Complement C5a in the sepsis syndrome - Too much of a good thing?

New England Journal of Medicine

Volumn 348, Issue 2, 2003, Pages 167-169

  Gerard, Craig ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT INHIBITOR; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 8; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY PRODUCTION; ARTICLE; COMPLEMENT INHIBITION; CYTOKINE PRODUCTION; HUMAN; IMMUNE SYSTEM; MEDIATOR RELEASE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEPSIS;

ANIMALS; COMPLEMENT ACTIVATION; COMPLEMENT C5A; HUMANS; MEMBRANE PROTEINS; RECEPTORS, COMPLEMENT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0037426723     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr022995     Document Type: Article

References (5)

1. Janeway CA. How the immune system works to protect the host from infection: A personal view. Proc Natl Acad Sci U S A 2001;98:7461-8.
2. Czermak BJ, Sarma V, Pierson CL, et al. Protective effects of C5a blockade in sepsis. Nat Med 1995;5:788-92.
3. Stevens JH, O'Hanley P, Shapiro JM, et al. Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J Clin Invest 1986;77:1812-6.
4. Riedemann NC, Guo RF, Neff TA, et al. Increased C5a receptor expression in sepsis. J Clin Invest 2002;110:101-8.
5. Drouin SM, Kildsgaard J, Haviland J, et al. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol 2001;166:2025-32.