Parallel Phosphatidylinositol-3 Kinase and p42/44 Mitogen-Activated Protein Kinase Signaling Pathways Subserve the Mitogenic and Antiapoptotic Actions of Insulin-Like Growth Factor I in Osteoblastic Cells

Endocrinology

Volumn 144, Issue 11, 2003, Pages 4886-4893

  Grey, Andrew ^a   Chen, Qi ^a   Xin, Xin ^a   Callon, Karen ^a   Cornish, Jill ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P42; PROTEIN P44; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; BONE METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; DIMERIZATION; EFFECTOR CELL; GENETIC TRANSFECTION; GROWTH REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; MEDIATOR RELEASE; MITOGENICITY; OSTEOBLAST; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL DIVISION; CELL LINE; CELL SURVIVAL; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; OSTEOBLASTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 0242721096     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0350     Document Type: Article

References (48)

1. Yakar S, Rosen CJ 2003 From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass. Exp Biol Med 228:245-252
2. Farquharson C, Milne J, Loveridge N 1993 Mitogenic action of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase. Bone Miner 22:105-115
3. Canalis E 1993 Insulin like growth factors and the local regulation of bone formation. Bone 14:273-276
4. Zhang W, Lee JC, Kumar S, Gowen M 1999 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. J Bone Miner Res 14:528-535
5. Hughes DE, Boyce BF 1997 Apoptosis in bone physiology and disease. Mol Pathol 50:132-137
6. Hill PA, Tumber A, Meikle MC 1997 Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology 138:3849-3858
7. McCarthy TL, Centrella M, Canalis E 1989 Regulatory effects of insulin-like growth factor I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:310-309
8. McCarthy TL, Ji C, Centrella M 2000 Links among growth factors, hormones, and nuclear factors with essential roles in bone formation. Crit Rev Oral Biol Med 11:409-422
9. Miyakoshi N, Kasukawa Y, Linkhart TA, Baylink DJ, Mohan S 2001 Evidence that anabolic effects of PTH on bone require IGF-I in growing mice. Endocrinology 142:4349-4356
10. Huang BK, Golden LA, Tarjan G, Madison LD, Stern PH 2000 Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts. J Bone Miner Res 15:188-197
11. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080
12. Hill PA, Reynolds JJ, Meikle MC 1997 Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function. Endocrinology 136:124-131
13. Ernst M, Rodan GA 1991 Estradiol regulation of insulin-like growth factor-1 expression in osteoblastic cells: evidence for transcriptional control. Mol Endcrinol 5:1081-1089
14. Canalis E, Avioli L 1992 Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells. J Bone Miner Res 7:1085-1092
15. Scharla SH, Strong DD, Mohan S, Baylink DJ, Linkhart TA 1991 1, 25-dihydroxyvitamin D3 differentially regulates the production of insulin-like growth factor I (IGF-1) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology 129:3139-3146
16. Zhao G, Monier-Faugere MC, Langub MC, Geng Z, Nakayama T, Pike JW, Chernausek SD, Rosen CJ, Donahue R, Melluche HH, Fagin JA, Clemens TL 2000 Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology 141:2674-2682
17. Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B 2001 The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res 16:2320-2329
18. Zhang M, Xuan S, Bouxsein M, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL 2002 Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277:44005-44012
19. Ogata N, Chizaku D, Kubota N, Terauchi Y, Tobe K, Azuma Y, Ohta T, Kadowaki T, Nakamura K, Kawaguchi H 2000 Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest 105: 935-943
20. LeRoith D 2000 Insulin-like growth factor I receptor signaling - overlapping or redundant pathways. Endocrinology 141:1287-1288
21. Petley T, Graff K, Jiang W, Yang H, Florini J 1999 Variation among cell types in the signaling pathways by which IGF-1 stimulates specific cellular responses. Horm Metab Res 31:70-75
22. Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT 1995 Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol 15:3049-3057
23. Parrizas M, Saltiel AR, LeRoith D 1997 Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. J Biol Chem 272:154-161
24. Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz RJ 1994 Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J Biol Chem 269:6193-6197
25. Franke TF, Yang SL, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN 1995 The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736
26. i proteins and protein kinase C but not p42/44 MAP kinases. Endocrinology 142:1098-1106
27. i proteins and PI-3 kinase. Endocrinology 143:4755-4763
28. Fang X, Yu S, LaPushin R, Lu Y, Furui T, Penn LZ, Stokoe D, Erickson JR, Bast Jr RC, Mills GB 2000 Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. Biochem J 352:135-143
29. Zhang R, DeGroot LJ 1997 A monoclonal antibody against rat calcitonin inhibits the growth of a rat medullary thyroid carcinoma cell line in vitro. Endocrinology 138:1697-1703
30. Isik FF, Gibran NS, Jang YC, Sandell L, Schwartz SM 1998 Vitronectin decreases microvascular endothelial cell apoptosis. J Cell Physiol 175:149-155
31. Hsieh CC, Yen MH, Liu HW, Lau YT 2000 Lysophosphatidylcholine induces apoptotic and non-apoptotic death in vascular smooth muscle cells: in comparison with oxidized LDL. Atherosclerosis 151:481-491
32. Datta SR, Brunet A, Greenberg ME 1999 Cellular survival: a play in three Akts. Gene Dev 13:2905-2927
33. Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ 1995 Gβγ subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem 270:16495-16498
34. s6k following exposure to UVA irradiation. J Biol Chem 276:20913-20923
35. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell C, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D 2002 Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110:771-781
36. Takahashi Y, Tobe K, Kadowaki H, Katsumata D, Fukushima Y, Yazaki Y, Akanuma Y, Kadowaki T 1997 Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts. Endocrinology 138:741-750
37. Coolican SA, Samuel DS, Ewton DZ, McWade FJ, Florini JR 1997 The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem 272:12699-12702
38. Valverde AM, Lorenzo M, Navarro P, Benito M 1997 Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes. Mol Endocrinol 11:595-607
39. i2 in human intestinal smooth muscle. J Biol Chem 276:7187-7194
40. Kim B, Leventhal PS, Saltiel AR, Feldman EL 1997 Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. J Biol Chem 272:21268-21273
41. Blume-Jensen P, Hunter T 2001 Oncogenic kinase signalling. Nature 411: 355-365
42. s6k. FEBS Lett 410:78-82
43. Peterson RT, Schreiber SL 1998 Translation control: connecting mitogens and the ribosome. Curr Biol 8:R248-R250
44. Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ 2001 p70S6 Kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci USA 98:9666-9670
45. Vanhaesebroeck B, Alessi DR 2000 The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346:561-576
46. Rintelen F, Stocker H, Thomas G, Hafen E 2001 PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci USA 98:15020-15025
47. Dalle S, Ricketts W, Imamura T, Vollenweider P, Olefsky JM 2001 Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem 276:15688-15695
48. Booth RA, Cummings C, Tiberi M, Liu XJ 2002 GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. J Biol Chem 277:6719-6725