-
1
-
-
0029830331
-
Cannabis: Pharmacology and toxicology in animals and humans
-
Adams, I. B. and Martin, B. R., Cannabis: pharmacology and toxicology in animals and humans, Addiction, 91 (1996) 1585-1614.
-
(1996)
Addiction
, vol.91
, pp. 1585-1614
-
-
Adams, I.B.1
Martin, B.R.2
-
2
-
-
34250002798
-
Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet
-
Aberle, J., Fedderwitz, I., Klages, N., George, E. and Beil, F. U., Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet, Horm Metab Res, 39 (2007) 395-397.
-
(2007)
Horm Metab Res
, vol.39
, pp. 395-397
-
-
Aberle, J.1
Fedderwitz, I.2
Klages, N.3
George, E.4
Beil, F.U.5
-
3
-
-
34250323489
-
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
-
Aguado, T., Carracedo, A., Julien, B., Velasco, G., Milman, G., Mechoulam, R., Alvarez, L., Guzmán, M. and Galve-Roperh, I., Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis, J Biol Chem, 282 (2007) 6854-6862.
-
(2007)
J Biol Chem
, vol.282
, pp. 6854-6862
-
-
Aguado, T.1
Carracedo, A.2
Julien, B.3
Velasco, G.4
Milman, G.5
Mechoulam, R.6
Alvarez, L.7
Guzmán, M.8
Galve-Roperh, I.9
-
4
-
-
36048978697
-
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity
-
Ahn, K., Johnson, D. S., Fitzgerald, L. R., Liimatta, M., Arendse, A., Stevenson, T., Lund, E. T., Nugent, R. A., Nomanbhoy, T. K., Alexander, J. P. and Cravatt, B. F., Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity, Biochemistry, 46 (2007) 13019-13030.
-
(2007)
Biochemistry
, vol.46
, pp. 13019-13030
-
-
Ahn, K.1
Johnson, D.S.2
Fitzgerald, L.R.3
Liimatta, M.4
Arendse, A.5
Stevenson, T.6
Lund, E.T.7
Nugent, R.A.8
Nomanbhoy, T.K.9
Alexander, J.P.10
Cravatt, B.F.11
-
5
-
-
27744466783
-
Mechanism of carbamate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes
-
Alexander, J. P. and Cravatt, B. F., Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes, Chem Biol, 12 (2005) 1179-1187.
-
(2005)
Chem Biol
, vol.12
, pp. 1179-1187
-
-
Alexander, J.P.1
Cravatt, B.F.2
-
6
-
-
0032988751
-
Deletion of a proline-rich region and a transmembrane domain in fatty acid amide hydrolase
-
Arreaza, G. and Deutsch, D. G., Deletion of a proline-rich region and a transmembrane domain in fatty acid amide hydrolase, FEBS Lett, 454 (1999) 57-60.
-
(1999)
FEBS Lett
, vol.454
, pp. 57-60
-
-
Arreaza, G.1
Deutsch, D.G.2
-
7
-
-
30344476972
-
In silico patent searching reveals a new cannabinoid receptor
-
Baker, D., Pryce, G., Davies, W. L. and Hiley, C. R., In silico patent searching reveals a new cannabinoid receptor, Trends Pharmacol Sci, 1 (2006) 1-4.
-
(2006)
Trends Pharmacol Sci
, vol.1
, pp. 1-4
-
-
Baker, D.1
Pryce, G.2
Davies, W.L.3
Hiley, C.R.4
-
8
-
-
16844374531
-
Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells
-
Bari, M., Battista, N., Fezza, F., Finazzió, A. and Maccarrone, M., Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamideinduced apoptosis, J Biol Chem, 280 (2005) 12212-12220.
-
(2005)
Implications for anandamideinduced apoptosis, J Biol Chem
, vol.280
, pp. 12212-12220
-
-
Bari, M.1
Battista, N.2
Fezza, F.3
Finazzió, A.4
Maccarrone, M.5
-
9
-
-
34250361495
-
Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
-
Battista, N., Bari, M., Tarditi, A., Mariotti, C., Bachoud-Lévi, A. C., Zuccato, C., Finazzió, A., Genitrini, S., Peschanski, M., Di Donato, S., Cattaneo, E. and Maccarrone, M., Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes, Neurobiol Dis, 27 (2007) 108-116.
-
(2007)
Neurobiol Dis
, vol.27
, pp. 108-116
-
-
Battista, N.1
Bari, M.2
Tarditi, A.3
Mariotti, C.4
Bachoud-Lévi, A.C.5
Zuccato, C.6
Finazzió, A.7
Genitrini, S.8
Peschanski, M.9
Di Donato, S.10
Cattaneo, E.11
Maccarrone, M.12
-
10
-
-
0034720298
-
Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol
-
Beltramo, M. and Piomelli, D., Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol, Neuroreport, 11 (2000) 1231-1235.
-
(2000)
Neuroreport
, vol.11
, pp. 1231-1235
-
-
Beltramo, M.1
Piomelli, D.2
-
11
-
-
0348010292
-
Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
-
Benito, C., Núñez, E., Toón, R.M., Carrier, E. J., Rábano, A.,Hillard, C. J. and Romero, J., Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains, J Neurosci, 23 (2003) 11136-11141.
-
(2003)
J Neurosci
, vol.23
, pp. 11136-11141
-
-
Benito, C.1
Núñez, E.2
Toón, R.M.3
Carrier, E.J.4
Rábano, A.5
Hillard, C.J.6
Romero, J.7
-
12
-
-
0031830516
-
An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
-
Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M. H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V. and Mechoulam, R., An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity, Eur J Pharmacol, 353 (1998) 23-31.
-
(1998)
Eur J Pharmacol
, vol.353
, pp. 23-31
-
-
Ben-Shabat, S.1
Fride, E.2
Sheskin, T.3
Tamiri, T.4
Rhee, M.H.5
Vogel, Z.6
Bisogno, T.7
De Petrocellis, L.8
Di Marzo, V.9
Mechoulam, R.10
-
13
-
-
0033574179
-
Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function
-
Bisogno, T., Berrendero, F., Ambrosino, G., Cebeira, M., Ramos, J. A., Fernandez-Ruiz, J. J. and Di Marzo, V., Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function, Biochem Biophys Res Commun, 256 (1999a) 377-380.
-
(1999)
Biochem Biophys Res Commun
, vol.256
, pp. 377-380
-
-
Bisogno, T.1
Berrendero, F.2
Ambrosino, G.3
Cebeira, M.4
Ramos, J.A.5
Fernandez-Ruiz, J.J.6
Di Marzo, V.7
-
14
-
-
0033006123
-
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin
-
Bisogno, T., Melck, D., De Petrocellis, L. and Di Marzo, V., Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin, J Neurochem, 72 (1999b) 2113-2119.
-
(1999)
J Neurochem
, vol.72
, pp. 2113-2119
-
-
Bisogno, T.1
Melck De Petrocellis L., D.2
Di Marzo, V.3
-
15
-
-
0034751335
-
Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
-
Bisogno, T., Hanus, L., De Petrocellis, L., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R. and Di Marzo, V., Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide, Br J Pharmacol, 134 (2001a) 845-852.
-
(2001)
Br J Pharmacol
, vol.134
, pp. 845-852
-
-
Bisogno, T.1
Hanus, L.2
De Petrocellis, L.3
Tchilibon, S.4
Ponde, D.E.5
Brandi, I.6
Moriello, A.S.7
Davis, J.B.8
Mechoulam, R.9
Di Marzo, V.10
-
16
-
-
0034850220
-
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
-
Bisogno, T., Maccarrone, M., De Petrocellis, L., Jarrahian, A., Finazzi-Agro, A., Hillard, C. and Di Marzo, V., The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors, Eur J Biochem, 268 (2001b) 1982-1989.
-
(2001)
Eur J Biochem
, vol.268
, pp. 1982-1989
-
-
Bisogno, T.1
Maccarrone, M.2
De Petrocellis, L.3
Jarrahian, A.4
Finazzi-Agro Hillard C., A.5
Di Marzo, V.6
-
17
-
-
10744229235
-
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
-
Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E. J., Gangadharan, U., Hobbs, C., Di Marzo, V. and Doherty, P., Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain, J Cell Biol, 163 (2003) 463-468.
-
(2003)
J Cell Biol
, vol.163
, pp. 463-468
-
-
Bisogno, T.1
Howell, F.2
Williams, G.3
Minassi, A.4
Cascio, M.G.5
Ligresti, A.6
Matias, I.7
Schiano-Moriello, A.8
Paul, P.9
Williams, E.J.10
Gangadharan, U.11
Hobbs, C.12
Di Marzo, V.13
Doherty, P.14
-
18
-
-
12944277105
-
Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
-
Boger, D. L., Sato, H., Lerner, A. E., Hedrick, M. P., Fecik, R. A., Miyauchi, H., Wilkie, G. D., Austin, B. J., Patricelli, M. P. and Cravatt, B. F., Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide, Proc Natl Acad Sci U S A, 97 (2000) 5044-5049.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5044-5049
-
-
Boger, D.L.1
Sato, H.2
Lerner, A.E.3
Hedrick, M.P.4
Fecik, R.A.5
Miyauchi, H.6
Wilkie, G.D.7
Austin, B.J.8
Patricelli, M.P.9
Cravatt, B.F.10
-
19
-
-
0035907462
-
Alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: Carbonyl group modification and alpha-substitution
-
Boger, D. L., Miyauchi, H. and Hedrick, M. P., Alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution, Bioorg Med Chem Lett, 11 (2001) 1517-1520.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 1517-1520
-
-
Boger, D.L.1
Miyauchi, H.2
Hedrick, M.P.3
-
20
-
-
20144377098
-
Discovery of a potent, selective, and efficacious class of reversible alphaketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics
-
Boger, D.L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimares, C. R., Jorgensen, W. L. and Cravatt, B. F., Discovery of a potent, selective, and efficacious class of reversible alphaketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics, J Med Chem, 48 (2005) 1849-1856.
