Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence

Ageing Research Reviews

Volumn 7, Issue 2, 2008, Pages 137-146

  Yang, De Guang ^a   Liu, Ling ^a   Zheng, Xiao Yan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Atherosclerosis; Endothelial progenitor cells (EPCs); p16INK4a; Senescence; Telomerase

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; REACTIVE OXYGEN METABOLITE; TELOMERASE;

ATHEROSCLEROSIS; CELL DIVISION; CELL FUNCTION; CELL REGENERATION; ENDOTHELIUM CELL; HUMAN; NEOPLASM; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SENESCENCE; SHORT SURVEY; STEM CELL; TUMOR CELL;

ANIMALS; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENDOTHELIAL CELLS; HUMANS; MODELS, BIOLOGICAL; STEM CELLS; TELOMERASE;

EID: 40949085119     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2008.02.001     Document Type: Short Survey

References (88)

1. Anversa P., Kajstura J., Leri A., and Bolli R. Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation 113 11 (2006) 1451-1463
2. Artandi S.E., and Attardi L.D. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Biochem. Biophys. Res. Commun. 331 (2005) 881-890
3. Assmus B., Urbich C., Aicher A., Hofmann W.K., Haendeler J., Rössig L., Spyridopoulos I., Zeiher A.M., and Dimmeler S. HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ. Res. 92 (2003) 1049-1055
4. Bartek J., Bartkova J., and Lukas J. DNA damage signaling guards against activated oncogenes and tumor progression. Oncogene 26 56 (2007) 7773-7779
5. Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., Vassiliou L.V., Kolettas E., Niforou K., Zoumpourlis V.C., Takaoka M., Nakagawa H., Tort F., Fugger K., Johansson F., Sehested M., Andersen C.L., Dyrskjot L., Orntoft T., Lukas J., Kittas C., Helleday T., Halazonetis T.D., Bartek J., and Gorgoulis V.G. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444 7119 (2006) 633-637
6. Beausejour C.M., and Campisi J. Ageing: balancing regeneration and cancer. Nature 443 7110 (2006) 404-405
7. Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat. Rev. Genet. 6 (2005) 611-622
8. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., and Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
9. Breitschopf K., Zeiher A.M., and Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett. 493 (2001) 21-25
10. Brookes S., Rowe J., Ruas M., Llanos S., Plark P.A., Lomax M., James M.C., Vatcheva R., Bates S., Vousden K.H., Parry D., Gruis N., Smit N., Bergman W., and Peters G. INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J. 21 (2002) 2936-2945
11. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87 (2000) 840-844
12. Cheung A.L., and Deng W. Telomere dysfunction, genome instability and cancer. Front. Biosci. 13 (2008) 2075-2090
13. Collado M., Gil J., Efeyan A., Guerra C., Schuhmacher A.J., Barradas M., Benguria A., Zaballos A., Flores J.M., Barbacid M., Beach D., and Serrano M. Tumor biology: senescence in premalignant tumors. Nature 436 7051 (2005) 642 Aug 4
14. Denchi E.L., and de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448 7157 (2007) 1068-1071
15. Dimmeler S., and Zeiher A.M. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?. J. Mol. Med. 82 (2004) 671-677
16. Dong X.X., Hui Z.J., Xiang W.X., Rong Z.F., Jian S., and Zhu C.J. Ginkgo biloba extract reduces endothelial progenitor-cell senescence through augmentation of telomerase activity. J. Cardiovasc. Pharmacol. 49 2 (2007) 111-115
17. Franke T.F., Hornik C.P., Segev L., Shostak G.A., and Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 22 (2003) 8983-8998
18. Furumoto K., Inoue E., Nagao N., Hiyama E., and Miwa N. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 63 (1998) 935-948
19. Griese D.P., Ehsan A., Melo L.G., Kong D., Zhang L., Mann M.J., Pratt R.E., Mulligan R.C., and Dzau V.J. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation 108 (2003) 2710-2715
20. Haendeler J., Hoffmann J., Brandes R.P., Zeiher A.M., and Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol. Cell. Biol. 23 (2003) 4598-4610
21. Harley C.B., Futcher A.B., and Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345 (1990) 458-460
22. He T., Smith L.A., Harrington S., Nath K.A., Caplice N.M., and Katusic Z.S. Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 35 (2004) 2378-2384
23. Heiss C., Keymel S., Niesler U., Ziemann J., Kelm M., and Kalka C. Impaired progenitor cell activity in age-related endothelial dysfunction. J. Am. Coll. Cardiol. 45 (2005) 1441-1448
24. Heitzer T., Schlinzig T., Krohn K., Meinertz T., and Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104 (2001) 2673-2678
25. Herbert, K.E., Mistry, Y., Hastings, R., Poolman, T., Niklason, L., Williams, B., 2007. Angiotensin II mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways. Circ. Res. November 8, 2007 [Epub ahead of print].
26. Higashi Y., Sasaki S., Nakagawa K., Matsuura H., Oshima T., and Chayama K. Endothelial function and oxidative stress in renovascular hypertension. N. Engl. J. Med. 346 (2002) 1954-1962
27. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., and Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. 348 (2003) 593-600
28. Hristov M., and Weber C. Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance. J. Cell. Mol. Med. 8 (2004) 498-508
29. Imanishi T., Hano T., Sawamura T., and Nishio I. Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin. Exp. Pharmacol. Physiol. 31 (2004) 407-413
30. Imanishi T., Moriwaki C., Hano T., and Nishio I. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. Hypertension 23 10 (2005) 1831-1837
31. Imanishi T., Kobayashi K., Hano T., and Nishio I. Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats. Hypertens. Res. 28 9 (2005) 763-772
32. Imanishi T., Hano T., and Nishio I. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J. Hypertens. 23 (2005) 1699-1706
33. Itahana K., Zou Y., Itahana Y., Martinez J.L., Beausejour C., Jacobs J.J., Van Lohuizen M., Band V., Campisi J., and Dimri G.P. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein BMI-1. Mol. Cell. Biol. 23 (2003) 389-401
34. INK4a in p53-independent telomere-directed senescence. Curr. Biol. 14 24 (2004) 2302-2308
35. Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene BMI-1 regulates cell proliferation and senescence through the INK4a locus. Nature 397 6715 (1999) 164-168
36. INK4a. Nature 443 7110 (September 28) (2006) 421-426
37. John S., Schlaich M., Langenfeld M., Weihprecht H., Schmitz G., Weidinger G., and Schmieder R.E. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study. Circulation 98 (1998) 211-216
38. Judith Campisi. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 4 (2005) 513-522
39. Kalka C., Masuda H., Takahashi T., Kalka-Moll W.M., Silver M., Kearney M., Li T., Isner J.M., and Asahara T. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. 97 (2000) 3422-3427
40. INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396 6706 (1998) 84-88
41. Kobayashi N., Mita S., and Yoshida K. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-[kappa]B induced by oxidative stress. Hypertension 42 5 (2003) 1004-1013
42. Kobayashi K., Imanishi T., and Akasaka T. Endothelial progenitor cell differentiation and senescence in an angiotensin II-infusion rat model. Hypertens. Res. 29 6 (2006) 449-455
43. INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 7110 (2006) 453-457 Sep 28
44. Kuki S., Imanishi T., Kobayashi K., Matsuo Y., Obana M., and Akasaka T. Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase. Circulaion 70 8 (2006) 1076-1081
45. Kurz D.J., Decary S., Hong Y., Trivier E., Akhmedov A., and Erusalimsky J.D. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J. Cell Sci. 117 (2004) 2417-2426
46. Landmesser U., Engberding N., Bahlmann F.H., Schaefer A., Wiencke A., Heineke A., Spiekermann S., Hilfiker-Kleiner D., Templin C., Kotlarz D., Mueller M., Fuchs M., Hornig B., Haller H., and Drexler H. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation 110 (2004) 1933-1939
47. Laufs U., Werner N., Link A., Endres M., Wassmann S., Jürgens K., Miche E., Böhm M., and Nickenig G. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109 (2004) 220-226
48. Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W., Greider C.W., and DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature 392 (1998) 569-574
49. Levenberg S., Zoldan J., Basevitch Y., and Langer R. Endothelial potential of human embryonic stem cells. Blood 110 3 (2007) 806-814
50. Liu Q.H., Guntuku S., Cui X.S., Matsuoka S., Cortez D., Tamai K., Luo G.B., Carattini-Rivera S., DeMayo F., Bradley A., Donehower L.A., and Elledge S.J. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev. 14 (2000) 1448-1459
51. Mathon N.F., and Lloyd A.C. Cell senescence and cancer. Nat. Rev. Cancer 1 (2001) 203-213
52. Michaloglou C., Vredeveld L.C., Soengas M.S., Denoyelle C., Kuilman T., van der Horst C.M., Majoor D.M., Shay J.W., Mooi W.J., and Peeper D.S. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436 7051 (2005) 720-724
53. Min L.J., Mogi M., Iwanami J., Li J.M., Sakata A., Fujita T., Tsukuda K., Iwai M., and Horiuchi M. Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence. Cardiovasc. Res. 76 3 (2007) 506-516
54. INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443 7110 (2006) 448-452 Sep 28
55. Murasawa S., Llevadot J., Silver M., Isner J.M., Losordo D.W., and Asahara T. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 106 (2002) 1133-1139
56. Murata H., Ihara Y., Nakamura H., Yodoi J., Sumikawa K., and Kondo T. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J. Biol. Chem. 278 (2003) 50226-50233
57. O'Driscoll G., Green D., Rankin J., Stanton K., and Taylor R. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. J. Clin. Invest. 100 (1997) 678-684
58. Perticone F., Ceravolo R., Pujia A., Ventura G., Iacopino S., Scozzafava A., Ferraro A., Chello M., Mastroroberto P., Verdecchia P., and Schillaci G. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104 (2001) 191-196
