CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands

Veterinary Immunology and Immunopathology

Volumn 126, Issue 3-4, 2008, Pages 273-282

  Buza, Joram ^a   Benjamin, Ponn ^a   Zhu, Jianzhung ^a   Wilson, Heather L ^a   Lipford, Grayson ^b   Krieg, Arthur M ^b   Babiuk, Lorne A ^a,c   Mutwiri, George K ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cattle; Innate immunity; RNA oligonucleotides; TLR7; TLR8

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; BAFILOMYCIN; CD14 ANTIGEN; GAMMA INTERFERON; GARDIQUIMOD; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; INTERLEUKIN 12; OLIGORIBONUCLEOTIDE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; CELL ACTIVATION; CELL FRACTIONATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSIVE ELEMENT; FEMALE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; IN VITRO STUDY; INCUBATION TIME; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD14; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; OLIGONUCLEOTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

ANIMALIA; BOS; BOVINAE; MUS;

EID: 56349146351     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.08.001     Document Type: Article

References (66)

1. Aich P., Wilson H.L., Rawlyk N.A., Jalal S., Kaushik R.S., Begg A.A., Potter A.A., Babiuk L.A., Abrahamsen M.S., and Griebel P.J. Microarray analysis of gene expression following preparation of sterile intestinal "Loops" in calves. Canadian Journal of Animal Science 85 (2005) 13-22
2. Ashkar A.A., Bauer S., Mitchell W.J., Vieira J., and Rosenthal K.L. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. Journal of Virology 77 (2003) 8948-8956
3. Boczkowski D., Nair S.K., Snyder D., and Gilboa E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. The Journal of Experimental Medicine 184 (1996) 465-472
4. Chen M., Griffith B.P., Lucia H.L., and Hsiung G.D. Efficacy of S26308 against guinea pig cytomegalovirus infection. Antimicrobial Agents and Chemotherapy 32 (1988) 678-683
5. Chu R.S., Targoni O.S., Krieg A.M., Lehmann P.V., and Harding C.V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. The Journal of Experimental Medicine 186 (1997) 1623-1631
6. Chuang T.H., and Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. European Cytokine Network 11 (2000) 372-378
7. Davis H.L., Weeratna R., Waldschmidt T.J., Tygrett L., Schorr J., Krieg A.M., and Weeranta R. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. Journal of Immunology 160 (1998) 870-876
8. Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (New York, N.Y.) 303 (2004) 1529-1531
9. Ellis J.A., Godson D., Campos M., Sileghem M., and Babiuk L.A. Capture immunoassay for ruminant tumor necrosis factor-alpha: comparison with bioassay. Veterinary Immunology and Immunopathology 35 (1993) 289-300
10. Ghosh T.K., Mickelson D.J., Fink J., Solberg J.C., Inglefield J.R., Hook D., Gupta S.K., Gibson S., and Alkan S.S. Toll-like receptor (TLR) 2-9 agonists-induced cytokines and chemokines. I. Comparison with T cell receptor-induced responses. Cellular Immunology 243 (2006) 48-57
11. Girart M.V., Fuertes M.B., Domaica C.I., Rossi L.E., and Zwirner N.W. Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12. Journal of Immunology 179 (2007) 3472-3479
12. Gomis S., Babiuk L., Godson D.L., Allan B., Thrush T., Townsend H., Willson P., Waters E., Hecker R., and Potter A. Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infection and Immunity 71 (2003) 857-863
13. Gorden K.B., Gorski K.S., Gibson S.J., Kedl R.M., Kieper W.C., Qiu X., Tomai M.A., Alkan S.S., and Vasilakos J.P. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. Journal of Immunology 174 (2005) 1259-1268
14. Gramzinski R.A., Doolan D.L., Sedegah M., Davis H.L., Krieg A.M., and Hoffman S.L. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infection and Immunity 69 (2001) 1643-1649
15. Griebel P.J., Brownlie R., Manuja A., Nichani A., Mookherjee N., Popowych Y., Mutwiri G., Hecker R., and Babiuk L.A. Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression. Veterinary Immunology and Immunopathology 108 (2005) 11-16
16. Hafez I.M., Maurer N., and Cullis P.R. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Therapy 8 (2001) 1188-1196
17. Hammerbeck D.M., Burleson G.R., Schuller C.J., Vasilakos J.P., Tomai M., Egging E., Cochran F.R., Woulfe S., and Miller R.L. Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Research 73 (2007) 1-11
18. Hart O.M., Athie-Morales V., O'Connor G.M., and Gardiner C.M. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. Journal of Immunology 175 (2005) 1636-1642
19. Hartmann G., and Krieg A.M. CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Therapy 6 (1999) 893-903
20. Heil F., Ahmad-Nejad P., Hemmi H., Hochrein H., Ampenberger F., Gellert T., Dietrich H., Lipford G., Takeda K., Akira S., Wagner H., and Bauer S. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. European Journal of Immunology 33 (2003) 2987-2997
21. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (New York, N.Y.) 303 (2004) 1526-1529
22. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., Horiuchi T., Tomizawa H., Takeda K., and Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunology 3 (2002) 196-200
23. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
24. Herbst-Kralovetz M., and Pyles R. Toll-like receptors, innate immunity and HSV pathogenesis. Herpes 13 (2006) 37-41
25. Hope J.C., Kwong L.S., Entrican G., Wattegedera S., Vordermeier H.M., Sopp P., and Howard C.J. Development of detection methods for ruminant interleukin (IL)-12. Journal of Immunological Methods 266 (2002) 117-126
26. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., and Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Journal of Immunology 168 (2002) 4531-4537
27. Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., and Murphy K.M. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (New York, N.Y.) 260 (1993) 547-549
