메뉴 건너뛰기




Volumn 32, Issue 6, 1996, Pages 1082-1088

Pharmacological considerations in the modulation of multidrug resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; ANTIMALARIAL AGENT; ANTISENSE OLIGONUCLEOTIDE; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; CYTOTOXIC AGENT; DEXVERAPAMIL; DOXORUBICIN; EPIPODOPHYLLOTOXIN DERIVATIVE; EPIRUBICIN; ETOPOSIDE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; HORMONE; IFOSFAMIDE; LIPOSOME; NORTAMOXIFEN; PACLITAXEL; PHENOTHIAZINE DERIVATIVE; RAPAMYCIN; TAMOXIFEN; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VERAPAMIL DERIVATIVE; VINCA ALKALOID; VINDESINE;

EID: 0029974821     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(96)00111-6     Document Type: Article
Times cited : (136)

References (69)
  • 1
    • 0023233801 scopus 로고
    • Multi-drug resistance in human cancer
    • Pastan I, Gottesman MM. Multi-drug resistance in human cancer. N Engl J Med 1987, 316, 1388-1393.
    • (1987) N Engl J Med , vol.316 , pp. 1388-1393
    • Pastan, I.1    Gottesman, M.M.2
  • 2
    • 0027263181 scopus 로고
    • Clinical significance of P-glycoprotein in multidrug resistance malignancies
    • Arceci RJ. Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood 1993, 81, 2215-2222.
    • (1993) Blood , vol.81 , pp. 2215-2222
    • Arceci, R.J.1
  • 3
    • 0027345632 scopus 로고
    • Function and regulation of the human multidrug resistance gene
    • Chin KV, Pastan I, Gottesman MM. Function and regulation of the human multidrug resistance gene. Adv Cancer Res 1993, 60, 157-180.
    • (1993) Adv Cancer Res , vol.60 , pp. 157-180
    • Chin, K.V.1    Pastan, I.2    Gottesman, M.M.3
  • 4
    • 0027120232 scopus 로고
    • P-glycoprotein and resistance to anticancer drugs
    • Ling V. P-glycoprotein and resistance to anticancer drugs. Cancer 1992, 69, 2603-2609.
    • (1992) Cancer , vol.69 , pp. 2603-2609
    • Ling, V.1
  • 5
    • 0025828251 scopus 로고
    • Multidrug resistance (MDR) in human cancers
    • Nooter K, Herwijer H. Multidrug resistance (MDR) in human cancers. Br J Cancer 1991, 63, 663-669.
    • (1991) Br J Cancer , vol.63 , pp. 663-669
    • Nooter, K.1    Herwijer, H.2
  • 7
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen CJ, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986, 47, 381-390.
    • (1986) Cell , vol.47 , pp. 381-390
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3
  • 9
    • 0028948976 scopus 로고
    • P-glycoprotein in adult solid tumors: Expression and prognostic significance
    • Leighton J, Goldstein L. P-glycoprotein in adult solid tumors: expression and prognostic significance. Hematol Oncol Clin North Am 1995, 9, 251-274.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 251-274
    • Leighton, J.1    Goldstein, L.2
  • 10
    • 0028964967 scopus 로고
    • P-glycoprotein in adult hematological malignancies
    • Marie J. P-glycoprotein in adult hematological malignancies. Hematol Oncol Clin North Am 1995, 9, 239-250.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 239-250
    • Marie, J.1
  • 11
    • 0028951303 scopus 로고
    • MDR expression in normal tissues: Pharmacologic implications for the clinical use of P-glycoprotein inhibitors
    • Lum B, Gosland M. MDR expression in normal tissues: pharmacologic implications for the clinical use of P-glycoprotein inhibitors. Hematol Oncol Clin North Am 1995, 9, 319-336.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 319-336
    • Lum, B.1    Gosland, M.2
  • 12
    • 0023741129 scopus 로고
    • Tissue distribution of P-glycoprotein encoded by a multidrug resistant gene as revealed by a monoclonal antibody, MRK16
    • Sugawara I, Kataoka I, Morischita Y. Tissue distribution of P-glycoprotein encoded by a multidrug resistant gene as revealed by a monoclonal antibody, MRK16. Cancer Res 1988, 48, 4611-4614.
