Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function

Diabetologia

Volumn 49, Issue 3, 2006, Pages 519-526

  Wobser, H ^a   Bonner, C ^a   Nolan, J J ^b,c   Byrne, M M ^b,c   Prehn, J H M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

AKT1; Apoptosis; HNF 1alpha; INS 1; MODY3; TCF1

Indexed keywords

CASPASE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SERINE; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FUNCTIONAL PROTEOMICS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNODETECTION; INSULINOMA; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; INSULINOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOSERINE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TIME FACTORS;

EID: 33244498036     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0119-x     Document Type: Article

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