Systemic blockade of complement C5a receptors reduces lipopolysacharride-induced responses in the paraventricular nucleus and the central amygdala

Neuroscience Letters

Volumn 424, Issue 1, 2007, Pages 10-15

  Crane, James W ^a   Buller, Kathryn M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Central amygdala; Complement C5a; Hypothalamic pituitary adrenal axis; Lipopolysaccharide; Paraventricular nucleus; PMX53

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT INHIBITOR; CORTICOTROPIN RELEASING FACTOR; LIPOPOLYSACCHARIDE; PMX 53; PROTEIN FOS; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MEDULLA OBLONGATA; NERVE CELL; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SOLITARY TRACT NUCLEUS; STRIA TERMINALIS; THALAMUS MIDLINE NUCLEUS; UPREGULATION;

AMYGDALA; ANIMALS; COMPLEMENT C5A; CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; NEUROIMMUNOMODULATION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTOR, ANAPHYLATOXIN C5A;

EID: 34548009138     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.07.012     Document Type: Article

References (50)

1. Asan E. Comparative single and double immunolabelling with antisera against catecholamine biosynthetic enzymes: criteria for the identification of dopaminergic, noradrenergic and adrenergic structures in selected rat brain areas. Histochemistry 99 (1993) 427-442
2. Berkenbosch F., Oers J.V., Rey A.D., Tilders F., and Besedovsky H. Corticotropin-releasing factor producing neurons in the rat activated by interleukin-1. Science 238 (1987) 524-526
3. Blatteis C.M., Li S., Li Z., Perlik V., and Feleder C. Signaling the brain in systemic inflammation: the role of complement. Front. Biosci. 9 (2004) 915-931
4. Buller K.M., Xu Y., Dayas C.V., and Day T.A. Dorsal and ventral medulla catecholamine cell groups contribute differentially to HPA axis responses to systemic interleukin-1β. Neuroendocrinology 73 (2001) 129-138
5. Buller K.M., Xu Y., and Day T.A. Indomethacin attenuates oxytocin and hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1β. J. Neuroendocrinol. 10 (1998) 519-528
6. Cavaillon J.-M., Fitting C., and Haeffner-Cavaillon N. Recombinant C5a enhances interleukin-1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages. Eur. J. Immunol. 20 (1990) 253-257
7. Crane J.W., Buller K.M., and Day T.A. Evidence that the bed nucleus of the stria terminalis contributes to the modulation of hypophysiotropic corticotropin-releasing factor cell responses to systemic interleukin-1. J. Comp. Neurol. 467 (2003) 232-242
8. Cunningham Jr. E.T., and Sawchenko P.E. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J. Comp. Neurol. 274 (1988) 60-76
9. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann. N.Y. Acad. Sci. 933 (2001) 222-234
10. Ericsson A., Kovacs K.J., and Sawchenko P.E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14 (1994) 897-913
11. Fallon J.H., Koziell D.A., and Moore R.Y. Catecholamine innervation of the basal forebrain. II. Amygdala, suprarhinal cortex and entorhinal cortex. J. Comp. Neurol. 180 (1978) 509-532
12. Farkas I., Takahashi M., Fukuda A., Yamamoto N., Akatsu H., Baranyi L., Tateyama H., Yamamoto T., Okada N., and Okada H. Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. J. Immunol. 170 (2003) 5764-5771
13. Finch A.M., Wong A.K., Paczkowski N.J., Wadi S.K., Craik D.J., Fairlie D.P., and Taylor S.M. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J. Med. Chem. 42 (1999) 1965-1974
14. Freudenberg M.A., and Galanos C. Interaction of lipopolysaccharides and lipid A with complement in rats and its relation to endotoxicity. Infect. Immunol. 19 (1978) 875-882
15. Givalois L., Dornand J., Mekaouche M., Solier M.D., Bristow A.F., Ixart G., Siaud I., Assenmacher I., and Barbanel G. Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats. Am. J. Physiol. 267 (1994) R164-R170
16. Guo R.-F., and Ward P.A. Role of C5a in inflammatory responses. Annu. Rev. Immunol. 23 (2005) 821-852
17. Hare A.S., Clarke G., and Tolchard S. Bacterial lipopolysaccharide-induced changes in FOS protein expression in the rat brain: correlation with thermoregulatory changes and plasma corticosterone. J. Neuroendocrinol. 7 (1995) 791-799
18. Haynes D.R., Harkin D.G., Bignold L.P., Hutchens M.J., Taylor S.M., and Fairlie D.P. Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist. Biochem. Pharmacol. 60 (2000) 729-733
19. Hermann G.E., Emch G.S., Tovar C.A., and Rogers R.C. c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve. Am. J. Physiol. 280 (2001) R289-R299
20. Ju G., Swanson L.W., and Simerly R.B. Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat. II. Chemoarchitecture. J. Comp. Neurol. 280 (1989) 603-621
21. Kalin N.H., Shelton S.E., and Davidson R.J. The role of the central nucleus of the amygdala in mediating fear and anxiety in the primate. J. Neurosci. 24 (2004) 5506-5515
