메뉴 건너뛰기




Volumn 128, Issue 7, 2005, Pages 1907-1918

Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3β

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; AXIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; SERINE; T CELL FACTOR PROTEIN; VASCULOTROPIN; WNT1 PROTEIN;

EID: 20444449617     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.02.067     Document Type: Article
Times cited : (105)

References (66)
  • 1
    • 0033858528 scopus 로고    scopus 로고
    • The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis
    • D.C. Chung The genetic basis of colorectal cancer insights into critical pathways of tumorigenesis Gastroenterology 119 2000 854 865
    • (2000) Gastroenterology , vol.119 , pp. 854-865
    • Chung, D.C.1
  • 3
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • K.W. Kinzler, B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 6
    • 0031659602 scopus 로고    scopus 로고
    • Ras - A versatile cellular switch
    • C. Rommel, E. Hafen Ras - A versatile cellular switch Curr Opin Genet Dev 8 1998 412 418
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 412-418
    • Rommel, C.1    Hafen, E.2
  • 9
    • 0033545565 scopus 로고    scopus 로고
    • Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells
    • R. Plattner, S. Gupta, R. Khosravi-Far, K.Y. Sato, M. Perucho, C.J. Der, E.J. Stanbridge Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells Oncogene 18 1999 1807 1817
    • (1999) Oncogene , vol.18 , pp. 1807-1817
    • Plattner, R.1    Gupta, S.2    Khosravi-Far, R.3    Sato, K.Y.4    Perucho, M.5    Der, C.J.6    Stanbridge, E.J.7
  • 10
    • 0035860246 scopus 로고    scopus 로고
    • MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF
    • A. Sodhi, S. Montaner, H. Miyazaki, J.S. Gutkind MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF Biochem Biophys Res Commun 287 2001 292 300
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 292-300
    • Sodhi, A.1    Montaner, S.2    Miyazaki, H.3    Gutkind, J.S.4
  • 11
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • J. Downward Targeting RAS signalling pathways in cancer therapy Nat Rev Cancer 3 2003 11 22
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 12
    • 0032584108 scopus 로고    scopus 로고
    • Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
    • F. Okada, J.W. Rak, B.S. Croix, B. Lieubeau, M. Kaya, L. Roncari, S. Shirasawa, T. Sasazuki, R.S. Kerbel Impact of oncogenes in tumor angiogenesis mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells Proc Natl Acad Sci U S A 95 1998 3609 3614
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3609-3614
    • Okada, F.1    Rak, J.W.2    Croix, B.S.3    Lieubeau, B.4    Kaya, M.5    Roncari, L.6    Shirasawa, S.7    Sasazuki, T.8    Kerbel, R.S.9
  • 13
    • 0032937784 scopus 로고    scopus 로고
    • Association of K-ras mutations with p16 methylation in human colon cancer
    • R.J. Guan, Y. Fu, P.R. Holt, A.B. Pardee Association of K-ras mutations with p16 methylation in human colon cancer Gastroenterology 116 1999 1063 1071
    • (1999) Gastroenterology , vol.116 , pp. 1063-1071
    • Guan, R.J.1    Fu, Y.2    Holt, P.R.3    Pardee, A.B.4
  • 14
    • 0030989155 scopus 로고    scopus 로고
    • Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
    • H. Aktas, H. Cai, G.M. Cooper Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1 Mol Cell Biol 17 1997 3850 3857
    • (1997) Mol Cell Biol , vol.17 , pp. 3850-3857
    • Aktas, H.1    Cai, H.2    Cooper, G.M.3
  • 16
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    • X. Zhang, J.P. Gaspard, D.C. Chung Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia Cancer Res 61 2001 6050 6054
    • (2001) Cancer Res , vol.61 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 17
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • M. Bienz, H. Clevers Linking colorectal cancer to Wnt signaling Cell 103 2000 311 320
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 18
    • 0032521433 scopus 로고    scopus 로고
    • Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
    • A.B. Sparks, P.J. Morin, B. Vogelstein, K.W. Kinzler Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer Cancer Res 58 1998 1130 1134
    • (1998) Cancer Res , vol.58 , pp. 1130-1134
    • Sparks, A.B.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 20
    • 0032492954 scopus 로고    scopus 로고
    • Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    • M.J. Hart, R. de los Santos, I.N. Albert, B. Rubinfeld, P. Polakis Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta Curr Biol 8 1998 573 581
    • (1998) Curr Biol , vol.8 , pp. 573-581
    • Hart, M.J.1    De Los Santos, R.2    Albert, I.N.3    Rubinfeld, B.4    Polakis, P.5
  • 21
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • H. Aberle, A. Bauer, J. Stappert, A. Kispert, R. Kemler beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J 16 1997 3797 3804
