Closing the gate to the active site: Effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase

Journal of Biological Chemistry

Volumn 282, Issue 6, 2007, Pages 3829-3836

  Mei, Giampiero ^a   Di Venere, Almerinda ^a   Gasperi, Valeria ^b   Nicolai, Eleonora ^a   Masuda, Kim R ^d   Finazzi Agrò, Alessandro ^a   Cravatt, Benjamin F ^d   Maccarrone, Mauro ^b,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID AMIDE HYDROLASE (FAAH); FITTING PROCEDURE; METHOXYARACHIDONYL FLUOROPHOSPHONATE;

AMINO ACIDS; BINDING ENERGY; BIOMEDICAL ENGINEERING; CONFORMATIONS; HYDROSTATIC PRESSURE;

ENZYMES;

FATTY ACID AMIDASE; GUANIDINE; PHOSPHONIC ACID DERIVATIVE; AMIDASE; ARACHIDONIC ACID DERIVATIVE; ENZYME INHIBITOR; FATTY-ACID AMIDE HYDROLASE; LIPOSOME; MEMBRANE PROTEIN; METHYL ARACHIDONYLFLUOROPHOSPHONATE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENERGY; ENZYME ACTIVITY; HYDRATION; HYDROSTATIC PRESSURE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; ANIMAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; ENZYME STABILITY; METABOLISM; PROTEIN CONFORMATION; RAT;

MAMMALIA;

AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; ENZYME INHIBITORS; ENZYME STABILITY; LIPOSOMES; MEMBRANE PROTEINS; PHOSPHONIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RATS;

EID: 33947491800     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605653200     Document Type: Article

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