IGF signaling pathway as a selective target of familial breast cancer therapy

Current Molecular Medicine

Volumn 8, Issue 8, 2008, Pages 727-740

  Shukla, Vivek ^a   Coumoul, Xavier ^b   Vassilopoulos, Athanassios ^a   Deng, Chu Xia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b INSERM   (France)

Author keywords

BRCA1; IGF IGF receptor; Inhibitor; Mouse model; SiRNA

Indexed keywords

3 BROMO 5 TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; AG 1034; AVE 1642; BMS 55417; BRCA1 PROTEIN; BRCA2 PROTEIN; CETUXIMAB; CP 751871; EXEMESTANE; GROWTH HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; INSM 18; INSULIN RECEPTOR SUBSTRATE 1; JV 1 36; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 19D12; MONOCLONAL ANTIBODY A12; MONOCLONAL ANTIBODY A2CHM; PEGVISOMANT; PROTEIN TYROSINE KINASE INHIBITOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; TAMOXIFEN; TYRPHOSTIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; PROTEIN KINASE INHIBITOR;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CLINICAL TRIAL; DISEASE MODEL; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; FAMILIAL CANCER; FAMILY HISTORY; GENE MUTATION; HUMAN; MALIGNANT TRANSFORMATION; METASTASIS; NONHUMAN; PROSTATE CANCER; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECURRENT CANCER; REVIEW; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; ANIMAL; BIOLOGICAL MODEL; BREAST TUMOR; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; GENETICS; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; FEMALE; GENES, BRCA1; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MODELS, BIOLOGICAL; PROTEIN KINASE INHIBITORS; RECEPTORS, SOMATOMEDIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SOMATOMEDINS;

EID: 59249095830     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652408786733694     Document Type: Review

References (190)

1. Lynch, H.T., Silva, E., Snyder, C. and Lynch, J.F. (2007) Breast J., 14, 3-13.
2. Roukos, D.H. and Briasoulis, E. (2007) Nat. Clin. Pract. Oncol., 4, 578-590.
3. Silva, E., Gatalica, Z., Snyder, C., Vranic, S., Lynch, J.F. and Lynch, H.T. (2007) Breast J., 14, 14-24.
4. Brody, L.C. and Biesecker, B.B. (1998) Medicine (Baltimore), 77, 208-226.
5. Alberg, A.J., Lam, A.P. and Helzlsouer, K.J. (1999) Curr. Opin. Oncol., 11, 435-441.
6. Eccles, D.M. and Pichert, G. (2005) Lancet Oncol., 6, 705-711.
7. Hall, J.M., Lee, M.K., Newman, B., Morrow, J.E., Anderson, L.A., Huey, B. and King, M.C. (1990) Science, 250, 1684-1689.
8. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P.A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L.M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayanth, P., Ward, J., Tonin, P., Narod, S., Bristow, P.K., Norris, F., H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J.C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A. and Skolnick, M.H. (1994) Science, 266, 66-71.
9. Easton, D.F., Pooley, K.A., Dunning, A.M., Pharoah, P.D., Thompson, D., Ballinger, D.G., Struewing, J.P., Morrison, J., Field, H., Luben, R., Wareham, N., Ahmed, S., Healey, C.S., Bowman, R., Meyer, K.B., Haiman, C.A., Kolonel, L.K., Henderson, B.E. Le., Marchand, L., Brennan, P., Sangrajrang, S., Gaborieau, V., Odefrey, F., Shen, C.Y., Wu, P.E., Wang, H.C., Eccles, D., Evans, D.G., Peto, J., Fletcher, O., Johnson, N., Seal, S., Stratton, M.R., Rahman, N., Chenevix-Trench, G., Bojesen, S.E., Nordestgaard, B.G., Axelsson, C.K., Garcia-Closas, M., Brinton, L., Chanock, S., Lissowska, J., Peplonska, B., Nevanlinna, H., Fagerholm, R., Eerola, H., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Hunter, D.J., Hankinson, S.E., Cox, D.G., Hall, P., Wedren, S., Liu, J., Low, Y.L., Bogdanova, N., Schurmann, P., Dork, T., Tollenaar, R.A., Jacobi, C.E., Devilee, P., Klijn, J.G., Sigurdson, A.J., Doody, M.M., Alexander, B.H., Zhang, J., Cox, A., Brock, I.W., MacPherson, G., Reed, M.W., Couch, F.J., Goode, E.L., Olson, J.E., Meijers-Heijboer, H., van den Ouweland, A., Uitterlinden, A., Rivadeneira, F., Milne, R.L., Ribas, G., Gonzalez-Neira, A., Benitez, J., Hopper, J.L., McCredie, M., Southey, M., Giles, G.G., Schroen, C., Justenhoven, C., Brauch, H., Hamann, U., Ko, Y.D., Spurdle, A.B., Beesley, J., Chen, X., Mannermaa, A., Kosma, V.M., Kataja, V., Hartikainen, J., et al. B.A. (2007) Nature, 447, 1087-1093.
