SP1 and SP3 regulate basal transcription of the human CYP2F1 gene

Drug Metabolism and Disposition

Volumn 33, Issue 8, 2005, Pages 1244-1253

  Wan, Jie ^a   Carr, Brian A ^a   Cutler, N Shane ^a   Lanza, Diane L ^a   Hines, Ronald N ^b   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 CYP 2F1; DNA; LUCIFERASE; OLIGONUCLEOTIDE; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL LINE; CELL STRAIN HEPG2; COMPARATIVE STUDY; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DROSOPHILA; ENZYME ACTIVITY; EXPRESSION VECTOR; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE CONSTRUCT; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LUNG ALVEOLUS CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DNA BINDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DNA; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; LUNG; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 22944485711     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.105.004069     Document Type: Article

References (40)

1. Blake MC, Jambou RC, Swick AG, Kahn JW, and Azizkhan JC (1990) Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol Cell Biol 10:6632-6641.
2. Boisclair YR, Brown AL, Casola S, and Rechler MM (1993) Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat. J Biol Chem 268:24892-24901.
3. Carr BA, Wan J, Hines RN, and Yost GS (2003) Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif. J Biol Chem 278:15473-15483.
4. Chen X, Azizkhan JC, and Lee DC (1992) The binding of transcription factor Sp1 to multiple sites is required for maximal expression from the rat transforming growth factor alpha promoter. Oncogene 7:1805-1815.
5. Conn KJ, Rich CB, Jensen DE, Fontanilla MR, Bashir MM, Rosenbloom J, and Foster JA (1996) Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription. J Biol Chem 271:28853-28860.
6. Dennig J, Hagen G, Beato M, and Suske G (1995) Members of the Sp transcription factor family control transcription from the uteroglobin promoter. J Biol Chem 270:12737-12744.
7. Ding X and Kaminsky LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149-173.
8. Ghayor C, Chadjichristos C, Herrouin JF, Ala-Kokko L, Suske G, Pujol JP, and Galera P (2001) Sp3 represses the Sp1-mediated transactivation of the human COL2A1 gene in primary and de-differentiated chondrocytes. J Biol Chem 276:36881-36895.
9. Hagen G, Muller S, Beato M, and Suske G (1994) Sp1-mediated transcriptional activation is repressed by Sp3. EMBO (Eur Mol Biol Organ) J 13:3843-3851.
10. Ihn H and Trojanowska M (1997) Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. Nucleic Acids Res 25:3712-3717.
11. Jiang P, Kumar A, Parrillo JE, Dempsey LA, Platt JL, Prinz RA, and Xu X (2002) Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J Biol Chem 277:8989-8998.
12. Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, and Urrutia R (2002) Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Biochem J 366:873-882.
13. Kriwacki RW, Schultz SC, Steitz TA, and Caradonna JP (1992) Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1. Proc Natl Acad Sci USA 89:9759-9763.
14. Lania L, Majello B, and De Luca P (1997) Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 29:1313-1323.
15. Lanza DL, Code E, Crespi CL, Gonzalez FJ, and Yost GS (1999) Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells. Drug Metab Dispos 27:798-803.
16. Lanza DL and Yost GS (2001) Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes. Drug Metab Dispos 29:950-953.
17. Li L, He S, Sun JM, and Davie JR (2004) Gene regulation by Sp1 and Sp3. Biochem Cell Biol 82:460-471.
18. Luc PV, Adesnik M, Ganguly S, and Shaw PM (1996) Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins. Biochem Pharmacol 51:345-356.
19. Majello B, De Luca P, and Lania L (1997) Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 272:4021-4026.
20. Marin M, Karis A, Visser P, Grosveld F, and Philipsen S (1997) Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 89:619-628.
21. Nakajima T, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, and Aoyama T (1994) Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem Res Toxicol 7:891-896.
22. Nichols WK, Mehta R, Skordos K, Mace K, Pfeifer AM, Carr BA, Minko T, Burchiel SW, and Yost GS (2003) 3-Methylindole-induced toxicity to human bronchial epithelial cell lines. Toxicol Sci 71:229-236.
23. Philipsen S and Suske G (1999) A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 27:2991-3000.
24. Powley MW and Carlson GP (2001) Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice. Toxicology 169:187-194.
25. Pugh BF and Tjian R (1991) Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev 5:1935-1945.
26. Rundlof AK, Carlsten M, and Arner ES (2001) The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1 and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene. J Biol Chem 276:30542-30551.
27. Ryu S, Zhou S, Ladurner AG, and Tjian R (1999) The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature (Lond) 397:446-450.
28. Saffer JD, Jackson SP, and Annarella MB (1991) Developmental expression of Sp1 in the mouse. Mol Cell Biol 11:2189-2199.
29. Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, and Suske G (2002) Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO (Eur Mol Biol Organ) J 21:5206-5215.
30. Shang Y, Hu X, DiRenzo J, Lazar MA, and Brown M (2000) Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852.
31. Sheets PL, Yost GS, and Carlson GP (2004) Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1. J Biochem Mol Toxicol 18:92-99.
32. Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, and Forkert PG (2004) Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. Drug Metab Dispos 32:1032-1039.
33. Suske G (1999) The Sp-family of transcription factors. Gene 238:291-300.
34. Wang H, Lanza DL, and Yost GS (1998) Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene. Arch Biochem Biophys 349:329-340.
35. Wiley SR, Kraus RJ, and Mertz JE (1992) Functional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters. Proc Natl Acad Sci USA 89:5814-5818.
36. Yost GS (2001) Bioactivation of toxicants by cytochrome p450-mediated dehydrogenation mechanisms. Adv Exp Med Biol 500:53-62.
37. Zhang J and Ding X (1998) Identification and characterization of a novel tissue-specific transcriptional activating element in the 5′-flanking region of the CYP2A3 gene predominantly expressed in rat olfactory mucosa. J Biol Chem 273:23454-23462.
38. Zhang J, Zhang QY, Guo J, Zhou Y, and Ding X (2000) Identification and functional characterization of a conserved, nuclear factor 1-like element in the proximal promoter region of CYP1A2 gene specifically expressed in the liver and olfactory mucosa. J Biol Chem 275:8895-8902.
39. Zhang W, Shields JM, Sogawa K, Fujii-Kuriyama Y, and Yang VW (1998) The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem 273:17917-17925.
40. Zhao X, Martin MM, and Elton TS (2001) The transcription factors Sp1 and Sp3 are required for human angiotensin II type 1 receptor gene expression in H295-R cells. Biochim Biophys Acta 1522:195-206.