    • (1988) Cancer Res , vol.48 , pp. 4611-4614
    • Sugawara, I.1    Kataoka, I.2    Morischita, Y.3
  • 13
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • Cordon-Cardo C, O'Brien JP, Casals D, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989, 816, 695-698.
    • (1989) Proc Natl Acad Sci USA , vol.816 , pp. 695-698
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Casals, D.3
  • 14
    • 0020527686 scopus 로고
    • Potentiation of vincristine and adriamycin in human hematopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors
    • Tsuruo T, Lida H, Tsukagoshi S, Sakurai Y. Potentiation of vincristine and adriamycin in human hematopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors. Cancer Res 1983, 43, 2267-2272.
    • (1983) Cancer Res , vol.43 , pp. 2267-2272
    • Tsuruo, T.1    Lida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 15
    • 0025991731 scopus 로고
    • Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells
    • Tamai I, Safa AR. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J Biol Chem 1991, 266, 16796-16800.
    • (1991) J Biol Chem , vol.266 , pp. 16796-16800
    • Tamai, I.1    Safa, A.R.2
  • 16
    • 0027406201 scopus 로고
    • Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance
    • Naito M, Tsuge H, Kuroko C, et al. Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. J Natl Cancer Inst 1993, 85, 311-316.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 311-316
    • Naito, M.1    Tsuge, H.2    Kuroko, C.3
  • 17
    • 0026654583 scopus 로고
    • Stereoisomers of calcium antagonist which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein
    • Hollt V, Kouba M, Dietel M, Vogt G. Stereoisomers of calcium antagonist which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem Pharmacol 1992, 43, 2601-2608.
    • (1992) Biochem Pharmacol , vol.43 , pp. 2601-2608
    • Hollt, V.1    Kouba, M.2    Dietel, M.3    Vogt, G.4
  • 18
    • 0026783227 scopus 로고
    • Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells
    • Clarke R, Currier S, Kaplan O, et al. Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells. J Natl Cancer Inst 1992, 84, 1506-1512.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1506-1512
    • Clarke, R.1    Currier, S.2    Kaplan, O.3
  • 19
    • 0023091199 scopus 로고
    • Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: Role of protein binding
    • Broxterman HJ, Kuiper CM, Schuurhuis GJ. Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: role of protein binding. Cancer Lett 1995, 35, 87-95.
    • (1995) Cancer Lett , vol.35 , pp. 87-95
    • Broxterman, H.J.1    Kuiper, C.M.2    Schuurhuis, G.J.3
  • 20
    • 0026711061 scopus 로고
    • A potent efflux inhibitor to circumvent anthracycline resistance in vivo
    • Genne P, Dimanche-Boitrel MT, Mauvernay RY, et al. A potent efflux inhibitor to circumvent anthracycline resistance in vivo. Cancer Res 1992, 52, 2797-2801.
    • (1992) Cancer Res , vol.52 , pp. 2797-2801
    • Genne, P.1    Dimanche-Boitrel, M.T.2    Mauvernay, R.Y.3
  • 21
    • 0027523976 scopus 로고
    • Reversal of multidrug resistance in breast cancer: Many more open questions than answers
    • Lehnert M. Reversal of multidrug resistance in breast cancer: many more open questions than answers. Annal Oncol 1993, 4, 11-13.
    • (1993) Annal Oncol , vol.4 , pp. 11-13
    • Lehnert, M.1
  • 22
    • 0028985382 scopus 로고
    • Characterization of the Mr 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cells
    • Alquist KC, Loe DW, Hipfner DR, Mackie JE, Cole SPC, Deeley RG. Characterization of the Mr 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cells. Cancer Res 1995, 55, 102-109.
    • (1995) Cancer Res , vol.55 , pp. 102-109
    • Alquist, K.C.1    Loe, D.W.2    Hipfner, D.R.3    Mackie, J.E.4    Cole, S.P.C.5    Deeley, R.G.6
  • 23
    • 0029157072 scopus 로고
    • Expression pattern of MRP in human tissues and adult solid tumor cell lines
    • Kruh GD, Gaughan KT, Godwin A, Chan A. Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst 1995, 87, 1256-1258.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1256-1258
    • Kruh, G.D.1    Gaughan, K.T.2    Godwin, A.3    Chan, A.4
  • 24
    • 0023237840 scopus 로고
    • Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients
    • Ozols RF, Cunnion RE, Klecker RW, et al. Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients. J Clin Oncol 1987, 5, 641-647.