10. Huijts, P.E., Vreeswijk, M.P., Kroeze-Jansema, K.H., Jacobi, C.E., Seynaeve, C., Krol-Warmerdam, E.M., Wijers-Koster, P.M., Blom, J.C., Pooley, K.A., Klijn, J.G., Tollenaar, R.A., Devilee, P. and van Asperen, C.J. (2007) Breast Cancer Res., 9, R78.
11. Willems, P.J. (2007) Clin. Genet., 72, 493-496.
12. Easton, D.F., Ford, D. and Bishop, D.T. (1995) Am. J. Hum. Genet., 56, 265-271.
13. Struewing, J.P., Hartge, P., Wacholder, S., Baker, S.M., Berlin, M., McAdams, M., Timmerman, M.M., Brody, L.C. and Tucker, M.A. (1997) N. Engl. J. Med., 336, 1401-1408.
14. Ford, D., Easton, D.F., Stratton, M., Narod, S., Goldgar, D., Devilee, P., Bishop, D.T., Weber, B., Lenoir, G., Chang-Claude, J., Sobol, H., Teare, M.D., Struewing, J., Arason, A., Scherneck, S., Peto, J., Rebbeck, T.R., Tonin, P., Neuhausen, S., Barkardottir, R., Eyfjord, J., Lynch, H., Ponder, B.A., Gayther, S.A., Zelada-Hedman, M. and the Breast Cancer Linkage Consortium. (1998) Am. J. Hum. Genet., 62, 676-689.
15. Marshall, M. and Solomon, S. (2007) Plast. Surg. Nurs., 27, 124-127.
16. Brodie, S.G. and Deng, C.X. (2001) Trends. Genet., 17, S18-22.
17. Brodie, S.G., Xu, X., Qiao, W., Li, W.M., Cao, L. and Deng, C.X. (2001) Oncogene, 20, 7514-7523.
18. Samani, A.A., Yakar, S., LeRoith, D. and Brodt, P. (2007) Endocr. Rev., 28, 20-47.
19. Riedemann, J. and Macaulay, V.M. (2006) Endocr. Relat. Cancer, 13(Suppl 1), S33-43.
20. Daughaday, W.H. (1989) Perspect. Biol. Med., 32, 194-211.
21. Daughaday, W.H., Hall, K., Salmon, W.D.Jr., Van den Brande, J.L. and Van Wyk, J.J. (1987) J. Clin. Endocrinol. Metab., 65, 1075-1076.
22. Terasawa, H., Kohda, D., Hatanaka, H., Nagata, K., Higashihashi, N., Fujiwara, H., Sakano, K. and Inagaki, F. (1994) EMBO J., 13, 5590-5597.
23. Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J. and de Vos, A.M. (2001) Biochemistry, 40, 11022-11029.
24. DeChiara, T.M., Efstratiadis, A. and Robertson, E.J. (1990) Nature, 345, 78-80.
25. Liu, J.P., Baker, J., Perkins, A.S., Robertson, E.J. and Efstratiadis, A. (1993) Cell, 75, 59-72.
26. Walenkamp, M.J., Karperien, M., Pereira, A.M., Hilhorst-Hofstee, Y., van Doorn, J., Chen, J.W., Mohan, S., Denley, A., Forbes, B., van Duyvenvoorde, H.A., van Thiel, S.W., Sluimers, C.A., Bax, J.J., de Laat, J.A., Breuning, M.B., Romijn, J.A. and Wit, J.M. (2005) J. Clin. Endocrinol. Metab., 90, 2855-2864.
27. Sara, V.R. and Hall, K. (1990) Physiol. Rev., 70, 591-614.
28. Allan, G.J., Flint, D.J. and Patel, K. (2001) Reproduction, 122, 31-39.
29. Nakae, J., Kido, Y. and Accili, D. (2001) Endocr. Rev., 22, 818-835.
30. Rubin, J.B., Shia, M.A. and Pilch, P.F. (1983) Nature, 305, 438-440.
31. Ullrich, A., Gray, A., Tam, A.W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kathuria, S., Chen, E., Jacobs, S., Francke, U., Ramchandran, J. and Fujita-Yamaguchi, Y. (1986) EMBO J., 5, 2503-2512.
32. Morgan, D.O., Edman, J.C., Standring, D.N., Fried, V.A., Smith, M.C., Roth, R.A. and Rutter, W.J. (1987) Nature, 329, 301-307.
33. Kornfeld, S. (1992) Annu. Rev. Biochem., 61, 307-330.
34. Soos, M.A. and Siddle, K. (1989) Biochem. J., 263, 553-563.
35. Treadway, J.L., Morrison, B.D., Goldfine, I.D. and Pessin, J.E. (1989) J. Biol. Chem., 264, 21450-21453.
36. Denley, A., Cosgrove, L.J., Booker, G.W., Wallace, J.C. and Forbes, B.E. (2005) Cytokine. Growth Factor Rev., 16, 421-439.
