The vascular trigger of type II daibetes mellitus

Experimental and Clinical Endocrinology and Diabetes

Volumn 116, Issue SUPPL. 1, 2008, Pages

  Lammert, E ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Diabetes; Pacreatic islet; VEGF

Indexed keywords

2 OXOGLUTARATE DEPENDENT NUCLEIC ACID DEMETHYLASE; BINDING PROTEIN; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 5 REGULATORY SUBUNIT ASSOCIATED PROTEIN 1 LIKE 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GENE PRODUCT; GLUCOSE; HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN AND INSULIN DEGRADING ENZYME; HOMEODOMAIN PROTEIN; HYPOXIA INDUCIBLE FACTOR 1BETA; INSULIN LIKE GROWTH FACTOR 2 MESSENGER RNA BINDING PROTEIN 2; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; VASCULOTROPIN A; WOLFRAMIN; ZINC TRANSPORTER; ZINC TRANSPORTER 8;

APOPTOSIS; BLOOD VESSEL FUNCTION; BODY MASS; CELL DEATH; CELL FUNCTION; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; GENE EXPRESSION; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW;

ANIMALS; BLOOD VESSELS; COMPUTER SIMULATION; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY;

EID: 54549085545     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081487     Document Type: Review

References (63)

1. Koning EJ de, Bonner-Weir S, Rabelink TJ. Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci 2008; 29: 218-227
2. Nikolova G, Strilic B, Lammert E. The vascular niche and its basement membrane. Trends Cell Biol 2007; 17: 19-25
3. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001; 294: 564-567
4. Yoshitomi H, Zaret KS. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 2004; 131: 807-817
5. Nikolova G, Jabs N, Konstantinova I et al. The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation. Dev Cell 2006; 10: 397-405
6. Lammert E, Gu G, MacLaughlin M et al. Role of VEGF-A in vascularization of pancreatic islets. Cuff Biol 2003; 13: 1070-1074
7. Iwashita N, Uchida T, Choi JB et al. Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 2007; 50: 380-389
8. Laurent G, Solari F, Mateescu B et al. Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling. Cell Metab 2008; 7: 113-124
9. Brissova M, Shostak A, Shiota M et al. Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function. Diabetes 2006; 55: 2974-2985
10. Aronne LJ. Classification of obesity and assessment of obesity-related health risks. Obes Res 2002; 10 (Suppl 2): 105S-115S
11. Graham TE, Kahn BB. Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes. Horm Metab Res 2007; 39: 717-721
12. Luca C de, Olefsky JM. Inflammation and insulin resistance. FEBS Lett 2008; 582: 97-105
13. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9: 193-205
14. Poitout V, Robertson RP. Minireview: Secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 2002; 143: 339-342
15. Yamaguchi S, Ishihara H, Yamada T et al. ATF4-Mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab 2008; 7: 269-276
16. Scheuner D, Vander Mierde D, Song B et al. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med 2005; 11: 757-764
17. Harding HP, Zeng H, Zhang Y et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 2001; 7: 1153-1163
18. Marchetti P, Bugliani M, Lupi R et al. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 2007; 50: 2486-2494
19. Laybutt DR, Preston AM, Akerfeldt MC et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 2007; 50: 752-763
20. Zhang W, Feng D, Li Y et al. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab 2006; 4: 491-497
21. Weber SM, Chambers KT, Bensch KG, Scarim AL, Corbett JA. PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. Am J Physiol Endocrinol Metab 2004; 287: E1171-E1177
22. Han KL, Choi JS, Lee JY et al. Therapeutic potential of peroxisome proliferators-activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 2008; 57: 737-745
23. Yamada T, Ishihara H, Tamura A et al. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum Mol Genet 2006; 15: 1600-1609
24. Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007; 8: 657-662
25. Grant SF, Thorleifsson G, Reynisdottir I et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323
26. Cauchi S, Meyre D, Dina C et al. Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 2006; 55: 2903-2908
27. Shu L, Sauter NS, Schulthess FT et al. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 2008; 57: 645-653
28. Lyssenko V, Lupi R, Marchetti P et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007; 117: 2155-2163