28. Hughes H.P., Rossow S., Campos M., Rossi-Campos A., Janssen S., Godson D.L., Daflon B., Voirol M.J., Gerber C., and Babiuk L.A. A slow release formulation for recombinant bovine interferon alpha I-1. Antiviral Research 23 (1994) 33-44
29. Ioannou X.P., Gomis S.M., Hecker R., Babiuk L.A., and van Drunen Littel-van den Hurk S. Safety and efficacy of CpG-containing oligodeoxynucleotides as immunological adjuvants in rabbits. Vaccine 21 (2003) 4368-4372
30. Ishii K.J., and Akira S. TLR ignores methylated RNA?. Immunity 23 (2005) 111-113
31. Ishii K.J., and Akira S. Innate immune recognition of, and regulation by, DNA. Trends in Immunology 27 (2006) 525-532
32. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 5 (2004) 987-995
33. Kadowaki N., Antonenko S., and Liu Y.J. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. Journal of Immunology 166 (2001) 2291-2295
34. Kawai T., and Akira S. Antiviral signaling through pattern recognition receptors. Journal of Biochemistry (Tokyo) 141 (2007) 137-145
35. Kende M., Lupton H.W., and Canonico P.G. Treatment of experimental viral infections with immunomodulators. Advances in Bioscience 68 (1988) 51-63
36. Klinman D.M., Yi A.K., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 2879-2883
37. Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nature Reviews Drug Discovery 5 (2006) 471-484
38. Krieg A.M., Love-Homan L., Yi A.K., and Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. Journal of Immunology 161 (1998) 2428-2434
39. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
40. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature Immunology 5 (2004) 190-198
41. Latz E., Visintin A., Espevik T., and Golenbock D.T. Mechanisms of TLR9 activation. Journal of Endotoxin Research 10 (2004) 406-412
42. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, CA) 25 (2001) 402-408
43. Lund J.M., Alexopoulou L., Sato A., Karow M., Adams N.C., Gale N.W., Iwasaki A., and Flavell R.A. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 5598-5603
44. Marcenaro E., Dondero A., and Moretta A. Multi-directional cross-regulation of NK cell function during innate immune responses. Transplant Immunology 17 (2006) 16-19
45. McCluskie M.J., and Davis H.L. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. Journal of Immunology 161 (1998) 4463-4466
46. Medzhitov R., and Janeway Jr. C.A. Innate immunity: impact on the adaptive immune response. Current Opinion in Immunology 9 (1997) 4-9
47. Mena A., Nichani A.K., Popowych Y., Godson D.L., Dent D., Townsend H.G.G., Mutwiri G.K., Hecker R., Babiuk L.A., and Griebel P. Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells. Immunology 110 (2003) 250-257
48. Mena A., Nichani A.K., Popowych Y., Ioannou X.P., Godson D.L., Mutwiri G.K., Hecker R., Babiuk L.A., and Griebel P. Bovine and ovine blood mononuclear leukocytes differ markedly in innate immune responses induced by class A and class B CpG-oligodeoxynucleotide. Oligonucleotides 13 (2003) 245-260
49. Menzies M., and Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Veterinary Immunology and Immunopathology 109 (2006) 23-30
50. Moretta A. The dialogue between human natural killer cells and dendritic cells. Current Opinion in Immunology 17 (2005) 306-311
51. Mutwiri G., Bateman C., Baca-Estrada M.E., Snider M., and Griebel P. Induction of immune responses in newborn lambs following enteric immunization with a human adenovirus vaccine vector. Vaccine 19 (2000) 1284-1293
52. Pan P.Y., Gu P., Li Q., Xu D., Weber K., and Chen S.H. Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation. Journal of Immunology 172 (2004) 4779-4789
53. Pinchuk L.M., Boyd B.L., Kruger E.F., Roditi I., and Furger A. Bovine dendritic cells generated from monocytes and bone marrow progenitors regulate immunoglobulin production in peripheral blood B cells. Comparative Immunology, Microbiology and Infectious Diseases 26 (2003) 233-249
54. Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (New York, N.Y.) 282 (1998) 2085-2088
55. Redford T.W., Yi A.K., Ward C.T., and Krieg A.M. Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides. Journal of Immunology 161 (1998) 3930-3935
56. Rutz M., Metzger J., Gellert T., Luppa P., Lipford G.B., Wagner H., and Bauer S. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. European Journal of Immunology 34 (2004) 2541-2550
57. Stamatatos L., Leventis R., Zuckermann M.J., and Silvius J.R. Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes. Biochemistry 27 (1988) 3917-3925
58. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annual Review of Immunology 21 (2003) 335-376
59. Trinchieri G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Current Opinion in Immunology 9 (1997) 17-23
60. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology 3 (2003) 133-146
61. Unanue E.R. Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance. Current Opinion in immunology 9 (1997) 35-43
62. Vasilakos J.P., Smith R.M., Gibson S.J., Lindh J.M., Pederson L.K., Reiter M.J., Smith M.H., and Tomai M.A. Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cellular Immunology 204 (2000) 64-74
63. Yi A.K., and Krieg A.M. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. Journal of Immunology 161 (1998) 4493-4497
64. Yi A.K., Tuetken R., Redford T., Waldschmidt M., Kirsch J., and Krieg A.M. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. Journal of Immunology 160 (1998) 4755-4761
65. Zimmermann S., Egeter O., Hausmann S., Lipford G.B., Rocken M., Wagner H., and Heeg K. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. Journal of Immunology 160 (1998) 3627-3630
66. Zitvogel L., Terme M., Borg C., and Trinchieri G. Dendritic cell-NK cell cross-talk: regulation and physiopathology. Current Topics in Microbiology and Immunology 298 (2006) 157-174