Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans

Toxicology

Volumn 254, Issue 1-2, 2008, Pages 1-10

  Carlson, Gary P ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Cytochrome P450; Lung; Styrene

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; CYTOCHROME P450 2A7; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2B6; CYTOCHROME P450 2B7; CYTOCHROME P450 2C18; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2F1; CYTOCHROME P450 2F2; CYTOCHROME P450 2J2; CYTOCHROME P450 2J3; CYTOCHROME P450 2S1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A43; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 4A11; CYTOCHROME P450 4B1; CYTOCHROME P450 4F3; STYRENE; STYRENE OXIDE; UNCLASSIFIED DRUG;

CARCINOGENICITY; CELL DAMAGE; CELL DEATH; CELL DIVISION; CHEMICAL ANALYSIS; COMPARATIVE STUDY; EPITHELIUM CELL; HUMAN; LIVER; LIVER METABOLISM; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; LUNG TUMOR; METABOLIC ACTIVATION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SPECIES COMPARISON;

CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INHALATION EXPOSURE; LUNG; LUNG NEOPLASMS; MICROSOMES; STYRENE;

MUS; RATTUS; RODENTIA;

EID: 56049111614     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.09.017     Document Type: Review

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