Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

Genes and Development

Volumn 15, Issue 1, 2001, Pages 50-65

  Elenbaas, Brian ^a   Spirio, Lisa ^a   Koerner, Frederick ^b   Fleming, Mark D ^c   Zimonjic, Drazen B ^d   Donaher, Joana Liu ^a   Popescu, Nicholas C ^d   Hahn, William C ^a,e,f   Weinberg, Robert A ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

C myc; Epithelial; Fibroblast; Mammary; Ras; Transformation

Indexed keywords

MATRIGEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER CELL CULTURE; CARCINOGENICITY; ENZYME ACTIVE SITE; FIBROBLAST; GENE AMPLIFICATION; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C MYC; ONCOGENE H RAS; ONCOGENE RAS; PRIORITY JOURNAL; STROMA;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BREAST; BREAST NEOPLASMS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; FEMALE; GENES, RAG-1; GENES, RAS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MICE; MICE, KNOCKOUT; TELOMERASE; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 0035177216     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.828901     Document Type: Article

References (51)

1. Molecular analysis of chemical carcinogenesis in the skin
2. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells
3. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
4. A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins
5. The ras gene family and human carcinogenesis
6. Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer
7. Increasing complexity of Ras signaling
8. Aberrant function of the Ras signal transduction pathway in human breast cancer
9. Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas
10. Human breast cancer cell lines as models of growth regulation and disease progression
11. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights
12. Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses
13. Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice
14. Predisposition to neoplastic transformation caused by gene replacement of H-ras1
15. Human papillomavirus type 16 E7 alleviates a proliferation block in early passage human mammary epithelial cells
16. Inactivation of p16 in human mammary epithelial cells by CpG island methylation
17. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
18. Creation of human tumour cells with defined genetic elements
19. Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression
20. Regulation of mammary gland growth and morphogenesis by the mammary fat pad: A species comparison
21. Recombinant retroviruses encoding simian virus 40 large T antigen and
22. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
23. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
24. Basement membrane complexes with biological activity
25. Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping
26. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
27. The loss of estrogen and progesterone receptor gene expression in human breast
28. Preferential growth of mammary tumors in intact mammary fatpads
29. RAG-1-deficient mice have no mature B and T lymphocytes
30. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
31. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
32. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts
33. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
34. Tumor suppressor p53 mutations and breast cancer: A critical analysis
35. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
36. Increased expression of mutated Haras during premalignant progression in SENCAR mouse skin
37. Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
38. What might a stromal response mean to prostate cancer progression?
39. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
40. Multicolor spectral karyotyping of human chromosomes
41. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
42. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
43. Telomerase activity in ductal carcinoma in situ of the breast
44. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
45. Isolation and growth of human mammary epithelial cells
46. Molecular cytogenetics of primary breast cancer by CGH
47. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours
48. Risky immortalization by telomerase
49. An improved procedure for chromosome preparations from solid tumors
50. Refined localization of the erbB-3 proto-oncogene by direct visualization of FISH signals on LUT-inverted and contrast-enhanced digital images of DAPI-banded chromosomes
51. Profile of genetic alterations and tumorigenicity of human breast cancer cells