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Volumn 30, Issue SUPPL. 1, 2008, Pages 53-59

Experimental models of sepsis and their clinical relevance

Author keywords

Animal models; Bacteremia; Endotoxin; Sepsis; Shock

Indexed keywords

ENDOTOXIN;

EID: 54049158480     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318181a343     Document Type: Conference Paper
Times cited : (208)

References (50)
  • 1
    • 35948948662 scopus 로고    scopus 로고
    • Sepsis: Definition, epidemiology, and diagnosis
    • Lever A, Mackenzie I: Sepsis: definition, epidemiology, and diagnosis. BMJ 335(7625):879-883, 2007.
    • (2007) BMJ , vol.335 , Issue.7625 , pp. 879-883
    • Lever, A.1    Mackenzie, I.2
  • 2
    • 33746754668 scopus 로고    scopus 로고
    • Markers for sepsis diagnosis: What is useful?
    • Reinhart K, Meisner M, Brunkhorst FM: Markers for sepsis diagnosis: what is useful? Crit Care Clin 22(3):503-519, 2006.
    • (2006) Crit Care Clin , vol.22 , Issue.3 , pp. 503-519
    • Reinhart, K.1    Meisner, M.2    Brunkhorst, F.M.3
  • 3
    • 0035495804 scopus 로고    scopus 로고
    • Immunotherapy of sepsis
    • Van der Poll T: Immunotherapy of sepsis. Lancet Infect Dis 1:165-174, 2001.
    • (2001) Lancet Infect Dis , vol.1 , pp. 165-174
    • Van der Poll, T.1
  • 4
    • 0141465216 scopus 로고    scopus 로고
    • Vital blood flow during hyperdynamic sepsis
    • Giantomasso DD, May CN, Bellomo R: Vital blood flow during hyperdynamic sepsis. Chest 124:1053-1059, 2003.
    • (2003) Chest , vol.124 , pp. 1053-1059
    • Giantomasso, D.D.1    May, C.N.2    Bellomo, R.3
  • 6
    • 0029855862 scopus 로고    scopus 로고
    • Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis
    • Piper RD, Cook DJ, Bone RC, Sibbald WJ: Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 24:2059-2070, 1996.
    • (1996) Crit Care Med , vol.24 , pp. 2059-2070
    • Piper, R.D.1    Cook, D.J.2    Bone, R.C.3    Sibbald, W.J.4
  • 7
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the united estates: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the united estates: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310, 2001.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 9
    • 0034088128 scopus 로고    scopus 로고
    • Spontaneous high systemic oxygen delivery increases survival rate in awake sheep during sustained endotoxemia
    • Pittet JF, Pastor CM, Morel DR: Spontaneous high systemic oxygen delivery increases survival rate in awake sheep during sustained endotoxemia. Crit Care Med 28:496-503, 2000.
    • (2000) Crit Care Med , vol.28 , pp. 496-503
    • Pittet, J.F.1    Pastor, C.M.2    Morel, D.R.3
  • 10
    • 0031985816 scopus 로고    scopus 로고
    • The value of animal models in the development of new drugs for the treatment of sepsis syndrome
    • Michie HR: The value of animal models in the development of new drugs for the treatment of sepsis syndrome. J Antimicrob Chemother 41:47-49, 1998.
    • (1998) J Antimicrob Chemother , vol.41 , pp. 47-49
    • Michie, H.R.1
  • 11
    • 0034778208 scopus 로고    scopus 로고
    • Animal models of sepsis
    • Freise H: Animal models of sepsis. J Invest Surg 14:195-212, 2001.
    • (2001) J Invest Surg , vol.14 , pp. 195-212
    • Freise, H.1
  • 12
    • 0034100624 scopus 로고    scopus 로고
    • Differential host inflammatory responses to viable versus antibiotic-killed bacteria in experimental microbial sepsis
    • Silverstein R, Wood JG, Xue Q, Norimatsu M, Horn D, Morrison DC: Differential host inflammatory responses to viable versus antibiotic-killed bacteria in experimental microbial sepsis. Infect Immun 68:2301-2308, 2000.
    • (2000) Infect Immun , vol.68 , pp. 2301-2308
    • Silverstein, R.1    Wood, J.G.2    Xue, Q.3    Norimatsu, M.4    Horn, D.5    Morrison, D.C.6
