A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

Diabetologia

Volumn 52, Issue 2, 2009, Pages 271-280

  Fex, M ^a,c   Haemmerle, G ^d   Wierup, N ^b,c   Dekker Nitert, M ^a,c   Rehn, M ^b   Ristow, M ^e   Zechner, R ^d   Sundler, F ^b,c   Holm, C ^b,c   Eliasson, L ^a,c   Mulder, H ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^d UNIVERSITY OF GRAZ   (Austria)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Beta cell mass; Insulin secretion; Lipid coupling factor; Membrane capacitance

Indexed keywords

ARGININE; GLUCOSE; HORMONE SENSITIVE LIPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DEPOLARIZATION; DISEASE MODEL; EXOCYTOSIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESPONSE; INTRAVENOUS GLUCOSE TOLERANCE TEST; KNOCKOUT MOUSE; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ADIPOSE TISSUE; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; EXOCYTOSIS; EXONS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SECRETORY VESICLES; STEROL ESTERASE;

EID: 58149473940     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1191-9     Document Type: Article

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