Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

Annual Review of Nutrition

Volumn 20, Issue , 2000, Pages 365-393

  Holm, C ^a   Osterlund, T ^a   Laurell, H ^a   Contreras, J A ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Adipose tissue; Cholesteryl ester hydrolase; Fatty acid mobilization; Perilipin; Protein kinase A

Indexed keywords

CATECHOLAMINE; INSULIN; TRIACYLGLYCEROL LIPASE;

CANCER; DIABETES MELLITUS; ENZYME ANALYSIS; ENZYME REGULATION; ENZYME STRUCTURE; FAMILIAL HYPERLIPEMIA; FATTY ACID METABOLISM; HOMEOSTASIS; HUMAN; LIPID METABOLISM; LIPOLYSIS; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; CHOLESTEROL ESTERASE; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 2; HUMANS; HYPERLIPIDEMIA, FAMILIAL COMBINED; LIPOLYSIS; MODELS, CHEMICAL; MODELS, MOLECULAR; NEOPLASMS; OBESITY;

EID: 0033826850     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.20.1.365     Document Type: Review

References (192)

1. Role of calcium ion in hormone-stimulated lipolysis
2. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
3. Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes
4. Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hypedipidemia
5. Familial combined hyperlipidemia and abnormal lipoprotein lipase
6. Regulation of adipose tissue lipolysis: Phosphorylation of hormone sensitive lipase in intact rat adipocytes
7. Hormone-sensitive lipase of rat adipose tissue: Identification and some properties of the enzyme protein
8. Diurnal rhythms and effects of fasting and refeeding on rat adipose tissue lipoprotein lipase
9. 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
10. Lipolytic activity in rat epididymal fat pads
11. Testis expression of hormone-sensitive lipase is conferred by a specific promoter that contains four regions binding testicular nuclear proteins
12. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes
13. Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose
14. Genetic and nongenetic determinants of regional fat distribution
15. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of cytosolic hormone-sensitive lipase to the surfaces of lipid storage droplets
16. Brown adipose tissue. More than an effector of thermogenesis?
17. Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation
18. Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription
19. Regulation of lipolysis in cardiac muscle: A system similar to the hormone-sensitive lipase of adipose tissue
20. Effect of adrenaline infusion on fatty acid and glucose turnover in lean and obese human subjects in the post-absorptive and fed states
21. Human hormone-sensitive lipase: Expression and large-scale purification from a baculovirus/insect cell system
22. Presence of hormone-sensitive lipase mRNA in J774 macrophages
23. Hormone-sensitive lipase is structurally related to acetylcholinesterase, bile salt-stimulated lipase, and several fungal lipases. Building of a three-dimensional model for the catalytic domain of hormone-sensitive lipase
24. Essential differences in cholesteryl ester metabolism between human monocyte-derived and J774 macrophages. Evidence against the presence of hormone-sensitive lipase in human macrophages
25. Cytosolic chotesterol ester hydrolase from bovine corpus luteum. Its purification, identification, and relationship to hormone-sensitive lipase
26. Direct evidence that cholesterol ester hydrolase from adrenal cortex is the same enzyme as hormone-sensitive lipase from adipose tissue
27. 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
28. Effect of growth hormone on carbohydrate and lipid metabolism
29. Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)
30. Structure and function of lipases
31. The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
32. ++ on lipolysis in human omental adipose tissue in vitro
33. Mechanism of hormone-stimulated lipolysis in adipocytes: Translocation of hormone-sensitive lipase to the lipid storage droplet
34. Antilipolytic action of insulin: Role of cAMP phosphodiesterase activation
35. Specific inhibition of the cGMP-inhibited cAMP phosphodiesterase blocks the insulin-like antilipolytic effect of growth hormone in rat adipocytes
36. Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells
37. Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages
38. Adrenergic regulation of adipocyte metabolism
39. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: Implications for the control of fat storage and fat mobilization
40. Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases?
41. Positional specificity of hormone-sensitive lipase from rat adipose tissue
42. Hormone-sensitive lipase of rat adipose tissue. Purification and some properties
43. Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol
44. Insulin inhibition of spontaneous adipose tissue lipolysis and effects upon fructose and glucose metabolism
45. Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice
46. In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin
47. Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia
48. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
49. Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase
50. Modulation of white adipose tissue lipolysis by nitric oxide
51. Adipose hormone-sensitive lipase preferentially releases polyunsaturated fatty acids from triglycerides
52. Activation of myocardial neutral triglyceride lipase and neutral cholesterol esterase by cAMP-dependent protein kinase
53. Studies on the metabolism of adipose tissue. 18. In vitro effects of insulin, epinephrine and glucagon on lipolysis and glycolysis in pigeon adipose tissue
54. Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase
55. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
56. Characterization of the promoter of human adipocyte hormone-sensitive lipase