-
(2005)
J Med Chem
, vol.48
, pp. 1849-1856
-
-
Boger, D.L.1
Miyauchi, H.2
Du, W.3
Hardouin, C.4
Fecik, R.A.5
Cheng, H.6
Hwang, I.7
Hedrick, M.P.8
Leung, D.9
Acevedo, O.10
Guimares, C.R.11
Jorgensen, W.L.12
Cravatt, B.F.13
-
21
-
-
33845863911
-
Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids
-
Börner, C.,Höllt, V., Sebald,W. andKraus, J., Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids, J Leukoc Biol, 81 (2007) 336-343.
-
(2007)
J Leukoc Biol
, vol.81
, pp. 336-343
-
-
Börner, C.1
Höllt, V.2
Sebald, W.3
Kraus, J.4
-
22
-
-
23344448837
-
Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease
-
Borovecki, F., Lovrecic, L., Zhou, J., Jeong, H., Then, F., Rosas, H. D., Hersch, S. M., Hogarth, P., Bouzanou, B., Jensen, R. V., Krainc, D., Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease, Proc Natl Acad Sci U S A, 102 (2005) 11023-11028.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11023-11028
-
-
Borovecki, F.1
Lovrecic, L.2
Zhou, J.3
Jeong, H.4
Then, F.5
Rosas, H.D.6
Hersch, S.M.7
Hogarth, P.8
Bouzanou, B.9
Jensen, R.V.10
Krainc, D.11
-
23
-
-
2242490907
-
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling
-
Bracey, M. H., Hanson, M. A., Masuda, K. R., Stevens, R. C. and Cravatt, B. F., Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling, Science, 298 (2002) 1793-1796.
-
(2002)
Science
, vol.298
, pp. 1793-1796
-
-
Bracey, M.H.1
Hanson, M.A.2
Masuda, K.R.3
Stevens, R.C.4
Cravatt, B.F.5
-
24
-
-
2942564630
-
Structural commonalities among integral membrane enzymes
-
Bracey, M. H., Cravatt, B. F. and Stevens, R. C., Structural commonalities among integral membrane enzymes, FEBS Lett, 567 (2004) 159-165.
-
(2004)
FEBS Lett
, vol.567
, pp. 159-165
-
-
Bracey, M.H.1
Cravatt, B.F.2
Stevens, R.C.3
-
25
-
-
0036774131
-
Regulation of anandamide tissue levels by N-arachidonylglycine
-
Burstein, S. H., Huang, S. M., Petros, T. J., Rossetti, R. G., Walker, J. M. and Zurier, R. B., Regulation of anandamide tissue levels by N-arachidonylglycine, Biochem Pharmacol, 64 (2002) 1147-1150.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1147-1150
-
-
Burstein, S.H.1
Huang, S.M.2
Petros, T.J.3
Rossetti, R.G.4
Walker, J.M.5
Zurier, R.B.6
-
26
-
-
34147137062
-
Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration
-
Caillé, S., Alvarez-Jaimes, L., Polis, I., Stouffer, D. G. and Parsons, L. H., Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration, J Neurosci, 27 (2007) 3695-3702.
-
(2007)
J Neurosci
, vol.27
, pp. 3695-3702
-
-
Caillé, S.1
Alvarez-Jaimes, L.2
Polis, I.3
Stouffer, D.G.4
Parsons, L.H.5
-
27
-
-
34848897836
-
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
-
Centonze, D., Bari, M., Rossi, S., Prosperetti, C., Furlan, R., Fezza, F., De Chiara, V., Battistini, L., Bernardi, G., Bernardini, S., Martino, G. and Maccarrone, M., The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis, Brain, 130 (2007a) 2543-2553.
-
(2007)
Brain
, vol.130
, pp. 2543-2553
-
-
Centonze, D.1
Bari, M.2
Rossi, S.3
Prosperetti, C.4
Furlan, R.5
Fezza, F.6
De Chiara, V.7
Battistini, L.8
Bernardi, G.9
Bernardini Martino G., S.10
Maccarrone, M.11
-
28
-
-
33947591537
-
The endocannabinoid system in targeting inflammatory neurodegenerative diseases
-
Centonze, D., Finazzi-Agró, A., Bernardi, G. and Maccarrone, M., The endocannabinoid system in targeting inflammatory neurodegenerative diseases, Trends Pharmacol Sci, 28 (2007b) 180-187.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 180-187
-
-
Centonze, D.1
Finazzi-Agró Bernardi G., A.2
Maccarrone, M.3
-
29
-
-
0030571562
-
Study of the amidase signature group
-
Chebrou, H., Bigey, F., Arnaud, A. and Galzy, P., Study of the amidase signature group. Biochim Biophys Acta, 1298 (1996) 285-293.
-
(1996)
Biochim Biophys Acta
, vol.1298
, pp. 285-293
-
-
Chebrou, H.1
Bigey, F.2
Arnaud, A.3
Galzy, P.4
-
30
-
-
5744238950
-
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: Evidence for a link between defects in the endocannabinoid system and problem drug use
-
Chiang, K. P., Gerber, A. L., Sipe, J. C. and Cravatt, B. F., Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use, Hum Mol Genet, 13 (2004) 2113-2119.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2113-2119
-
-
Chiang, K.P.1
Gerber, A.L.2
Sipe, J.C.3
Cravatt, B.F.4
-
31
-
-
0029904838
-
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
-
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A. and Gilula, N. B., Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides, Nature, 384 (1996) 83-87.
-
(1996)
Nature
, vol.384
, pp. 83-87
-
-
Cravatt, B.F.1
Giang, D.K.2
Mayfield, S.P.3
Boger, D.L.4
Lerner, R.A.5
Gilula, N.B.6
-
32
-
-
0037207093
-
The enzymatic inactivation of the fatty acid amide class of signaling lipids
-
Cravatt, B. F. and Lichtman, A. H., The enzymatic inactivation of the fatty acid amide class of signaling lipids, Chem Phys Lipids, 121 (2002) 135-148.
-
(2002)
Chem Phys Lipids
, vol.121
, pp. 135-148
-
-
Cravatt, B.F.1
Lichtman, A.H.2
-
33
-
-
0042572380
-
Fatty acid amide hydrolase: An emerging therapeutic target in the endocannabinoid system
-
Cravatt, B. F. and Lichtman, A. H., Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system, Curr Opin Chem Biol, 7 (2003) 469-475.
-
(2003)
Curr Opin Chem Biol
, vol.7
, pp. 469-475
-
-
Cravatt, B.F.1
Lichtman, A.H.2
-
34
-
-
33645024219
-
tBiochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs
-
Cupini, L. M., Bari, M., Battista, N., Argiró, G., Finazzi-Agró, A., Calabresi, P. and Maccarrone, M., tBiochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs, Cephalalgia, 26 (2006) 277-281.
-
(2006)
Cephalalgia
, vol.26
, pp. 277-281
-
-
Cupini, L.M.1
Bari, M.2
Battista, N.3
Argiró, G.4
Finazzi-Agró, A.5
Calabresi, P.6
Maccarrone, M.7
-
35
-
-
0034986485
-
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide
-
Day, T. A., Rakhshan, F., Deutsch, D. G. and Barker, E. L., Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide, Mol Pharmacol, 59 (2001) 1369-1375.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1369-1375
-
-
Day, T.A.1
Rakhshan, F.2
Deutsch, D.G.3
Barker, E.L.4
-
36
-
-
0031550564
-
Novel inhibitors of brain, neuronal and basophilic anandamide amidohydrolase
-
De Petrocellis, L., Melck, D., Ueda, N., Maurelli, S., Kurahashi, Y., Yamamoto, S., Marino, G. and Di Marzo, V., Novel inhibitors of brain, neuronal and basophilic anandamide amidohydrolase, Biochem Biophys Res Commun, 231 (1997) 82-88.
-
(1997)
Biochem Biophys Res Commun
, vol.231
, pp. 82-88
-
-
De Petrocellis, L.1
Melck, D.2
Ueda, N.3
Maurelli, S.4
Kurahashi, Y.5
Yamamoto Marino G., S.6
Di Marzo, V.7
-
37
-
-
1842611887
-
The endocannabinoid system: A general view and latest additions
-
De Petrocellis, L., Cascio, M. G. and Di Marzo, V., The endocannabinoid system: a general view and latest additions, Br J Pharmacol, 141 (2004) 765-774.
-
(2004)
Br J Pharmacol
, vol.141
, pp. 765-774
-
-
De Petrocellis, L.1
Cascio, M.G.2
Di Marzo, V.3
-
38
-
-
0028903996
-
Anandamide amidohydrolase activity in rat brain microsomes
-
Desarnaud, F., Cadas, H. and Piomelli, D., Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization, J Biol Chem, 270 (1995) 6030-6035.