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 22
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, P. Polakis Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly Science 272 1996 1023 1026
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 24
    • 0032821768 scopus 로고    scopus 로고
    • A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
    • G.M. Thomas, S. Frame, M. Goedert, I. Nathke, P. Polakis, P. Cohen A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin FEBS Lett 458 1999 247 251
    • (1999) FEBS Lett , vol.458 , pp. 247-251
    • Thomas, G.M.1    Frame, S.2    Goedert, M.3    Nathke, I.4    Polakis, P.5    Cohen, P.6
  • 25
    • 0032511194 scopus 로고    scopus 로고
    • GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
    • C. Yost, G.H. Farr III, S.B. Pierce, D.M. Ferkey, M.M. Chen, D. Kimelman GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis Cell 93 1998 1031 1041
    • (1998) Cell , vol.93 , pp. 1031-1041
    • Yost, C.1    Farr III, G.H.2    Pierce, S.B.3    Ferkey, D.M.4    Chen, M.M.5    Kimelman, D.6
  • 26
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • O. Tetsu, F. McCormick Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 30
    • 0033856281 scopus 로고    scopus 로고
    • Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
    • T.J. Koh, C.J. Bulitta, J.V. Fleming, G.J. Dockray, A. Varro, T.C. Wang Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis J Clin Invest 106 2000 533 539
    • (2000) J Clin Invest , vol.106 , pp. 533-539
    • Koh, T.J.1    Bulitta, C.J.2    Fleming, J.V.3    Dockray, G.J.4    Varro, A.5    Wang, T.C.6
  • 31
    • 0032847443 scopus 로고    scopus 로고
    • H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
    • J. Espada, M. Perez-Moreno, V.M. Braga, P. Rodriguez-Viciana, A. Cano H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes J Cell Biol 146 1999 967 980
    • (1999) J Cell Biol , vol.146 , pp. 967-980
    • Espada, J.1    Perez-Moreno, M.2    Braga, V.M.3    Rodriguez-Viciana, P.4    Cano, A.5
  • 32
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 34
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling
    • C. Sutherland, I.A. Leighton, P. Cohen Inactivation of glycogen synthase kinase-3 beta by phosphorylation new kinase connections in insulin and growth-factor signalling Biochem J 296 1993 15 19
    • (1993) Biochem J , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 35
    • 0034693230 scopus 로고    scopus 로고
    • Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling
    • V.W. Ding, R.H. Chen, F. McCormick Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling J Biol Chem 275 2000 32475 32481
    • (2000) J Biol Chem , vol.275 , pp. 32475-32481
    • Ding, V.W.1    Chen, R.H.2    McCormick, F.3
  • 36
    • 0034625355 scopus 로고    scopus 로고
    • Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C
    • R.H. Chen, W.V. Ding, F. McCormick Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C J Biol Chem 275 2000 17894 17899
    • (2000) J Biol Chem , vol.275 , pp. 17894-17899
    • Chen, R.H.1    Ding, W.V.2    McCormick, F.3
  • 37
    • 0035843148 scopus 로고    scopus 로고
    • Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    • C. Desbois-Mouthon, A. Cadoret, M.J. Blivet-Van Eggelpoel, F. Bertrand, G. Cherqui, C. Perret, J. Capeau Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation Oncogene 20 2001 252 259
    • (2001) Oncogene , vol.20 , pp. 252-259
    • Desbois-Mouthon, C.1    Cadoret, A.2    Blivet-Van Eggelpoel, M.J.3    Bertrand, F.4    Cherqui, G.5    Perret, C.6    Capeau, J.7
  • 38
    • 0141616620 scopus 로고    scopus 로고
    • LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
    • O. Ossipova, N. Bardeesy, R.A. DePinho, J.B. Green LKB1 (XEEK1) regulates Wnt signalling in vertebrate development Nat Cell Biol 5 2003 889 894
    • (2003) Nat Cell Biol , vol.5 , pp. 889-894
    • Ossipova, O.1    Bardeesy, N.2    DePinho, R.A.3    Green, J.B.4
  • 42
    • 0035816261 scopus 로고    scopus 로고
    • Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas
    • M. Ueda, R.M. Gemmill, J. West, R. Winn, M. Sugita, N. Tanaka, M. Ueki, H.A. Drabkin Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas Br J Cancer 85 2001 64 68
    • (2001) Br J Cancer , vol.85 , pp. 64-68
    • Ueda, M.1    Gemmill, R.M.2    West, J.3    Winn, R.4    Sugita, M.5    Tanaka, N.6    Ueki, M.7    Drabkin, H.A.8
  • 47
    • 0032919897 scopus 로고    scopus 로고
    • Use of a promoterless Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation
    • G. Behre, L.T. Smith, D.G. Tenen Use of a promoterless Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation Biotechniques 26 1999 24 26 28
    • (1999) Biotechniques , vol.26 , pp. 24-26
    • Behre, G.1    Smith, L.T.2    Tenen, D.G.3
  • 49
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) J Biol Chem 269 1994 5241 5248
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 51
