The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: Implications for the design of selective inhibitors

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 42818-42825

  Jin, Lei ^a   Pluskey, Scott ^a   Petrella, Eugene C ^a   Cantin, Susan M ^a   Gorga, Joan C ^a   Rynkiewicz, Michael J ^a   Pandey, Pramod ^a   Strickler, James E ^a   Babine, Robert E ^a   Weaver, David T ^a   Seidl, Katherine J ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; CATALYSIS; CELLS; CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLIZATION; IMMUNOLOGY;

HOMOLOGY; IMMUNE RESPONSE; PHOSPHORYLATION; TYROSINE KINASE;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; IMMUNOMODULATING AGENT; PEPTIDE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE ZAP 70; PROTEIN KINASE ZAP 70 INHIBITOR; PROTEIN SUBUNIT; STAUROSPORINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME STRUCTURE; IMMUNE RESPONSE; IMMUNOMODULATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SEQUENCE ANALYSIS; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE ACTIVATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; BINDING SITES; CATALYTIC DOMAIN; CLONING, MOLECULAR; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS; STAUROSPORINE; STEREOISOMERISM; TIME FACTORS; TRANSFECTION; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

ANIMALIA;

EID: 5644297083     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407096200     Document Type: Article

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