37. Laviola, L., Natalicchio, A. and Giorgino, F. (2007) Curr. Pharm. Des., 13, 663-669.
38. D'Ercole, A.J. (1996) Endocrinol. Metab. Clin. North Am., 25, 573-590.
39. Frystyk, J. (2004) Growth Horm. IGF Res., 14, 337-375.
40. Jones, J.I. and Clemmons, D.R. (1995) Endocr. Rev., 16, 3-34.
41. Laursen, L.S., Kjaer-Sorensen, K., Andersen, M.H. and Oxvig, C. (2007) Mol. Endocrinol., 21, 1246-1257.
42. Moralez, A.M., Maile, L.A., Clarke, J., Busby, W.H. Jr. and Clemmons, D.R. (2005) J. Cell, Physiol., 203, 328-334.
43. Mishra, S. and Murphy, L.J. (2003) Endocrinology, 144, 4042-4050.
44. Fu, P., Thompson, J.A. and Bach, L.A. (2007) J. Biol. Chem., 282, 22298-22306.
45. Kato, H., Faria, T.N., Stannard, B., Roberts, C.T. Jr. and LeRoith, D. (1994) Mol. Endocrinol., 8, 40-50.
46. Hongo, A., D'Ambrosio, C., Miura, M., Morrione, A. and Baserga, R. (1996) Oncogene, 12, 1231-1238.
47. Hermanto, U., Zong, C.S. and Wang, L.H. (2000) Cell Growth Differ., 11, 655-664.
48. Grey, A., Chen, Q., Xu, X., Callon, K. and Cornish, J. (2003) Endocrinology, 144, 4886-4893.
49. Rommel, C., Clarke, B.A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G.D. and Glass, D.J. (1999) Science, 286, 1738-1741.
50. Zong, C.S., Zeng, L., Jiang, Y., Sadowski, H.B. and Wang, L.H. (1998) J. Biol. Chem., 273, 28065-28072.
51. Beitner-Johnson, D., Blakesley, V.A., Shen-Orr, Z., Jimenez, M., Stannard, B., Wang, L.M., Pierce, J. and LeRoith, D. (1996) J. Biol. Chem., 271, 9287-9290.
52. Dey, B.R., Frick, K., Lopaczynski, W., Nissley, S.P. and Furlanetto, R.W. (1996) Mol. Endocrinol., 10, 631-641.
53. Seely, B.L., Reichart, D.R., Staubs, P.A., Jhun, B.H., Hsu, D., Maegawa, H., Milarski, K.L., Saltiel, A.R. and Olefsky, J.M. (1995) J. Biol. Chem., 270, 19151-19157.
54. Buckley, D.A., Cheng, A., Kiely, P.A., Tremblay, M.L. and O'Connor, R. (2002) Mol. Cell, Biol., 22, 1998-2010.
55. Akekawatchai, C., Holland, J.D., Kochetkova, M., Wallace, J.C. and McColl, S.R. (2005) J. Biol. Chem., 280, 39701-39708.
56. Dufourny, B., Alblas, J., van Teeffelen, H.A., van Schaik, F.M., van der Burg, B., Steenbergh, P.H. and Sussenbach, J.S. (1997) J. Biol. Chem., 272, 31163-31171.
57. Brisken, C., Ayyannan, A., Nguyen, C., Heineman, A., Reinhardt, F., Tan, J., Dey, S.K., Dotto, G.P. and Weinberg, R.A. (2002) Dev. Cell, 3, 877-887.
58. Kalluri, H.S., Vemuganti, R. and Dempsey, R.J. (2007) Eur. J. Neurosci., 25, 1041-1048.
59. Yang, W., Zhang, Y., Li, Y., Wu, Z. and Zhu, D. (2007) J. Biol. Chem., 282, 3799-3808.
60. Diehl, J.A., Cheng, M., Roussel, M.F. and Sherr, C.J. (1998) Genes Dev., 12, 3499-3511.
61. Muise-Helmericks, R.C., Grimes, H.L., Bellacosa, A., Malstrom, S.E., Tsichlis, P.N. and Rosen, N. (1998) J. Biol. Chem., 273, 29864-29872.
62. Dufourny, B., van Teeffelen, H.A., Hamelers, I.H., Sussenbach, J.S. and Steenbergh, P.H. (2000) J. Endocrinol., 166, 329-338.
63. Hamelers, I.H., van Schaik, R.F., Sipkema, J., Sussenbach, J.S. and Steenbergh, P.H. (2002) J. Biol. Chem., 277, 47645-47652.
64. Dupont, J., Pierre, A., Froment, P. and Moreau, C. (2003) Horm. Metab. Res., 35, 740-750.
65. Medema, R.H., Kops, G.J., Bos, J.L. and Burgering, B.M. (2000) Nature, 404, 782-787.
66. Fujita, N., Sato, S., Katayama, K. and Tsuruo, T. (2002) J. Biol. Chem., 277, 28706-28713.
67. Adesanya, O.O., Zhou, J., Samathanam, C., Powell-Braxton, L. and Bondy, C.A. (1999) Proc. Natl. Acad. Sci. USA, 96, 3287-3291.