    • (1987) J Clin Oncol , vol.5 , pp. 641-647
    • Ozols, R.F.1    Cunnion, R.E.2    Klecker, R.W.3
  • 26
    • 0022196456 scopus 로고
    • The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans
    • Echizen H, Brecht T, Niedergesass S. The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans. Am Heart J 1985, 109, 210-217.
    • (1985) Am Heart J , vol.109 , pp. 210-217
    • Echizen, H.1    Brecht, T.2    Niedergesass, S.3
  • 27
    • 0026012803 scopus 로고
    • Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines
    • HauBermann K, Benz B, Gekeler V. Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines. Eur J Pharmacol 1991, 40, 53-59.
    • (1991) Eur J Pharmacol , vol.40 , pp. 53-59
    • Haubermann, K.1    Benz, B.2    Gekeler, V.3
  • 28
    • 0029025957 scopus 로고
    • Phase I and pharmacokinetic study of the multidrug resistance modulator and dexverapamil with EPOCH chemotherapy
    • Wilson WH, Jamis-Dow C, Bryant G, et al. Phase I and pharmacokinetic study of the multidrug resistance modulator and dexverapamil with EPOCH chemotherapy. J Clin Oncol 1995, 13, 1985-1994.
    • (1995) J Clin Oncol , vol.13 , pp. 1985-1994
    • Wilson, W.H.1    Jamis-Dow, C.2    Bryant, G.3
  • 29
    • 0029049257 scopus 로고
    • Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma
    • Motzer R, Lyn P, Fischer P, et al. Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma. J Clin Oncol 1995, 13, 1958-1965.
    • (1995) J Clin Oncol , vol.13 , pp. 1958-1965
    • Motzer, R.1    Lyn, P.2    Fischer, P.3
  • 30
    • 0029027893 scopus 로고
    • Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy
    • Wilson WH, Bates SE, Fojo A, et al. Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy. J Clin Oncol 1995, 13, 1995-2004.
    • (1995) J Clin Oncol , vol.13 , pp. 1995-2004
    • Wilson, W.H.1    Bates, S.E.2    Fojo, A.3
  • 31
    • 0027243899 scopus 로고
    • Different modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites
    • Kirk J, Houlbrook S, Stuart NSA, Stratford IJ, Harris AL, Carmichael J. Different modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites. Br J Cancer 1993, 67, 1189-1195.
    • (1993) Br J Cancer , vol.67 , pp. 1189-1195
    • Kirk, J.1    Houlbrook, S.2    Stuart, N.S.A.3    Stratford, I.J.4    Harris, A.L.5    Carmichael, J.6
  • 32
    • 0026445750 scopus 로고
    • High-dose oral tamoxifen, a potential multidrug-resistance-reversal agent: Phase I trial in combination with vinblastine
    • Trump DL, Smith DC, Ellis PG, et al. High-dose oral tamoxifen, a potential multidrug-resistance-reversal agent: phase I trial in combination with vinblastine. J Natl Cancer Inst 1992, 84, 1811-1816.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1811-1816
    • Trump, D.L.1    Smith, D.C.2    Ellis, P.G.3
  • 34
    • 0028844643 scopus 로고
    • Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia
    • Berman E, McBride M, Lin S, Menedez-Botet C, Tong W. Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia. Leukemia 1995, 9, 1631-1637.
    • (1995) Leukemia , vol.9 , pp. 1631-1637
    • Berman, E.1    McBride, M.2    Lin, S.3    Menedez-Botet, C.4    Tong, W.5
  • 35
    • 0027057396 scopus 로고
    • Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance
    • Yahanda M, Adler KM, Fisher GA, et al. Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J Clin Oncol 1992, 10, 1624-1634.
    • (1992) J Clin Oncol , vol.10 , pp. 1624-1634
    • Yahanda, M.1    Adler, K.M.2    Fisher, G.A.3
  • 36
    • 0000829338 scopus 로고
    • Bilirubin: A physiological substrate for the multidrug transporter
    • Gosland M, Brophy N, Duran G. Bilirubin: a physiological substrate for the multidrug transporter. Proc Am Assoc Cancer Res 1991, 32, 426.