57. Metabolic consequences of a family history of NIDDM (the Botnia study): Evidence for sex-specific parental effects
58. The postnatal development of hormone sensitive lipase in brown and white adipose tissue of the rat
59. The AMP-activated protein kinase - Fuel gauge of the mammalian cell?
60. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells
61. Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives
62. Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and lipoprotein lipase: Identification of a superfamily of esterases and lipases
63. Neutron crystallographic evidence of lipase-colipase complex activation by a micelle
64. Lipolytic stimulation modulates the subcellular distribution of hormone-sensitive lipase in 3T3-L1 cells
65. The lipoprotein lipase (Asn291→Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia
66. The lipolytic response to cortico-tropin
67. Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue
68. Human adipose tissue hormone-sensitive lipase: Identification and comparison with other species
69. Large-scale purification and kinetic properties of recombinant hormone-sensitive lipase from baculovirus-insect cell systems
70. Identification of the active site serine of hormone-sensitive lipase by site-directed mutagenesis
71. Hormone-sensitive lipase in brown adipose tissue: Identification and effect of cold exposure
72. Incorporation of hormone-sensitive lipase into phosphatidylcholine vesicles
73. Hormone-sensitive lipase: Sequence, expression, and chromosomal localization to 19 cent-q13.3
74. Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes
75. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase
76. cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators
77. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
78. Tumor necrosis factor alpha: A key component of the obesity-diabetes link
79. Activation and phosphorylation of purified adipose tissue hormone-sensitive lipase by cyclic AMP-dependent protein kinase
80. ATP-dependent and cyclic AMP-dependent activation of rat adipose tissue lipase by protein kinase from rabbit skeletal muscle
81. Influence of body fat distribution on free fatty acid metabolism in obesity
82. Down-regulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages
83. Inhibition of hormone-sensitive lipase by intermediary lipid metabolites
84. Dealing with energy demand: The AMP-activated protein kinase
85. Expression of hormone-sensitive lipase mRNA in macrophages
86. Activation of hormone-sensitive lipase and phosphorylase kinase by pudried cyclic GMP-dependent protein kinase
87. The putative role of the hormone-sensitive lipase gene in the pathogenesis of type II diabetes mellitus and abdominal obesity
88. Effect of weight loss on whole body and cellular lipid metabolism in severely obese humans
89. Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies
90. Fat cell adrenergic receptors and the control of white and brown fat cell function
91. Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle
92. Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle
93. Sequence similarities between hormone-sensitive lipase and five prokaryotic enzymes
94. Gene organization and primary structure of human hormone-sensitive lipase: Possible significance of a sequence homology with a lipase of Moraxella TA 144, an antarctic bacterium
95. Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells
96. Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects
97. The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1→13.2 is not duplicated on 19p13.3
98. Species-specific alternative splicing generates a catalytically inactive form of human hormone-sensitive lipase
99. Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones
100. Depot-specific differences in adipose tissue gene expression in lean and obese subjects
101. Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1→q13.2
102. Modified low density lipoprotein enhances the secretion of bile salt-stimulated cholesterol esterose by human monocyte-macrophages. Species-specific difference in macrophage cholesteryl ester hydrolase
103. Isolation and characterization of the gene for mouse hormone-sensitive lipase
104. Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues
105. Hormone-sensitive lipase and the control of lipolysis in adipocytes
106. Human hormone-sensitive lipase: Genetic mapping, identification of a new dinucleotide repeat, and association with obesity and NIDDM
107. Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy
108. Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: Functional consequences
109. Regional differences in adipose tissue lipolysis from lean and obese women: Existence of postreceptor alterations
110. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: Wortmannin-sensitive inhibition by insulin
111. Norepinephrine-induced lipolysis in rat fat cells from visceral and subcutaneous sites: Role of hormone-sensitive lipase and lipid droplets
112. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in b-cells
113. Regulation of adipose tissue lipolysis: Effects of noradrenaline and insulin on phosphorylation of hormone-sensitive lipase and on lipolysis in intact rat adipocytes
114. Purification of hormone-sensitive lipase by high-performance ion exchange chromatography
115. Rapid purification of detergent-solubilized bovine hormone-sensitive lipase by high performance hydrophobic interaction chromatography
116. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
117. The alpha/beta hydrolase fold
118. The regulatory and basal phosphorylation sites of hormone-sensitive lipase are dephosphorylated by protein phosphatase-1, 2A and 2C but not by protein phosphatase-2B
119. Phosphorylation of the basal site of hormone-sensitive lipase by glycogen synthase kinase-4
120. Expression of lipoprotein lipase in rat muscle: Regulation by feeding and hypothyroidism
