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1
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0028908222
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The role of natural killer cells in host-parasite interactions
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Scott P, Trinchieri G. The role of natural killer cells in host-parasite interactions. Curr Opin Immunol. 7:1995;34-40.
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(1995)
Curr Opin Immunol
, vol.7
, pp. 34-40
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Scott, P.1
Trinchieri, G.2
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2
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0027715483
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Cytokine cross-talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity
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Trinchieri G, Kubin M, Bellone G, Cassatella MC. Cytokine cross-talk between phagocytic cells and lymphocytes: relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity. J Cell Biochem. 53:1993;301-308.
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(1993)
J Cell Biochem
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, pp. 301-308
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Trinchieri, G.1
Kubin, M.2
Bellone, G.3
Cassatella, M.C.4
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3
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0024353079
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TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
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Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 7:1989;145-173.
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Annu Rev Immunol
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Mosmann, T.R.1
Coffman, R.L.2
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4
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0028970060
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Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
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Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 13:1995;251-276.
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(1995)
Annu Rev Immunol
, vol.13
, pp. 251-276
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Trinchieri, G.1
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6
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0028316546
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Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
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Kubin M, Chow JM, Trinchieri G. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood. 83:1994;1847-1855.
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(1994)
Blood
, vol.83
, pp. 1847-1855
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Kubin, M.1
Chow, J.M.2
Trinchieri, G.3
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7
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0030064148
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The interleukin-12 p40 gene promoter is primed by interferon-γ In monocytic cells
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of special interest. Partial characterization of the IL-12 p40 promoter, with identification of the Ets site, and analysis of the transcriptional regulation of IFN-γ p40 and p35 genes by LPS and IFN-γ.
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Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dzialo R, Trinchieri G. The interleukin-12 p40 gene promoter is primed by interferon-γ in monocytic cells. of special interest J Exp Med. 183:1996;147-157 Partial characterization of the IL-12 p40 promoter, with identification of the Ets site, and analysis of the transcriptional regulation of IFN-γ p40 and p35 genes by LPS and IFN-γ.
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(1996)
J Exp Med
, vol.183
, pp. 147-157
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Ma, X.1
Chow, J.M.2
Gri, G.3
Carra, G.4
Gerosa, F.5
Wolf, S.F.6
Dzialo, R.7
Trinchieri, G.8
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8
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0027240219
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Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells
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D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J Exp Med. 178:1993;1041-1048.
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(1993)
J Exp Med
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, pp. 1041-1048
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D'Andrea, A.1
Aste-Amezaga, M.2
Valiante, N.M.3
Ma, X.4
Kubin, M.5
Trinchieri, G.6
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9
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0026701132
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Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells
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D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste-Amezaga M, Chan SH, Kobayashi M, Young D, Nickbarg E, et al. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med. 176:1992;1387-1398.
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J Exp Med
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D'Andrea, A.1
Rengaraju, M.2
Valiante, N.M.3
Chehimi, J.4
Kubin, M.5
Aste-Amezaga, M.6
Chan, S.H.7
Kobayashi, M.8
Young, D.9
Nickbarg, E.10
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10
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0029014952
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+ T cells
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of outstanding interest. This paper reports the first description of the functional role of IL-12 production by dendritic cells and how the balance of locally produced IL-12 and IL-4 during cognate antigen presentation have a major role in determining either Th1 or Th2 cell differentiation.
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+ T cells. of outstanding interest J Immunol. 154:1995;5071-5079 This paper reports the first description of the functional role of IL-12 production by dendritic cells and how the balance of locally produced IL-12 and IL-4 during cognate antigen presentation have a major role in determining either Th1 or Th2 cell differentiation.
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(1995)
J Immunol
, vol.154
, pp. 5071-5079
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Macatonia, S.E.1
Hosken, N.A.2
Litton, M.3
Vieira, P.4
Hsieh, C.5
Culpepper, J.A.6
Wysocka, M.7
Trinchieri, G.8
Murphy, K.M.9
O'Garra, A.10
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11
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0030067458
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IL-12 synthesis by human Langerhans cells
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Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH. IL-12 synthesis by human Langerhans cells. J Immunol. 156:1996;1402-1407.
