메뉴 건너뛰기




Volumn 3, Issue 2, 2008, Pages 133-137

Pathogen-related signal transduction pathways of dendritic cells: Perspectives for cancer immunotherapy

Author keywords

Cancer immunotherapy; Dendritic cell; RIG I; RNA virus; SOCS; TLRs

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; JANUS KINASE; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; RNA HELICASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; VIRUS RNA;

EID: 54949124968     PISSN: 15743624     EISSN: None     Source Type: Journal    
DOI: 10.2174/157436208784223116     Document Type: Review
Times cited : (2)

References (47)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006; 7: 131-137.
    • (2006) Nat Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 3
    • 33748475531 scopus 로고    scopus 로고
    • Type I interferon gene induction by the interferon regulatory factor family of transcription factors
    • Honda K, Takaoka A, Taniguchi T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006; 25: 349-360.
    • (2006) Immunity , vol.25 , pp. 349-360
    • Honda, K.1    Takaoka, A.2    Taniguchi, T.3
  • 4
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117: 979-987.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 979-987
    • Kaisho, T.1    Akira, S.2
  • 6
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takala K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takala, K.2
  • 7
    • 2942679083 scopus 로고    scopus 로고
    • The immunobiology of the TLR9 subfamily
    • Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol 2004; 25: 381-386.
    • (2004) Trends Immunol , vol.25 , pp. 381-386
    • Wagner, H.1
  • 8
    • 20044382430 scopus 로고    scopus 로고
    • Toll-like receptor 3 promotes cross-priming to virus-infected cells
    • Schulz O, Diebold SS, Chen M, et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005; 433: 887-892.
    • (2005) Nature , vol.433 , pp. 887-892
    • Schulz, O.1    Diebold, S.S.2    Chen, M.3
  • 9
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004; 10: 1366-1373.
    • (2004) Nat Med , vol.10 , pp. 1366-1373
    • Wang, T.1    Town, T.2    Alexopoulou, L.3    Anderson, J.F.4    Fikrig, E.5    Flavell, R.A.6
  • 10
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004; 303: 1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3
  • 11
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis E, Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis, E.5    Sousa, C.6
  • 12
    • 1842631428 scopus 로고    scopus 로고
    • Recognition of single-stranded RNA viruses by Toll-like receptor 7
    • Lund JM, Alexopoulou L, Sato A, et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 2004; 101: 5598-5603.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5598-5603
    • Lund, J.M.1    Alexopoulou, L.2    Sato, A.3
  • 13
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR 7
    • Hornung V, Guenthner-Biller M, Bourquin C, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR 7. Nat Med 2005; 11: 263-270.
    • (2005) Nat Med , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3
  • 14
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Ann Rev Immunol 2002; 20: 709-760.
    • (2002) Ann Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 15
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 16
    • 3142683548 scopus 로고    scopus 로고
    • TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • Krug A, French AR, Barchet W, et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004; 21: 107-119.
    • (2004) Immunity , vol.21 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3
  • 17
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of HSV-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of HSV-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198: 513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 18
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003; 301: 640-643.
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 19
    • 0042679529 scopus 로고    scopus 로고
    • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    • Hoebe K, Du X, Georgel P, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003; 424: 743-748.
    • (2003) Nature , vol.424 , pp. 743-748
    • Hoebe, K.1    Du, X.2    Georgel, P.3
  • 20
    • 4344566281 scopus 로고    scopus 로고
    • The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
    • Hemmi H, Takeuchi O, Sato S, et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 2004; 199: 1641-1650.