22. Kovacs K.J. c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochem. Int. 33 (1998) 287-297
23. Lacroix S., and Rivest S. Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins. J. Comp. Neurol. 387 (1997) 307-324
24. LeDoux J.E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23 (2000) 155-184
25. Nataf S., Stahel P.F., Davoust N., and Barnum S.R. Complement anaphylatoxin receptors on neurons: new tricks for old receptors?. Trends Neurosci. 22 (1999) 397-402
26. O'Barr S.A., Caguioa J., Gruol D., Perkins G., Ember J.A., Hugli T., and Cooper N.R. Neuronal expression of a functional receptor for the C5a complement activation fragment. J. Immunol. 166 (2001) 4154-4162
27. Okusawa S., Yancey K.B., van der Meer J.W., Endres S., Lonnemann G., Hefter K., Frank M.M., Burke J.F., Dinarello C.A., and Gelfand J.A. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha. J. Exp. Med. 168 (1988) 443-448
28. Osaka H., McGinty A., Hoepken U.E., Lu B., Gerard C., and Pasinetti G.M. Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration. Neuroscience 88 (1999) 1073-1082
29. Palkovitz M., Mezey E., Skirboli L.R., and Hokfelt T. Adrenergic projections from the lower brainstem to the hypothalamic paraventricular nucleus, the lateral hypothalamic area and the central nucleus of the amygdala in rats. J. Chem. Neuroanat. 5 (1992) 407-415
30. Pare D., Quirk G.J., and LeDoux J.E. New vistas on amygdala networks in conditioned fear. J. Neurophysiol. 92 (2004) 1-9
31. Riedemann N.C., Guo R.F., and Ward P.A. Novel strategies for the treatment of sepsis. Nat. Med. 9 (2003) 517-524
32. Rivest S., and Rivier C. Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by physical stress or interleukin. Endocrinology 129 (1991) 2049-2057
33. Romanovsky A.A., Simons C.T., Szekely M., and Kulchitsky V.A. The vagus nerve in the thermoregulatory response to systemic inflammation. Am. J. Physiol. 273 (1997) R407-R413
34. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., and Vale W.W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238 (1987) 522-524
35. Schindler R., Gelfand J.A., and Dinarello C.A. Recombinant C5a stimulates transcription ofrather than translation of interleukin-1 (IL-1β) and tumor necrosis factor: translation signal provided by lipopolysacharride or IL-1β itself. Blood 76 (1990) 1631-1638
36. Smith D.W., and Day T.A. Neurochemical identification of fos-positive neurons using two-colour immunoperoxidase staining. J. Neurosci. Methods 47 (1993) 73-83
37. Strachan A.J., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. Br. J. Pharmacol. 134 (2001) 1778-1786
38. Strachan A.J., Woodruff T.M., Haaima G., Fairlie D.P., and Taylor S.M. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. J. Immunol. 164 (2000) 6560-6565
39. Tilders F.J.H., De Rijk R.H., Van Dam A.-M., Vincent V.A., Schotanus K., and Persoons J.H.A. Activation of the hypothalamus-pituitary-adrenal axis by bacterial endotoxins: routes and intermediate signals. Psychoneuroendocrinology 19 (1994) 209-232
40. Tolchard S., Hare A.S., Nutt D.J., and Clarke G. TNF alpha mimics the endocrine but not the thermoregulatory responses of bacterial lipopolysaccharide (LPS): correlation with FOS-expression in the brain. Neuropharmacology 35 (1996) 243-248
41. Turnbull A.V., and Rivier C. Regulation of the HPA axis by cytokines. Brain Behav. Immun. 9 (1995) 253-275
42. Uehara A., Gottschall P.E., Dahl R.R., and Arimura A. Interleukin-1 stimulates ACTH release by an indirect mechanism which requires endogenous corticotropin releasing factor. Endocrinology 121 (1987) 1580-1582
43. Ward P.A. The dark side of C5a in sepsis. Nat. Rev. Immunol. 4 (2004) 133-142
44. Weidenfeld J., Itzik A., Goshen I., Yirmiya R., and Ben-Hur T. Role of the central amygdala in modulating the pituitary-adrenocortical and clinical responses in experimental herpes simplex virus-1 encephalitis. Neuroendocrinology 81 (2005) 267-272
45. Woodruff T.M., Arumugam T.V., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. J. Immunol. 171 (2003) 5514-5520
46. Woodruff T.M., Arumugam T.V., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats. J. Surg. Res. 116 (2004) 81-90
47. Woodruff T.M., Strachan A.J., Dryburgh N., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis Rheum. 46 (2002) 2476-2485
48. Woodruff T.M., Crane J.W., Proctor L.M., Buller K.M., Shek A.B., de Vos K., Pollitt S., Williams H.M., Shiels I.A., Monk P.N., and Taylor S.M. Complement C5a receptor antagonists protect against striatal degeneration in a rat model of Huntington's disease. FASEB J. 20 (2006) 1407-1417
49. Xu Y., Day T.A., and Buller K.M. The central amygdala modulates hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1beta administration. Neuroscience 94 (1999) 175-183
50. Zhang Y.H., Lu J., Elmquist J.K., and Saper C.B. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J. Comp. Neurol. 463 (2003) 3-12