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(1996)
J Immunol
, vol.156
, pp. 1402-1407
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Kang, K.1
Kubin, M.2
Cooper, K.D.3
Lessin, S.R.4
Trinchieri, G.5
Rook, A.H.6
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12
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0030063347
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IL-12 expression in AIDS-related lymphoma B cell lines
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of special interest. A detailed analysis of IL-12 production in B cell lines of different origin, also reporting the expression of at least one chain of the IL-12 receptor on B cells.
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Benjamin D, Sharma V, Kubin M, Klein JL, Sartori A, Holliday J, Trinchieri G. IL-12 expression in AIDS-related lymphoma B cell lines. of special interest J Immunol. 156:1996;1626-1637 A detailed analysis of IL-12 production in B cell lines of different origin, also reporting the expression of at least one chain of the IL-12 receptor on B cells.
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(1996)
J Immunol
, vol.156
, pp. 1626-1637
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-
Benjamin, D.1
Sharma, V.2
Kubin, M.3
Klein, J.L.4
Sartori, A.5
Holliday, J.6
Trinchieri, G.7
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13
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0028878655
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Interleukin-12 gene expression after viral infection in the mouse
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of special interest. This paper reports data clearly showing that virus infection, like that with other microorganisms, induce IL-12 production.
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Coutelier JP, Van Broeck J, Wolf SF. Interleukin-12 gene expression after viral infection in the mouse. of special interest J Virol. 69:1995;1955-1958 This paper reports data clearly showing that virus infection, like that with other microorganisms, induce IL-12 production.
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(1995)
J Virol
, vol.69
, pp. 1955-1958
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Coutelier, J.P.1
Van Broeck, J.2
Wolf, S.F.3
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14
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0029991620
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Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway
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of outstanding interest. This paper reports on IL-12 induction by bacterial products other than LPS and on its mechanism of action, a topic of investigation of active interest in many laboratories interested in the mechanisms by which microorganisms activate innate immunity and inflammation.
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Cleveland MG, Gorham JD, Murphy TL, Tuomanen E, Murphy KM. Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. of outstanding interest Infect Immun. 64:1996;1906-1912 This paper reports on IL-12 induction by bacterial products other than LPS and on its mechanism of action, a topic of investigation of active interest in many laboratories interested in the mechanisms by which microorganisms activate innate immunity and inflammation.
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(1996)
Infect Immun
, vol.64
, pp. 1906-1912
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Cleveland, M.G.1
Gorham, J.D.2
Murphy, T.L.3
Tuomanen, E.4
Murphy, K.M.5
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15
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0029984358
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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
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of special interest. This paper identifies CpG motifs in bacterial DNA as proinflammatory agents, inducing IL-12 among other cytokines.
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Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. of special interest Proc Natl Acad Sci USA. 93:1996;2879-2883 This paper identifies CpG motifs in bacterial DNA as proinflammatory agents, inducing IL-12 among other cytokines.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2879-2883
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Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
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16
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8944253295
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Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
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of outstanding interest. This paper demonstrates that when the proinflammatory CpG motifs are present in the constructs used to induce intradermal gene immunization, these sequences greatly enhance the efficiency of the vaccination.
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Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M, Silverman GJ, Lotz M, Carson DA, Raz E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. of outstanding interest Science. 273:1996;352-354 This paper demonstrates that when the proinflammatory CpG motifs are present in the constructs used to induce intradermal gene immunization, these sequences greatly enhance the efficiency of the vaccination.
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(1996)
Science
, vol.273
, pp. 352-354
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-
Sato, Y.1
Roman, M.2
Tighe, H.3
Lee, D.4
Corr, M.5
Nguyen, M.6
Silverman, G.J.7
Lotz, M.8
Carson, D.A.9
Raz, E.10
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17
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13344259977
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Interleukin-12 is produced by dendritic cells and mediates Th1 development as well as IFN-γ production by Th1 cells
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of special interest. A careful and detailed analysis of the production of IL-12 by human and mouse dendritic cells and of its physiological significance in IL-12 induction.
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Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, Enk A, Steinman RM, Romani N, Schuler G. Interleukin-12 is produced by dendritic cells and mediates Th1 development as well as IFN-γ production by Th1 cells. of special interest Eur J Immunol. 26:1996;659-668 A careful and detailed analysis of the production of IL-12 by human and mouse dendritic cells and of its physiological significance in IL-12 induction.
