-
1
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
A.C. Alonso, I. Grundke-Iqbal and K. Iqbal, Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules, Nat Med 2 (1996), 783-787.
-
(1996)
Nat Med
, vol.2
, pp. 783-787
-
-
Alonso, A.C.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
2
-
-
0031012497
-
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
-
A.D. Alonso, I. Grundke-Iqbal, H.S. Barra and K. Iqbal, Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau, Proc Natl Acad Sci USA 94 (1997), 298-303.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 298-303
-
-
Alonso, A.D.1
Grundke-Iqbal, I.2
Barra, H.S.3
Iqbal, K.4
-
3
-
-
0035851157
-
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein
-
A.D. Alonso, T. Zaidi, M. Novak, H.S. Barra, I. Grundke-Iqbal and K. Iqbal, Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein, J Biol Chem 276 (2001), 37967-37973.
-
(2001)
J Biol Chem
, vol.276
, pp. 37967-37973
-
-
Alonso, A.D.1
Zaidi, T.2
Novak, M.3
Barra, H.S.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
4
-
-
0035811050
-
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
-
A. Alonso, T. Zaidi, M. Novak, I. Grundke-Iqbal and K. Iqbal, Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments, Proc Natl Acad Sci USA 98 (2001), 6923-6928.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6923-6928
-
-
Alonso, A.1
Zaidi, T.2
Novak, M.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
5
-
-
20044367108
-
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
-
C. Andorfer, C.M. Acker, Y. Kress, P.R. Hof, K. Duff and P. Davies, Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms, J Neurosci 25 (2005), 5446-5454.
-
(2005)
J Neurosci
, vol.25
, pp. 5446-5454
-
-
Andorfer, C.1
Acker, C.M.2
Kress, Y.3
Hof, P.R.4
Duff, K.5
Davies, P.6
-
6
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
C. Andorfer, Y. Kress, M. Espinoza, R. de Silva, K.L. Tucker, Y.A. Barde, K. Duff and P. Davies, Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86 (2003), 582-590.
-
(2003)
J Neurochem
, vol.86
, pp. 582-590
-
-
Andorfer, C.1
Kress, Y.2
Espinoza, M.3
de Silva, R.4
Tucker, K.L.5
Barde, Y.A.6
Duff, K.7
Davies, P.8
-
7
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte and B.T. Hyman, Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease, Neurology 42 (1992), 631-639.
-
(1992)
Neurology
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
8
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
A.A. Asuni, A. Boutajangout, D. Quartermain and E.M. Sigurdsson, Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements, J Neurosci 27 (2007), 9115-9129.
-
(2007)
J Neurosci
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
9
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
F. Bard, C. Cannon, R. Barbour, R.L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, I. Lieberburg, R. Motter, M. Nguyen, F. Soriano, N. Vasquez, K. Weiss, B. Welch, P. Seubert, D. Schenk and T. Yednock, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat Med 6 (2000), 916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
10
-
-
0242664588
-
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor ARA014418
-
R. Bhat, Y. Xue, S. Berg, S. Hellberg, M. Ormö, Y. Nilsson, A.C. Radesäter, E. Jerning, P.O. Markgren, T. Borgegård, M. Nylöf, A. Giménez-Cassina, F. Hernández, J.J. Lucas, J. Díaz-Nido and J. Avila, Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor ARA014418, J Biol Chem 278 (2003), 45937-45945.
-
(2003)
J Biol Chem
, vol.278
, pp. 45937-45945
-
-
Bhat, R.1
Xue, Y.2
Berg, S.3
Hellberg, S.4
Ormö, M.5
Nilsson, Y.6
Radesäter, A.C.7
Jerning, E.8
Markgren, P.O.9
Borgegård, T.10
Nylöf, M.11
Giménez-Cassina, A.12
Hernández, F.13
Lucas, J.J.14
Díaz-Nido, J.15
Avila, J.16
-
11
-
-
3042558276
-
Glycogen synthase kinase 3: A drug target for CNS therapies
-
R.V. Bhat, S.L. Budd Haeberlein and J. Avila, Glycogen synthase kinase 3: a drug target for CNS therapies, J Neurochem 89 (2004), 1313-1317.
-
(2004)
J Neurochem
, vol.89
, pp. 1313-1317
-
-
Bhat, R.V.1
Budd Haeberlein, S.L.2
Avila, J.3
-
12
-
-
0034030039
-
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
-
X. Bi, T.S. Haque, J. Zhou, A.G. Skillman, B. Lin, C.E. Lee, I.D. Kuntz, J.A. Ellman and G. Lynch, Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus, J Neurochem 74 (2000), 1469-1477.