    • (1991) Proc Am Assoc Cancer Res , vol.32 , pp. 426
    • Gosland, M.1    Brophy, N.2    Duran, G.3
  • 37
    • 0041959046 scopus 로고
    • Selective inhibition of hepatic P-glycoprotein mediated excretion by SDZ PSC 833 and dexniguldipine
    • Thalhammer T, Swatonek H, Riegler S, Gajdzk L, Graf J. Selective inhibition of hepatic P-glycoprotein mediated excretion by SDZ PSC 833 and dexniguldipine. Anti-cancer Drugs 1994, 5, S1, 16-36.
    • (1994) Anti-cancer Drugs , vol.5 , Issue.S1 , pp. 16-36
    • Thalhammer, T.1    Swatonek, H.2    Riegler, S.3    Gajdzk, L.4    Graf, J.5
  • 39
    • 0030069632 scopus 로고    scopus 로고
    • Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer
    • Boote D, Dennis I, Twentyman P, et al. Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer. J Clin Oncol 1996, 14, 610-618.
    • (1996) J Clin Oncol , vol.14 , pp. 610-618
    • Boote, D.1    Dennis, I.2    Twentyman, P.3
  • 40
    • 0000576983 scopus 로고
    • A phase I trial of etoposide with the oral cyclosporin SDZ PSC 833, a modulator of multidrug resistance
    • Hausdorff J, Fisher GA, Halsey J, et al. A phase I trial of etoposide with the oral cyclosporin SDZ PSC 833, a modulator of multidrug resistance. Proc Am Soc Clin Oncol 1995, 14, 181-407.
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 181-407
    • Hausdorff, J.1    Fisher, G.A.2    Halsey, J.3
  • 41
    • 0000160345 scopus 로고
    • Phase I trial of paclitaxel in combination with SDZ PSC 833, a multidrug resist-ance modulator
    • Collins HL, Fisher GA, Hausdorff J, et al. Phase I trial of paclitaxel in combination with SDZ PSC 833, a multidrug resist-ance modulator. Proc Am Soc Clin Oncol 1995, 14, 181-406.
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 181-406
    • Collins, H.L.1    Fisher, G.A.2    Hausdorff, J.3
  • 43
    • 0028180014 scopus 로고
    • Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport
    • Thalhammer T, Stapf V, Gajdzik L, Graf J. Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport. Eur J Pharmacol 1994, 270, 213-220.
    • (1994) Eur J Pharmacol , vol.270 , pp. 213-220
    • Thalhammer, T.1    Stapf, V.2    Gajdzik, L.3    Graf, J.4
  • 44
    • 0026717924 scopus 로고
    • Postnatal development of organic cation transport and mdr gene expression in mouse kidney
    • Dutt A, Priebe T, Teeter L. Postnatal development of organic cation transport and mdr gene expression in mouse kidney. J Pharmacol Exp Ther 1992, 261, 1222-1230.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 1222-1230
    • Dutt, A.1    Priebe, T.2    Teeter, L.3
  • 45
    • 0028264139 scopus 로고
    • Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH
    • Zacherl J, Hamilton G, Thalhammer T, et al. Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH. Cancer Chemother Pharmacol 1994, 34, 125-132.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 125-132
    • Zacherl, J.1    Hamilton, G.2    Thalhammer, T.3
  • 46
    • 0026669192 scopus 로고
    • Functional involvement of P-glycoprotein in blood-brain barrier
    • Tatsuta T, Naito M, Oh-hara T, Sugawara T, Tsuruo T. Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 1992, 267, 20383-20391.
    • (1992) J Biol Chem , vol.267 , pp. 20383-20391
    • Tatsuta, T.1    Naito, M.2    Oh-Hara, T.3    Sugawara, T.4    Tsuruo, T.5
  • 47
    • 0027842835 scopus 로고
    • Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals
    • Borst P, Schinkel AH, Smit JJM, et al. Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals. Pharmacol Ther 1993, 60, 289-299.