68. Stromberg, T., Ekman, S., Gimita, L., Dimberg, L.Y., Larsson, O., Axelson, M., Lennartsson, J., Hellman, U., Carlson, K., Osterborg, A., Vanderkerken, K., Nilsson, K. and Jernberg-Wiklund, H. (2006) Blood, 107, 669-678.
69. Varela-Nieto, I., Hartl, M., Gorospe, I. and Leon, Y. (2007) Curr. Pharm. Des., 13, 687-703.
70. Tu, W., Cheung, P.T. and Lau, Y.L. (2000) J. Immunol., 165, 1331-1336.
71. Zheng, W.H., Kar, S. and Quirion, R. (2002) Mol. Pharmacol., 62, 225-233.
72. Feldser, D., Agani, F., Iyer, N.V., Pak, B., Ferreira, G. and Semenza, G.L. (1999) Cancer Res., 59, 3915-3918.
73. Zelzer, E., Levy, Y., Kahana, C., Shilo, B.Z., Rubinstein, M. and Cohen, B. (1998) EMBO J. 17, 5085-5094.
74. Shigematsu, S., Yamauchi, K., Nakajima, K., Iijima, S., Aizawa, T. and Hashizume, K. (1999) Endocr. J., 46(Suppl), S59-62.
75. Fukuda, R., Hirota, K., Fan, F., Jung, Y.D., Ellis, L.M. and Semenza, G.L. (2002) J. Biol. Chem., 277, 38205-38211.
76. Bjorndahl, M., Cao, R., Nissen, L.J., Clasper, S., Johnson, L.A., Xue, Y., Zhou, Z., Jackson, D., Hansen, A.J. and Cao, Y. (2005) Proc. Natl. Acad. Sci. USA, 102, 15593-15598.
77. Carroll, V.A. and Ashcroft, M. (2006) Cancer Res., 66, 6264-6270.
78. Guvakova, M.A., Adams, J.C. and Boettiger, D. (2002) J. Cell Sci., 115, 4149-4165.
79. Mira, E., Manes, S., Lacalle, R.A., Marquez, G. and Martinez, A.C. (1999) Endocrinology, 140, 1657-1664.
80. Dunn, S.E., Torres, J.V., Oh, J.S., Cykert, D.M. and Barrett, J.C. (2001) Cancer Res., 61, 1367-1374.
81. Zhang, D. and Brodt, P. (2003) Oncogene, 22, 974-982.
82. Zhang, D., Bar-Eli, M., Meloche, S. and Brodt, P. (2004) J. Biol. Chem., 279, 19683-19690.
83. van Golen, C.M., Schwab, T.S., Kim, B., Soules, M.E., Su Oh, S., Fung, K., van Golen, K.L. and Feldman, E.L. (2006) Cancer Res., 66, 6570-6578.
84. Ma, Z., Dong, A., Kong, M. and Qian, J. (2007) Cell Mol. Biol. Lett., 12, 556-572.
85. Kaleko, M., Rutter, W.J. and Miller, A.D. (1990) Mol. Cell Biol., 10, 464-473.
86. Sell, C., Rubini, M., Rubin, R., Liu, J.P., Efstratiadis, A. and Baserga, R. (1993) Proc. Natl. Acad. Sci. USA, 90, 11217-11221.
87. Sell, C., Dumenil, G., Deveaud, C., Miura, M., Coppola, D., DeAngelis, T., Rubin, R., Efstratiadis, A. and Baserga, R. (1994) Mol. Cell Biol., 14, 3604-3612.
88. Mantzoros, C.S., Tzonou, A., Signorello, L.B., Stampfer, M., Trichopoulos, D. and Adami, H.O. (1997) Br. J. Cancer, 76, 1115-1118.
89. Chan, J.M., Stampfer, M.J., Giovannucci, E., Gann, P.H., Ma, J., Wilkinson, P., Hennekens, C.H. and Pollak, M. (1998) Science, 279, 563-566.
90. Stuver, S.O., Kuper, H., Tzonou, A., Lagiou, P., Spanos, E., Hsieh, C.C., Mantzoros, C. and Trichopoulos, D. (2000) Int. J. Cancer, 87, 118-121.
91. Pezzino, V., Papa, V., Milazzo, G., Gliozzo, B., Russo, P. and Scalia, P.L. (1996) Ann. N.Y. Acad. Sci., 784, 189-201.
92. Ueda, S., Tsuda, H., Sato, K., Takeuchi, H., Shigekawa, T., Matsubara, O., Hiraide, H. and Mochizuki, H. (2006) Cancer Sci., 97, 597-604.
93. Shimizu, C., Hasegawa, T., Tani, Y., Takahashi, F., Takeuchi, M., Watanabe, T., Ando, M., Katsumata, N. and Fujiwara, Y. (2004) Hum. Pathol., 35, 1537-1542.
