Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

Biochemical Pharmacology

Volumn 77, Issue 7, 2009, Pages 1273-1282

  Reisman, Scott A ^a   Aleksunes, Lauren M ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Hepatoprotection; Nrf2; Oleanolic acid; Oxidative stress

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MESSENGER RNA; METALLOTHIONEIN; OLEANOLIC ACID; PARACETAMOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE INDUCTION; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETAMINOPHEN; ANIMALS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2 TRANSCRIPTION FACTOR; OLEANOLIC ACID;

EID: 61449208761     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.12.028     Document Type: Article

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