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(1996)
Eur J Immunol
, vol.26
, pp. 659-668
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-
Heufler, C.1
Koch, F.2
Stanzl, U.3
Topar, G.4
Wysocka, M.5
Trinchieri, G.6
Enk, A.7
Steinman, R.M.8
Romani, N.9
Schuler, G.10
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18
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0029046307
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Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of IL-1-α And IL-12 p40/p35 and triggers prolonged, efficient antigen presentation
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Scheicher C, Mehlig M, Dienes HP, Reske K. Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of IL-1-α and IL-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur J Immunol. 25:1995;1566-1572.
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(1995)
Eur J Immunol
, vol.25
, pp. 1566-1572
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Scheicher, C.1
Mehlig, M.2
Dienes, H.P.3
Reske, K.4
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19
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0028956699
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Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
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of outstanding interest. The first demonstration that the CD40-CD40L activation pathway induces IL-12 production.
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Shu U, Kiniwa M, Wu CY, Maliszewski C, Vezzio N, Hakimi J, Gately M, Delespesse G. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. of outstanding interest Eur J Immunol. 25:1995;1125-1128 The first demonstration that the CD40-CD40L activation pathway induces IL-12 production.
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(1995)
Eur J Immunol
, vol.25
, pp. 1125-1128
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Shu, U.1
Kiniwa, M.2
Wu, C.Y.3
Maliszewski, C.4
Vezzio, N.5
Hakimi, J.6
Gately, M.7
Delespesse, G.8
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20
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0030064804
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CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages
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Kennedy MK, Picha KS, Fanslow WC, Grabstein KH, Alderson MR, Clifford KN, Chin WA, Mohler KM. CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. Eur J Immunol. 26:1996;370-378.
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(1996)
Eur J Immunol
, vol.26
, pp. 370-378
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Kennedy, M.K.1
Picha, K.S.2
Fanslow, W.C.3
Grabstein, K.H.4
Alderson, M.R.5
Clifford, K.N.6
Chin, W.A.7
Mohler, K.M.8
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21
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0029831666
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High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
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of special interest. Demonstration that signaling from both CD40 and MHC class II molecules on dendritic cells induces IL-12 production, and that this production is down-regulated by IL-4 and IL-10, similarly to that previously reported for monocytes/macrophages.
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Koch F, Stanzl U, Jennewein P, Janke K, Heufler C, Kämpgen E, Romani N, Schuler G. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. of special interest J Exp Med. 184:1996;741-746 Demonstration that signaling from both CD40 and MHC class II molecules on dendritic cells induces IL-12 production, and that this production is down-regulated by IL-4 and IL-10, similarly to that previously reported for monocytes/macrophages.
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(1996)
J Exp Med
, vol.184
, pp. 741-746
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Koch, F.1
Stanzl, U.2
Jennewein, P.3
Janke, K.4
Heufler, C.5
Kämpgen, E.6
Romani, N.7
Schuler, G.8
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22
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0029812593
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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
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Cella M, Scheidegger D, Plamer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 184:1996;747-752.
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J Exp Med
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, pp. 747-752
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Cella, M.1
Scheidegger, D.2
Plamer-Lehmann, K.3
Lane, P.4
Lanzavecchia, A.5
Alber, G.6
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23
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0027939611
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Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
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Gazzinelli RT, Wysocka M, Hayashi S, Deukers EY, Hieny S, Caspar P, Trinchieri G, Sher A. Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol. 153:1994;2533-2543.
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(1994)
J Immunol
, vol.153
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Gazzinelli, R.T.1
Wysocka, M.2
Hayashi, S.3
Deukers, E.Y.4
Hieny, S.5
Caspar, P.6
Trinchieri, G.7
Sher, A.8
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24
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0028209541
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Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice
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Tripp CS, Gately MK, Hakimi J, Ling P, Unanue ER. Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice. J Immunol. 152:1994;1883-1887.
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J Immunol
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Tripp, C.S.1
Gately, M.K.2
Hakimi, J.3
Ling, P.4
Unanue, E.R.5
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25
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0028987562
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Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
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Wysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, Trinchieri G. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol. 25:1995;672-676.