-
(1995)
Identification and partial characterization, J Biol Chem
, vol.270
, pp. 6030-6035
-
-
Desarnaud, F.1
Cadas, H.2
Piomelli, D.3
-
39
-
-
0027180394
-
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
-
Deutsch, D. G. and Chin, S. A., Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist, Biochem, 46 (1993) 791-796.
-
(1993)
Biochem
, vol.46
, pp. 791-796
-
-
Deutsch, D.G.1
Chin, S.A.2
-
40
-
-
0031550548
-
Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor
-
Deutsch, D. G., Lin, S., Hill, W. A., Morse, K. L., Salehani, D., Arreaza, G., Omeir, R. L. and Makriyannis, A., Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor, Biochem Biophys Res Commun, 231 (1997a) 217-221.
-
(1997)
Biochem Biophys Res Commun
, vol.231
, pp. 217-221
-
-
Deutsch, D.G.1
Lin, S.2
Hill, W.A.3
Morse, K.L.4
Salehani, D.5
Arreaza, G.6
Omeir, R.L.7
Makriyannis, A.8
-
41
-
-
0031048819
-
Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase
-
Deutsch, D. G., Omeir, R., Arreaza, G., Salehani, D., Prestwich, G. D., Huang, Z. and Howlett, A., Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase, Biochem Pharmacol, 53 (1997b) 255-260.
-
(1997)
Biochem Pharmacol
, vol.53
, pp. 255-260
-
-
Deutsch, D.G.1
Omeir, R.2
Arreaza, G.3
Salehani, D.4
Prestwich, G.D.5
Huang, Z.6
Howlett, A.7
-
42
-
-
0024263922
-
Determination and characterisation of a cannabinoid receptor in rat brain
-
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. and Howlett, A. C., Determination and characterisation of a cannabinoid receptor in rat brain, Mol Pharmacol, 34 (1988) 605-613.
-
(1988)
Mol Pharmacol
, vol.34
, pp. 605-613
-
-
Devane, W.A.1
Dysarz, F.A.2
Johnson, M.R.3
Melvin, L.S.4
Howlett, A.C.5
-
43
-
-
0027078685
-
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
-
Devane, W. A., Hannus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. and Mechoulam, R., Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, 258 (1992) 1946-1949.
-
(1992)
Science
, vol.258
, pp. 1946-1949
-
-
Devane, W.A.1
Hannus, L.2
Breuer, A.3
Pertwee, R.G.4
Stevenson, L.A.5
Griffin, G.6
Gibson, D.7
Mandelbaum, A.8
Etinger, A.9
Mechoulam, R.10
-
45
-
-
0028589390
-
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
-
Di Marzo, V., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J. C. and Pomelli, D., Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Nature, 372 (1994) 686-691.
-
(1994)
Nature
, vol.372
, pp. 686-691
-
-
Di Marzo, V.1
Fontana, A.2
Cadas, H.3
Schinelli, S.4
Cimino, G.5
Schwartz, J.C.6
Pomelli, D.7
-
46
-
-
0032459475
-
Biochemistry of the endogenous ligands of cannabinoid receptors
-
Di Marzo, V. and Deutsch, D. G., Biochemistry of the endogenous ligands of cannabinoid receptors, Neurobiol Dis, 5 (1998) 386-404.
-
(1998)
Neurobiol Dis
, vol.5
, pp. 386-404
-
-
Di Marzo, V.1
Deutsch, D.G.2
-
47
-
-
0033567190
-
Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
-
Di Marzo, V., Bisogno, T., De Petrocellis, L., Melck, D., Orlando, P. and Wagner, J. A., Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages, Eur J Biochem, 264 (1999) 258-267.
-
(1999)
Eur J Biochem
, vol.264
, pp. 258-267
-
-
Di Marzo, V.1
Bisogno, T.2
De Petrocellis, L.3
Melck, D.4
Orlando, P.5
Wagner, J.A.6
-
48
-
-
0033936028
-
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
-
Di Marzo, V., Hill, M. P., Bisogno, T., Crossman, A. R. and Brotchie, J. M., Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease, FASEB J, 14 (2000) 1432-1438.
-
(2000)
FASEB J
, vol.14
, pp. 1432-1438
-
-
Di Marzo, V.1
Hill, M.P.2
Bisogno, T.3
Crossman, A.R.4
Brotchie, J.M.5
-
49
-
-
0036678094
-
Brain monoglyceride lipase participating in endocannabinoid inactivation
-
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S. and Piomelli, D., Brain monoglyceride lipase participating in endocannabinoid inactivation, Proc Natl Acad Sci USA, 99 (2002) 10819-10824.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10819-10824
-
-
Dinh, T.P.1
Carpenter, D.2
Leslie, F.M.3
Freund, T.F.4
Katona, I.5
Sensi, S.L.6
Kathuria, S.7
Piomelli, D.8
-
50
-
-
6944247598
-
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
-
Dinh, T. P., Kathuria, S. and Piomelli, D., RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol, Mol Pharmacol, 66 (2004) 1260-1264.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1260-1264
-
-
Dinh, T.P.1
Kathuria, S.2
Piomelli, D.3
-
51
-
-
0031847458
-
Synthesis and characterization of diazomethylarachidonyl ketone: An irreversible inhibitor of N-arachidonylethanolamine amidohydrolase
-
Edgemond, W. S., Greenberg, M. J., McGinley, P. J., Muthian, S., Campbell, W. B. and Hillard, C. J., Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase, J Pharmacol Exp Ther, 286 (1998) 184-190.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 184-190
-
-
Edgemond, W.S.1
Greenberg, M.J.2
McGinley, P.J.3
Muthian, S.4
Campbell, W.B.5
Hillard, C.J.6
-
52
-
-
0028818054
-
Peptidyl alphaketoheterocyclic inhibitors of human neutrophil elastase 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles
-
Edwards, P. D., Zottola, M. A., Davis, M., Williams, J. and Tuthill, P. A., Peptidyl alphaketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles, J Med Chem, 38 (1995) 3972-3982.
-
(1995)
J Med Chem
, vol.38
, pp. 3972-3982
-
-
Edwards, P.D.1
Zottola, M.A.2
Davis, M.3
Williams, J.4
Tuthill, P.A.5
-
53
-
-
2942525207
-
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
-
Fegley, D., Kathuria, S., Mercier, R., Li, C., Goutopoulos, A., Makriyannis, A. and Piomelli, D., Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172, Proc Natl Acad Sci U S A, 101 (2004) 8756-8761.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8756-8761
-
-
Fegley, D.1
Kathuria, S.2
Mercier, R.3
Li, C.4
Goutopoulos Makriyannis A., A.5
Piomelli, D.6
-
54
-
-
0030590440
-
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
-
Felder, C. C., Nielsen, A., Briley, E. M., Palkovits, M., Priller, J., Axelrod, J., Nguyen, D. N., Richardson, J. M., Riggin, R. M., Koppel, G. A., Paul, S. M. and Becker, G. W., Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat, FEBS Lett, 393 (1996) 231-235.
-
(1996)
FEBS Lett
, vol.393
, pp. 231-235
-
-
Felder, C.C.1
Nielsen, A.2
Briley, E.M.3
Palkovits, M.4
Priller, J.5
Axelrod, J.6
Nguyen, D.N.7
Richardson, J.M.8
Riggin, R.M.9
Koppel, G.A.10
Paul, S.M.11
Becker, G.W.12
-
55
-
-
0015223123
-
R., Acyl-transfer reactions of amides and esters with alcohols and thiols
-
Fersht, A. R., Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases, Concerning the N protonation of amides and amide-imidate equilibria, J Am Chem Soc, 93 (1971) 3504-3515.
-
(1971)
A reference system for the serine and cysteine proteinases, Concerning the N protonation of amides and amide-imidate equilibria, J Am Chem Soc
, vol.93
, pp. 3504-3515
-
-
Fersht, A.1
-
56
-
-
0037219107
-
J., Plant-derived, synthetic and endogenous cannabinoidsas neuroprotective agents
-
Fowler, C. J., Plant-derived, synthetic and endogenous cannabinoidsas neuroprotective agents. Non-psychoactive cannabinoids,'entourage' compounds and inhibitors of N-acyl ethanolamine breakdown as therapeutic strategies to avoid psychotropic effects, Brain Res Rev, 41 (2003) 26-43.
-
(2003)
Non-psychoactive cannabinoids,'entourage' compounds and inhibitors of N-acyl ethanolamine breakdown as therapeutic strategies to avoid psychotropic effects, Brain Res Rev
, vol.41
, pp. 26-43
-
-
Fowler, C.1
-
57
-
-
0345303765
-
Anandamide hydrolysis: A new target for antianxiety drugs?
-
Gaetani, S., Cuomo, V. and Piomelli, D., Anandamide hydrolysis: a new target for antianxiety drugs?, Trends Mol Med 9 (2003) 474-478.
