The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay

Molecular Immunology

Volumn 35, Issue 18, 1998, Pages 1161-1170

  Pisetsky, David S ^a   Reich III, Charles F ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anti DNA; Antigenicity; Oligonucleotides; Phosphorothioates

Indexed keywords

DNA; DNA ANTIBODY; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANTIGEN BINDING; ANTIGENICITY; ARTICLE; IMMUNOASSAY; IMMUNOGENICITY; NUCLEIC ACID STRUCTURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN NUCLEIC ACID INTERACTION; SEQUENCE ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; BASE SEQUENCE; BINDING SITES, ANTIBODY; CATTLE; DNA, SINGLE-STRANDED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; OLIGONUCLEOTIDES, ANTISENSE; THIONUCLEOTIDES; THYMUS GLAND;

BACTERIA (MICROORGANISMS);

EID: 0032469771     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(98)00108-4     Document Type: Article

References (33)

1. Ali, R., Dersimonian, H., Stollar B.D., 1985. Binding of monoclonal anti-native DNA autoantibodies to DNA of varying size and conformation. Molec. Immunol. 22, 1415-1422.
2. Braun, R.P., Lee, J.S., 1988. Immunogenic duplex nucleic acids are nuclease resistant. J. Immunol. 141, 2084-2089.
3. Brown, D.A., Kang, S.-H., Gryaznov, S.M., DeDionisio, L., Heidenreich, O., Sullivan, S., Xu, X, Nerenberg, M.I., 1994. Effect of phosphorothioate modification of oligodeoxynucleotides on specific-protein binding. J. Biol. Chem. 269, 26801-26805.
4. Casperson, G.F., Voss, E.W. Jr., 1983. Specificity of anti-DNA antibodies in SLE-I. Definition and gross specificity of antibody populations in human SLE plasma. Molec. Immunol. 20, 573-580.
5. Eilat, D., Anderson, W.F., 1994. Structure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies. Mol. Immunol. 31, 1377-1390.
6. Frey, P.A., Sammons, R.D., 1985. Bond order and charge localization in nucleoside phosphorothioates. Science 228, 541-545.
7. Guvakova, M.A., Yakubov, L.A., Vlodavsky, I., Tonkinson, J.L., Stein, C.A., 1995. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J. Biol. Chem. 270, 2620-2627.
8. Herrmann, M., Winkler, T.H., Fehr, H., Kalden, J.R., 1995. Preferential recognition of specific DNA motifs by anti-double-stranded DNA autoantibodies. Eur. J. Immunol. 25, 1897-1904.
9. Iyengar, R., Eckstein, F., Frey, P.A., 1984. Phosphorus - oxygen bond order in adenosine 5′-o-phosphorothioate dianion. J. Am. Chem. Soc. 106, 8309-8310.
10. Klinman, D.M., Yi, A.-K., Beaucage, S.L., Conover, J., Kreig, A.M., 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. U.S.A. 93, 2879-2883.
11. Krieg, A.M., Yi, A.-K., Matson, S., Waldschmidt, T.J., Bishop, G.A., Teasdale, R., Koretzky, G.A., Klinman, D.M., 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549.
12. Latimer, L.J., Agazie, Y.M., Braun, R.P., Hampel, K.J., Lee, J.S., 1995. Specificity of monoclonal antibodies produced against phosphorothioate and ribo modified DNAs. Molec. Immunol. 32, 1057-1064.
13. Lipford, G.B., Bauer, M., Blank, C., Reiter, R., Wagner, H., Heeg, K., 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine and adjuvants. Eur. J. Immunol. 27, 2340-2344.
14. Milligan, J.F., Matteucci, M.D., Martin, J.C., 1993. Current concepts in antisense drug design. J. Med. Chem. 36, 1923-1937.
15. Papalian, M., Lafer, E., Wong, R., Stollar, B.D., 1980. Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20-1200 base pairs. J. Clin. Invest. 65, 469-477.
16. Perez, J.R., Li, Y., Stein, C.A., Majumder, S., Van Oorschot, A., Narayanan, R., 1994. Sequence-independent induction of Sp1 transcription factor activity by phosporothioate oligodeoxynucleotides. Proc. Natl. Acad. Sci. U.S.A. 91, 5957-5961.
17. Pisetsky, D.S., 1992. Anti-DNA antibodies in systemic lupus erythematosus. Rheum. Dis. Clin. N. A. 18, 437-454.
18. Pisetsky, D.S., 1996a. Immune activation by bacterial DNA: a new genetic code. Immunity 5, 303-310.
19. Pisetsky, D.S., 1996b. The immunologic properties of DNA. J. Immunol. 156, 421-423.
20. Pisetsky, D.S., Reich, C.F., 1994a. Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. Life Sci. 54, 101-107.
21. Pisetsky, D.S., Reich, C.F., 1994b. The influence of DNA size on the binding of anti-DNA antibodies in the solid and fluid phase. Clin. Immunol. Immunopath. 72, 350-356.
22. Pisetsky, D.S., Reich, C., 1993. Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. Molec. Biol. Rep. 18, 217-221.
23. Sano, H., Takai, O., Harata, N., Yoshinaga, K., Kodama-Kamada, I., Sasaki, T., 1989. Binding properties of human anti-DNA antibodies to cloned human DNA fragments. Scand. J. Immunol. 30, 51-63.
24. Shoeman, R.L., Hartig, R., Huang, Y., Grub, S., Traub, P., 1997. Fluorescence microscopic comparison of the binding of phosphodiester and phosphorothioate (Antisense) oligodeoxyribonucleotides to subcellular structures, including intermediate filaments, the endoplasmic reticulum, and the nuclear interior. Antisense Nuc. Acid Drug Dev. 7, 291-308.
25. Stein, C.A., Cheng, Y.-C., 1993. Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261, 1004-1012.
26. Stein, C.A., Subasinghe, C., Shinozuka, K., Cohen, J.S., 1988. Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucl. Acids Res. 16, 3209-3221.
27. Stollar, B.D., 1994. Molecular analysis of anti-DNA antibodies. FASEB J. 8, 337-342.
28. Stollar, D., Levine, L., Marmur, J., 1962. Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. II. Characterization of antibodies in several sera. Biochim. Biophys. Acta, 61, 7-18.
29. Stollar, B.D., Zon, G., Pastor, R.W., 1986. A recognition site on synthetic helical oligonucleotides for monoclonal anti-native DNA autoantibody. Proc. Natl. Acad. Sci. U.S.A. 83, 4469-4473.
30. Swanson, P.C., Ackroyd, C., Glick, G.D., 1996. Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding. Biochem. 35, 1624-1633.
31. Wagner, R.W., 1994. Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333-335.
32. Wagner, R.W., 1995. The state of the art in antisense research. Nature Med. 1, 1116-1118.
33. Zhao, Q., Temsamani, J., Iadarola, P.L., Jiang, Z., Agrawal, S., 1996. Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem. Pharm. 51, 173-182.