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(1995)
Eur J Immunol
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Wysocka, M.1
Kubin, M.2
Vieira, L.Q.3
Ozmen, L.4
Garotta, G.5
Scott, P.6
Trinchieri, G.7
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26
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0028085437
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Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon
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Heinzel FP, Rerko RM, Ling P, Hakimi J, Schoenhaut DS. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun. 62:1994;4244-4249.
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Infect Immun
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Heinzel, F.P.1
Rerko, R.M.2
Ling, P.3
Hakimi, J.4
Schoenhaut, D.S.5
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27
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0027982098
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IL-12, IFN-γ And TNF-α are the key cytokines of the generalized Schwartzman reaction
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Ozmen L, Pericin M, Hakimi J, Chizzonite RA, Wysocka M, Trinchieri G, Gately M, Garotta G. IL-12, IFN-γ and TNF-α are the key cytokines of the generalized Schwartzman reaction. J Exp Med. 180:1994;907-916.
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(1994)
J Exp Med
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Ozmen, L.1
Pericin, M.2
Hakimi, J.3
Chizzonite, R.A.4
Wysocka, M.5
Trinchieri, G.6
Gately, M.7
Garotta, G.8
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28
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16044363695
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IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
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of outstanding interest. Description of the IL-12 p40 KO mouse and characterization of its ability to respond to LPS and to mediate a Th1 response, generate cytotoxic T lymphocyte, or to be sensitized for a delayed-type hypersensitivity response.
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Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu CY, Ferrante J, Stewart C, Sarmiento U, Faherty DA, Gately MK. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. of outstanding interest Immunity. 4:1996;471-481 Description of the IL-12 p40 KO mouse and characterization of its ability to respond to LPS and to mediate a Th1 response, generate cytotoxic T lymphocyte, or to be sensitized for a delayed-type hypersensitivity response.
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(1996)
Immunity
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Magram, J.1
Connaughton, S.E.2
Warrier, R.R.3
Carvajal, D.M.4
Wu, C.Y.5
Ferrante, J.6
Stewart, C.7
Sarmiento, U.8
Faherty, D.A.9
Gately, M.K.10
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29
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0029080727
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A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
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Okamura H, Nagata K, Komatsu T, Tanimoto T, Nukata Y, Tanabe F, Akita K, Torigoe K, Okura T, Fukuda S. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun. 63:1995;3966-3972.
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Okamura, H.1
Nagata, K.2
Komatsu, T.3
Tanimoto, T.4
Nukata, Y.5
Tanabe, F.6
Akita, K.7
Torigoe, K.8
Okura, T.9
Fukuda, S.10
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30
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0028845730
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Cloning of a new cytokine that induces IFN-γ production by T cells
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of outstanding interest. Cloning and preliminary characterization of IL-18.
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Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukuda Y, Hattori K. Cloning of a new cytokine that induces IFN-γ production by T cells. of outstanding interest Nature. 378:1995;88-91 Cloning and preliminary characterization of IL-18.
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Nature
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Okamura, H.1
Tsutsi, H.2
Komatsu, T.3
Yutsudo, M.4
Hakura, A.5
Tanimoto, T.6
Torigoe, K.7
Okura, T.8
Nukuda, Y.9
Hattori, K.10
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31
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15844367093
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Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
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Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, et al. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol. 156:1996;4274-4279.
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J Immunol
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Ushio, S.1
Namba, M.2
Okura, T.3
Hattori, K.4
Nukada, Y.5
Akita, K.6
Tanabe, F.7
Konishi, K.8
Micallef, M.9
Fujii, M.10
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32
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0027264849
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Interleukin-12 is required for the T-lymphocyte independent induction of interferon-γ By an intracellular parasite and induces resistance in T-deficient hosts
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Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A. Interleukin-12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc Natl Acad Sci USA. 90:1993;6115-6119.
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Proc Natl Acad Sci USA
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Gazzinelli, R.T.1
Hieny, S.2
Wynn, T.A.3
Wolf, S.4
Sher, A.5
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33
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0028973003
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IL-1β is required for IL-12 to induce production of IFN-γ By NK cells. A role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens
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Hunter CA, Chizzonite R, Remington JS. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens. J Immunol. 155:1995;4347-4354.