-
(2003)
Trends Mol Med
, vol.9
, pp. 474-478
-
-
Gaetani Cuomo V., S.1
Piomelli, D.2
-
58
-
-
0030903752
-
Molecular characterization of human and mouse fatty acid amide hydrolases
-
Giang, D. K. and Cravatt, B. F., Molecular characterization of human and mouse fatty acid amide hydrolases, Proc Natl Acad Sci U S A, 94 (1997) 2238-2242.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 2238-2242
-
-
Giang, D.K.1
Cravatt, B.F.2
-
59
-
-
0037389484
-
Evidence against the presence of an anandamide transporter
-
Glaser, S. T., Abumrad, N. A., Fatade, F., Kaczocha, M., Studholme, K. M. and Deutsch, D. G., Evidence against the presence of an anandamide transporter, Proc Natl Acad Sci U S A, 100 (2003) 4269-4274.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4269-4274
-
-
Glaser, S.T.1
Abumrad, N.A.2
Fatade, F.3
Kaczocha, M.4
Studholme, K.M.5
Deutsch, D.G.6
-
60
-
-
0032898720
-
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors
-
Goparaju, S. K., Ueda, N., Taniguchi, K. and Yamamoto, S., Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors, Biochem Pharmacol, 57 (1999a) 417-423.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 417-423
-
-
Goparaju, S.K.1
Ueda, N.2
Taniguchi, K.3
Yamamoto, S.4
-
61
-
-
0032883310
-
Anandamide amidohydrolase of porcine brain:CDNA cloning, functional expression and site-directed mutagenesis
-
Goparaju, S. K., Kurahashi, Y., Suzuki, H., Ueda, N. and Yamamoto, S., Anandamide amidohydrolase of porcine brain:cDNA cloning, functional expression and site-directed mutagenesis, Biochim Biophys Acta, 1441 (1999b) 77-84.
-
(1999)
Biochim Biophys Acta
, vol.1441
, pp. 77-84
-
-
Goparaju, S.K.1
Kurahashi, Y.2
Suzuki, H.3
Ueda, N.4
Yamamoto, S.5
-
62
-
-
0037104758
-
Experimental parkinsonism alters endocannabinoid degradation: Implications for striatal glutamatergic transmission
-
Gubellini, P., Picconi, B., Bari, M., Battista, N., Calabresi, P., Centonze, D., Bernardi, G., Finazzi-Agró, A. and Maccarrone, M., Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission, J Neurosci, 22 (2002) 6900-6907.
-
(2002)
J Neurosci
, vol.22
, pp. 6900-6907
-
-
Gubellini, P.1
Picconi, B.2
Bari, M.3
Battista, N.4
Calabresi, P.5
Centonze, D.6
Bernardi Finazzi-Agró A., G.7
Maccarrone, M.8
-
63
-
-
3242751838
-
Segregation of two endocannabinoid-hydrolyzing enzymes into preand postsynaptic compartments in the rat hippocampus, cerebellum and amygdale
-
Gulyas, A. I., Cravatt, B. F., Bracey, M. H., Dinh, T. P., Piomelli, D., Boscia, F. and Freund, T. F., Segregation of two endocannabinoid-hydrolyzing enzymes into preand postsynaptic compartments in the rat hippocampus, cerebellum and amygdale, Eur J Neurosci, 20 (2004) 441-458.
-
(2004)
Eur J Neurosci
, vol.20
, pp. 441-458
-
-
Gulyas, A.I.1
Cravatt, B.F.2
Bracey, M.H.3
Dinh, T.P.4
Piomelli, D.5
Boscia, F.6
Freund, T.F.7
-
64
-
-
21244465211
-
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation
-
Guo, Y., Wang, H., Okamoto, Y., Ueda, N., Kingsley, P. J., Marnett, L. J., Schmid, H. H., Das, S. K. and Dey, S. K., N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation, J Biol Chem, 280 (2005) 23429-23432.
-
(2005)
J Biol Chem
, vol.280
, pp. 23429-23432
-
-
Guo, Y.1
Wang, H.2
Okamoto, Y.3
Ueda, N.4
Kingsley, P.J.5
Marnett, L.J.6
Schmid, H.H.7
Das, S.K.8
Dey, S.K.9
-
65
-
-
0035957425
-
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
-
Hanus, L., Abu-Lafi, S., Fride, E., Breuer, A., Vogel, Z., Shalev, D. E., Kustanovich, I. and Mechoulam, R. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor, Proc Natl Acad Sci U S A, 98 (2001) 3662-3665.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3662-3665
-
-
Hanus, L.1
Abu-Lafi, S.2
Fride, E.3
Breuer, A.4
Vogel, Z.5
Shalev, D.E.6
Kustanovich, I.7
Mechoulam, R.8
-
66
-
-
0021722983
-
M., Cannabinoid inhibition of adenylate cyclase
-
Howlett, A. C. and Fleming, R. M., Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes, Mol Pharmacol, 26 (1984) 532-528.
-
(1984)
Pharmacology of the response in neuroblastoma cell membranes, Mol Pharmacol
, vol.26
, pp. 528-532
-
-
Howlett, A.C.1
Fleming, R.2
-
67
-
-
18444376760
-
G., International Union of Pharmacology
-
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., Mechoulam, R. and Pertwee, R. G., International Union of Pharmacology. XXVII. Classification of cannabinoid receptors, Pharmacol Rev, 54 (2002) 161-202.
-
(2002)
XXVII. Classification of cannabinoid receptors, Pharmacol Rev
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
Devane, W.A.6
Felder, C.C.7
Herkenham, M.8
Mackie, K.9
Martin, B.R.10
Mechoulam, R.11
Pertwee, R.12
-
68
-
-
0035900694
-
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain
-
Huang, S. M., Bisogno, T., Petros, T. J., Chang, S. Y., Zavitsanos, P. A., Zipkin, R. E., Sivakumar, R., Coop, A., Maeda, D. Y., De Petrocellis, L., Burstein, S., Di Marzo, V. and Walker, J. M., Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain, J Biol Chem, 276 (2001) 42639-42644.
-
(2001)
J Biol Chem
, vol.276
, pp. 42639-42644
-
-
Huang, S.M.1
Bisogno, T.2
Petros, T.J.3
Chang, S.Y.4
Zavitsanos, P.A.5
Zipkin, R.E.6
Sivakumar, R.7
Coop, A.8
Maeda, D.Y.9
De Petrocellis, L.10
Burstein, S.11
Di Marzo, V.12
Walker, J.M.13
-
69
-
-
0029022840
-
Abnormal gene product identified in Huntington's disease lymphocytes and brain
-
Ide, K., Nukina, N., Masuda, N., Goto, J., Kanazawa, I., Abnormal gene product identified in Huntington's disease lymphocytes and brain, Biochem Biophys Res Commun, 209 (1995) 1119-1125.
-
(1995)
Biochem Biophys Res Commun
, vol.209
, pp. 1119-1125
-
-
Ide, K.1
Nukina, N.2
Masuda, N.3
Goto, J.4
Kanazawa, I.5
-
70
-
-
0036183319
-
Molecular basis for species-specific sensitivity to "hot" chili peppers
-
Jordt, S. E. and Julius, D., Molecular basis for species-specific sensitivity to "hot" chili peppers, Cell, 108 (2002) 421-430.
-
(2002)
Cell
, vol.108
, pp. 421-430
-
-
Jordt, S.E.1
Julius, D.2
-
71
-
-
0037581663
-
Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
-
Jung, J., Hwang, S. W., Kwak, J., Lee, S. Y., Kang, C. J., Kim, W. B., Kim, D. and Oh, U., Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel, J Neurosci, 19 (1999) 529-538.
-
(1999)
J Neurosci
, vol.19
, pp. 529-538
-
-
Jung, J.1
Hwang, S.W.2
Kwak, J.3
Lee, S.Y.4
Kang, C.J.5
Kim, W.B.6
Kim, D.7
Oh, U.8
-
72
-
-
0037234363
-
Modulation of anxiety through blockade of anandamide hydrolysis
-
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., La Rana, G., Calignano, A., Giustino, A., Tattoli, M., Palmery, M., Cuomo, V. and Piomelli, D., Modulation of anxiety through blockade of anandamide hydrolysis, Nat Med, 9 (2003) 76-81.
-
(2003)
Nat Med
, vol.9
, pp. 76-81
-
-
Kathuria, S.1
Gaetani, S.2
Fegley, D.3
Valiño, F.4
Duranti, A.5
Tontini, A.6
Mor, M.7
Tarzia, G.8
La Rana, G.9
Calignano, A.10
Giustino, A.11
Tattoli, M.12
Palmery Cuomo V., M.13
Piomelli, D.14
-
73
-
-
0036409093
-
An alternative mechanism for amidase signature enzymes
-
Labahn, J., Neumann, S., Büldt, G., Kula, M. R. and Granzin, J., An alternative mechanism for amidase signature enzymes, J Mol Biol, 322 (2002) 1053-1064.
-
(2002)
J Mol Biol
, vol.322
, pp. 1053-1064
-
-
Labahn, J.1
Neumann, S.2
Büldt, G.3
Kula, M.R.4
Granzin, J.5
-
74
-
-
30044435435
-
The cannabinoid agonist WIN55, 212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins
-
Lauckner, J. E., Hille, B. and Mackie, K., The cannabinoid agonist WIN55, 212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins, Proc Natl Acad Sci U S A, 102 (2005) 19144-19149.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19144-19149
-
-
Lauckner, J.E.1
Hille, B.2
Mackie, K.3
-
75
-
-
33645935391
-
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids
-
Leung, D., Saghatelian, A., Simon, G. M. and Cravatt, B. F., Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids, Biochemistry, 45 (2006) 4720-4726.
-
(2006)
Biochemistry
, vol.45
, pp. 4720-4726
-
-
Leung, D.1
Saghatelian, A.2
Simon, G.M.3
Cravatt, B.F.4
-
76
-
-
0036089489
-
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo
-
Lichtman, A. H., Hawkins, E. G., Griffin, G. and Cravatt, B. F., Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo, J Pharmacol Exp Ther, 302 (2002) 73-79.