  • 14
    • 0034923010 scopus 로고    scopus 로고
    • Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: Examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants
    • Taylor FB: Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants. Crit Care Med 29:78-89, 2001.
    • (2001) Crit Care Med , vol.29 , pp. 78-89
    • Taylor, F.B.1
  • 17
    • 0035026505 scopus 로고    scopus 로고
    • Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated
    • Chung CS, Wang W, Chaudry IH, Ayala A: Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated. Am J Physiol Gastrointest Liver Physiol 280(5):G812-G818, 2001.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , Issue.5
    • Chung, C.S.1    Wang, W.2    Chaudry, I.H.3    Ayala, A.4
  • 18
    • 15844372716 scopus 로고    scopus 로고
    • Rocha e Silva M: Effects of fluid resuscitation on splanchnic perfusion in a canine severe sepsis model
    • Lagoa CE, Poli de Figueiredo LF, Cruz RJ Jr, Silva E, Rocha e Silva M: Effects of fluid resuscitation on splanchnic perfusion in a canine severe sepsis model. Crit Care 8:221-228, 2004.
    • (2004) Crit Care , vol.8 , pp. 221-228
    • Lagoa, C.E.1    Poli de Figueiredo, L.F.2    Cruz Jr, R.J.3    Silva, E.4
  • 19
    • 33750574624 scopus 로고    scopus 로고
    • Rocha e Silva M: Small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis
    • Garrido AG, Cruz RJ Jr, Poli de Figueiredo LF, Rocha e Silva M: Small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis. Crit Care 10(R62):1-9, 2006.
    • (2006) Crit Care , vol.10 , Issue.R62 , pp. 1-9
    • Garrido, A.G.1    Cruz Jr, R.J.2    Poli de Figueiredo, L.F.3
  • 20
    • 33750002319 scopus 로고    scopus 로고
    • Rocha e Silva M, Poli-de-Figueiredo LF: Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis
    • Rahal L, Garrido AG, Cruz R Jr, Rocha e Silva M, Poli-de-Figueiredo LF: Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis. Braz J Med Biol Res 39(9):1205-1215, 2006.
    • (2006) Braz J Med Biol Res , vol.39 , Issue.9 , pp. 1205-1215
    • Rahal, L.1    Garrido, A.G.2    Cruz Jr, R.3
  • 22
    • 34548764841 scopus 로고    scopus 로고
    • Characterization of an animal model of severe sepsis associated with respiratory dysfunction
    • Azevedo LCP, Park M, Noritomi DT, Maciel AT, Brunialti MK, Salomão R: Characterization of an animal model of severe sepsis associated with respiratory dysfunction. Clinics 62(4)491-498, 2007.
    • (2007) Clinics , vol.62 , Issue.4 , pp. 491-498
    • Azevedo, L.C.P.1    Park, M.2    Noritomi, D.T.3    Maciel, A.T.4    Brunialti, M.K.5    Salomão, R.6
  • 23
    • 0032734064 scopus 로고    scopus 로고
    • Temporal sequence of pulmonary and systemic inflammatory response to grade de polymicrobial peritonitis in mice
    • Stamme C, Bundschuh DS, Hartung T, Gebert U, Wollin L, Nürsing R, Wendel A, Uhlig S: Temporal sequence of pulmonary and systemic inflammatory response to grade de polymicrobial peritonitis in mice. Infect Immun 67:5642-5650, 1999.
    • (1999) Infect Immun , vol.67 , pp. 5642-5650
    • Stamme, C.1    Bundschuh, D.S.2    Hartung, T.3    Gebert, U.4    Wollin, L.5    Nürsing, R.6    Wendel, A.7    Uhlig, S.8
  • 25
    • 0022460859 scopus 로고
    • Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock
    • Natanson C, Fink MP, Ballantyne HK, MacVittie TJ, Conklin JJ, Parrillo JE: Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 78:259-270, 1986.
    • (1986) J Clin Invest , vol.78 , pp. 259-270
    • Natanson, C.1    Fink, M.P.2    Ballantyne, H.K.3    MacVittie, T.J.4    Conklin, J.J.5    Parrillo, J.E.6
  • 26
    • 0025354406 scopus 로고
    • Laboratory models of sepsis and septic shock
    • Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 49:186-196, 1990.
    • (1990) J Surg Res , vol.49 , pp. 186-196