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • E. Schreiber, P. Matthias, M.M. Muller, W. Schaffner Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells Nucleic Acids Res 17 1989 6419
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 52
    • 0034710915 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
    • M.P. Playford, D. Bicknell, W.F. Bodmer, V.M. Macaulay Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin Proc Natl Acad Sci U S A 97 2000 12103 12108
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12103-12108
    • Playford, M.P.1    Bicknell, D.2    Bodmer, W.F.3    Macaulay, V.M.4
  • 54
    • 0036144406 scopus 로고    scopus 로고
    • Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells
    • T. Mizushima, H. Nakagawa, Y.G. Kamberov, E.L. Wilder, P.S. Klein, A.K. Rustgi Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells Cancer Res 62 2002 277 282
    • (2002) Cancer Res , vol.62 , pp. 277-282
    • Mizushima, T.1    Nakagawa, H.2    Kamberov, Y.G.3    Wilder, E.L.4    Klein, P.S.5    Rustgi, A.K.6
  • 56
    • 0037415737 scopus 로고    scopus 로고
    • Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
    • R. Dajani, E. Fraser, S.M. Roe, M. Yeo, V.M. Good, V. Thompson, T.C. Dale, L.H. Pearl Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex EMBO J 22 2003 494 501
    • (2003) EMBO J , vol.22 , pp. 494-501
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3    Yeo, M.4    Good, V.M.5    Thompson, V.6    Dale, T.C.7    Pearl, L.H.8
  • 57
    • 0036860704 scopus 로고    scopus 로고
    • The Wnt signalling pathway
    • J. Huelsken, J. Behrens The Wnt signalling pathway J Cell Sci 115 2002 3977 3978
    • (2002) J Cell Sci , vol.115 , pp. 3977-3978
    • Huelsken, J.1    Behrens, J.2
  • 58
    • 0034282519 scopus 로고    scopus 로고
    • Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis
    • T. Yamada, A.S. Takaoka, Y. Naishiro, R. Hayashi, K. Maruyama, C. Maesawa, A. Ochiai, S. Hirohashi Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis Cancer Res 60 2000 4761 4766
    • (2000) Cancer Res , vol.60 , pp. 4761-4766
    • Yamada, T.1    Takaoka, A.S.2    Naishiro, Y.3    Hayashi, R.4    Maruyama, K.5    Maesawa, C.6    Ochiai, A.7    Hirohashi, S.8
  • 60
    • 0035899466 scopus 로고    scopus 로고
    • IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition
    • O.G. Morali, V. Delmas, R. Moore, C. Jeanney, J.P. Thiery, L. Larue IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition Oncogene 20 2001 4942 4950
    • (2001) Oncogene , vol.20 , pp. 4942-4950
    • Morali, O.G.1    Delmas, V.2    Moore, R.3    Jeanney, C.4    Thiery, J.P.5    Larue, L.6
  • 61
    • 0032720620 scopus 로고    scopus 로고
    • Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation
    • H. Yuan, J. Mao, L. Li, D. Wu Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation J Biol Chem 274 1999 30419 30423
    • (1999) J Biol Chem , vol.274 , pp. 30419-30423
    • Yuan, H.1    Mao, J.2    Li, L.3    Wu, D.4
  • 62
    • 0035804215 scopus 로고    scopus 로고
    • Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/-human colon carcinoma cells
    • C. Tan, P. Costello, J. Sanghera, D. Dominguez, J. Baulida, A.G. de Herreros, S. Dedhar Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/-human colon carcinoma cells Oncogene 20 2001 133 140
    • (2001) Oncogene , vol.20 , pp. 133-140
    • Tan, C.1    Costello, P.2    Sanghera, J.3    Dominguez, D.4    Baulida, J.5    De Herreros, A.G.6    Dedhar, S.7
  • 63
    • 0032530482 scopus 로고    scopus 로고
    • Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    • M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, S. Dedhar Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase Proc Natl Acad Sci U S A 95 1998 11211 11216
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11211-11216
    • Delcommenne, M.1    Tan, C.2    Gray, V.3    Rue, L.4    Woodgett, J.5    Dedhar, S.6
  • 64
    • 12144286634 scopus 로고    scopus 로고
    • Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways
    • D. Xie, D. Yin, X. Tong, J. O'Kelly, A. Mori, C. Miller, K. Black, D. Gui, J.W. Said, H.P. Koeffler Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways Cancer Res 64 2004 1987 1996
    • (2004) Cancer Res , vol.64 , pp. 1987-1996
    • Xie, D.1    Yin, D.2    Tong, X.3    O'Kelly, J.4    Mori, A.5    Miller, C.6    Black, K.7    Gui, D.8    Said, J.W.9    Koeffler, H.P.10
  • 65
    • 0037666792 scopus 로고    scopus 로고
    • Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
    • A.A. Troussard, N.M. Mawji, C. Ong, A. Mui, R. St-Arnaud, S. Dedhar Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation J Biol Chem 278 2003 22374 22378
    • (2003) J Biol Chem , vol.278 , pp. 22374-22378
    • Troussard, A.A.1    Mawji, N.M.2    Ong, C.3    Mui, A.4    St-Arnaud, R.5    Dedhar, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.