    • (1993) Pharmacol Ther , vol.60 , pp. 289-299
    • Borst, P.1    Schinkel, A.H.2    Smit, J.J.M.3
  • 49
    • 0028229150 scopus 로고
    • Disruption of the mouse mdrla p-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel AH, Smit JJM, van Tellingen O, et al. Disruption of the mouse mdrla P-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994, 77, 491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.M.2    Van Tellingen, O.3
  • 50
    • 0028817068 scopus 로고
    • Relationship between P-glycoprotein expression and cyclosporin A in kidney
    • Garcia Del Moral R, O'Valle F, Andujar M, et al. Relationship between P-glycoprotein expression and cyclosporin A in kidney. Am J Pathol 1995, 146, 398-408.
    • (1995) Am J Pathol , vol.146 , pp. 398-408
    • Garcia Del Moral, R.1    O'Valle, F.2    Andujar, M.3
  • 51
    • 0028132031 scopus 로고
    • Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver
    • Vollrath V, Wielandt AM, Acuna C, Duarte I, Andrade L, Chianale J. Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. J Hepatol 1994, 21, 754-763.
    • (1994) J Hepatol , vol.21 , pp. 754-763
    • Vollrath, V.1    Wielandt, A.M.2    Acuna, C.3    Duarte, I.4    Andrade, L.5    Chianale, J.6
  • 53
    • 0029165482 scopus 로고
    • Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer
    • Berg SL, Tocher A, O'Shaughnessy JA, et al. Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer. J Clin Oncol 1995, 13, 2039-2042.
    • (1995) J Clin Oncol , vol.13 , pp. 2039-2042
    • Berg, S.L.1    Tocher, A.2    O'Shaughnessy, J.A.3
  • 54
    • 0029036741 scopus 로고
    • Tolerance, safety, and kinetics of the new antineoplastic compound dexniguldipine-HCl after oral administration: A phase I dose-escalation trial
    • Ukena D, Boewer C, Oldenkott B, et al. Tolerance, safety, and kinetics of the new antineoplastic compound dexniguldipine-HCl after oral administration: a phase I dose-escalation trial. Cancer Chem Pharmacol 1995, 36, 160-164.
    • (1995) Cancer Chem Pharmacol , vol.36 , pp. 160-164
    • Ukena, D.1    Boewer, C.2    Oldenkott, B.3
  • 55
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991, 66, 85-92.
    • (1991) Cell , vol.66 , pp. 85-92
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 56
    • 0028199806 scopus 로고
    • Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance
    • Bartlett NL, Lum BL, Fisher GA, et al. Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance. J Clin Oncol 1994, 12, 835-842.
    • (1994) J Clin Oncol , vol.12 , pp. 835-842
    • Bartlett, N.L.1    Lum, B.L.2    Fisher, G.A.3
  • 57
    • 0041959045 scopus 로고
    • Phase II trial of oncep chemotherapy in patients with relapsed non-Hodgkin's lymphoma (NHL)
    • Yuen A, Sikic B, Horning S. Phase II trial of Oncep chemotherapy in patients with relapsed non-Hodgkin's lymphoma (NHL). Proc Am Soc Clin Oncol 1995, 14, 392.
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 392
    • Yuen, A.1    Sikic, B.2    Horning, S.3
  • 58
    • 0027518277 scopus 로고
    • Multidrug resistance and mutagenesis
    • Ferguson LR, Baguley BC. Multidrug resistance and mutagenesis. Mutation Res 1993, 225, 79-90.
    • (1993) Mutation Res , vol.225 , pp. 79-90
    • Ferguson, L.R.1    Baguley, B.C.2
  • 59
    • 0027165416 scopus 로고
    • Modulation of multidrug resistance: At the threshold
    • Sikic B. Modulation of multidrug resistance: at the threshold. J Clin Oncol 1993, 11, 1629-1635.
    • (1993) J Clin Oncol , vol.11 , pp. 1629-1635
    • Sikic, B.1
  • 60
    • 0027518135 scopus 로고
    • Clinical trials of modulation of multidrug resistance: Pharmacokinetic and pharmacodynamic considerations
    • Lum BL, Fisher GA, Brophy NA, et al. Clinical trials of modulation of multidrug resistance: pharmacokinetic and pharmacodynamic considerations. Cancer 1993, 72, 3502-3514.