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 73-79
-
-
Lichtman, A.H.1
Hawkins, E.G.2
Griffin, G.3
Cravatt, B.F.4
-
77
-
-
4644354869
-
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity
-
Lichtman, A. H., Leung, D., Shelton, C. C., Saghatelian, A., Hardouin, C., Boger, D. L. and Cravatt, B. F., Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity, J Pharmacol Exp Ther, 311 (2004) 441-448.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 441-448
-
-
Lichtman, A.H.1
Leung, D.2
Shelton, C.C.3
Saghatelian, A.4
Hardouin, C.5
Boger, D.L.6
Cravatt, B.F.7
-
78
-
-
2442425261
-
Further evidence for the existence of a specific process for the membrane transport of anandamide
-
Ligresti, A., Morera, E., Van Der Stelt, M., Monory, K., Lutz, B., Ortar, G. and Di Marzo, V., Further evidence for the existence of a specific process for the membrane transport of anandamide, Biochem J, 380 (2004) 265-272.
-
(2004)
Biochem J
, vol.380
, pp. 265-272
-
-
Ligresti, A.1
Morera, E.2
Van Der Stelt, M.3
Monory, K.4
Lutz Ortar G., B.5
Di Marzo, V.6
-
79
-
-
33748608009
-
A biosynthetic pathway for anandamide
-
Liu, J., Wang, L., Harvey-White, J., Osei-Hyiaman, D., Razdan, R., Gong, Q., Chan, A. C., Zhou, Z., Huang, B. X., Kim, H. Y. and Kunos, G., A biosynthetic pathway for anandamide, Proc Natl Acad Sci U S A, 103 (2006) 13345-13350.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13345-13350
-
-
Liu, J.1
Wang, L.2
Harvey-White, J.3
Osei-Hyiaman, D.4
Razdan, R.5
Gong, Q.6
Chan, A.C.7
Zhou, Z.8
Huang, B.X.9
Kim, H.Y.10
Kunos, G.11
-
80
-
-
0035924218
-
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors
-
López-Rodríguez, M. L., Viso, A., Ortega-Gutiérrez, S., Lastres-Becker, I., González, S., Fernández-Ruiz, J. and Ramos, J. A., Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors, J Med Chem, 44 (2001) 4505-4508.
-
(2001)
J Med Chem
, vol.44
, pp. 4505-4508
-
-
López-Rodríguez, M.L.1
Viso, A.2
Ortega-Gutiérrez, S.3
Lastres-Becker, I.4
González, S.5
Fernández-Ruiz, J.6
Ramos, J.A.7
-
81
-
-
33749261955
-
Targeting the CB2 receptor for immune modulation
-
Lunn, C. A., Reich, E. P. and Bober, L., Targeting the CB2 receptor for immune modulation, Expert Opin Ther Targets, 5 (2006) 653-663.
-
(2006)
Expert Opin Ther Targets
, vol.5
, pp. 653-663
-
-
Lunn, C.A.1
Reich, E.P.2
Bober, L.3
-
82
-
-
33645299083
-
Fatty acid amide hydrolase: A potential target for next generation therapeutics
-
Maccarrone, M., Fatty acid amide hydrolase: a potential target for next generation therapeutics, Curr Pharm Des, 12 (2006) 759-772.
-
(2006)
Curr Pharm Des
, vol.12
, pp. 759-772
-
-
Maccarrone, M.1
-
83
-
-
3042569771
-
Anandamide hydrolase: A guardian angel of human reproduction?
-
Maccarrone, M. and Finazzi-Agró, A., Anandamide hydrolase: a guardian angel of human reproduction?, Trends Pharmacol Sci, 25 (2004a) 353-357.
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 353-357
-
-
Maccarrone, M.1
Finazzi-Agró, A.2
-
84
-
-
0033610794
-
Anandamide hydrolysis by human cells in culture and brain
-
Maccarrone, M., van der Stelt, M., Rossi, A., Veldink, G. A., Vliegenthart, J. F. and Finazzi-óA., Anandamide hydrolysis by human cells in culture and brain, J Biol Chem, 273 (1998) 32332-32339.
-
(1998)
J Biol Chem
, vol.273
, pp. 32332-32339
-
-
Maccarrone, M.1
van der Stelt, M.2
Rossi, A.3
Veldink, G.A.4
Vliegenthart, J.F.5
Finazzi, ó.A.6
-
85
-
-
0008894432
-
Down-regulation of anandamide hydrolase in mouse uterus by sex hormones
-
Maccarrone, M., De Felici, M., Bari, M., Klinger, F., Siracusa, G. and Finazzi-Agro, A., Down-regulation of anandamide hydrolase in mouse uterus by sex hormones, Eur J Biochem, 267 (2000a) 2991-2997.
-
(2000)
Eur J Biochem
, vol.267
, pp. 2991-2997
-
-
Maccarrone, M.1
De Felici, M.2
Bari, M.3
Klinger Siracusa G., F.4
Finazzi-Agro, A.5
-
86
-
-
0034655926
-
Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage
-
Maccarrone, M., Valensise, H., Bari, M., Lazzarin, N., Romanini, C. and Finazzi-Agró, A., Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage, Lancet, 355 (2000b) 1326-1329.
-
(2000)
Lancet
, vol.355
, pp. 1326-1329
-
-
Maccarrone, M.1
Valensise, H.2
Bari, M.3
Lazzarin Romanini C., N.4
Finazzi-Agró, A.5
-
87
-
-
0035877059
-
Progesterone up-regulates anandamide hydrolase in human lymphocytes: Role of cytokines and implications for fertility
-
Maccarrone, M., Valensise, H., Bari, M., Lazzarin, N., Romanini, C. and Finazzi-Agró, A., Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility, J Immunol, 166 (2001) 7183-7189.
-
(2001)
J Immunol
, vol.166
, pp. 7183-7189
-
-
Maccarrone, M.1
Valensise, H.2
Bari, M.3
Lazzarin Romanini C., N.4
Finazzi-Agró, A.5
-
88
-
-
0038305991
-
Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3
-
Maccarrone, M., Di Rienzo, M., Finazzi-Agró, A. and Rossi, A., Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3, J Biol Chem, 278 (2003a) 13318-13324.
-
(2003)
J Biol Chem
, vol.278
, pp. 13318-13324
-
-
Maccarrone, M.1
Di Rienzo Finazzi-Agró A., M.2
Rossi, A.3
-
89
-
-
0041856520
-
Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros, Evidence for a synergistic effect of leptin
-
Maccarrone, M., Bari, M., Di Rienzo, M., Finazzi-Agro, A. and Rossi, A., Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros, Evidence for a synergistic effect of leptin, J Biol Chem, 278 (2003b) 32726-32732.
-
(2003)
J Biol Chem
, vol.278
, pp. 32726-32732
-
-
Maccarrone, M.1
Bari, M.2
Di Rienzo Finazzi-Agro A., M.3
Rossi, A.4
-
90
-
-
11244306367
-
Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone
-
Maccarrone, M., Gasperi, V., Fezza, F., Finazzi-Agro, A. and Rossi, A., Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone, Eur J Biochem, 271 (2004b) 4666-4676.
-
(2004)
Eur J Biochem
, vol.271
, pp. 4666-4676
-
-
Maccarrone, M.1
Gasperi, V.2
Fezza Finazzi-Agro A., F.3
Rossi, A.4
-
91
-
-
0033839170
-
Cannabinoid properties of methylfluorophosphonate analogs
-
Martin, B. R., Beletskaya, I., Patrick, G., Jefferson, R., Winckler, R., Deutsch, D. G., Di Marzo, V., Dasse, O., Mahadevan, A. and Razdan, R. K., Cannabinoid properties of methylfluorophosphonate analogs, J Pharmacol Exp Ther, 294 (2000) 1209-1218.
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 1209-1218
-
-
Martin, B.R.1
Beletskaya, I.2
Patrick, G.3
Jefferson, R.4
Winckler, R.5
Deutsch, D.G.6
Di Marzo, V.7
Dasse, O.8
Mahadevan, A.9
Razdan, R.K.10
-
92
-
-
11144356025
-
Prostaglandin ethanolamides (prostamides): In vitro pharmacology and metabolism
-
Matias, I., Chen, J., De Petrocellis, L., Bisogno, T., Ligresti, A., Fezza, F., Krauss, A. H., Shi, L., Protzman, C. E., Li, C., Liang, Y., Nieves, A. L., Kedzie, K. M., Burk, R. M., Di Marzo, V. and Woodward, D. F., Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism, J Pharmacol Exp Ther, 309 (2004) 745-757.
-
(2004)
J Pharmacol Exp Ther
, vol.309
, pp. 745-757
-
-
Matias, I.1
Chen, J.2
De Petrocellis, L.3
Bisogno, T.4
Ligresti, A.5
Fezza, F.6
Krauss, A.H.7
Shi, L.8
Protzman, C.E.9
Li, C.10
Liang, Y.11
Nieves, A.L.12
Kedzie, K.M.13
Burk, R.M.14
Di Marzo, V.15
Woodward, D.F.16
-
93
-
-
0029619298
-
Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'
-
Maurelli, S., Bisogno, T., De Petrocellis, L., Di Luccia, A., Marino, G. and Di Marzo, V., Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase', FEBS Lett, 377 (1995) 82-86.