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J Immunol
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Hunter, C.A.1
Chizzonite, R.2
Remington, J.S.3
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35
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0028943066
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Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon and tumor necrosis factor α
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Flesch IEA, Hess JH, Huang S, Aguet M, Rothe J, Bluethmann H, Kaufmann SHE. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon and tumor necrosis factor α J Exp Med. 181:1995;1615-1621.
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J Exp Med
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Flesch, I.E.A.1
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Huang, S.3
Aguet, M.4
Rothe, J.5
Bluethmann, H.6
Kaufmann, S.H.E.7
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36
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0029040855
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Regulation of interleukin-12 expression in human monocytes: Selective priming by IFN-γ Of LPS-inducible p35 and p40 genes
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of special interest. A careful characterization of the regulation of the human IL-12 p35 and p40 genes at the mRNA level, as induced by LPS in conjunction with IFN-γ and granulocyte macrophage-colony stimulating factor.
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Hayes MP, Wang J, Norcross MA. Regulation of interleukin-12 expression in human monocytes: selective priming by IFN-γ of LPS-inducible p35 and p40 genes. of special interest Blood. 86:1995;646-650 A careful characterization of the regulation of the human IL-12 p35 and p40 genes at the mRNA level, as induced by LPS in conjunction with IFN-γ and granulocyte macrophage-colony stimulating factor.
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(1995)
Blood
, vol.86
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Hayes, M.P.1
Wang, J.2
Norcross, M.A.3
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37
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0029143632
-
Regulation of interleukin 12 p40 expression through an NF-κB half-site
-
of special interest. Partial characterization of the IL-12 p40 promoter with identification of the NF-κB site.
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Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin 12 p40 expression through an NF-κB half-site. of special interest Mol Cell Biol. 15:1995;5258-5267 Partial characterization of the IL-12 p40 promoter with identification of the NF-κB site.
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Mol Cell Biol
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Murphy, T.L.1
Cleveland, M.G.2
Kulesza, P.3
Magram, J.4
Murphy, K.M.5
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38
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0029959459
-
+ T cells and accompanied by overproduction of IL-12, IFN-γ And TNF-α
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of outstanding interest. This paper, together with [39], clearly demonstrates the important role of endogenous IL-12 in controlling the production of proinflammatory cytokines, including IL-12, during infection.
-
+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α of outstanding interest J Immunol. 157:1996;798-805 This paper, together with [39], clearly demonstrates the important role of endogenous IL-12 in controlling the production of proinflammatory cytokines, including IL-12, during infection.
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(1996)
J Immunol
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, pp. 798-805
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Gazzinelli, R.T.1
Wysocka, M.2
Hieny, S.3
Scharton-Kersten, T.4
Cheever, A.5
Kühn, R.6
Müller, W.7
Trinchieri, G.8
Sher, A.9
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39
-
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0028815553
-
Interleukin-10 is a central regulator of the responses to LPS in murine models of endotoxic shock and the Schwartzman reaction but not endotoxin tolerance
-
of outstanding interest. See annotation [38].
-
Berg DJ, Kühn R, Rajewsky K, Müller W, Menon S, Davidson N, Grünig G, Rennick D. Interleukin-10 is a central regulator of the responses to LPS in murine models of endotoxic shock and the Schwartzman reaction but not endotoxin tolerance. of outstanding interest J Clin Invest. 96:1995;2339-2347 See annotation [38].
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(1995)
J Clin Invest
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, pp. 2339-2347
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Berg, D.J.1
Kühn, R.2
Rajewsky, K.3
Müller, W.4
Menon, S.5
Davidson, N.6
Grünig, G.7
Rennick, D.8
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40
-
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0028226995
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Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites
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Finkelman FD, Madden KB, Cheever AW, Katona IM, Morris SC, Gately MK, Hubbard BR, Gause WC, Urban JF Jr. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med. 179:1994;1563-1572.
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Finkelman, F.D.1
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Katona, I.M.4
Morris, S.C.5
Gately, M.K.6
Hubbard, B.R.7
Gause, W.C.8
Urban J.F., Jr.9
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41
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0029984051
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Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ And interleukin-10
-
of special interest. This study analyzes the priming effects of IL-12 and IL-4 on the pattern of cytokine production in human CD4 and CD8 clones and reports the unexpected finding that IL-12 alone primes for both IFN-γ and IL-10 production.