-
(2000)
J Neurochem
, vol.74
, pp. 1469-1477
-
-
Bi, X.1
Haque, T.S.2
Zhou, J.3
Skillman, A.G.4
Lin, B.5
Lee, C.E.6
Kuntz, I.D.7
Ellman, J.A.8
Lynch, G.9
-
13
-
-
0031007546
-
Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
-
M.L. Billingsley and R.L. Kincaid, Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration, Biochem J 323 (1997), 577-591.
-
(1997)
Biochem J
, vol.323
, pp. 577-591
-
-
Billingsley, M.L.1
Kincaid, R.L.2
-
14
-
-
10944248857
-
Tau, tangles, and Alzheimer's disease
-
L.I. Binder, A.L. Guillozet-Bongaarts, F. Garcia-Sierra and R.W. Berry, Tau, tangles, and Alzheimer's disease, Biochim Biophys Acta 1739 (2005), 216-223.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 216-223
-
-
Binder, L.I.1
Guillozet-Bongaarts, A.L.2
Garcia-Sierra, F.3
Berry, R.W.4
-
15
-
-
0024988546
-
Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study
-
W. Bondareff, C.M. Wischik, M. Novak, W.B. Amos, A. Klug and M. Roth, Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study, Am J Pathol 137 (1990), 711-723.
-
(1990)
Am J Pathol
, vol.137
, pp. 711-723
-
-
Bondareff, W.1
Wischik, C.M.2
Novak, M.3
Amos, W.B.4
Klug, A.5
Roth, M.6
-
16
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol 82 (1991), 239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
17
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
L. Buée, T. Bussìere, V. Buée-Scherrer, A. Delacourte and P.R. Hof, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res Brain Res Rev 33 (2000), 95-130.
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buée, L.1
Bussìere, T.2
Buée-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
18
-
-
33344458827
-
M1 receptors play a central role in modulating AD-like pathology in transgenic mice
-
A. Caccamo, S. Oddo, L.M. Billings, K.N. Green, H. Martinez-Coria, A. Fisher and F.M. LaFerla, M1 receptors play a central role in modulating AD-like pathology in transgenic mice, Neuron 49 (2006), 671-682.
-
(2006)
Neuron
, vol.49
, pp. 671-682
-
-
Caccamo, A.1
Oddo, S.2
Billings, L.M.3
Green, K.N.4
Martinez-Coria, H.5
Fisher, A.6
LaFerla, F.M.7
-
19
-
-
0036483326
-
Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease
-
A. Castro, S. Conde, M.I. Rodriguez-Franco and A. Martinez, Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease, Mini Rev Med Chem 2 (2002), 37-50.
-
(2002)
Mini Rev Med Chem
, vol.2
, pp. 37-50
-
-
Castro, A.1
Conde, S.2
Rodriguez-Franco, M.I.3
Martinez, A.4
-
20
-
-
33745167938
-
Protein-misfolding diseases and chaperone-based therapeutic approaches
-
T.K. Chaudhuri and S. Paul, Protein-misfolding diseases and chaperone-based therapeutic approaches, FEBS J 273 (2006), 1331-1349.
-
(2006)
FEBS J
, vol.273
, pp. 1331-1349
-
-
Chaudhuri, T.K.1
Paul, S.2
-
21
-
-
35848962080
-
Disease-modifying therapies for Alzheimer disease: Challenges to early intervention
-
J.L. Cummings, R. Doody and C. Clark, Disease-modifying therapies for Alzheimer disease: challenges to early intervention, Neurology 69 (2007), 1622-1634.
-
(2007)
Neurology
, vol.69
, pp. 1622-1634
-
-
Cummings, J.L.1
Doody, R.2
Clark, C.3
-
22
-
-
33749241872
-
Current strategies for the treatment of Alzheimer's disease and other tauopathies
-
C.A. Dickey and L. Petrucelli, Current strategies for the treatment of Alzheimer's disease and other tauopathies, Expert Opin Ther Targets 10 (2006), 665-676.
-
(2006)
Expert Opin Ther Targets
, vol.10
, pp. 665-676
-
-
Dickey, C.A.1
Petrucelli, L.2
-
23
-
-
33646246733
-
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
-
C.A. Dickey, J. Dunmore, B. Lu, J.W. Wang, W.C. Lee, A. Kamal, F. Burrows, C. Eckman, M. Hutton and L. Petrucelli, HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites, FASEB J 20 (2006), 753-755.
