Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation

Cell Growth and Differentiation

Volumn 11, Issue 12, 2000, Pages 655-664

  Hermanto, U ^a   Zong, C S ^a   Wang, L H ^a  

^a Box 1124 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYROSINE KINASE RECEPTOR;

ARTICLE; BREAST CANCER; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR GROWTH;

BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL SURVIVAL; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; HUMANS; IMMUNOBLOTTING; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PRECIPITIN TESTS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED; TYROSINE; UP-REGULATION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034523626     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Oncogenes and signal transduction
2. Signal transduction via the MAP kinases: Proceed at your own RSK
3. The mitogen-activated protein kinase signal transduction pathway
4. Signal transduction and growth control in normal and cancer cells
5. Signal transduction by receptors with tyrosine kinase activity
6. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
7. The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
8. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor
9. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
10. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
11. Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes
12. Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
13. The pathway to signal achievement
14. The function of GRB2 in linking the insulin receptor to Ras signaling pathways
15. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
16. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
17. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
18. Activation of Raf as a result of recruitment to the plasma membrane
19. Transcriptional regulation by MAP kinases
20. MAP kinase-dependent pathways in cell cycle control
21. Integration of MAP kinase signal transduction pathways at the serum response element
22. Mitogen-activated protein kinase pathways
23. Signal transduction through MAP kinase cascades
24. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
25. EGF receptor expression, regulation, and function in breast cancer
26. ERBB2 oncogene in human breast cancer and its clinical significance
27. Type 1 IGF receptor in human breast diseases
28. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer
29. Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer
30. The prognostic value of insulin-like growth factor-1 in breast cancer patients. Results of a follow-up study on 126 patients
31. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
32. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: Correlation with clinical parameters and disease-free survival
33. Hyperexpression of mitogen-activated protein kinase in human breast cancer
34. Grb2 overexpression in nuclei and cytoplasm of human breast cells: A histochemical and biochemical study of normal and neoplastic mammary tissue specimens
35. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulinlike growth factor I receptor antisense ribonucleic acid
36. The T61 human breast cancer xenograft: An experimental model of estrogen therapy of breast cancer
37. Type I insulin-like growth factor receptor function in breast cancer
38. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer
39. Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells
40. 2-M of ErbB2-positive breast cancer cells
41. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
42. A synthetic inhibitor of the mitogen-activated protein kinase cascade
43. Epidermal growth factor receptor gene expression in estrogen receptor-positive and negative human breast cancer cell lines
44. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas
45. An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture
46. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
47. Transformation of mammalian cells by constitutively active MAP kinase kinase
48. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
49. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
50. Investigation of the MEK-MAP kinase-Rsk pathway in human breast cancer
51. Overexpression of the Grb2 gene in human breast cancer cell lines
52. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
53. The mitogen-activated protein kinase pathway mediates growth arrest or E1A-dependent apoptosis in SKBR3 human breast cancer cells
54. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
55. Enhancement of transforming potential of human insulin-like growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence
56. Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor
57. Accumulation of fatty alcohol in MCF-7 breast cancer cells