Plasma concentrations and anti-L-cytokine effects of α-melanocyte stimulating hormone in septic patients

Critical Care Medicine

Volumn 28, Issue 5, 2000, Pages 1403-1407

  Catania, Anna ^a   Cutuli, Mariagrazia ^a   Garofalo, Letizia ^a   Airaghi, Lorena ^a   Valenza, Franco ^a   Lipton, James M ^b   Gattinoni, Luciano ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cytokine production; Interleukin 1; Lipopolysaccharide; Sepsis syndrome; Septic shock; Systemic inflammation; Tumor necrosis factor ; Whole blood; melanocyte stimulating hormone

Indexed keywords

ALPHA INTERMEDIN; CYTOKINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; IMMUNOMODULATION; INFLAMMATION; INTENSIVE CARE UNIT; MALE; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

EID: 0034112590     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200005000-00024     Document Type: Article

References (33)

1. 1. Neugebauer EA, Holaday JW (Eds): Handbook of Mediators of Septic Shock. Boca Raton, CRC Press, 1993
2. 2. Baumann H, Gauldie J: The acute phase response. Immunol Today 1994; 15:74-78
3. 3. Fisher CJ Jr, Dhainaut JF, Opal SM, et al: Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trial. JAMA 1994; 271:1836-1843
4. 4. Abraham E, Wunderink R, Silverman H, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor α in patients with sepsis syndrome: A randomized, controlled, double-blind, multicenter clinical trial. JAMA 1995; 273:934-941
5. 5. Fisher CJ Jr, Agosti JM, Opal SM, et al: Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. N Engl J Med 1996; 334:1697-1702
6. 6. Catania A, Lipton JM: α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993; 14:564-576
7. 7. Lipton JM, Catania A: Antiinflammatory influence of the neuroimmunomodulator α-MSH. Immunol Today 1997; 18:140-145
8. 8. Catania A, Garofalo L, Cutuli M, et al: Melanocortin peptides inhibit production of proinflammatory cytokines in blood of HIV-infected patients. Peptides 1998; 19:1099-1104
9. 9. Rajora N, Boccoli G, Burns D, et al: α-MSH modulates local and circulating tumor necrosis factor-α in experimental brain inflammation. J Neurosci 1997; 17:2181-2186
10. 10. Delgado RH, Carlin A, Airaghi L, et al: Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J Leukoc Biol 1998; 63:740-745
11. 11. Delgado RH, Demitri MT, Carlin A, et al: Inhibition of systemic inflammation by central action of the neuropeptide α-MSH. Neuroimmunomodulation 1999; 6:187-192
12. 12. Star RA, Rajora N, Huang J, et al: Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc Natl Acad Sci U S A 1995; 92:8016-8020
13. 13. Lipton JM, Ceriani G, Macaluso A, et al: Antiinflammatory influence of the neuropeptide α-MSH in acute, chronic, and systemic inflammation. Ann NY Acad Sci 1994; 741:137-148
14. 14. Rajora N, Ceriani G, Catania A, et al: α-MSH production, receptors and influence on neopterin in a human monocyte/macrophage cell line. J Leukoc Biol 1996; 59:248-253
15. 15. Catania A, Rajora N, Capsoni F, et al: The neuropeptide α-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 1996; 17:675-679
16. 16. Bone RC, Fisher CJ, Clemmer TP, et al: Sepsis syndrome: A valid clinical entity. Crit Care Med 1989; 17:389-395
17. 17. Le Gall Jr, Lemeshow S, Saulnier F: A new simplified acute physiology score (SAPS II) based on a European North American Multicenter Study. JAMA 1993; 270:2957-2963
18. 18. Beutler B, Cerami A: Tumor necrosis, cachexia, shock and inflammation: A common mediator. Annu Rev Biochem 1988; 57:505-518
19. 19. Mason MJ, Van Epps D: Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by α-melanocyte-stimulating hormone. J Immunol 1989; 142:1646-1651
20. 20. Manna SK, Aggarwal BB: α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa-B activation induced by various inflammatory agents. J Immunol 1998; 161:2873-2880
21. 21. Börer H, Qiu F, Zimmermann T, et al: Role of NFkB in mortality of sepsis. J Clin Invest 1997; 100:972-985
22. 22. Tatro JB: Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides. Neuroimmunomodulation 1996; 3:259-284
23. 23. Catania A, Suffredini AF, Lipton JM: Endotoxin causes α-MSH release in normal human subjects. Neuroimmunomodulation 1995; 2:248-253
24. 24. Tiligada E, Wilson JF: D2- but not D1-dopamine receptors are involved in the inhibitory control of α-melanocyte-stimulating hormone release from the rat hypothalamus. Exp Brain Res 1989; 74:645-648
25. 25. Hahn PY, Wang P, Tait SM, et al: Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock 1995; 4:269-273
26. 26. Shih ST, Khorram O, Lipton JM, et al: Central administration of α-MSH antiserum augments fever in the rabbit. Am J Physiol 1986; 250:R803-R806
27. 27. Guarini S, Bazzani C, Bertolini A: Resuscitating effect of melanocortin peptides after prolonged respiratory arrest. Br J Pharmacol 1997; 121:1454-1460
28. 28. Damas P, Reuter A, Gysen P, et al: Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 1989; 17:975-978
29. 29. Offner F, Philippé J, Vogelaers D, et al: Serum tumor necrosis factor levels in patients with infectious disease and septic shock. J Lab Clin Med 1990; 116:100-105
30. 30. Calandra T, Baumgartner JD, Grau GE, et al: Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. J Infect Dis 1990; 161:982-987
31. 31. Pinsky MR, Vincent J-L, Devierce J, et al: Serum cytokine levels in human septic shock. Chest 1993; 103:565-575
32. 32. Granowitz EV, Porat R, Mier JW, et al: Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans. J Immunol 1993; 151: 1637-1645
33. 33. Catania A, Airaghi L, Garofalo L, et al: The neuropeptide α-MSH in HIV infection and other disorders in humans. Ann NY Acad Sci 1998; 840:848-856