121. Type L hormone-sensitive lipase hydrolyzes endogenous triacylglycerols in muscle in exercised rats
122. Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry
123. Identification of essential aspartic acid and histidine residues of hormone-sensitive lipase: Apparent residues of the catalytic triad
124. Domain-structure analysis of recombinant rat hormone-sensitive lipase
125. Regional differences in the control of lipolysis in human adipose tissue
126. No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families
127. Possible role of lipoprotein lipase in the regulation of endogenous triacylglycerols in the rat heart
128. Hormonal activation of type-L hormone- sensitive lipase measured in defatted heart powders
129. Inhibition of hormone-sensitive lipase gene expression by cAMP and phorbol esters in 3T3-F442A and BFC-1 adipocytes
130. Human liver aryl-acetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase
131. Regulation of hormone-sensitive lipase expression by glucose in 3T3-F442A adipocytes
132. Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues
133. Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin
134. Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol
135. The fourth musketeer - From Alexandre Dumas to Claude Bernard
136. Evidence for hormone-sensitive lipase mRNA expression in human monocyte/macrophages
137. Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome
138. Comparison of hormone-sensitive lipase activity in visceral and subcutaneous human adipose tissue
139. Multiple lipolysis defects in the insulin resistance (metabolic) syndrome
140. Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia
141. Effects of weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity
142. Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta 2-adrenoceptors
143. An epinephrine-sensitive lipolytic activity in adipose tissue
144. Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3',5'-phosphate
145. Metabolism of isolated fat cells. 3. The similar inhibitory action of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline
146. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
147. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP)
148. Atherosclerosis - An inflammatory disease
149. Multilocus genetic determinants of LDL particle size in coronary artery disease families
150. Morphologic and molecular changes induced by recombinant human leptin in the white and brown adipose tissues of C57BL/6 mice
151. Characterization of a colchicine receptor protein in rat epididymal adipose tissue
152. Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells
153. Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region
154. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein
155. Detection of an amino acid polymorphism in hormone-sensitive lipase in Japanese subjects
156. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes
157. Hormone-sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophages
158. Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages
159. Domain structure of hormone-sensitive lipase
160. Evidence for a multi-domain structure for hormone-sensitive lipase
161. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes
162. BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: A potential new insulin-sensitizing mechanism for thiazo-lidinediones
163. Adipose tissue lipolysis and hormone-sensitive lipase expression during very-low-calorie diet in obese female identical twins
164. Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase
165. Phosphorylation of hormone-sensitive lipase by cyclic GMP-dependent protein kinase
166. Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin
167. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
168. Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes
169. Lipotransin: A novel docking protein for hormone-sensitive lipase
170. Regulation of hormone-sensitive lipase during fasting
171. Differences in hormone-sensitive lipase expression in white adipose tissue from various anatomic locations of the rat
172. Hormone-sensitive lipase (Lipe): Sequence analysis of the 129Sv mouse Lipe gene
173. Identification of genetic variation in the human hormone-sensitive lipase gene and 5' sequences: Homology of 5' sequences with mouse promoter and identification of potential regulatory elements
174. Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes
175. The antilipolytic effects of insulin and epidermal growth factor in rat adipocytes are mediated by different mechanisms
176. Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients
177. p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue
178. Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue
179. Mechanisms involved in the adaptations of the adipocyte adrenergic signal-transduction system and their modulation by growth hormone during the lactation cycle in the rat
180. Novel form of lipolysis induced by leptin
181. Hormone-sensitive lipase maps to proximal chromosome 7 in mice and is genetically distinct from the Ad and Tub loci
182. Retinyl ester hydrolysis and retinol efflux from BFC-1b adipocytes
183. Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase
184. Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate
185. Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: Possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase
186. Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue
187. The protein phosphatases responsible for dephosphorylation of hormone-sensitive lipase in isolated rat adipocytes
188. Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level
189. 2+-dependent mechanism
190. Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease
191. A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity
192. Hormone-sensitive lipase - A multipurpose enzyme in lipid metabolism