Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: Conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3709-3720

  Van der Stelt, Mario ^a   Van Kuik, J Albert ^a   Bari, Monica ^b   Van Zadelhoff, Guus ^a   Leeflang, Bas R ^a   Veldink, Gerrit A ^a   Finazzi Agrò, Alessandro ^b   Vliegenthart, Johannes F G ^a   Maccarrone, Mauro ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

13 HYDROXYOCTADECA 9,11 DIENOYL N (2 HYDROXYETHYL)AMINE; 15 HYDROXYEICOSA 5,8,11,13 TETRAENOYL N (2 HYDROXYETHYL)AMINE; 2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CARRIER PROTEIN; CHLOROFORM; FATTY ACID AMIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; ISOMERISM; MALE; MOLECULAR DYNAMICS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR AFFINITY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; BRAIN; CANNABINOIDS; CARRIER PROTEINS; CHLOROFORM; CYCLOHEXANOLS; ENDOCANNABINOIDS; GLYCERIDES; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TUMOR CELLS, CULTURED; WATER;

EID: 0037103365     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020818q     Document Type: Article

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