-
Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste-Amezaga M, Frank I, Trinchieri G. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. of special interest J Exp Med. 183:1996;2559-2569 This study analyzes the priming effects of IL-12 and IL-4 on the pattern of cytokine production in human CD4 and CD8 clones and reports the unexpected finding that IL-12 alone primes for both IFN-γ and IL-10 production.
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(1996)
J Exp Med
, vol.183
, pp. 2559-2569
-
-
Gerosa, F.1
Paganin, C.2
Peritt, D.3
Paiola, F.4
Scupoli, M.T.5
Aste-Amezaga, M.6
Frank, I.7
Trinchieri, G.8
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42
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0029893865
-
IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-α
-
Daftarian PM, Kumar A, Kryworuchko M, Diaz-Mitoma F. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-α J Immunol. 157:1996;12-20.
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(1996)
J Immunol
, vol.157
, pp. 12-20
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Daftarian, P.M.1
Kumar, A.2
Kryworuchko, M.3
Diaz-Mitoma, F.4
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43
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0030584733
-
IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
-
of special interest. Demonstration that IL-12 acutely induces IL-10 production from T cells, a mechanism proposed as paracrine negative feedback for IL-12 production and proinflammatory responses.
-
Meyaard L, Hovenkamp E, Otto SA, Miedema F. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. of special interest J Immunol. 156:1996;2776-2782 Demonstration that IL-12 acutely induces IL-10 production from T cells, a mechanism proposed as paracrine negative feedback for IL-12 production and proinflammatory responses.
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(1996)
J Immunol
, vol.156
, pp. 2776-2782
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Meyaard, L.1
Hovenkamp, E.2
Otto, S.A.3
Miedema, F.4
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44
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0030002449
-
IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells
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Jeannin P, Delneste Y, Seveso M, Life P, Bonnefoy J. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J Immunol. 156:1996;3159-3165.
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J Immunol
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Jeannin, P.1
Delneste, Y.2
Seveso, M.3
Life, P.4
Bonnefoy, J.5
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45
-
-
0030210830
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IL-12 induces human T cells secreting IL-10 with IFN-γ
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Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-γ J Immunol. 157:1996;1127-1131.
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J Immunol
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Windhagen, A.1
Anderson, D.E.2
Carrizosa, A.3
Williams, R.E.4
Hafler, D.A.5
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46
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0028043326
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Interleukin 12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes
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Trinchieri G. Interleukin 12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes. Blood. 84:1994;4008-4027.
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Blood
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Trinchieri, G.1
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47
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0030029222
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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
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Stüber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med. 183:1996;693-698.
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Stüber, E.1
Strober, W.2
Neurath, M.3
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48
-
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0028859172
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Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens
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Kanangat S, Nair S, Babu JS, Rouse BT. Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. J Leuk Biol. 57:1995;310-316.
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Kanangat, S.1
Nair, S.2
Babu, J.S.3
Rouse, B.T.4
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49
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0029096181
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Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
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of outstanding interest. Demonstration of the role of IL-12-induced IFN-γ production by NK cells in the defense against murine cytomegalovirus.
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Orange JS, Wang B, Terhorst C, Biron CA. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. of outstanding interest J Exp Med. 182:1995;1045-1056 Demonstration of the role of IL-12-induced IFN-γ production by NK cells in the defense against murine cytomegalovirus.
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(1995)
J Exp Med
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Orange, J.S.1
Wang, B.2
Terhorst, C.3
Biron, C.A.4
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50
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0030460358
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Does IL-12 play a role in the viral immune response?
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Monteiro J, Trinchieri G. Does IL-12 play a role in the viral immune response? Ann NY Acad Sci. 795:1996;366-367.
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(1996)
Ann NY Acad Sci
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Monteiro, J.1
Trinchieri, G.2
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51
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0030060232
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An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections
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of special interest. This paper presents evidence that in virus infection IL-12 may be induced by contrasting mechanisms, with different requirements for IL-12.
