Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes

FEBS Letters

Volumn 404, Issue 1, 1997, Pages 111-114

  Spurway, Tracey D ^a   Pogson, Christopher I ^b   Sherratt, H Stanley A ^a   Agius, Loranne ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Laboratories   (United Kingdom)

Author keywords

Adipocyte; Etomoxir; Hepatocyte; Lipolysis; Rat; Triacylglycerol

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ETOMOXIR; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENANTIOMER; FATTY ACID OXIDATION; IN VITRO STUDY; LIPID METABOLISM; LIPOLYSIS; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADIPOCYTES; ANIMALS; CELLS, CULTURED; EPOXY COMPOUNDS; ESTERIFICATION; FATTY ACIDS; HYPOGLYCEMIC AGENTS; LIPOLYSIS; LIVER; MALE; RATS; RATS, WISTAR; TRIGLYCERIDES;

ANIMALIA;

EID: 0031035102     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00103-8     Document Type: Article

References (24)

1. Randle, P.J. (1963) Lancet 1, 785-789.
2. Selby, P.L. and Sherratt, H.S.A. (1989) Trends Pharmacol. Sci. 10, 495-500.
3. Wolf, H.P.O. (1990) in: New Antidiabetic Drugs (Bailey, C.J. and Flatt, P.R. eds.) Smith-Gordon, Nishimura.
4. Koundakjian, P.P, Turnbull, D.M., Bone, A.J., Younan, S.I.M. and Sherratt, H.S.A. (1984) Biochem. Pharmacol. 33, 465-473.
5. Reaven, G.M., Chang, H. and Hoffman, B.B. (1988) Diabetes 37, 28-32.
6. Wolf, H.P.O., Eistetter, K. and Ludwig, G. (1982) Diabetologia 22, 456-463.
7. McCune, S.A., Nomura, T. and Harris, R.A. (1979) Lipids 14, 880-882.
8. Ide, T. and Ontko, J.A. (1981) J. Biol. Chem. 256, 10247-10255.
9. Tutwiler, G.F., Kirsch, T., Mohrbacher, R.J. and Ho, W. (1978) Metabolism 27, 1539-1556.
10. Collier, G.R., Traianedes, K. and O'Dea, K. (1989) Diabetologia 32, 477A.
11. Collier, G.R., Traianedes, K., Macaulay, S.L. and O'Dea, K. (1993) Horm. Metab. Res. 25, 9-12.
12. Vaartjes, W.J., De Haas, C.G.M. and Haagsman, H.P. (1986) Biochem. Pharmacol. 35, 4267-4272.
13. Agius, L., Pillay, D., Alberti, K.G.M.M. and Sherratt, H.S.A. (1985) Biochem. Pharmacol. 34, 2651-2654.
14. Agius, L., Meredith, E.J. and Sherratt, H.S.A. (1991) Biochem. Pharmacol. 42, 1717-1720.
15. Agius, L., Peak, M. and Sherratt, H.S.A. (1991) Biochem. Pharmacol. 42, 1711-1715.
16. Emmison, N., Zammit, V.A. and Agius, L. (1992) Biochem. J. 285 655-660.
17. Agius, L., Chowdhury, M.H., Davis, S.N. and Alberti, K.G.M.M. (1986) Diabetes 35, 1286-1293.
18. Clifton, P.M., Chang, L. and Mackinnon, A.M. (1988) Anal. Biochem. 172, 165-168.
19. Mangiapane, E.H. and Brindley, D.N. (1986) Biochem. J. 233, 151-160.
20. Christie, A.W., McCormick, D.K.T., Emmison, N., Kraemer, F.B., Alberti, K.G.M.M. and Yeaman, S.J. (1996) Diabetologia 39 45-53.
21. Kaikaus, R.M., Sui, Z., Lysenko, N., Wu, N.Y., Ortizde Montellano, P.R., Ockner, R.K. and Bass, N.M. (1993) J. Biol. Chem. 268, 26866-26871.
22. Spurway, T.D., Sherratt, H.S.A., Pogson, C.I. and Agius, L. (1996) Biochem. J., in press.
23. Vestemar, V., Medic-Saric, M. and Rendic, S. (1994) J. Pharm. Sci. 83, 485-490.
24. Rósen, P. and Reinauer, H. (1984) Metabolism 33, 177-185.