94. Chong, Y.M., Williams, S.L., Elkak, A., Sharma, A.K. and Mokbel, K. (2006) Anticancer Res., 26, 167-173.
95. Knowlden, J.M., Hutcheson, I.R., Barrow, D., Gee, J.M. and Nicholson, R.I. (2005) Endocrinology, 146, 4609-4618.
96. Bates, P., Fisher, R., Ward, A., Richardson, L., Hill, D.J. and Graham, C.F. (1995) Br. J. Cancer, 72, 1189-1193.
97. Hadsell, D.L., Murphy, K.L., Bonnette, S.G., Reece, N., Laucirica, R. and Rosen, J.M. (2000) Oncogene, 19, 889-898.
98. Yee, D., Paik, S., Lebovic, G.S., Marcus, R.R., Favoni, R.E., Cullen, K.J., Lippman, M.E. and Rosen, N. (1989) Mol. Endocrinol., 3, 509-517.
99. Paik, S. (1992) Breast Cancer Res. Treat., 22, 31-38.
100. Gebauer, G., Jager, W. and Lang, N. (1998) Anticancer Res., 18, 1191-1195.
101. Hankinson, S.E., Willett, W.C., Colditz, G.A., Hunter, D.J., Michaud, D.S., Deroo, B., Rosner, B., Speizer, F.E. and Pollak, M. (1998) Lancet, 351, 1393-1396.
102. Toniolo, P., Bruning, P.F., Akhmedkhanov, A., Bonfrer, J.M., Koenig, K.L., Lukanova, A., Shore, R.E. and Zeleniuch-Jacquotte, A. (2000) Int. J. Cancer, 88, 828-832.
103. Allen, N.E., Roddam, A.W., Allen, D.S., Fentiman, I.S., Dos Santos Silva, I., Peto, J., Holly, J.M. and Key, T.J. (2005) Br. J. Cancer, 92, 1283-1287.
104. Wagner, K., Hemminki, K., Israelsson, E., Grzybowska, E., Klaes, R., Chen, B., Butkiewicz, D., Pamula, J., Pekala, W. and Forsti, A. (2005) Endocr. Relat. Cancer, 12, 917-928.
105. Cleveland, R.J., Gammon, M.D., Edmiston, S.N., Teitelbaum, S.L., Britton, J.A., Terry, M.B., Eng, S.M., Neugut, A.I., Santella, R.M. and Conway, K. (2006) Carcinogenesis, 27, 758-765.
106. Jernstrom, H., Sandberg, T., Bageman, E., Borg, A. and Olsson, H. (2005) Br. J. Cancer, 92, 857-866.
107. (2006) Int. J. Gynecol. Cancer, 16(Suppl 2), 497.
108. Figer, A., Karasik, Y.P., Baruch, R.G., Chetrit, A., Papa, M.Z., Sade, R.B., Rizel, S. and Friedman, E. (2002) Isr. Med. Assoc. J., 4, 759-762.
109. Yang, J.L., Ow, K.T., Russell, P.J., Ham, J.M. and Crowe, P.J. (1996) Ann. Surg. Oncol., 3, 574-579.
110. Pollak, M., Blouin, M.J., Zhang, J.C. and Kopchick, J.J. (2001) Br. J. Cancer, 85, 428-430.
111. Wu, Y., Cui, K., Miyoshi, K., Hennighausen, L., Green, J.E., Setser, J., LeRoith, D. and Yakar, S. (2003) Cancer Res., 63, 4384-4388.
112. Carboni, J.M., Lee, A.V., Hadsell, D.L., Rowley, B.R., Lee, F.Y., Bol, D.K., Camuso, A.E., Gottardis, M., Greer, A.F., Ho, C.P., Hurlburt, W., Li, A., Saulnier, M., Velaparthi, U., Wang, C., Wen, M.L., Westhouse, R.A., Wittman, M., Zimmermann, K., Rupnow, B.A. and Wong, T.W. (2005) Cancer Res., 65, 3781-3787.
113. Jackson, J.G., Zhang, X., Yoneda, T. and Yee, D. (2001) Oncogene, 20, 7318-7325.
114. Sachdev, D., Hartell, J.S., Lee, A.V., Zhang, X. and Yee, D. (2004) J. Biol. Chem., 279, 5017-5024.
115. Lane, T.F., Deng, C., Elson, A., Lyu, M.S., Kozak, C.A. and Leder, P. (1995) Genes Dev., 9, 2712-2722.
116. Deng, C.X. (2006) Nucleic Acids Res., 34, 1416-1426.
117. Thakur, S., Zhang, H.B., Peng, Y., Le, H., Carroll, B., Ward, T., Yao, J., Farid, L.M., Couch, F.J., Wilson, R.B. and Weber, B.L. (1997) Mol. Cell, Biol., 17, 444-452.
118. Wilson, C.A., Payton, M.N., Elliott, G.S., Buaas, F.W., Cajulis, E.E., Grosshans, D., Ramos, L., Reese, D.M., Slamon, D.J. and Calzone, F.J. (1997) Oncogene, 14, 1-16.