29. Li J, Mizukami Y, Zhang X, Jo WS, Chung DC. Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. Gastroenterology 2005; 128: 1907-1918
30. Giles RH, Lolkema MP, Snijckers CM et al. Interplay between VHL/ HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene 2006; 25: 3065-3070
31. Levy L, Neuveut C, Renard CA et al. Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem 2002; 277: 42386-42393
32. Lobov IB, Rao S, Carroll TJ et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 2005; 437: 417-421
33. Freedman DA, Folkman J. CDK2 translational down-regulation during endothelial senescence. Exp Cell Res 2005; 307: 118-130
34. Yang DG, Liu L, Zheng XY. Cyclin-dependent kinase inhibitor p16(INK4a) and telomerase may co-modulate endothelial progenitor cells senescence. Ageing Res Rev 2008; 7: 137-146
35. Song Z, Wang Y, Xie L, Zang X, Yin H. Expression of senescence-related genes in human corneal endothelial cells. Mol Vis 2008; 14: 161-170
36. Krishnamurthy J, Ramsey MR, Ligon KL et al. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006; 443: 453-457
37. Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004; 131: 797-806
38. Hallaq H, Pinter E, Enciso J et al. A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Development 2004; 131: 5197-5209
39. Kubo A, Chen V, Kennedy M et al. The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood 2005; 105: 4590-4597
40. Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM. PPAR-gamma in the Cardiovascular System. PPAR Res 2008; 2008: 745-804
41. Biscetti F, Gaetani E, Flex A et al. Selective activation of PPAR{alpha} and PPAR{gamma} induces neoangiogenesis through a VEGF-dependent mechanism. Diabetes 2008
42. Moibi JA, Gupta D, Jetton TL et al. Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes 2007: 56: 88-95
43. Konstantinova I, Nikolova G, Ohara-Imaizumi M et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 2007; 129: 359-370
44. Ahren B. Autonomic regulation of islet hormone secretion-implications for health and disease. Diabetologia 2000; 43: 393-410
45. Gilon P, Henquin JC. Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev 2001; 22: 565-604
46. Bonner-Weir S, Orci L. New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 1982; 31: 883-889
47. Nikolova G, Lammert E. Interdependent development of blood vessels and organs. Cell Tissue Res 2003; 314: 33-42
48. Normund Jabs IF, Martin BB, Gromada J, Ferrara N, Claes BW, Lammert E. Reduced insulin secretion and content in VEGF-A deficient mouse pancreatic islets. Exp Clin Endocrinol & Diabetes 2008; in press
49. Cali AM, Caprio S. Prediabetes and type 2 diabetes in youth: an emerging epidemic disease? Curr Opin Endocrinol Diabetes Obes 2008; 15: 123-127
50. Gunton JE, Kulkarni RN, Yim S et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005; 122: 337-349
51. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47
52. Gerken T, Girard CA, Tung YC et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472
53. Lynch JA, George AM, Eisenhauer PB et al. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular enclothelial cell cultures. J Neurosci Res 2006; 83: 1262-1270
54. Bernstein HG, Lendeckel U, Bukowska A et al. Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary. J Chem Neuroanat 2008; 35: 216-224
55. Schnitzler MM, Derst C, Daut J, Preisig-Muller R. ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart. J Physiol 2000; 525 (Pt 2): 307-317
56. Yoshida H, Feig JE, Morrissey A et al. K ATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits. J Mol Cell Cardiol 2004; 37: 857-869
57. Inoue H, Tanizawa Y, Wasson J et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 1998; 20: 143-148
58. Strom TM, Hortnagel K, Hofmann S et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Hum Mal Genet 1998; 7: 2021-2028
59. Sharma MR, Tuszynski GP, Sharma MC. Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem 2004; 91: 398-409
60. Mitsios N, Pennucci R, Krupinski J et al. Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke. Brain Pathol 2007; 17: 11-23
61. Ager EI, Pask AJ, Shaw G, Renfree MB. Expression and protein localisation of IGF2 in the marsupial placenta. BMC Dev Biol 2008; 8: 17
62. Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53: 2330-2337
63. Baumhueter S, Mendel DB, Conley PB et al. HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes Dev 1990: 4: 372-379