-
(2006)
FASEB J
, vol.20
, pp. 753-755
-
-
Dickey, C.A.1
Dunmore, J.2
Lu, B.3
Wang, J.W.4
Lee, W.C.5
Kamal, A.6
Burrows, F.7
Eckman, C.8
Hutton, M.9
Petrucelli, L.10
-
24
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
C.A. Dickey, A. Kamal, K. Lundgren, N. Klosak, R.M. Bailey, J. Dunmore, P. Ash, S. Shoraka, J. Zlatkovic, C.B. Eckman, C. Patterson, D.W. Dickson, N.S. Nahman Jr, M. Hutton, F. Burrows and L. Petrucelli, The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins, J Clin Invest 117 (2007), 648-658.
-
(2007)
J Clin Invest
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman Jr, N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
25
-
-
33745916443
-
Peptide neuroprotection through specific interaction with brain tubulin
-
I. Divinski, M. Holtser-Cochav, I. Vulih-Schultzman, R.A. Steingart and I. Gozes, Peptide neuroprotection through specific interaction with brain tubulin, J Neurochem 98 (2006), 973-984.
-
(2006)
J Neurochem
, vol.98
, pp. 973-984
-
-
Divinski, I.1
Holtser-Cochav, M.2
Vulih-Schultzman, I.3
Steingart, R.A.4
Gozes, I.5
-
26
-
-
0037457966
-
Chaperones increase association of tau protein with microtubules
-
F. Dou, W.J. Netzer, K. Tanemura, F. Li, F.U. Hartl, A. Takashima, G.K. Gouras, P. Greengard and H. Xu, Chaperones increase association of tau protein with microtubules, Proc Natl Acad Sci USA 100 (2003), 721-726.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 721-726
-
-
Dou, F.1
Netzer, W.J.2
Tanemura, K.3
Li, F.4
Hartl, F.U.5
Takashima, A.6
Gouras, G.K.7
Greengard, P.8
Xu, H.9
-
27
-
-
34147130637
-
Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity
-
S. Emadi, H. Barkhordarian, M.S. Wang, P. Schulz and M.R. Sierks, Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity, J Mol Biol 368 (2007), 1132-1144.
-
(2007)
J Mol Biol
, vol.368
, pp. 1132-1144
-
-
Emadi, S.1
Barkhordarian, H.2
Wang, M.S.3
Schulz, P.4
Sierks, M.R.5
-
28
-
-
33845530335
-
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but preformed neurofibrillary tangles do not revert
-
T. Engel, P. Goñi-Oliver, J.J. Lucas, J. Avila and F. Hernández, Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but preformed neurofibrillary tangles do not revert, J Neurochem 99 (2006), 1445-1455.
-
(2006)
J Neurochem
, vol.99
, pp. 1445-1455
-
-
Engel, T.1
Goñi-Oliver, P.2
Lucas, J.J.3
Avila, J.4
Hernández, F.5
-
30
-
-
0642340251
-
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: Implications in future therapy
-
A. Fisher, Z. Pittel, R. Haring, N. Bar-Ner, M. Kliger-Spatz, N. Natan, I. Egozi, H. Sonego, I. Marcovitch and R. Brandeis, M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy, J Mol Neurosci 20 (2003), 349-356.
-
(2003)
J Mol Neurosci
, vol.20
, pp. 349-356
-
-
Fisher, A.1
Pittel, Z.2
Haring, R.3
Bar-Ner, N.4
Kliger-Spatz, M.5
Natan, N.6
Egozi, I.7
Sonego, H.8
Marcovitch, I.9
Brandeis, R.10
-
31
-
-
37049003111
-
M1 muscarinic agonists target major hallmarks of Alzheimer's disease - an update
-
A. Fisher, M1 muscarinic agonists target major hallmarks of Alzheimer's disease - an update, Curr Alzheimer Res 4 (2007), 577-580.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 577-580
-
-
Fisher, A.1
-
32
-
-
0032935789
-
Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment
-
I. Genis, A. Fisher, D.M. Michaelson Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment, J Neurochem 72 (1999), 206-213.
-
(1999)
J Neurochem
, vol.72
, pp. 206-213
-
-
Genis, I.1
Fisher, A.2
Michaelson, D.M.3
-
33
-
-
0038708285
-
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
-
P. Giannakopoulos, F.R. Herrmann, T. Bussière, C. Bouras, E. Kövari, D.P. Perl, J.H. Morrison, G. Gold and P.R. Hof, Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease, Neurology 60 (2003), 1495-1500.
