A conditional model reveals that induction of hepatocyte nuclear factor-1α in Hnf1α-null mutant β-cells can activate silenced genes postnatally, whereas overexpression is deleterious

Diabetes

Volumn 55, Issue 8, 2006, Pages 2202-2211

  Luco, Reini F ^a   Maestro, Miguel A ^a   Del Pozo, Natalia ^a   Philbrick, William M ^b   De La Ossa, Pablo Perez ^c   Ferrer, Jorge ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

DCoH, dimerization cofactor of HNF1; HNF, hepatocyte nuclear factor; MODY, maturity onset diabetes of the young; PCD, pterin 4a carbinolamine dehydratase; tTA, tetracycline dependent transactivator

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1ALPHA; TCF1 PROTEIN, MOUSE; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE ACTIVATION; GENE DOSAGE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE; MATURITY ONSET DIABETES MELLITUS; MODEL; MOUSE; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RNA EXTRACTION; ANIMAL; APOPTOSIS; CELL CULTURE; CELL DIVISION; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; MALE; MOUSE MUTANT; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; DIABETES MELLITUS; FLUORESCENT ANTIBODY TECHNIQUE; GENE DOSAGE; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRACYCLINE; TRANSCRIPTION, GENETIC;

EID: 33749353493     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1534     Document Type: Article

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