    • Fink, M.P.1    Heard, S.O.2
  • 27
    • 33746774247 scopus 로고    scopus 로고
    • Nakagawa NK, Nogueira RA, Correia CJ, Shiwa SR, Cruz JWMC, Poli de Figueiredo LF, Rocha e Silva M, Sannomiya P: Leukocyte-endothelium interactions after hemorrhagic shock/reperfusion and cecal ligation/puncture: an intravital microscopic study in rat mesentery. Shock 26:180-186, 2006.
    • Nakagawa NK, Nogueira RA, Correia CJ, Shiwa SR, Cruz JWMC, Poli de Figueiredo LF, Rocha e Silva M, Sannomiya P: Leukocyte-endothelium interactions after hemorrhagic shock/reperfusion and cecal ligation/puncture: an intravital microscopic study in rat mesentery. Shock 26:180-186, 2006.
  • 28
    • 34347227828 scopus 로고    scopus 로고
    • In vivo observation of mesenteric leukocyte-endothelial interactions after cecal ligation/puncture and surgical sepsis source control
    • Nakagawa NK, Jukemura J, Aikawa P, Nogueira RA, Poli-de-Figueiredo LF, Sannomiya P: In vivo observation of mesenteric leukocyte-endothelial interactions after cecal ligation/puncture and surgical sepsis source control. Clinics 62(3):321-326, 2007.
    • (2007) Clinics , vol.62 , Issue.3 , pp. 321-326
    • Nakagawa, N.K.1    Jukemura, J.2    Aikawa, P.3    Nogueira, R.A.4    Poli-de-Figueiredo, L.F.5    Sannomiya, P.6
  • 30
    • 0018964280 scopus 로고
    • Sepsis and septic shock - a review of laboratory models and a proposal
    • Wicherman KA, Baue AE, Chaudry IH: Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 29:189-201, 1980.
    • (1980) J Surg Res , vol.29 , pp. 189-201
    • Wicherman, K.A.1    Baue, A.E.2    Chaudry, I.H.3
  • 31
    • 0024593749 scopus 로고
    • Hyper and hypodynamic models of sepsis in guinea pigs
    • Durkot MJ, Wolfe RR: Hyper and hypodynamic models of sepsis in guinea pigs. J Surg Res 46:118-122, 1989.
    • (1989) J Surg Res , vol.46 , pp. 118-122
    • Durkot, M.J.1    Wolfe, R.R.2
  • 35
    • 0035152225 scopus 로고    scopus 로고
    • Experimental models of gram-negative sepsis
    • Parker SJ, Watkins PE: Experimental models of gram-negative sepsis. Br J Surg 88:22-30, 2001.
    • (2001) Br J Surg , vol.88 , pp. 22-30
    • Parker, S.J.1    Watkins, P.E.2
  • 37
    • 0022376757 scopus 로고
    • Evaluation of cardiac output, total peripheral resistance, and plasma concentration of vasopressin in the conscious unrestrained rat during endotoxemia
    • Brackett DJ, Schaefer CF, Tompkins P, Fagraeus L, Peters U, Wilson MF: Evaluation of cardiac output, total peripheral resistance, and plasma concentration of vasopressin in the conscious unrestrained rat during endotoxemia. Circ Shock 17:273-284, 1985.
    • (1985) Circ Shock , vol.17 , pp. 273-284
    • Brackett, D.J.1    Schaefer, C.F.2    Tompkins, P.3    Fagraeus, L.4    Peters, U.5    Wilson, M.F.6
  • 38
    • 0024636499 scopus 로고
    • Septic hemodynamics produced by infusion of endotoxin
    • Johnston TD, Hampton WW, Fry DE: Septic hemodynamics produced by infusion of endotoxin. Curr Surg 46:101-103, 1989.
    • (1989) Curr Surg , vol.46 , pp. 101-103
    • Johnston, T.D.1    Hampton, W.W.2    Fry, D.E.3
  • 39
    • 0032700430 scopus 로고    scopus 로고
    • The 21-aminosteroid U74389G enhances hepatic blood flow and preserves sinusoidal endothelial cell function and structure in endotoxin-shocked dogs
    • Spapen H, Zhang H, Wisse E, Baekeland M, Seynaeve C, Eddouks M, Vincent JL: The 21-aminosteroid U74389G enhances hepatic blood flow and preserves sinusoidal endothelial cell function and structure in endotoxin-shocked dogs. J Surg Res 86:183-191, 1999.
    • (1999) J Surg Res , vol.86 , pp. 183-191
    • Spapen, H.1    Zhang, H.2    Wisse, E.3    Baekeland, M.4    Seynaeve, C.5    Eddouks, M.6    Vincent, J.L.7
  • 40
    • 0032841352 scopus 로고    scopus 로고