-
(1995)
FEBS Lett
, vol.377
, pp. 82-86
-
-
Maurelli, S.1
Bisogno, T.2
De Petrocellis, L.3
Di Luccia Marino G., A.4
Di Marzo, V.5
-
94
-
-
4744345923
-
A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide
-
McFarland, M. J., Porter, A. C., Rakhshan, F. R., Rawat, D. S., Gibbs, R. A. and Barker, E. L., A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide, J Biol Chem, 279 (2004) 41991-41997.
-
(2004)
J Biol Chem
, vol.279
, pp. 41991-41997
-
-
McFarland, M.J.1
Porter, A.C.2
Rakhshan, F.R.3
Rawat, D.S.4
Gibbs, R.A.5
Barker, E.L.6
-
95
-
-
22244484464
-
Structure and function of fatty acid amide hydrolase
-
McKinney, M. K. and Cravatt, B. F., Structure and function of fatty acid amide hydrolase, Annu Rev Biochem, 74 (2005) 411-432.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 411-432
-
-
McKinney, M.K.1
Cravatt, B.F.2
-
96
-
-
33644872117
-
Evolutionary origins of the endocannabinoid system
-
McPartland, J. M., Matias, I., Di Marzo, V. and Glass, M., Evolutionary origins of the endocannabinoid system, Gene, 370 (2006) 64-74.
-
(2006)
Gene
, vol.370
, pp. 64-74
-
-
McPartland, J.M.1
Matias, I.2
Di Marzo, V.3
Glass, M.4
-
97
-
-
0029012014
-
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
-
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., Pertwee, R. G., Griffine, G., Bayewitchf, M., Bargf, J. and Vogelf, Z., Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem Pharmacol, 50 (1995) 83-90.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, L.3
Ligumsky, M.4
Kaminski, N.E.5
Schatz, A.R.6
Gopher, A.7
Almog, S.8
Martin, B.R.9
Compton, D.R.10
Pertwee, R.G.11
Griffine, G.12
Bayewitchf, M.13
Bargf, J.14
Vogelf, Z.15
-
98
-
-
0036156353
-
Cannabinoids and brain injury: Therapeutic implications
-
Mechoulam, R., Panikashvili, D. and Shohami, E., Cannabinoids and brain injury: therapeutic implications, Trends Mol Med, 8 (2002) 58-61.
-
(2002)
Trends Mol Med
, vol.8
, pp. 58-61
-
-
Mechoulam Panikashvili D., R.1
Shohami, E.2
-
99
-
-
33947491800
-
Closing the gate to the active site: Effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase
-
Mei,G., DiVenere,A.,Gasperi,V., Nicolai, E.,Masuda, K.R., Finazzi-Agró,A., Cravatt, B. F. and Maccarrone, M., Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase, J Biol Chem, 282 (2007) 3829-3836.
-
(2007)
J Biol Chem
, vol.282
, pp. 3829-3836
-
-
Mei, G.1
DiVenere, A.2
Gasperi, V.3
Nicolai, E.4
Masuda, K.R.5
Finazzi-Agró, A.6
Cravatt, B.F.7
Maccarrone, M.8
-
100
-
-
4744354729
-
Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl- 3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structureactivity relationships, and molecular modeling studies
-
Mor, M., Rivara, S., Lodola, A., Plazzi, P. V., Tarzia, G., Duranti, A., Tontini, A., Piersanti, G., Kathuria, S. and Piomelli, D., Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl- 3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structureactivity relationships, and molecular modeling studies, J Med Chem, 47 (2004) 4998-5008.
-
(2004)
J Med Chem
, vol.47
, pp. 4998-5008
-
-
Mor, M.1
Rivara, S.2
Lodola, A.3
Plazzi, P.V.4
Tarzia, G.5
Duranti, A.6
Tontini, A.7
Piersanti, G.8
Kathuria, S.9
Piomelli, D.10
-
101
-
-
33947330328
-
Identification of a novel endocannabinoidhydrolyzing enzyme expressed by microglial cells
-
Muccioli, G. G., Xu, C., Odah, E., Cudaback, E., Cisneros, J. A., Lambert, D. M., López Rodríguez, M. L., Bajjalieh, S. and Stella, N., Identification of a novel endocannabinoidhydrolyzing enzyme expressed by microglial cells, J Neurosci, 27 (2007) 2883-2889.
-
(2007)
J Neurosci
, vol.27
, pp. 2883-2889
-
-
Muccioli, G.G.1
Xu, C.2
Odah, E.3
Cudaback, E.4
Cisneros, J.A.5
Lambert, D.M.6
López Rodríguez, M.L.7
Bajjalieh, S.8
Stella, N.9
-
102
-
-
0027515373
-
Molecular characterization of a peripheral receptor for cannabinoids
-
Munro, S., Thomas, K. L. and Abu-Shaar, M., Molecular characterization of a peripheral receptor for cannabinoids, Nature, 365 (1993) 61-65.
-
(1993)
Nature
, vol.365
, pp. 61-65
-
-
Munro, S.1
Thomas, K.L.2
Abu-Shaar, M.3
-
103
-
-
34548494339
-
Genetic polymorphisms of the endocannabinoid system
-
Norrod, A. G. and Puffenbarger, R. A., Genetic polymorphisms of the endocannabinoid system, Chem Biodivers, 4 (2007) 1926-1932.
-
(2007)
Chem Biodivers
, vol.4
, pp. 1926-1932
-
-
Norrod, A.G.1
Puffenbarger, R.A.2
-
104
-
-
14844323175
-
Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes
-
Oddi, S., Bari, M., Battista, N., Barsacchi, D., Cozzani, I. and Maccarrone, M., Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes, Cell Mol Life Sci, 62 (2005) 386-395.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 386-395
-
-
Oddi, S.1
Bari, M.2
Battista, N.3
Barsacchi Cozzani I., D.4
Maccarrone, M.5
-
105
-
-
0038810313
-
Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species
-
Oka, S., Tsuchie,A., Tokumura, A.,Muramatsu,M., Suhara,Y., Takayama, H.,Waku, K., and Sugiura, T., Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species, J Neurochem, 85 (2003) 1374-1381.
-
(2003)
J Neurochem
, vol.85
, pp. 1374-1381
-
-
Oka, S.1
Tsuchie, A.2
Tokumura, A.3
Muramatsu, M.4
Suhara, Y.5
Takayama, H.6
Waku, K.7
Sugiura, T.8
-
106
-
-
1242294480
-
Molecular characterization of a phospholipase D generating anandamide and its congeners
-
Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N., Molecular characterization of a phospholipase D generating anandamide and its congeners, J Biol Chem, 279 (2004), 5298-5305.
-
(2004)
J Biol Chem
, vol.279
, pp. , 5298-5305
-
-
Okamoto, Y.1
Morishita, J.2
Tsuboi, K.3
Tonai, T.4
Ueda, N.5
-
107
-
-
0037542450
-
Novel selective and metabolically stable inhibitors of anandamide cellular uptake
-
Ortar, G., Ligresti, A., De Petrocellis, L., Morera, E. and Di Marzo, V., Novel selective and metabolically stable inhibitors of anandamide cellular uptake, Biochem Pharmacol, 65 (2003) 1473-1481.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1473-1481
-
-
Ortar, G.1
Ligresti, A.2
De Petrocellis Morera E., L.3
Di Marzo, V.4
-
108
-
-
0029800322
-
The uterus is a potential site for anandamide synthesis and hydrolysis: Differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the preiimplantation period
-
Paria, B. C., Deutsch, D. G. and Dey, S. K., The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the preiimplantation period, Mol Reprod Dev, 45 (1996) 183-192.
-
(1996)
Mol Reprod Dev
, vol.45
, pp. 183-192
-
-
Paria, B.C.1
Deutsch, D.G.2
Dey, S.K.3
-
109
-
-
0032891426
-
Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the preiimplantation period
-
Paria, B. C., Zhao, X., Wang, J., Das, S. K. and Dey, S. K., Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the preiimplantation period, Biol Repro, 60 (1999) 1151-1157.
-
(1999)
Biol Repro
, vol.60
, pp. 1151-1157
-
-
Paria, B.C.1
Zhao, X.2
Wang, J.3
Das, S.K.4
Dey, S.K.5
-
110
-
-
0942276562
-
Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta
-
Park, B., Gibbons, H. M., Mitchell, M. D. and Glass, M., Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta, Placenta, 24 (2003) 990-995.
-
(2003)
Placenta
, vol.24
, pp. 990-995
-
-
Park, B.1
Gibbons, H.M.2
Mitchell, M.D.3
Glass, M.4
-
111
-
-
0033607236
-
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a non conventional catalytic mechanism
-
Patricelli, M. P. and Cravatt, B. F., Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a non conventional catalytic mechanism, Biochemistry, 38 (1999) 14125-14130.
-
(1999)
Biochemistry
, vol.38
, pp. 14125-14130
-
-
Patricelli, M.P.1
Cravatt, B.F.2
-
112
-
-
0032573124
-
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: Identification of the transmembrane domain as a site for oligomerization
-
Patricelli, M. P., Lashuel, H. A., Giang, D. K., Kelly, J. W. and Cravatt, B.F., Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization, Biochemistry, 37(43): (1998) 15177-15187.
-
(1998)
Biochemistry
, vol.37
, Issue.43
, pp. 15177-15187
-
-
Patricelli, M.P.1
Lashuel, H.A.2
Giang, D.K.3
Kelly, J.W.4
Cravatt, B.F.5
-
113
-
-
0033520099
-
Chemical and mutagenic investigations of fatty acid amide hydrolase: Evidence for a family of serine hydrolases with distinct catalytic properties
-
Patricelli, M. P., Lovato, M. A. and Cravatt, B. F., Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties, Biochemistry, 38 (1999) 9804-9812.