119. Xu, X., Weaver, Z., Linke, S.P., Li, C., Gotay, J., Wang, X.W., Harris, C.C., Ried, T. and Deng, C.X. (1999) Mol. Cell, 3, 389-395.
120. ElShamy, W.M. and Livingston, D.M. (2004) Nat. Cell Biol., 6, 954-967.
121. Deng, C.X. and Brodie, S.G. (2000) Bioessays, 22, 728-737.
122. Voskuil, D.W., Bosma, A., Vrieling, A., Rookus, M.A. and van 't Veer, L.J. (2004) Breast Cancer Res. Treat., 84, 225-233.
123. Werner, H., Bach, M.A., Stannard, B., Roberts, C.T. Jr. and LeRoith, D. (1992) Mol. Endocrinol., 6, 1545-1558.
124. Werner, H., Re, G.G., Drummond, I.A., Sukhatme, V.P., Rauscher, F.J., 3rd, Sens, D.A., Garvin, A.J., LeRoith, D. and Roberts, C.T. Jr. (1993) Proc. Natl. Acad. Sci. USA, 90, 5828-5832.
125. Maor, S.B., Abramovitch, S., Erdos, M.R., Brody, L.C. and Werner, H. (2000) Mol. Genet. Metab., 69, 130-136.
126. Werner, H., Shalita-Chesner, M., Abramovitch, S., Idelman, G., Shaharabani-Gargir, L. and Glaser, T. (2000) Mol. Genet. Metab., 71, 315-320.
127. Abramovitch, S. and Werner, H. (2003) Horm. Metab Res., 35, 758-762.
128. Maor, S., Yosepovich, A., Papa, M.Z., Yarden, R.I., Mayer, D., Friedman, E. and Werner, H. (2007) Cancer Lett., 257, 236-243.
129. Sarfstein, R., Maor, S., Reizner, N., Abramovitch, S. and Werner, H. (2006) Mol. Cell Endocrinol., 252, 241-246.
130. Xu, X., Qiao, W., Linke, S.P., Cao, L., Li, W.M., Furth, P.A., Harris, C.C. and Deng, C.X. (2001) Nat. Genet., 28, 266-271.
131. Bachelier, R., Xu, X., Wang, X., Li, W., Naramura, M., Gu, H. and Deng, C.X. (2003) Oncogene, 22, 528-537.
132. Cao, L., Li, W., Kim, S., Brodie, S.G. and Deng, C.X. (2003) Genes Dev., 17, 201-213.
133. Bachelier, R., Xu, X., Li, C., Qiao, W., Furth, P.A., Lubet, R.A. and Deng, C.X. (2005) Oncol. Rep., 14, 1117-1120.
134. Cao, L., Kim, S., Xiao, C., Wang, R.H., Coumoul, X., Wang, X., Li, W.M., Xu, X.L., De Soto, J.A., Takai, H., Mai, S., Elledge, S.J., Motoyama, N. and Deng, C.X. (2006) EMBO J., 25, 2167-2177.
135. Cao, L., Xu, X., Cao, L.L., Wang, R.H., Coumoul, X., Kim, S.S. and Deng, C.X. (2007) Carcinogenesis, 28, 1401-1407.
136. Shukla, V., Coumoul, X., Cao, L., Wang, R., Xiao, C., Xu, X., Ando, S., Yakar, S., LeRoith, D. and Deng, D. (2006) Cancer Res., 66, 7151-7157.
137. Hudelist, G., Wagner, T., Rosner, M., Fink-Retter, A., Gschwantler-Kaulich, D., Czerwenka, K., Kroiss, R., Tea, M., Pischinger, K., Kostler, W.J., Attems, J., Mueller, R., Blaukopf, C., Kubista, E., Hengstschlager, M. and Singer, C.F. (2007) Endocr. Relat. Cancer, 14, 1053-1062.
138. Fan, S., Wang, J., Yuan, R., Ma, Y., Meng, Q., Erdos, M.R., Pestell, R.G., Yuan, F., Auborn, K.J., Goldberg, I.D. and Rosen, E.M. (1999) Science, 284, 1354-1356.
139. Fan, S., Ma, Y.X., Wang, C., Yuan, R.Q., Meng, Q., Wang, J.A., Erdos, M., Goldberg, I.D., Webb, P., Kushner, P.J., Pestell, R.G. and Rosen, E.M. (2001) Oncogene, 20, 77-87.
140. Hosey, A.M., Gorski, J.J., Murray, M.M., Quinn, J.E., Chung, W.Y., Stewart, G.E., James, C.R., Farragher, S.M., Mulligan, J.M., Scott, A.N., Dervan, P.A., Johnston, P.G., Couch, F.J., Daly, P.A., Kay, E., McCann, A., Mullan, P.B. and Harkin, D.P. (2007) J. Natl. Cancer Inst., 99, 1683-1694.
