Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-α (HNF1A) function in INS-1 insulinoma cells

Diabetologia

Volumn 52, Issue 1, 2009, Pages 136-144

  Farrelly, A M ^a   Wobser, H ^b   Bonner, C ^b   Anguissola, S ^b   Rehm, M ^b   Concannon, C G ^b   Prehn, J H M ^b   Byrne, M M ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

AKT1; Beta cell mass; Cell size; HNF1A; INS 1; MODY; MTOR; S6K1

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; DOXYCYCLINE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P70; S6 KINASE; SERINE; THREONINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SIZE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; INSULINOMA; MATURITY ONSET DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION; THYMOMA;

ANIMALS; CELL LINE, TUMOR; CELL SIZE; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; INSULINOMA; POLYMERASE CHAIN REACTION; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 57249094217     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1168-8     Document Type: Article

References (48)

1. SS Fajans GI Bell KS Polonsky 2001 Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young N Engl J Med 345 971 980
2. TM Frayling MP Bulamn S Ellard 1997 Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K Diabetes 46 720 725
3. S Ellard K Colclough 2006 Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young Human Mutat 27 854 869
4. K Yamagata N Oda PJ Kaisaki 1996 Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature 384 455 458
5. M Blumenfeld M Maury T Chouard M Yaniv H Condamine 1991 Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse Development 113 589 599
6. DT Odom N Zizlsperger DB Gordon 2004 Control of pancreas and liver gene expression by HNF transcription factors Science 303 1378 1381
7. J Holmkvist C Cervin V Lyssenko 2006 Common variants in HNF-1 alpha and risk of type 2 diabetes Diabetologia 49 2882 2891
8. M Pontoglio S Sreenan M Roe 1998 Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice J Clin Invest 101 2215 2222
9. MM Byrne J Sturis S Menzel 1996 Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12 Diabetes 45 1503 1510
10. H Wang K Hagenfeldt-Johansson LA Otten BR Gauthier PL Herrera CB Wollheim 2002 Experimental models of transcription factor-associated maturity-onset diabetes of the young Diabetes 51 Suppl 3 S333 S342
11. H Wang PA Antinozzi KA Hagenfeldt P Maechler CB Wollheim 2000 Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction EMBO J 19 4257 4264
12. H Wobser C Bonner JJ Nolan MM Byrne JH Prehn 2006 Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function Diabetologia 49 519 526
13. H Wobser H Dussmann D Kogel 2002 Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death J Biol Chem 277 6413 6421
14. J Heitman NR Movva MN Hall 1991 Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 253 905 909
15. K Inoki T Zhu KL Guan 2003 TSC2 mediates cellular energy response to control cell growth and survival Cell 115 577 590
16. Y Sancak CC Thoreen TR Peterson 2007 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase Mol Cell 25 903 915
17. DA Guertin DM Sabatini 2007 Defining the role of mTOR in cancer Cancer Cell 12 9 22
18. S Wullschleger R Loewith MN Hall 2006 TOR signaling in growth and metabolism Cell 124 471 484
19. E Jacinto V Facchinetti D Liu 2006 SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity Cell 127 125 137
20. DD Sarbassov DA Guertin SM Ali DM Sabatini 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 1098 1101
21. J Huang CC Dibble M Matsuzaki BD Manning 2008 The TSC1-TSC2 complex is required for proper activation of mTOR complex 2 Mol Cell Biol 28 4104 4115
22. H Wang P Maechler KA Hagenfeldt CB Wollheim 1998 Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line EMBO J 17 6701 6713
23. A Nicosia P Monaci L Tomei 1990 A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1 Cell 61 1225 1236
24. S Rozen H Skaletsky 2000 Primer3 on the WWW for general users and for biologist programmers Methods Mol Biol 132 365 386
25. AC Gingras B Raught N Sonenberg 2001 Regulation of translation initiation by FRAP/mTOR Genes Dev 15 807 826
26. MK Holz J Blenis 2005 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase J Biol Chem 280 26089 26093
27. I Ruvinsky O Meyuhas 2006 Ribosomal protein S6 phosphorylation: from protein synthesis to cell size Trends Biochem Sci 31 342 348
28. M van Engeland LJ Nieland FC Ramaekers B Schutte CP Reutelingsperger 1998 Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure Cytometry 31 1 9
29. X Wang A Beugnet M Murakami S Yamanaka CG Proud 2005 Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins Mol Cell Biol 25 2558 2572
30. A Pause GJ Belsham AC Gingras 1994 Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function Nature 371 762 767
31. CJ Sherr JM Roberts 1999 CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev 13 1501 1512
32. WK Miskimins G Wang M Hawkinson R Miskimins 2001 Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation Mol Cell Biol 21 4960 4967
33. DM Gwinn DB Shackelford DF Egan 2008 AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol Cell 30 214
34. Q Yang K Yamagata K Fukui 2002 Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells Diabetes 51 1785 1792
35. KM Hannan Y Brandenburger A Jenkins 2003 mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF Mol Cell Biol 23 8862 8877
36. J Montagne MJ Stewart H Stocker E Hafen SC Kozma G Thomas 1999 Drosophila S6 kinase: a regulator of cell size Science 285 2126 2129
37. I Ruvinsky N Sharon T Lerer 2005 Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis Genes Dev 19 2199 2211
38. KA Hagenfeldt-Johansson PL Herrera H Wang A Gjinovci H Ishihara CB Wollheim 2001 Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice Endocrinology 142 5311 5320
39. E Giordano V Cirulli D Bosco D Rouiller P Halban P Meda 1993 B-cell size influences glucose-stimulated insulin secretion Am J Physiol 265 C358 364
40. Y Luo SO Marx H Kiyokawa A Koff J Massague AR Marks 1996 Rapamycin resistance tied to defective regulation of p27Kip1 Mol Cell Biol 16 6744 6751
41. M Shapira E Kakiashvili T Rosenberg DD Hershko 2006 The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells Breast Cancer Res 8 R46
42. RF Luco MA Maestro N del Pozo WM Philbrick PP de la Ossa J Ferrer 2006 A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious Diabetes 55 2202 2211
43. T Shioi JR McMullen PM Kang 2002 Akt/protein kinase B promotes organ growth in transgenic mice Mol Cell Biol 22 2799 2809
44. S Fatrai L Elghazi N Balcazar 2006 Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity Diabetes 55 318 325
45. NM Conus BA Hemmings RB Pearson 1998 Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k J Biol Chem 273 4776 4782
46. M Frodin N Sekine E Roche 1995 Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1 J Biol Chem 270 7882 7889
47. S Khoo MH Cobb 1997 Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion Proc Natl Acad Sci U S A 94 5599 5604
48. PJ Papst H Sugiyama M Nagasawa JJ Lucas JL Maller N Terada 1998 Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis J Biol Chem 273 15077 15084