Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary

Cancer Research

Volumn 60, Issue 24, 2000, Pages 7052-7056

  Sato, N ^a   Tsunoda, H ^a   Nishida, M ^a   Morishita, Y ^a   Takimoto, Y ^a   Kubo, T ^a   Noguchi, M ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CHROMOSOME 10Q; CLEAR CELL CARCINOMA; CONTROLLED STUDY; ENDOMETRIOSIS; ENDOMETRIUM CARCINOMA; FEMALE; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; OVARY CARCINOMA; OVARY CYST; POINT MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA, CLEAR CELL; CARCINOMA, ENDOMETRIOID; CHROMOSOMES, HUMAN, PAIR 10; DISEASE PROGRESSION; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LASERS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MODELS, GENETIC; MUTATION; OVARIAN NEOPLASMS; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PTEN PHOSPHOHYDROLASE; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEINS;

EID: 0034671218     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
2. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
3. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
4. Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines
5. Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma
6. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
7. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
8. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease
9. 1growth arrest in glioma cells
10. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate
11. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
12. The multiple roles of PTEN in tumor suppression
13. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
14. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
15. PTEN/MMAC1 mutations in hepatocellular carcinomas
16. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
17. PTEN gene alterations in lymphoid neoplasms
18. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
19. PTEN/MMAC1 mutation in endometrial cancers
20. Frequent PTEN/MMAC1 mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
21. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
22. Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas
23. Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas
24. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
25. Mutation of the PTEN tumor suppressor gene endomentrial hyperplaias
26. Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ
27. Ovarian carcinoma arising endometriosis
28. The development of malignancy in endometriosis
29. Histologic transformation of benign endometriosis to early epithelial ovarian cancer
30. Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts
31. Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of common lineage
32. Laser capture microdissection