141. Renehan, A.G., Frystyk, J. and Flyvbjerg, A. (2006) Trends. Endocrinol. Metab., 17, 328-336
142. Hursting, S.D., Switzer, B.R., French, J.E. and Kari, F.W. (1993) Cancer Res., 53, 2750-2757.
143. Dunn, S.E., Kari, F.W., French, J., Leininger, J.R., Travlos, G., Wilson, R. and Barrett, J.C. (1997) Cancer Res., 57, 4667-4672.
144. Chatzistamou, I., Schally, A.V., Varga, J.L., Groot, K., Armatis, P., Busto, R. and Halmos, G. (2001) J. Clin. Endocrinol. Metab., 86, 2144-2152.
145. Friend, K.E., Khandwala, H.M., Flyvbjerg, A., Hill, H., Li, J. and McCutcheon, I.E. (2001) Growth Horm. IGF Res., 11, 84-91.
146. Divisova, J., Kuiatse, I., Lazard, Z., Weiss, H., Vreeland, F., Hadsell, D.L., Schiff, R., Osborne, C.K. and Lee, A.V. (2006) Breast Cancer Res. Treat., 98, 315-327.
147. Zhang, X. and Yee, D. (2002) Cancer Res., 62, 4369-4375.
148. Aberg, N.D., Brywe, K.G. and Isgaard, J. (2006) Sci. World J., 6, 53-80.
149. Adamo, M.L. and Farrar, R.P. (2006) Ageing Res. Rev., 5, 310-331.
150. Arteaga, C.L. and Osborne, C.K. (1989) Cancer Res., 49, 6237-6241.
151. Kull, F.C., Jr., Jacobs, S., Su, Y.F., Svoboda, M.E., Van Wyk, J.J. and Cuatrecasas, P. (1983) J. Biol. Chem., 258, 6561-6566.
152. Li, S.L., Liang, S.J., Guo, N., Wu, A.M. and Fujita-Yamaguchi, Y. (2000) Cancer Immunol. Immunother., 49, 243-252.
153. Burtrum, D., Zhu, Z., Lu, D., Anderson, D.M., Prewett, M., Pereira, D.S., Bassi, R., Abdullah, R., Hooper, A.T., Koo, H., Jimenez, X., Johnson, D., Apblett, R., Kussie, P., Bohlen, P., Witte, L., Hicklin, D.J. and Ludwig, D.L. (2003) Cancer Res., 63, 8912-8921.
154. Maloney, E.K., McLaughlin, J.L., Dagdigian, N.E., Garrett, L.M., Connors, K.M., Zhou, X.M., Blattler, W.A., Chittenden, T. and Singh, R. (2003) Cancer Res., 63, 5073-5083.
155. Sachdev, D., Li, S.L., Hartell, J.S., Fujita-Yamaguchi, Y., Miller, J.S. and Yee, D. (2003) Cancer Res., 63, 627-635.
156. Ye, J.J., Liang, S.J., Guo, N., Li, S.L., Wu, A.M., Giannini, S., Sachdev, D., Yee, D., Brunner, N., Ikle, D. and Fujita- Yamaguchi, Y. (2003) Horm. Metab Res., 35, 836-842.
157. Cohen, B.D., Baker, D.A., Soderstrom, C., Tkalcevic, G., Rossi, A.M., Miller, P.E., Tengowski, M.W., Wang, F., Gualberto, A., Beebe, J.S. and Moyer, J.D. (2005) Clin. Cancer Res., 11, 2063-2073.
158. Lu, D., Zhang, H., Ludwig, D., Persaud, A., Jimenez, X., Burtrum, D., Balderes, P., Liu, M., Bohlen, P., Witte, L. and Zhu, Z. (2004) J. Biol. Chem., 279, 2856-2865.
159. Lu, D., Zhang, H., Koo, H., Tonra, J., Balderes, P., Prewett, M., Corcoran, E., Mangalampalli, V., Bassi, R., Anselma, D., Patel, D., Kang, X., Ludwig, D.L., Hicklin, D.J., Bohlen, P., Witte, L. and Zhu, Z. (2005) J. Biol. Chem., 280, 19665-19672.
160. Clemmons, D.R. (2007) Nat. Rev. Drug Discov., 6, 821-833.
161. Jackson-Booth, P.G., Terry, C., Lackey, B., Lopaczynska, M. and Nissley, P. (2003) Horm. Metab. Res., 35, 850-856.
162. Bohula, E.A., Playford, M.P. and Macaulay, V.M. (2003) Anticancer Drugs, 14, 669-682.
163. Wang, Y., Hailey, J., Williams, D., Wang, Y., Lipari, P., Malkowski, M., Wang, X., Xie, L., Li, G., Saha, D., Ling, W.L., Cannon-Carlson, S., Greenberg, R., Ramos, R.A., Shields, R., Presta, L., Brams, P., Bishop, W.R. and Pachter, J.A. (2005) Mol. Cancer Ther., 4, 1214-1221.
164. Goya, M., Miyamoto, S., Nagai, K., Ohki, Y., Nakamura, K., Shitara, K., Maeda, H., Sangai, T., Kodama, K., Endoh, Y., Ishii, G., Hasebe, T., Yonou, H., Hatano, T., Ogawa, Y. and Ochiai, A. (2004) Cancer Res., 64, 6252-6258.
