Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3746-3753

  Fex, Malin ^a   Olofsson, Charlotta S ^a   Fransson, Ulrika ^a   Bacos, Karl ^a   Lindvall, Håkan ^a   Sörhede Winzell, Maria ^a   Rorsman, Patrik ^a,b   Holm, Cecilia ^a   Mulder, Hindrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; CALCIUM ION; CHOLESTEROL ESTERASE; CYCLIC AMP; GLUCOSE; GLYCEROL; HORMONE SENSITIVE LIPASE; INSULIN; LIPOPROTEIN LIPASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL SECRETION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY ACID OXIDATION; GLUCOSE OXIDATION; INSULIN RELEASE; LIPID HYDROLYSIS; LIPID STORAGE; LIPOLYSIS; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CHOLESTEROL ESTERASE; FATS; FEMALE; GLUCOSE; GLYCERIDES; INSULIN; ISLETS OF LANGERHANS; LIPOLYSIS; MICE; OXIDATION-REDUCTION; PALMITATES;

EID: 3843052408     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1673     Document Type: Article

References (46)

1. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH1994 β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci USA 91:10878-10882
2. Koyama K, Chen G, Wang MY, Lee Y, Shimabukuro M, Newgard CB, Unger RH 1997 β-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46:1276-1280
3. Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, Chen S, McGarry JD 1996 Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97:2728-2735
4. Unger RH 1995 Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870
5. Unger RH, Zhou YT, Orci L 1999 Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci USA 96:2327-2332
6. Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V 2001 Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50:315-321
7. Sako Y, Grill VE 1990 A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589
8. Kelpe CL, Johnson LM, Poitout V 2002 Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology 143:3326-3332
9. Mulder H, Holst LS, Svensson H, Degerman E, Sundler F, Ahren B, Rorsman P, Holm C 1999 Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in β-cells. Diabetes 48:228-232
10. Holm C, Österlund T, Laurell H, Contreras JA 2000 Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annu Rev Nutr 20:365-393
11. Roduit R, Masiello P, Wang SP, Li H, Mitchell GA, Prentki M 2001 A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice. Diabetes 50:1970-1975
12. Mulder H, Sörhede-Winzell M, Contreras J-A, Fex M, Ström K, Ploug T, Galbo H, Arner P, Lundberg C, Sundler F, Ahrén B, Holm C 2003 Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact. J Biol Chem 278:36380-36388
13. Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA 2003 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144:3456-3462
14. Talts JF, Brakebusch C, Fässler R 1999 Integrin gene targeting. Methods Mol Biol 129:153-187
15. Grober J, Lucas S, Sörhede-Winzell M, Zaghini I, Mairal A, Contreras JA, Besnard P, Holm C, Langin D 2003 Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa. J Biol Chem 278:6510-6515
16. Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, Shionoiri F, Yahagi N, Kraemer FB, Tsutsumi O, Yamada N 2000 Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci USA 97:787-792
17. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
18. Hellmer J, Arner P, Lundin A 1989 Automatic luminometric kinetic assay of glycerol for lipolysis studies. Anal Biochem 177:132-137
19. Tornqvist H, Björgell P, Krabisch L, Beitrage P 1978 Monoacylmonoalkylglycerol as a substrate for diacylglycerol hydrolase activity in adipose tissue. J Lipid Res 19:654-656
20. Österlund T, Danielsson B, Degerman E, Contreras JA, Edgren G, Davis RC, Schotz MC, Holm C 1996 Domain-structure analysis of recombinant rat hormone-sensitive lipase. Biochem J 319:411-420
21. Folch J, Lees M, Sloane-Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
22. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450
23. Lindvall H, Nevsten P, Ström K, Wallenberg R, Sundler F, Langin D, Sörhede Winzell M, Holm C 2004 A novel hormone-sensitive lipase isoform expressed in pancreatic β-cells. J Biol Chem 279:3828-3836
24. Fredrikson G, Stralfors P, Nilsson NO, Belfrage P 1981 Hormone-sensitive lipase of rat adipose tissue. Purification and some properties. J Biol Chem 256:6311-6320
25. Prentki M, Corkey BE 1996 Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283
26. Elks ML 1993 Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208-214
27. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd 3rd AE 2001 Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic β-cells (HIT). Diabetes 50:56-62
28. Ahren B 1998 Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes. Bioessays 20:642-651
29. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M 1989 A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells. J Biol Chem 264:21608-21612
30. Henquin JC 2000 Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751-1760
31. + channel-independent insulinotropic action of glucose. Diabetes 48:1543-1549
32. Deeney JT, Gromada J, Hoy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE 2000 Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI β-cells). J Biol Chem 275:9363-9368
33. Yaney GC, Korchak HM, Corkey BE 2000 Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal β-cells. Endocrinology 141:1989-1998
34. Mulder H, Lu D, Finley J, An J, Cohen J, Antinozzi PA, McGarry JD, Newgard CB 2001 Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) β-cells. J Biol Chem 276:6479-6484
35. Jones PM, Persaud SJ 1998 Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic β-cells. Endocr Rev 19:429-461
36. Anthonsen MW, Rönnstrand L, Wernstedt C, Degerman E, Holm C 1998 Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation prop-erties in vitro. J Biol Chem 273:215-221
37. Sörhede-Winzell S, Svensson H, Arner P, Ahrén B, Holm C 2001 The expression of hormone-sensitive lipase in clonal β-cells and rat islets is induced by long-term exposure to high glucose. Diabetes 50:2225-2230
38. Wang SP, Laurin N, Himms-Hagen J, Rudnicki MA, Levy E, Robert MF, Pan L, Oligny L, Mitchell GA 2001 The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 9:119-128
39. Marshall BA, Tordjman K, Host HH, Ensor NJ, Kwon G, Marshall CA, Coleman T, McDaniel ML, Semenkovich CF 1999 Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. J Biol Chem 274:27426-27432
40. Mulder H, Yang S, Sörhede Winzell M, Holm C, Ahrén B 2004 Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion. Diabetes 53:122-128
41. Masiello P, Novelli M, Bombara M, Fierabracci V, Vittorini S, Prentki M, Bergamini E 2002 The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets. Metabolism 51:110-114
42. Degerman E, Belfrage P, Manganiello VC 1997 Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J Biol Chem 272: 6823-6826
43. Stenson Holst L, Mulder H, Manganiello V, Sundler F, Ahren B, Holm C, Degerman E 1998 Protein kinase B is expressed in pancreatic β-cells and activated upon stimulation with insulin-like growth factor I. Biochem Biophys Res Commun 250:181-186
44. Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR 1999 Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96:329-339
45. Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Stenson Holst L 2002 Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic β-cell exocytosis and release of insulin. J Biol Chem 277:37446-37455
46. Sörhede Winzell M, Svensson H, Enerbäck S, Ravnskjaer K, Mandrup S, Esser V, Arner P, Alves-Guerra MC, Miroux B, Sundler F, Ahrén B, Holm C 2003 Pancreatic β-cell lipotoxicity induced by overexpression of hormone-sensitive lipase. Diabetes 52:2057-2065