    • (2004) J Exp Med , vol.199 , pp. 1641-1650
    • Hemmi, H.1    Takeuchi, O.2    Sato, S.3
  • 21
    • 22544455673 scopus 로고    scopus 로고
    • Cell type-specific involvement of RIG-I in antiviral response
    • Kato H, Sato S, Yoneyama M, et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005; 23: 19-28.
    • (2005) Immunity , vol.23 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3
  • 22
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5: 730-737
    • (2004) Nat Immunol , vol.5 , pp. 730-737
    • Yoneyama, M.1    Kikuchi, M.2    Natsukawa, T.3
  • 23
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/H-Box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    • Yoneyama M, Kikuchi M, Matsumoto K, et al. Shared and unique functions of the DExD/H-Box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005; 175: 2851-2858.
    • (2005) J Immunol , vol.175 , pp. 2851-2858
    • Yoneyama, M.1    Kikuchi, M.2    Matsumoto, K.3
  • 24
    • 26844503987 scopus 로고    scopus 로고
    • The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    • Rothenfusser S, Goutagny N, DiPerna G, et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol 2005; 175: 5260-5268.
    • (2005) J Immunol , vol.175 , pp. 5260-5268
    • Rothenfusser, S.1    Goutagny, N.2    DiPerna, G.3
  • 25
    • 22544455673 scopus 로고    scopus 로고
    • Cell type specific involvement of RIG-I in antiviral response
    • Kato H, Sato S, Yoneyama M, et al. Cell type specific involvement of RIG-I in antiviral response. Immunity 2005; 23: 19-28.
    • (2005) Immunity , vol.23 , pp. 19-28
    • Kato, H.1    Sato, S.2    Yoneyama, M.3
  • 26
    • 33646342149 scopus 로고    scopus 로고
    • Differential role of MDA5 and RIG-I in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S, et al. Differential role of MDA5 and RIG-I in the recognition of RNA viruses. Nature 2006; 441: 101-105.
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 27
    • 33744791510 scopus 로고    scopus 로고
    • Essential role of mda-5 in type I IFN responses to polyriboinosinic: Polyribocytidylic acid and encephalomyocarditis picornavirus
    • Gitlin L, Barchet W, Gilfillan S, et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA 2006; 103: 8459-8464.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8459-8464
    • Gitlin, L.1    Barchet, W.2    Gilfillan, S.3
  • 28
    • 33750976374 scopus 로고    scopus 로고
    • 5′-Triphosphate RNA is the ligand for RIG-I
    • Hornung V, Ellegast J, Kim S, et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 2006; 5801: 994-997.
    • (2006) Science , vol.5801 , pp. 994-997
    • Hornung, V.1    Ellegast, J.2    Kim, S.3
  • 29
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E, Curran J, Hofmann K, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437: 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3
  • 30
    • 27144440523 scopus 로고    scopus 로고
    • IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    • Kawai T, Takahashi K, Sato S, et al. IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6: 981-988.
    • (2005) Nat Immunol , vol.6 , pp. 981-988
    • Kawai, T.1    Takahashi, K.2    Sato, S.3
  • 31
    • 24144461689 scopus 로고    scopus 로고
    • Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF3
    • Seth RB, Sun L, Ea CK, Chen ZJ. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF3. Cell 2005; 122: 669-682.
    • (2005) Cell , vol.122 , pp. 669-682
    • Seth, R.B.1    Sun, L.2    Ea, C.K.3    Chen, Z.J.4
  • 32
    • 24944538819 scopus 로고    scopus 로고
    • VISA is an adapter protein required for virus-triggered IFN-beta signaling
    • Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19: 727-740.
    • (2005) Mol Cell , vol.19 , pp. 727-740
    • Xu, L.G.1    Wang, Y.Y.2    Han, K.J.3    Li, L.Y.4    Zhai, Z.5    Shu, H.B.6
  • 33
    • 33746479050 scopus 로고    scopus 로고
    • Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
    • Saha SK, Pietras EM, He JQ, et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J 2006; 25: 3257-3263.
    • (2006) EMBO J , vol.25 , pp. 3257-3263
    • Saha, S.K.1    Pietras, E.M.2    He, J.Q.3
  • 34
    • 9244236078 scopus 로고    scopus 로고
    • A FADD-dependent innate immune mechanism in mammalian cells
    • Balachandran S, Thomas E, Barber GN. A FADD-dependent innate immune mechanism in mammalian cells. Nature 2004; 432: 401-485.
    • (2004) Nature , vol.432 , pp. 401-485