165. Feng, Y., Zhu, Z., Xiao, X., Choudhry, V., Barrett, J.C. and Dimitrov, D.S. (2006) Mol. Cancer Ther., 5, 114-120.
166. Gable, K.L., Maddux, B.A., Penaranda, C., Zavodovskaya, M., Campbell, M.J., Lobo, M., Robinson, L., Schow, S., Kerner, J.A., Goldfine, I.D. and Youngren, J.F. (2006) Mol. Cancer Ther., 5, 1079-1086.
167. Girnita, A., All-Ericsson, C., Economou, M.A., Astrom, K., Axelson, M., Seregard, S., Larsson, O. and Girnita, L. (2006) Clin. Cancer Res., 12, 1383-1391.
168. Parrizas, M., Gazit, A., Levitzki, A., Wertheimer, E. and Le- Roith, D. (1997) Endocrinology, 138, 1427-1433.
169. Wen, B., Deutsch, E., Marangoni, E., Frascona, V., Maggiorella, L., Abdulkarim, B., Chavaudra, N. and Bourhis, J. (2001) Br. J. Cancer, 85, 2017-2021.
170. Haluska, P., Carboni, J.M., Loegering, D.A., Lee, F.Y., Wittman, M., Saulnier, M.G., Frennesson, D.B., Kalli, K.R., Conover, C.A., Attar, R.M., Kaufmann, S.H., Gottardis, M. and Erlichman, C. (2006) Cancer Res., 66, 362-371.
171. Garcia-Echeverria, C., Pearson, M.A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H.G., Cozens, R., Evans, D.B., Fabbro, D., Furet, P., Porta, D.G., Liebetanz, J., Martiny-Baron, G., Ruetz, S. and Hofmann, F. (2004) Cancer Cell, 5, 231-239.
172. Mitsiades, C.S., Mitsiades, N.S., McMullan, C.J., Poulaki, V., Shringarpure, R., Akiyama, M., Hideshima, T., Chauhan, D., Joseph, M., Libermann, T.A., Garcia-Echeverria, C., Pearson, M.A., Hofmann, F., Anderson, K.C. and Kung, A.L. (2004) Cancer Cell, 5, 221-230.
173. Girnita, A., Girnita, L., del Prete, F., Bartolazzi, A., Larsson, O. and Axelson, M. (2004) Cancer Res., 64, 236-242.
174. Vasilcanu, D., Girnita, A., Girnita, L., Vasilcanu, R., Axelson, M. and Larsson, O. (2004) Oncogene, 23, 7854-7862.
175. Min, Y., Adachi, Y., Yamamoto, H., Ito, H., Itoh, F., Lee, C.T., Nadaf, S., Carbone, D.P. and Imai, K. (2003) Cancer Res., 63, 6432-6441.
176. Surmacz, E. (2003) Oncogene, 22, 6589-6597.
177. Kohno, M. and Pouyssegur, J. (2003) Prog. Cell Cycle Res., 5, 219-224.
178. Catrina, S.B., Lewitt, M., Massambu, C., Dricu, A., Grunler, J., Axelson, M., Biberfeld, P. and Brismar, K. (2005) Br. J. Cancer, 92, 1467-1474.
179. Catrina, S.B., Botusan, I.R., Rantanen, A., Catrina, A.I., Pyakurel, P., Savu, O., Axelson, M., Biberfeld, P., Poellinger, L. and Brismar, K. (2006) Clin. Cancer Res., 12, 4506-4514.
180. Brahimi-Horn, M.C. and Pouyssegur, J. (2007) FEBS Lett., 581, 3582-3591.
181. Semenza, G.L. (2007) Science, 318, 62-64.
182. Zhang, D., Samani, A.A. and Brodt, P. (2003) Horm. Metab. Res., 35, 802-808.
183. Stawowy, P., Kallisch, H., Kilimnik, A., Margeta, C., Seidah, N.G., Chretien, M., Fleck, E. and Graf, K. (2004) Biochem. Biophys. Res. Commun., 321, 531-538.
184. Nuti, E., Tuccinardi, T. and Rossello, A. (2007) Curr. Pharm. Des., 13, 2087-2100.
185. Werner, H., Karnieli, E., Rauscher, F.J. and LeRoith, D. (1996) Proc. Natl. Acad. Sci. USA, 93, 8318-8323.
186. Abramovitch, S., Glaser, T., Ouchi, T. and Werner, H. (2003) FEBS Lett., 541, 149-154.
187. Pauwels, E.K. and Erba, P. (2007) Drug News Perspect., 20, 213-220.
188. Torchilin, V.P. (2007) AAPS J., 9, E128-147.
189. Shukla, V., Coumoul, X. and Deng, C.X. (2007) Int. J. Biol. Sci., 3, 91-99.
190. Shukla, V., Coumoul, X., Wang, R.H., Kim, H.S. and Deng, C.X. (2007) Nat. Genet., 39, 1145-1150.