59. Portakal O., Ozkaya O., Erden Inal M., Bozan B., Koşan M., and Sayek I. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clim. Biochem. 33 (2000) 279-284
60. Quereda V., Martinalbo J., Dubus P., Carnero A., and Malumbres M. Genetic cooperation between p21(Cip1) and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene (2007) Jun 18
61. Rajaraman S., Choi J., Cheung P., Beaudry V., Moore H., and Artandi S.E. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc. Natl. Acad. Sci. 104 45 (2007) 17747-17752
62. Ramirez R.D., Morales C.P., Herbert B.S., Rohde J.M., Passons C., Shay J.W., and Wright W.E. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15 (2001) 398-403
63. Rauscher F.M., Goldschmidt-Clermont P.J., Davis B.H., Wang T., Gregg D., Ramaswami P., Pippen A.M., Annex B.H., Dong C., and Taylor D.A. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 108 (2003) 457-463
64. Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z., Tsao H., De Luca M., Catricalà C., and O'Toole K.M. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell. Biol. 22 (2002) 5157-5172
65. Ross. The pathogenesis of atherosclerosis. N. Engl. J Med. 340 (1999) 115-126
66. Sage J., Miller A.L., Perez-Mancera P.A., Wysocki J.M., and Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424 6945 (2003) 223-228
67. INK4a mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells. Cancer Res. 60 (2000) 2616-2622
68. Sata M., Saiura A., Kunisato A., Tojo A., Okada S., Tokuhisa T., Hirai H., Makuuchi M., Hirata Y., and Nagai R. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat. Med. 8 (2002) 403-409
69. Satoh, M., Ishikawa, Y., Takahashi, Y., Itoh, T., Minami, Y., Nakamura, M., 2007. Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease. Atherosclerosis, November 3, 2007 [Epub ahead of print].
70. Schmidt-Lucke C., Rössig L., Fichtlscherer S., Vasa M., Britten M., Kämper U., Dimmeler S., and Zeiher A.M. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 111 (2005) 2981-2987
71. INK4a participates in a G1 arrest checkpoint in response to DNA damage. Mol. Cell. Biol. 18 1 (1998) 378-387
72. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol. 8 9 (2007) 703-713
73. INK4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413 6851 (2001) 86-91
74. Sumi M., Sata M., Miura S., Rye K.A., Toya N., Kanaoka Y., Yanaga K., Ohki T., Saku K., and Nagai R. Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis. Vascul. Biol. 27 4 (2007) 813-818
75. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., Magner M., Isner J.M., and Asahara T. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. 5 (1999) 434-438
76. Tateishi-Yuyama E., Matsubara H., Murohara T., Ikeda U., Shintani S., Masaki H., Amano K., Kishimoto Y., Yoshimoto K., Akashi H., Shimada K., Iwasaka T., and Imaizumi T. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial. Lancet 360 (2002) 427-435
77. Thum T., Hoeber S., Froese S., Klink I., Stichtenoth D.O., Galuppo P., Jakob M., Tsikas D., Anker S.D., Poole-Wilson P.A., Borlak J., Ertl G., and Bauersachs J. Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1. Circ. Res. 100 3 (2007) 434-443
78. Thum T., Fraccarollo D., Thum S., Schultheiss M., Daiber A., Wenzel P., Munzel T., Ertl G., and Bauersachs J. Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Arterioscler. Thromb. Vasc. Biol. 27 4 (2007) 748-754
79. Titia de Lange. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
80. Torella D., Rota M., Nurzynska D., Musso E., Monsen A., Shiraishi I., Zias E., Walsh K., Rosenzweig A., Sussman M.A., Urbanek K., Nadal-Ginard B., Kajstura J., Anversa P., and Leri A. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 94 (2004) 514-524
81. Toyokuni S., Okamoto K., Yodoi J., and Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 358 (1995) 1-3
82. Urata Y., Ihara Y., Murata H., Goto S., Koji T., Yodoi J., Inoue S., and Kondo T. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J. Biol. Chem. 281 (2006) 13092-13102
83. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., Zeiher A.M., and Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ. Res. 89 (2001) E1-E7
84. Walter D.H., Rittig K., Bahlmann F.H., Kirchmair R., Silver M., Murayama T., Nishimura H., Losordo D.W., Asahara T., and Isner J.M. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 105 (2002) 3017-3024
85. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., Böhm M., and Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N. Engl. J. Med. 353 (2005) 999-1007
86. Wong J.M., and Collins K. Telomere maintenance and disease. Lancet 362 (2003) 983-988
87. Wu C., Miloslavskaya I., Demontis S., Maestro R., and Galaktionov K. Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 432 7017 (2004) 640-645 Dec 2
88. Zhu X., Kumar R., Mandal M., Sharma N., Sharma H.W., Dhingra U., Sokoloski J.A., Hsiao R., and Narayanan R. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6091-6095