-
Orange JS, Biron CA. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. of special interest J Immunol. 156:1996;1138-1142 This paper presents evidence that in virus infection IL-12 may be induced by contrasting mechanisms, with different requirements for IL-12.
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(1996)
J Immunol
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, pp. 1138-1142
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Orange, J.S.1
Biron, C.A.2
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52
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0028957492
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Mechanism of interleukin 12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoids
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Orange JS, Salazar-Mather TP, Opal SM, Spencer RL, Miller AH, McEwen BS, Biron CA. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J Exp Med. 181:1995;901-914.
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J Exp Med
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Orange, J.S.1
Salazar-Mather, T.P.2
Opal, S.M.3
Spencer, R.L.4
Miller, A.H.5
McEwen, B.S.6
Biron, C.A.7
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53
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0028786927
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The in vivo antiviral activity of IL-12 is mediated by IFN-γ
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Ozmen L, Aguet M, Trinchieri G, Garotta G. The in vivo antiviral activity of IL-12 is mediated by IFN-γ J Virol. 69:1995;8147-8150.
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J Virol
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Ozmen, L.1
Aguet, M.2
Trinchieri, G.3
Garotta, G.4
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54
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0028863450
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IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system
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Bi Z, Quandt P, Komatsu T, Barna M, Reiss CS. IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J Immunol. 155:1995;5684-5689.
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J Immunol
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Bi, Z.1
Quandt, P.2
Komatsu, T.3
Barna, M.4
Reiss, C.S.5
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55
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0029903048
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Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection
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Matsuo R, Kobayashi M, Herndon DN, Pollard RB, Suzuki F. Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection. J Leuk Biol. 59:1996;623-630.
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J Leuk Biol
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Matsuo, R.1
Kobayashi, M.2
Herndon, D.N.3
Pollard, R.B.4
Suzuki, F.5
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56
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0028265155
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Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones
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Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni M, Sampognaro S, Maggi E, Romagnani S, Trinchieri G. Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med. 179:1994;1273-1283.
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Manetti, R.1
Gerosa, F.2
Giudizi, M.G.3
Biagiotti, R.4
Parronchi, P.5
Piccinni, M.6
Sampognaro, S.7
Maggi, E.8
Romagnani, S.9
Trinchieri, G.10
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57
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0025819340
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Induction of IFN-γ production by NK cell stimulatory factor (NKSF): Characterization of the responder cells and synergy with other inducers
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Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G. Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J Exp Med. 173:1991;869-879.
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J Exp Med
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Chan, S.H.1
Perussia, B.2
Gupta, J.W.3
Kobayashi, M.4
Pospisil, M.5
Young, H.A.6
Wolf, S.F.7
Young, D.8
Clark, S.C.9
Trinchieri, G.10
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58
-
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0029015464
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H1 cells
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of outstanding interest. Demonstration that Th1 clones downregulate the β chain of the IFN-γ receptor, thus becoming insensitive to the IFN-γ that they produce.
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H1 cells. of outstanding interest Science. 269:1995;245-247 Demonstration that Th1 clones downregulate the β chain of the IFN-γ receptor, thus becoming insensitive to the IFN-γ that they produce.
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(1995)
Science
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, pp. 245-247
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Pernis, A.1
Gupta, S.2
Golob, K.J.3
Garfein, E.4
Coffman, R.L.5
Schindler, C.6
Rothman, P.7
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59
-
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0029071483
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Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
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of outstanding interest. Mouse Th2 clones lose the ability to respond to IL-12 with signal transduction, probably a mechanism in part responsible for the stable phenotypes of the clones.
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Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. of outstanding interest Immunity. 2:1995;665-675 Mouse Th2 clones lose the ability to respond to IL-12 with signal transduction, probably a mechanism in part responsible for the stable phenotypes of the clones.
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(1995)
Immunity
, vol.2
, pp. 665-675
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Szabo, S.J.1
Jacobson, N.G.2
Dighe, A.S.3
Gubler, U.4
Murphy, K.M.5
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60
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0029608656
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Interleukin-12 in the pathogenesis and therapy of HIV disease
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Chehimi J, Paganin C, Frank I, Chouaib S, Trinchieri G. Interleukin-12 in the pathogenesis and therapy of HIV disease. Res Immunol. 146:1995;605-614.
