Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide

Toxicology Letters

Volumn 150, Issue 3, 2004, Pages 335-339

  Carlson, Gary P ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

CYP2E1 knockout mice; Hepatotoxicity; Pneumotoxicity; Styrene

Indexed keywords

BIOCHEMICAL MARKER; CYTOCHROME P450 2E1; CYTOCHROME P450 2F2; CYTOCHROME P450 ISOENZYME; IDITOL DEHYDROGENASE; LACTATE DEHYDROGENASE; STYRENE; STYRENE OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; KNOCKOUT MOUSE; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER TOXICITY; LUNG ALVEOLUS CELL; LUNG LAVAGE; LUNG TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; WILD TYPE;

ANIMALS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOCHROME P-450 CYP2E1; EPOXY COMPOUNDS; INJECTIONS, INTRAPERITONEAL; L-IDITOL 2-DEHYDROGENASE; LIVER; LUNG; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; STYRENE;

EID: 1942452895     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.02.004     Document Type: Article

References (20)

1. Bond J.A. Review of the toxicology of styrene. Crit. Rev. Toxicol. 19:1989;227-249.
2. Carlson G.P. Comparison of mouse strains for susceptibility to styrene-induced hepatotoxicity and pneumotoxicity. J. Toxicol. Environ. Health Part A. 51:1997a;177-187.
3. Carlson G.P. Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice. J. Toxicol. Environ. Health Part A. 51:1997b;477-488.
4. Carlson G.P. In vitro metabolism of styrene to styrene oxide in liver and lung of CYP2E1 knockout mice. J. Toxicol. Environ. Health. 66:2003;681-689.
5. Cohen J.T., Carlson G., Charnley G., Coggon D., Delzell E., Graham J.D., Greim H., Krewski D., Medinsky M., Monson R., Paustenbach D., Petersen B., Rappaport S., Ryan P.B., Thompson K. A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene. J. Toxicol. Environ. Health Part B. 5:2002;1-263.
6. Cruzan G., Cushman J.R., Andrews L.S., Granville G.C., Miller R.R., Hardy C.J., Coombs D.W., Mullins P.A. Subchronic inhalation studies of styrene in CD rats and CD-1 mice. Fund. Appl. Pharmacol. 35:1997;152-167.
7. Gadberry M.G., DeNicola D.B., Carlson G.P. Pneumotoxicity and hepatotoxicity of styrene and styrene oxide. J. Toxicol. Environ. Health. 48:1996;273-294.
8. Gerlach, U., 1983. Sorbitol dehydrogenase. In: Bergmeyer, H.U. (Ed.), Methods of Enzymatic Analysis, third ed. Verlag Chemie, Weinheim, pp. 112-117.
9. Ghanayem B.I., Wang H., Sumner S. Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity. Toxicol. Pathol. 28:2000;839-850.
10. Green T., Toghill A., Foster J.R. The role of cytochromes P-450 in styrene induced pulmonary toxicity and carcinogenicity. Toxicology. 169:2001;107-117.
11. Hynes D.E., DeNicola D.B., Carlson G.P. Metabolism of styrene by mouse and rat isolated lung cells. Toxicol. Sci. 51:1999;195-201.
12. Miller R.R., Newhook R., Poole A. Styrene production, use, and human exposure. Crit. Rev. Toxicol. 24(S1):1994;S1-S10.
13. Morgan D.L., Mahler J.F., Dill J.A., Price H.C., O'Connor R.W., Adkins B. Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fund. Appl. Toxicol. 21:1993a;326-333.
14. Morgan D.L., Mahler J.F., O'Connor R.W., Price H.C., Adkins B. Styrene inhalation toxicity studies in mice. I. Hepatotoxicity in B6C3F1 mice. Fund. Appl. Toxicol. 20:1993b;325-335.
15. Nakajima T., Elovaara E., Gonzalez F.J., Gelboin H.V., Raunio H., Pelkonen O., Vainio H., Aoyama T. Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem. Res. Toxicol. 7:1994a;891-896.
16. Nakajima T., Wang R.S., Elovaara E., Gonzalez F.J., Gelboin H.V., Vainio H., Aoyama T. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochem. Pharmacol. 48:1994b;637-642.
17. Redinbaugh M.G., Turley R.B. Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions. Anal. Biochem. 153:1986;267-271.
18. Sumner S.J., Fennell T.R. Review of the metabolic fate of styrene. Crit. Rev. Toxicol. 24(S1):1994;S11-S33.
19. 14C ] styrene Toxicologist. 60:2001;403.
20. Vassault A., 1983. Lactate dehydrogenase. In: UV method with pyruvate and NADH. In: Bergmeyer, H.U. (Ed.), Methods of Enzymatic Analysis, third ed. Verlag Chemie, Weinheim, pp. 118-125.