-
(2003)
Neurology
, vol.60
, pp. 1495-1500
-
-
Giannakopoulos, P.1
Herrmann, F.R.2
Bussière, T.3
Bouras, C.4
Kövari, E.5
Perl, D.P.6
Morrison, J.H.7
Gold, G.8
Hof, P.R.9
-
34
-
-
0029979798
-
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
-
T. Gómez-Isla, J.L. Price, D.W. McKeel Jr, J.C. Morris, J.H. Growdon and B.T. Hyman, Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease, J Neurosci 16 (1996), 4491-4500.
-
(1996)
J Neurosci
, vol.16
, pp. 4491-4500
-
-
Gómez-Isla, T.1
Price, J.L.2
McKeel Jr, D.W.3
Morris, J.C.4
Growdon, J.H.5
Hyman, B.T.6
-
35
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
-
T. Gómez-Isla, R. Hollister, H. West, S. Mui, J.H. Growdon, R.C. Petersen, J.E. Parisi and B.T. Hyman, Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease, Ann Neurol 41 (1997), 17-24.
-
(1997)
Ann Neurol
, vol.41
, pp. 17-24
-
-
Gómez-Isla, T.1
Hollister, R.2
West, H.3
Mui, S.4
Growdon, J.H.5
Petersen, R.C.6
Parisi, J.E.7
Hyman, B.T.8
-
36
-
-
13444287985
-
Novel aspects of astrocyte protection
-
The femtomolar-acting NAP interacts with microtubules
-
I. Gozes and I. Divinski, The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection, J Alzheimers Dis 6 (2004), S37-S41.
-
(2004)
J Alzheimers Dis
, vol.6
-
-
Gozes, I.1
Divinski, I.2
-
37
-
-
34147210784
-
Activity-dependent neuroprotective protein: From gene to drug candidate
-
I. Gozes, Activity-dependent neuroprotective protein: from gene to drug candidate, Pharmacol Ther 114 (2007), 146-154.
-
(2007)
Pharmacol Ther
, vol.114
, pp. 146-154
-
-
Gozes, I.1
-
38
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski and L.I. Binder, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci USA 83 (1986), 4913-4917.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
39
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
I. Grundke-Iqbal, K. Iqbal, M. Quinlan, Y.C. Tung, M.S. Zaidi and H.M. Wisniewski, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments, J Biol Chem 261 (1986), 6084-6089.
-
(1986)
J Biol Chem
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
40
-
-
34548191034
-
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
-
D.P. Hanger, H.L. Byers, S. Wray, K.Y. Leung, M.J. Saxton, A. Seereeram, C.H. Reynolds, M.A. Ward and B.H. Anderton, Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis, J Biol Chem 282 (2007), 23645-23654.
-
(2007)
J Biol Chem
, vol.282
, pp. 23645-23654
-
-
Hanger, D.P.1
Byers, H.L.2
Wray, S.3
Leung, K.Y.4
Saxton, M.J.5
Seereeram, A.6
Reynolds, C.H.7
Ward, M.A.8
Anderton, B.H.9
-
41
-
-
0034612220
-
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
-
V. Heiser, E. Scherzinger, A. Boeddrich, E. Nordhoff, R. Lurz, N. Schugardt, H. Lehrach and E. Wanker, Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy, Proc Natl Acad Sci USA 12 (2000), 6739-6744.
-
(2000)
Proc Natl Acad Sci USA
, vol.12
, pp. 6739-6744
-
-
Heiser, V.1
Scherzinger, E.2
Boeddrich, A.3
Nordhoff, E.4
Lurz, R.5
Schugardt, N.6
Lehrach, H.7
Wanker, E.8
-
42
-
-
0042926482
-
Nitration of tau protein is linked to neurodegeneration in tauopathies
-
T. Horiguchi, K. Uryu, B.I. Giasson, H. Ischiropoulos, R. LightFoot, C. Bellmann, C. Richter-Landsberg, V.M. Lee and J.Q. Trojanowski, Nitration of tau protein is linked to neurodegeneration in tauopathies, Am J Pathol 163 (2003), 1021-1031.
-
(2003)
Am J Pathol
, vol.163
, pp. 1021-1031
-
-
Horiguchi, T.1
Uryu, K.2
Giasson, B.I.3
Ischiropoulos, H.4
LightFoot, R.5
Bellmann, C.6
Richter-Landsberg, C.7
Lee, V.M.8
Trojanowski, J.Q.9
-
43
-
-
33845966445
-
Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats
-
M. Hrnkova, N. Zilka, Z. Minichova, P. Koson and M. Novak, Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats, Brain Res 1130 (2007), 206-213.