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Res Immunol
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Chehimi, J.1
Paganin, C.2
Frank, I.3
Chouaib, S.4
Trinchieri, G.5
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62
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0030055867
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Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus
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of special interest. This paper carefully analyzes the decreased ability of peripheral blood mononuclear cells from HIV patients to produce IL-12 and analyzes the effect of HIV infection on the expression of the p40 and p35 genes.
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Chougnet C, Wynn TA, Clerici M, Landay AL, Kessler HA, Rusnak J, Melcher GP, Sher A, Shearer GM. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. of special interest J Infect Dis. 174:1996;48-53 This paper carefully analyzes the decreased ability of peripheral blood mononuclear cells from HIV patients to produce IL-12 and analyzes the effect of HIV infection on the expression of the p40 and p35 genes.
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J Infect Dis
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Chougnet, C.1
Wynn, T.A.2
Clerici, M.3
Landay, A.L.4
Kessler, H.A.5
Rusnak, J.6
Melcher, G.P.7
Sher, A.8
Shearer, G.M.9
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63
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Impaired interleukin-12 production in human immunodeficiency virus-infected patients
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Chehimi J, Starr S, Frank I, D'Andrea A, Ma X, MacGregor RR, Sennelier J, Trinchieri G. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J Exp Med. 179:1994;1361-1366.
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J Exp Med
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Chehimi, J.1
Starr, S.2
Frank, I.3
D'Andrea, A.4
Ma, X.5
MacGregor, R.R.6
Sennelier, J.7
Trinchieri, G.8
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64
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0029970931
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Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: Requirement of gamma-interferon for IL-12 secretion
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Fantuzzi L, Gessani S, Borghi P, Varano B, Conti L, Puddu P, Belardelli F. Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma-interferon for IL-12 secretion. J Virology. 70:1996;4121-4124.
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J Virology
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Fantuzzi, L.1
Gessani, S.2
Borghi, P.3
Varano, B.4
Conti, L.5
Puddu, P.6
Belardelli, F.7
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65
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Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects
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Denis M, Ghadirian E. Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects. AIDS Res Hum Retrov. 10:1994;1619-1627.
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Denis, M.1
Ghadirian, E.2
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66
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0028791730
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Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens
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Daftarian MP, Diaz-Mitoma F, Creery WD, Cameron W, Kumar A. Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens. Clin Diag Lab Immunol. 2:1995;712-718.
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Daftarian, M.P.1
Diaz-Mitoma, F.2
Creery, W.D.3
Cameron, W.4
Kumar, A.5
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67
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0029818545
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Mechanism of suppression of cell-mediated immunity by measles virus
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of outstanding interest. Measles virus infection of monocytes selectively blocks their ability to produce IL-12 with a mechanism that is probably mediated by the virus binding to its own receptor on the monocytes, that is, the CD46 or membrane co-factor protein.
-
Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, Griffin DE. Mechanism of suppression of cell-mediated immunity by measles virus. of outstanding interest Science. 273:1996;228-231 Measles virus infection of monocytes selectively blocks their ability to produce IL-12 with a mechanism that is probably mediated by the virus binding to its own receptor on the monocytes, that is, the CD46 or membrane co-factor protein.
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Science
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Karp, C.L.1
Wysocka, M.2
Wahl, L.M.3
Ahearn, J.M.4
Cuomo, P.J.5
Sherry, B.6
Trinchieri, G.7
Griffin, D.E.8
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68
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0028817016
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Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages
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Panusak JR, Merolla R, Rebert NA, Hoffmann SP, Tsivitse P, Cirino NM, Silverman RH, Rankin JA. Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. J Clin Invest. 96:1995;2445-2453.
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J Clin Invest
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Panusak, J.R.1
Merolla, R.2
Rebert, N.A.3
Hoffmann, S.P.4
Tsivitse, P.5
Cirino, N.M.6
Silverman, R.H.7
Rankin, J.A.8
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69
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0029099861
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Interleukin-12 treatment during immunization elicits a T helper cell type 1-like immune response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity
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Tang YW, Graham BS. Interleukin-12 treatment during immunization elicits a T helper cell type 1-like immune response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity. J Infect Dis. 172:1995;734-738.
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Tang, Y.W.1
Graham, B.S.2
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