    • Clinical gram-positive sepsis: Does it fundamentally differ from gram-negative bacterial sepsis?
    • Opal SM, Cohen J: Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis? Crit Care Med 27:1608-1616, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 1608-1616
    • Opal, S.M.1    Cohen, J.2
  • 42
    • 0029365750 scopus 로고
    • Effect of a recombinant human granulocyte colony-stimulating factor on hemodynamic and response in a porcine model of Pseudomonas sepsis
    • Haberstroh J, Breuer H, Lucke I, Massarrat K, Fruh R, Mand U, Hagedorn P, Brunnberg L, von Specht BU: Effect of a recombinant human granulocyte colony-stimulating factor on hemodynamic and response in a porcine model of Pseudomonas sepsis. Shock 4:216-224, 1995.
    • (1995) Shock , vol.4 , pp. 216-224
    • Haberstroh, J.1    Breuer, H.2    Lucke, I.3    Massarrat, K.4    Fruh, R.5    Mand, U.6    Hagedorn, P.7    Brunnberg, L.8    von Specht, B.U.9
  • 44
    • 52649166829 scopus 로고    scopus 로고
    • Rocha e Silva M: Gas tonometry for gastrointestinal mucosal perfusion: experimental models of trauma, shock, and complex surgical maneuvers. Part 1
    • Poli de Figueiredo LF, Silva E, Cruz RJ Jr, Rocha e Silva M: Gas tonometry for gastrointestinal mucosal perfusion: experimental models of trauma, shock, and complex surgical maneuvers. Part 1. Acta Cir Bras 17(4):211-219, 2002.
    • (2002) Acta Cir Bras , vol.17 , Issue.4 , pp. 211-219
    • Poli de Figueiredo, L.F.1    Silva, E.2    Cruz Jr, R.J.3
  • 45
    • 33646714046 scopus 로고    scopus 로고
    • Rocha e Silva M: Gas tonometry for gastrointestinal mucosal perfusion: experimental and clinical sepsis. Part 2
    • Silva E, Poli de Figueiredo LF, Cruz RJ Jr, Rocha e Silva M: Gas tonometry for gastrointestinal mucosal perfusion: experimental and clinical sepsis. Part 2. Acta Cir Bras 17(5):281-287, 2002.
    • (2002) Acta Cir Bras , vol.17 , Issue.5 , pp. 281-287
    • Silva, E.1    Poli de Figueiredo, L.F.2    Cruz Jr, R.J.3
  • 46
    • 0032896706 scopus 로고    scopus 로고
    • Persistent gastric intramucosal ischemia in patients with sepsis following resuscitation from shock
    • Oud L, Haupt MT: Persistent gastric intramucosal ischemia in patients with sepsis following resuscitation from shock. Chest 115:1390-1396, 1999.
    • (1999) Chest , vol.115 , pp. 1390-1396
    • Oud, L.1    Haupt, M.T.2
  • 47
    • 0031849680 scopus 로고    scopus 로고
    • Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients
    • Doig CJ, Sutherland LR, Sandham JD, Fick GIL, Verhoef M, Meddings JB: Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 158:444-451, 1998.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 444-451
    • Doig, C.J.1    Sutherland, L.R.2    Sandham, J.D.3    Fick, G.I.L.4    Verhoef, M.5    Meddings, J.B.6
  • 48
    • 0029937134 scopus 로고    scopus 로고
    • Sepsis/septic shock: Participation of the microcirculation: an abbreviated review
    • Hinshaw LB: Sepsis/septic shock: participation of the microcirculation: an abbreviated review. Crit Care Med 24:1072-1078, 1996.
    • (1996) Crit Care Med , vol.24 , pp. 1072-1078
    • Hinshaw, L.B.1
  • 49
    • 0021369066 scopus 로고
    • A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans
    • Shaw JH, Wolfe RR: A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans. Surgery 95:553-561, 1984.
    • (1984) Surgery , vol.95 , pp. 553-561
    • Shaw, J.H.1    Wolfe, R.R.2
  • 50
    • 0018830102 scopus 로고
    • Fibrin in peritonitis. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis
    • Ahrenholz DH, Simmons RL: Fibrin in peritonitis. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis. Surgery 88:41-47, 1980.
    • (1980) Surgery , vol.88 , pp. 41-47
    • Ahrenholz, D.H.1    Simmons, R.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.