-
(2007)
Brain Res
, vol.1130
, pp. 206-213
-
-
Hrnkova, M.1
Zilka, N.2
Minichova, Z.3
Koson, P.4
Novak, M.5
-
44
-
-
33847711478
-
Disease-modifying therapies in Alzheimer's disease: How far have we come?
-
M. Hüll, M. Berger and M. Heneka, Disease-modifying therapies in Alzheimer's disease: how far have we come? Drugs 66 (2006), 2075-2093.
-
(2006)
Drugs
, vol.66
, pp. 2075-2093
-
-
Hüll, M.1
Berger, M.2
Heneka, M.3
-
45
-
-
22144497090
-
Pharmacological approaches of neurofibrillary degeneration
-
K. Iqbal and I. Grundke-Iqbal, Pharmacological approaches of neurofibrillary degeneration, Curr Alzheimer Res 2 (2005), 335-341.
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 335-341
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
46
-
-
34548299424
-
Developing pharmacological therapies for Alzheimer disease
-
K. Iqbal and I. Grundke-Iqbal, Developing pharmacological therapies for Alzheimer disease, Cell Mol Life Sci 64 (2007), 2234-2244.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2234-2244
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
47
-
-
25844477102
-
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease
-
J.S. Jacobsen, P. Reinhart and M.N. Pangalos, Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease, NeuroRx 2 (2005), 612-626.
-
(2005)
NeuroRx
, vol.2
, pp. 612-626
-
-
Jacobsen, J.S.1
Reinhart, P.2
Pangalos, M.N.3
-
48
-
-
12344323961
-
Tau phosphorylation in neuronal cell function and dysfunction
-
G.V. Johnson and W.H. Stoothoff, Tau phosphorylation in neuronal cell function and dysfunction, J Cell Sci 117 (2004), 5721-5729.
-
(2004)
J Cell Sci
, vol.117
, pp. 5721-5729
-
-
Johnson, G.V.1
Stoothoff, W.H.2
-
49
-
-
0029887388
-
Effect of monoclonal antibodies in preventing carboxypeptidase A aggregation
-
T. Katzav-Gozansky, E. Hanan and B. Solomon, Effect of monoclonal antibodies in preventing carboxypeptidase A aggregation, Biotechnol Appl Biochem 23 (1996), 227-230.
-
(1996)
Biotechnol Appl Biochem
, vol.23
, pp. 227-230
-
-
Katzav-Gozansky, T.1
Hanan, E.2
Solomon, B.3
-
50
-
-
25644456097
-
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
-
M. Kitazawa, S. Oddo, T.R. Yamasaki, K.N. Green and F.M. LaFerla, Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease, J Neurosci 25 (2005), 8843-8853.
-
(2005)
J Neurosci
, vol.25
, pp. 8843-8853
-
-
Kitazawa, M.1
Oddo, S.2
Yamasaki, T.R.3
Green, K.N.4
LaFerla, F.M.5
-
51
-
-
33750582961
-
Therapeutic approaches to Alzheimer's disease
-
H.W. Klafki, M. Staufenbiel, J. Kornhuber and J. Wiltfang, Therapeutic approaches to Alzheimer's disease, Brain 129 (2006), 2840-2855.
-
(2006)
Brain
, vol.129
, pp. 2840-2855
-
-
Klafki, H.W.1
Staufenbiel, M.2
Kornhuber, J.3
Wiltfang, J.4
-
52
-
-
10944273982
-
Phosphorylated tau and the neurodegenerative foldopathies
-
K.S. Kosik and H. Shimura, Phosphorylated tau and the neurodegenerative foldopathies, Biochim Biophys Acta 1739 (2005), 298-310.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 298-310
-
-
Kosik, K.S.1
Shimura, H.2
-
53
-
-
0026676007
-
Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments
-
H. Ksiezak-Reding, W.K. Liu and S.H. Yen, Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments, Brain Res 597 (1992), 209-219.
