Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 22, 2008, Pages 9745-9756

  Sawada, Geri A ^a   Raub, Thomas J ^a   William Higgins, J ^a   Brennan, Nancy K ^b   Moore, Teiah M ^b   Tombline, Gregory ^b,c   Detty, Michael R ^b  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Chalcogenopyrylium dyes; Inhibitors; Multidrug resistance; P glycoprotein; Transporters

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCEIN; CHALCOGENOPYRYLIUM DYE; DYE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; VERAPAMIL;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; NONHUMAN;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM CHANNEL BLOCKERS; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CELLS, CULTURED; CHALCOGENS; DOGS; DRUG RESISTANCE, MULTIPLE; FLUORESCEINS; FLUORESCENT DYES; HUMANS; INHIBITORY CONCENTRATION 50; P-GLYCOPROTEIN; VERAPAMIL;

EID: 54849418385     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.065     Document Type: Article

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