Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: Indications for a long-chain acyl-CoA ester binding motif

Diabetologia

Volumn 50, Issue 8, 2007, Pages 1670-1677

  Branstrom R ^a   Leibiger, I B ^a   Leibiger, B ^a   Klement, G ^b   Nilsson, J ^b   Arhem P ^b   Aspinwall, C A ^a,d   Corkey, B E ^e   Larsson, O ^a,c   Berggren, P O ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d University of Arizona   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Basic Science; Beta cell signal transduction; Cells; Lipids lipoproteins; Other techniques

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); AMINO ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; PALMITOYL COENZYME A; SULFONYLUREA RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; INTRACELLULAR MEMBRANE; MOUSE; NONHUMAN; OOCYTE; PANCREAS ISLET BETA CELL; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; WILD TYPE;

ACYL COENZYME A; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; DIAZOXIDE; FEMALE; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, OBESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OOCYTES; PALMITOYL COENZYME A; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

EID: 34447125915     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0697-x     Document Type: Article

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