    • Balachandran, S.1    Thomas, E.2    Barber, G.N.3
  • 35
    • 33645786318 scopus 로고    scopus 로고
    • Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses
    • Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses. J Immunol 2006; 176: 4520-4524.
    • (2006) J Immunol , vol.176 , pp. 4520-4524
    • Takahashi, K.1    Kawai, T.2    Kumar, H.3    Sato, S.4    Yonehara, S.5    Akira, S.6
  • 36
    • 33748501271 scopus 로고    scopus 로고
    • Induction of efficient antitumor immunity using dendritic cells activated by Sendai virus and its modulation of exogenous interferon-beta gene
    • Shibata S, Okano S, Yonemitsu Y, et al. Induction of efficient antitumor immunity using dendritic cells activated by Sendai virus and its modulation of exogenous interferon-beta gene. J Immunol 2006; 177: 3564-3576.
    • (2006) J Immunol , vol.177 , pp. 3564-3576
    • Shibata, S.1    Okano, S.2    Yonemitsu, Y.3
  • 37
    • 33847229473 scopus 로고    scopus 로고
    • Development of immunostimulatory virotherapy using non-transmissible Sendai virus-activated dendritic cells
    • Yoneyama Y, Ueda Y, Akutsu Y, et al. Development of immunostimulatory virotherapy using non-transmissible Sendai virus-activated dendritic cells. Biochem Biophys Res Commun 2007; 355: 129-135.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 129-135
    • Yoneyama, Y.1    Ueda, Y.2    Akutsu, Y.3
  • 38
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 2003; 4: 1169-1176.
    • (2003) Nat Immunol , vol.4 , pp. 1169-1176
    • Kubo, M.1    Hanada, T.2    Yoshimura, A.3
  • 39
    • 2542478996 scopus 로고    scopus 로고
    • The Role of Suppressors of Cytokine Signaling (SOCS) Proteins in Regulation of the Immune Response
    • Alexander WS, Hilton DJ. The Role of Suppressors of Cytokine Signaling (SOCS) Proteins in Regulation of the Immune Response. Ann Rev Immunol 2004; 22: 503-529.
    • (2004) Ann Rev Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 40
    • 0034841006 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling
    • Greenhalgh CJ, Hilton DJ. Negative regulation of cytokine signaling. J Leukoc Biol 2001; 70: 348-356.
    • (2001) J Leukoc Biol , vol.70 , pp. 348-356
    • Greenhalgh, C.J.1    Hilton, D.J.2
  • 41
    • 0347955360 scopus 로고    scopus 로고
    • Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA
    • Ryo A, Suizu F, Yoshida Y, et al. Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell 2003; 12: 1413-1426.
    • (2003) Mol Cell , vol.12 , pp. 1413-1426
    • Ryo, A.1    Suizu, F.2    Yoshida, Y.3
  • 42
    • 0033520467 scopus 로고    scopus 로고
    • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    • Marine JC, Topham DJ, McKay C, et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 1999; 98: 609-616.
    • (1999) Cell , vol.98 , pp. 609-616
    • Marine, J.C.1    Topham, D.J.2    McKay, C.3
  • 43
    • 0033520326 scopus 로고    scopus 로고
    • SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
    • Alexander WS, Starr R, Fenner JE, et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 1999; 98: 597-608.
    • (1999) Cell , vol.98 , pp. 597-608
    • Alexander, W.S.1    Starr, R.2    Fenner, J.E.3
  • 44
    • 0035008978 scopus 로고    scopus 로고
    • SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
    • Naka T, Tsutsui H, Fujimoto M, et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 2001; 14: 535-545.
    • (2001) Immunity , vol.14 , pp. 535-545
    • Naka, T.1    Tsutsui, H.2    Fujimoto, M.3
  • 45
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • Hanada T, Yoshida H, Kato S, et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003; 19: 437-450.
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1    Yoshida, H.2    Kato, S.3
  • 46
    • 11144254962 scopus 로고    scopus 로고
    • Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
    • Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat Biotechnol 2004; 22: 1546-1553.
    • (2004) Nat Biotechnol , vol.22 , pp. 1546-1553
    • Shen, L.1    Evel-Kabler, K.2    Strube, R.3    Chen, S.Y.4
  • 47
    • 0036850946 scopus 로고    scopus 로고
    • SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    • Kinjyo I, Hanada T, Inagaki-Ohara K, et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 2002; 17: 583-591.
    • (2002) Immunity , vol.17 , pp. 583-591
    • Kinjyo, I.1    Hanada, T.2    Inagaki-Ohara, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.