-
(1999)
Biochemistry
, vol.38
, pp. 9804-9812
-
-
Patricelli, M.P.1
Lovato, M.A.2
Cravatt, B.F.3
-
114
-
-
0028009093
-
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
-
Picot, D., Loll, P. J. and Garavito, R. M., The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1, Nature, 367 (1994) 243-249.
-
(1994)
Nature
, vol.367
, pp. 243-249
-
-
Picot, D.1
Loll, P.J.2
Garavito, R.M.3
-
115
-
-
0242268553
-
The molecular logic of endocannabinoid signalling
-
Piomelli, D., The molecular logic of endocannabinoid signalling, Nature Rev Neurosci, 4 (2003) 873-884.
-
(2003)
Nature Rev Neurosci
, vol.4
, pp. 873-884
-
-
Piomelli, D.1
-
116
-
-
0032467803
-
Endogenous cannabinoid signaling
-
Piomelli, D., Beltramo, M., Giuffrida, A. and Stella, N., Endogenous cannabinoid signaling, Neurobiol Dis, 6 (1998) 462-473.
-
(1998)
Neurobiol Dis
, vol.6
, pp. 462-473
-
-
Piomelli, D.1
Beltramo Giuffrida A., M.2
Stella, N.3
-
117
-
-
0034212295
-
The endocannabinoid system as a target for therapeutic drugs
-
Piomelli, D., Giuffrida, A., Calignano, A. and de Fonseca, F. R., The endocannabinoid system as a target for therapeutic drugs, Trends Pharmacol Sci, 21 (2000) 218-224.
-
(2000)
Trends Pharmacol Sci
, vol.21
, pp. 218-224
-
-
Piomelli, D.1
Giuffrida, A.2
Calignano, A.3
de Fonseca, F.R.4
-
118
-
-
33746474287
-
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)
-
Piomelli, D., Tarzia, G., Duranti, A., Tontini, A., Mor, M., Compton, T. R., Dasse, O., Monaghan, E. P., Parrott, J. A. and Putman, D., Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597), CNS Drug Rev, 12 (2006) 21-38.
-
(2006)
CNS Drug Rev
, vol.12
, pp. 21-38
-
-
Piomelli, D.1
Tarzia, G.2
Duranti, A.3
Tontini, A.4
Mor, M.5
Compton, T.R.6
Dasse, O.7
Monaghan, E.P.8
Parrott, J.A.9
Putman, D.10
-
119
-
-
0036260823
-
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
-
Porter, A. C., Sauer, J. M., Knierman, M. D., Becker, G. W., Berna, M. J., Bao, J., Nomikos, G. G., Carter, P., Bymaster, F. P., Leese, A. B. and Felder, C. C., Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor, J Pharmacol Exp Ther, 301 (2002) 1020-1024.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 1020-1024
-
-
Porter, A.C.1
Sauer, J.M.2
Knierman, M.D.3
Becker, G.W.4
Berna, M.J.5
Bao, J.6
Nomikos, G.G.7
Carter, P.8
Bymaster, F.P.9
Leese, A.B.10
Felder, C.C.11
-
120
-
-
0035856379
-
Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase
-
Puffenbarger, R. A., Kapulina, O., Howell, J. M. and Deutsch, D. G., Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase, Neurosci Lett, 314 (2001) 21-24.
-
(2001)
Neurosci Lett
, vol.314
, pp. 21-24
-
-
Puffenbarger, R.A.1
Kapulina, O.2
Howell, J.M.3
Deutsch, D.G.4
-
121
-
-
0030463487
-
The volatile oil composition of fresh and air-dried buds of Cannabis sativa
-
Ross, S. A. and Elsohly, M. A., The volatile oil composition of fresh and air-dried buds of Cannabis sativa, J Nat Prod, 59 (1996) 49-51.
-
(1996)
J Nat Prod
, vol.59
, pp. 49-51
-
-
Ross, S.A.1
Elsohly, M.A.2
-
122
-
-
38049012986
-
Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: Relation with serotonin levels
-
Rossi, C., Pini, L. A., Cupini, M. L., Calabresi, P. and Sarchielli, P., Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels, Eur J Clin Pharmacol, 64 (2008) 1-8.
-
(2008)
Eur J Clin Pharmacol
, vol.64
, pp. 1-8
-
-
Rossi, C.1
Pini, L.A.2
Cupini, M.L.3
Calabresi, P.4
Sarchielli, P.5
-
123
-
-
35649015179
-
The orphan receptor GPR55 is a novel cannabinoid receptor
-
Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N. O., Leonova, J., Elebring, T., Nilsson, K., Drmota, T. and Greasley, P. J., The orphan receptor GPR55 is a novel cannabinoid receptor, Br J Pharmacol, 152 (2007) 1092-1101.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1092-1101
-
-
Ryberg, E.1
Larsson, N.2
Sjögren, S.3
Hjorth, S.4
Hermansson, N.O.5
Leonova, J.6
Elebring, T.7
Nilsson, K.8
Drmota, T.9
Greasley, P.J.10
-
124
-
-
0033524644
-
Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain
-
Sawzdargo, M., Nguyen, T., Lee, D. K., Lynch, K. R., Cheng, R., Heng, H. H., George, S. R. and O'Dowd, B. F., Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain, Brain Res Mol Brain Res, 64 (1999) 193-198.
-
(1999)
Brain Res Mol Brain Res
, vol.64
, pp. 193-198
-
-
Sawzdargo, M.1
Nguyen, T.2
Lee, D.K.3
Lynch, K.R.4
Cheng, R.5
Heng, H.H.6
George, S.R.7
O'Dowd, B.F.8
-
125
-
-
0042832959
-
Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors
-
Segall, Y., Quistad, G. B., Nomura, D. K. and Casida, J. E., Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors, Bioorg Med Chem Lett, 13 (2003) 3301-3303.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 3301-3303
-
-
Segall, Y.1
Quistad, G.B.2
Nomura, D.K.3
Casida, J.E.4
-
126
-
-
0037013923
-
Structure of malonamidase E2 reveals a novel Ser-Ser-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature
-
Shin, S., Lee, T. H., Ha, N. C., Koo, H. M., Kim, S. Y., Lee, H. S., Kim, Y. S. and Oh, B. H., Structure of malonamidase E2 reveals a novel Ser-Ser-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature, EMBO J, 21 (2002) 2509-2516.
-
(2002)
EMBO J
, vol.21
, pp. 2509-2516
-
-
Shin, S.1
Lee, T.H.2
Ha, N.C.3
Koo, H.M.4
Kim, S.Y.5
Lee, H.S.6
Kim, Y.S.7
Oh, B.H.8
-
127
-
-
33750873334
-
Spider toxins activate the capsaicin receptor to produce inflammatory pain
-
Siemens, J., Zhou, S., Piskorowski, R., Nikai, T., Lumpkin, E. A., Basbaum, A. I., King, D. and Julius, D., Spider toxins activate the capsaicin receptor to produce inflammatory pain, Nature, 444 (2006) 208-212.
-
(2006)
Nature
, vol.444
, pp. 208-212
-
-
Siemens, J.1
Zhou, S.2
Piskorowski, R.3
Nikai, T.4
Lumpkin, E.A.5
Basbaum, A.I.6
King, D.7
Julius, D.8
-
128
-
-
33748743637
-
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway
-
Simon, G. M. and Cravatt, B. F., Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway, J Biol Chem, 281 (2006) 26465-26472.
-
(2006)
J Biol Chem
, vol.281
, pp. 26465-26472
-
-
Simon, G.M.1
Cravatt, B.F.2
-
129
-
-
0037062436
-
A missense mutation in human fatty acid amide hydrolase associated with problem drug use
-
Sipe, J. C., Chiang, K., Gerber, A. L., Beutler, E. and Cravatt, B. F., A missense mutation in human fatty acid amide hydrolase associated with problem drug use, Proc Natl Acad Sci U S A, 99 (2002) 8394-8399.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8394-8399
-
-
Sipe, J.C.1
Chiang, K.2
Gerber, A.L.3
Beutler, E.4
Cravatt, B.F.5
-
130
-
-
17844411014
-
Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
-
Sipe, J. C., Waalen, J., Gerber, A. and Beutler, E., Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH), Int J Obesity, 29 (2005) 755-799.
-
(2005)
Int J Obesity
, vol.29
, pp. 755-799
-
-
Sipe, J.C.1
Waalen, J.2
Gerber, A.3
Beutler, E.4
-
131
-
-
33947697100
-
Biochemistry and pharmacology of endovanilloids
-
Starowicz, K., Nigam, S. and Di Marzo, V., Biochemistry and pharmacology of endovanilloids, Pharmacol Ther, 114 (2007) 13-33.
-
(2007)
Pharmacol Ther
, vol.114
, pp. 13-33
-
-
Starowicz Nigam S., K.1
Di Marzo, V.2
-
132
-
-
0030870722
-
A second endogenous cannabinoid that modulates long-term potentiation
-
Stella, N., Schweitzer, P. and Piomelli, D., A second endogenous cannabinoid that modulates long-term potentiation, Nature, 388 (1997) 773-778.
-
(1997)
Nature
, vol.388
, pp. 773-778
-
-
Stella Schweitzer P., N.1
Piomelli, D.2
-
134
-
-
0028970517
-
Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
-
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A. and Waku, K., Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain, Biochem Biophys Res Commun, 215 (1995) 89-95.
