J. Anderson, and J. Alberola-lla. 1993. Regulation of lymphocyte function by protein phosphorylation. Annu. Rev. Immunol. 11:451-199.
30. Plas, D. R., R. Johnson, J. T. Pingel, R. J. Mattews, M. Dalton, G. Roy, A. C. Chan, and M. L. Thomas. 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173-1176.
31. Qian, D., M. Mollenauer, and A. Weiss. 1996. Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med. 183:611-620.
32. Qian, D., I. Prenner-Griswold, M. R. Rosner, and F. W. Fitch. 1993. Multiple components of the T cell antigen receptor complex become tyrosine phosphorylated upon activation. J. Biol. Chem. 268:4488-4493.
33. Reth, M. 1989. Antigen receptor tail clue. Nature (London) 338:383-384.
34. Richards, J. D., M. R. Gold, S. L. Hourihane, A. L. DeFranco, and L. Matsuuchi. 1996. Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein tyrosine kinase. J. Biol. Chem. 271:6458-6466.
35. Samelson, L. E., and R. D. Klausner. 1992. Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J. Biol. Chem. 267:24913-24916.
36. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell 79:913-922.
37. Smith, D., and K. Johnson. 1988. Single-step purification of polypeptides expressed in E. coli as fusions with glutathione-S-transferase. Gene 67:31-40.
38. Straus, D. B., A. C. Chan, B. Patai, and A. Weiss. 1996. SH2 domain function is essential for the role of the lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:9976-9981.
39. 2+ mobilization through distinct pathways. EMBO J. 13:1341-1349.
40. Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of vav. Nature (London) 374:467-470.
41. Turner, M., P. J. Mee, P. S. Costello, O. Williams, A. A. Price, L. P. Duddy, M. T. Furlong, R. L. Geahlen, and V. L. Tybulewicz. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (London) 378:298-302.
42. van Oers, N. S. C., N. Killeen, and A. Weiss. 1994. ZAP-70 is constitutively associated with tyrosine phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1:675-685.
43. Venkataraman, L., D. A. Francis, Z. Wang, J. Liu, T. L. Rothstein, and R. Sen. 1994. Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity 1:189-196.
44. Wange, R. L., R. Guitian, N. Isakov, J. D. Watts, R. Aebersold, and L. E. Samelson. 1995. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270:18730-18733.
45. 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling. J. Biol. Chem. 270:944-948.
46. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP-70 binds to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells. J. Biol. Chem. 268:19797-19801.
47. Watts, J. D., M. Affolter, D. L. Krebs, R. L. Wange, L. E. Samelson, and R. Aebersold. 1994. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269:29520-29529.
48. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263-274.
49. ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517-1522.
50. ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells. J. Immunol. 150:3853-3861.
51. vav activity. Mol. Cell. Biol. 15:4337-4346.
52. Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signaling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature (London) 374:470-473.
53. Zhao, Q., R. V. Schoborg, and D. J. Pintel. 1994. Alternative splicing of pre-mRNA.s encoding the nonstructural proteins of minute virus of mice is facilitated by sequences within the downstream intron. J. Virol. 68:2849-2859.