    • (1993) Cancer , vol.72 , pp. 3502-3514
    • Lum, B.L.1    Fisher, G.A.2    Brophy, N.A.3
  • 61
    • 0022885525 scopus 로고
    • The effect of verapamil on the pharmacokinetics of adriamycin
    • Kerr DJ, Graham J, Cummings J, et al. The effect of verapamil on the pharmacokinetics of adriamycin. Cancer Chemother Pharmacol 1986, 18, 239-242.
    • (1986) Cancer Chemother Pharmacol , vol.18 , pp. 239-242
    • Kerr, D.J.1    Graham, J.2    Cummings, J.3
  • 62
    • 0027479023 scopus 로고
    • Effects of verapamil on the pharmacokinetics and metabolism of epirubicin
    • Mross K, Hamm K, Hossfeld DK. Effects of verapamil on the pharmacokinetics and metabolism of epirubicin. Cancer Chemother Pharmacol 1993, 31, 369-375.
    • (1993) Cancer Chemother Pharmacol , vol.31 , pp. 369-375
    • Mross, K.1    Hamm, K.2    Hossfeld, D.K.3
  • 63
    • 0026589774 scopus 로고
    • Intermittent high-dose tamoxifen as a potential modifier of multidrug resistance
    • Millward MJ, Cantwell BMJ, Lien EA, et al. Intermittent high-dose tamoxifen as a potential modifier of multidrug resistance. Eur J Cancer 1992, 28A, 805-810.
    • (1992) Eur J Cancer , vol.28 A , pp. 805-810
    • Millward, M.J.1    Cantwell, B.M.J.2    Lien, E.A.3
  • 64
    • 0024418287 scopus 로고
    • Pharmacokinetics of vincristine in cancer patients treated with nifedipine
    • Fedeli L, Clozza M, Boschetti E, et al. Pharmacokinetics of vincristine in cancer patients treated with nifedipine. Cancer 1989, 64, 1805-1811.
    • (1989) Cancer , vol.64 , pp. 1805-1811
    • Fedeli, L.1    Clozza, M.2    Boschetti, E.3
  • 65
    • 0026543580 scopus 로고
    • A phase I study on the reversal of multidrug resistance (MDR) in vivo: Nifedipine plus etoposide
    • Philip PA, Joel S, Monkman SC, et al. A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide. Br J Cancer 1992, 65, 267-270.
    • (1992) Br J Cancer , vol.65 , pp. 267-270
    • Philip, P.A.1    Joel, S.2    Monkman, S.C.3
  • 66
    • 0027067753 scopus 로고
    • Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance
    • Lum BL, Kaubisch S, Fisher GA, et al. Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance. J Clin Oncol 1992, 10, 1635-1642.
    • (1992) J Clin Oncol , vol.10 , pp. 1635-1642
    • Lum, B.L.1    Kaubisch, S.2    Fisher, G.A.3
  • 67
    • 0007827873 scopus 로고
    • Phase I trial of etoposide with cyclosporine SDZ PSC 833, a modulator of multidrug resistance (MDR)
    • Fisher GA, Hausdorff J, Lum BL, et al. Phase I trial of etoposide with cyclosporine SDZ PSC 833, a modulator of multidrug resistance (MDR). Proc Am Soc Clin Oncol 1994, 13, 43.
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 43
    • Fisher, G.A.1    Hausdorff, J.2    Lum, B.L.3
  • 68
    • 0008196514 scopus 로고
    • A phase I trial of doxorubicin (D) and PSC833, a modulator of multidrug resist-ance (MDR)
    • Erlichman C, Moore M, Thiessen J, et al. A phase I trial of doxorubicin (D) and PSC833, a modulator of multidrug resist-ance (MDR). Proc Am Soc Clin Oncol 1994, 13, 134.
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 134
    • Erlichman, C.1    Moore, M.2    Thiessen, J.3
  • 69
    • 0007786284 scopus 로고
    • Phase I and pharmacokinetic study of SDZ PSC 833 per os in combination with doxorubicin in patients with solid tumors
    • Giaccone G, Linn SC, Catimel G, et al. Phase I and pharmacokinetic study of SDZ PSC 833 per os in combination with doxorubicin in patients with solid tumors. Proc Am Soc Clin Oncol 1994, 13, 142.
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 142
    • Giaccone, G.1    Linn, S.C.2    Catimel, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.