-
(1995)
Biochem Biophys Res Commun
, vol.215
, pp. 89-95
-
-
Sugiura, T.1
Kondo, S.2
Sukagawa, A.3
Nakane, S.4
Shinoda, A.5
Itoh Yamashita A., K.6
Waku, K.7
-
135
-
-
0034614374
-
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor
-
Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Natane, S., Kodaka, T., Suhara, Y., Takayama, H. and Waku, K., Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells, J Biol Chem, 275 (2000a) 605-612.
-
(2000)
Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells, J Biol Chem
, vol.275
, pp. 605-612
-
-
Sugiura, T.1
Kondo, S.2
Kishimoto, S.3
Miyashita, T.4
Natane, S.5
Kodaka, T.6
Suhara, Y.7
Takayama, H.8
Waku, K.9
-
136
-
-
0036019386
-
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
-
Sugiura, T., Kobayashi, Y., Oka, S. and Waku, K., Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance, Prostaglandins Leukot Essent Fatty Acids, 66 (2002) 173-192.
-
(2002)
Prostaglandins Leukot Essent Fatty Acids
, vol.66
, pp. 173-192
-
-
Sugiura, T.1
Kobayashi Oka S., Y.2
Waku, K.3
-
137
-
-
3042737612
-
Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D
-
Sun, Y. X., Tsuboi, K., Okamoto, Y., Tonai, T., Murakami, M., Kudo, I. and Ueda, N., Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D, Biochem J, 380 (2004) 749-756.
-
(2004)
Biochem J
, vol.380
, pp. 749-756
-
-
Sun, Y.X.1
Tsuboi, K.2
Okamoto, Y.3
Tonai, T.4
Murakami, M.5
Kudo, I.6
Ueda, N.7
-
138
-
-
33746301093
-
Synthesis and structureactivity relationships of FAAH inhibitors: Cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring
-
Tarzia, G., Duranti, A., Gatti, G., Piersanti, G., Tontini, A., Rivara, S., Lodola, A., Plazzi, P. V., Mor, M., Kathuria, S. and Piomelli, D., Synthesis and structureactivity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring, Chem Med Chem, 1 (2006) 130-139.
-
(2006)
Chem Med Chem
, vol.1
, pp. 130-139
-
-
Tarzia, G.1
Duranti, A.2
Gatti, G.3
Piersanti, G.4
Tontini, A.5
Rivara, S.6
Lodola, A.7
Plazzi, P.V.8
Mor, M.9
Kathuria, S.10
Piomelli, D.11
-
139
-
-
15744378565
-
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
-
Tsuboi, K., Sun, Y. X., Okamoto, Y., Araki, N., Tonai, T. and Ueda, N., Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase, J Biol Chem, 280 (2005) 11082-11092.
-
(2005)
J Biol Chem
, vol.280
, pp. 11082-11092
-
-
Tsuboi, K.1
Sun, Y.X.2
Okamoto, Y.3
Araki, N.4
Tonai, T.5
Ueda, N.6
-
140
-
-
0028787812
-
Partial purification and characterization of the porcine brain enzymehydrolyzing and synthesizing anandamide
-
Ueda, N., Kurahashi, Y., Yamamoto, S. and Tokunaga, T., Partial purification and characterization of the porcine brain enzymehydrolyzing and synthesizing anandamide, J Biol Chem, 270 (1995) 23823-23827.
-
(1995)
J Biol Chem
, vol.270
, pp. 23823-23827
-
-
Ueda, N.1
Kurahashi Yamamoto S., Y.2
Tokunaga, T.3
-
141
-
-
2442636258
-
Endovanilloids
-
van der Stelt, M. and Di Marzo, V., Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels, Eur J Biochem, 271 (2004) 1827-1834.
-
(2004)
Putative endogenous ligands of transient receptor potential vanilloid 1 channels, Eur J Biochem
, vol.271
, pp. 1827-1834
-
-
van der Stelt, M.1
Di Marzo, V.2
-
142
-
-
0037103365
-
Oxygenated metabolites of anandamide and 2-arachidonoyl-glycerol: Conformational analysis and interaction with cannabinoid receptors, membrane transporter and fatty acid amide hydrolase
-
van der Stelt, M., van Kuik, J. A., Bari, M., van Zadelhoff, G., Leeflang, B. R., Veldink, G. A., Finazzi-Agró, A., Vliegenthart, J. F. and Maccarrone, M., Oxygenated metabolites of anandamide and 2-arachidonoyl-glycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter and fatty acid amide hydrolase, J Med Chem, 45 (2002) 3709-3720.
-
(2002)
J Med Chem
, vol.45
, pp. 3709-3720
-
-
van der Stelt, M.1
van Kuik, J.A.2
Bari, M.3
van Zadelhoff, G.4
Leeflang, B.R.5
Veldink, G.A.6
Finazzi-Agró, A.7
Vliegenthart, J.F.8
Maccarrone, M.9
-
143
-
-
26844504226
-
Identification and functional characterization of brainstem cannabinoid CB2 receptors
-
Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., Marnett, L. J., Di Marzo, V., Pittman, Q. J., Patel, K. D. and Sharkey, K. A., Identification and functional characterization of brainstem cannabinoid CB2 receptors, Science, 310 (2005) 329-332.
-
(2005)
Science
, vol.310
, pp. 329-332
-
-
Van Sickle, M.D.1
Duncan, M.2
Kingsley, P.J.3
Mouihate, A.4
Urbani, P.5
Mackie, K.6
Stella, N.7
Makriyannis, A.8
Piomelli, D.9
Davison, J.S.10
Marnett, L.J.11
Di Marzo, V.12
Pittman, Q.J.13
Patel, K.D.14
Sharkey, K.A.15
-
144
-
-
25844465639
-
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase
-
Vandevoorde, S., Saha, B., Mahadevan, A., Razdan, R. K., Pertwee, R. G., Martin, B. R. and Fowler, C. J., Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase, Biochem Biophys Res Commun, 337 (2005) 104-109.
-
(2005)
Biochem Biophys Res Commun
, vol.337
, pp. 104-109
-
-
Vandevoorde, S.1
Saha, B.2
Mahadevan, A.3
Razdan, R.K.4
Pertwee, R.G.5
Martin, B.R.6
Fowler, C.J.7
-
145
-
-
0037193680
-
Transcriptional regulation of the mouse fatty acid amide hydrolase gene
-
Waleh, N. S., Cravatt, B. F., Apte-Deshpande, A., Terao, A. and Kilduff, T. S., Transcriptional regulation of the mouse fatty acid amide hydrolase gene, Gene, 291 (2002) 203-210.
-
(2002)
Gene
, vol.291
, pp. 203-210
-
-
Waleh, N.S.1
Cravatt, B.F.2
Apte-Deshpande, A.3
Terao, A.4
Kilduff, T.S.5
-
146
-
-
0032535642
-
Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation
-
Wan, M., Cravatt, B. F., Ring, H. Z., Zhang, X. and Francke, U., Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation, Genomics, 54 (1998) 408-414.
-
(1998)
Genomics
, vol.54
, pp. 408-414
-
-
Wan, M.1
Cravatt, B.F.2
Ring, H.Z.3
Zhang, X.4
Francke, U.5
-
147
-
-
33746669402
-
Fatty acid amide hydrolase deficiency limits early pregnancy events
-
Wang, H., Xie, H., Guo, Y., Zhang, H., Takahashi, T., Kingsley, P. J., Marnett, L. J., Das, S. K., Cravatt, B. F. and Dey, S. K., Fatty acid amide hydrolase deficiency limits early pregnancy events, J Clin Invest, 116 (2006) 2122-2131.
-
(2006)
J Clin Invest
, vol.116
, pp. 2122-2131
-
-
Wang, H.1
Xie, H.2
Guo, Y.3
Zhang, H.4
Takahashi, T.5
Kingsley, P.J.6
Marnett, L.J.7
Das, S.K.8
Cravatt, B.F.9
Dey, S.K.10
-
148
-
-
33845981826
-
A second fatty acid amide hydrolase with variable distribution among placental mammals
-
Wei, B. Q., Mikkelsen, T. S., McKinney, M. K., Lander, E. S. and Cravatt, B. F., A second fatty acid amide hydrolase with variable distribution among placental mammals, J Biol Chem, 281 (2006) 36569-36578.
-
(2006)
J Biol Chem
, vol.281
, pp. 36569-36578
-
-
Wei, B.Q.1
Mikkelsen, T.S.2
McKinney, M.K.3
Lander, E.S.4
Cravatt, B.F.5
-
149
-
-
0030769202
-
Structure and function of a squalene cyclase
-
Wendt, K. U., Poralla, K. and Schulz, G.E., Structure and function of a squalene cyclase, Science, 277 (1997) 1811-1815.
-
(1997)
Science
, vol.277
, pp. 1811-1815
-
-
Wendt, K.U.1
Poralla, K.2
Schulz, G.E.3
-
150
-
-
0033048369
-
GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat
-
Yang, H. Y., Karoum, F., Felder, C., Badger, H., Wang, T. C. and Markey, S. P., GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat, J Neurochem, 72 (1999) 1959-1968.
-
(1999)
J Neurochem
, vol.72
, pp. 1959-1968
-
-
Yang, H.Y.1
Karoum, F.2
Felder, C.3
Badger, H.4
Wang, T.C.5
Markey, S.P.6
|