-
(1992)
Brain Res
, vol.597
, pp. 209-219
-
-
Ksiezak-Reding, H.1
Liu, W.K.2
Yen, S.H.3
-
54
-
-
34347378629
-
Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: A ligand based approach results in successful scaffold hopping
-
G. Larbig, M. Pickhardt, D.G. Lloyd, B. Schmidt and E. Mandelkow, Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping, Curr Alzheimer Res 4 (2007), 315-323.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 315-323
-
-
Larbig, G.1
Pickhardt, M.2
Lloyd, D.G.3
Schmidt, B.4
Mandelkow, E.5
-
55
-
-
33745449875
-
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice
-
S. Le Corre, H.W. Klafki, N. Plesnila, G. Hübinger, A. Obermeier, H. Sahagún, B. Monse, P. Seneci, J. Lewis, J. Eriksen, C. Zehr, M. Yue, E. McGowan, D.W. Dickson, M. Hutton and H.M. Roder, An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice, Proc Natl Acad Sci USA 103 (2006), 9673-9678.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9673-9678
-
-
Le Corre, S.1
Klafki, H.W.2
Plesnila, N.3
Hübinger, G.4
Obermeier, A.5
Sahagún, H.6
Monse, B.7
Seneci, P.8
Lewis, J.9
Eriksen, J.10
Zehr, C.11
Yue, M.12
McGowan, E.13
Dickson, D.W.14
Hutton, M.15
Roder, H.M.16
-
56
-
-
84880185178
-
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies
-
V.M. Lee and J.Q. Trojanowski, Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now, J Alzheimers Dis 9 (2006), 257-262.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 257-262
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
57
-
-
0028065142
-
Analysis of microtubule-associated protein tau glycation in paired helical filaments
-
M.D. Ledesma, P. Bonay, C. Colaço and J. Avila, Analysis of microtubule-associated protein tau glycation in paired helical filaments, J Biol Chem 269 (1994), 21614-21619.
-
(1994)
J Biol Chem
, vol.269
, pp. 21614-21619
-
-
Ledesma, M.D.1
Bonay, P.2
Colaço, C.3
Avila, J.4
-
58
-
-
38449088277
-
Antibody-based approaches in Alzheimer's research: Safety, pharmacokinetics, metabolism, and analytical tools
-
P. Lichtlen and M.H. Mohajeri, Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools, J Neurochem 104 (2008), 859-874.
-
(2008)
J Neurochem
, vol.104
, pp. 859-874
-
-
Lichtlen, P.1
Mohajeri, M.H.2
-
59
-
-
34547183507
-
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies
-
W. Luo, F. Dou, A. Rodina, S. Chip, J. Kim, Q. Zhao, K. Moulick, J. Aguirre, N. Wu, P. Greengard and G. Chiosis, Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies, Proc Natl Acad Sci USA 104, 9511-9516.
-
Proc Natl Acad Sci USA
, vol.104
, pp. 9511-9516
-
-
Luo, W.1
Dou, F.2
Rodina, A.3
Chip, S.4
Kim, J.5
Zhao, Q.6
Moulick, K.7
Aguirre, J.8
Wu, N.9
Greengard, P.10
Chiosis, G.11
-
61
-
-
33847239940
-
Structural principles of tau and the paired helical filaments of Alzheimer's disease
-
E. Mandelkow, M. von Bergen, J. Biernat and E.M. Mandelkow, Structural principles of tau and the paired helical filaments of Alzheimer's disease, Brain Pathol 17 (2007), 83-90.
-
(2007)
Brain Pathol
, vol.17
, pp. 83-90
-
-
Mandelkow, E.1
von Bergen, M.2
Biernat, J.3
Mandelkow, E.M.4
-
62
-
-
34248354279
-
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
-
Y. Matsuoka, A.J. Gray, C. Hirata-Fukae, S.S. Minami, E.G. Waterhouse, M.P. Mattson, F.M. LaFerla, I. Gozes and P.S. Aisen, Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage, J Mol Neurosci 31 (2007), 165-170.
-
(2007)
J Mol Neurosci
, vol.31
, pp. 165-170
-
-
Matsuoka, Y.1
Gray, A.J.2
Hirata-Fukae, C.3
Minami, S.S.4
Waterhouse, E.G.5
Mattson, M.P.6
LaFerla, F.M.7
Gozes, I.8
Aisen, P.S.9
-
63
-
-
41149175575
-
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
-
Y. Matsuoka, Y. Jouroukhin, A.J. Gray, L. Ma, C. Hirata-Fukae, H.F. Li, L. Feng, L. Lecanu, B.R. Walker, E. Planel, O. Arancio, I. Gozes and P.S. Aisen, A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease, J Pharmacol Exp Ther 325 (2008), 146-153.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 146-153
-
-
Matsuoka, Y.1
Jouroukhin, Y.2
Gray, A.J.3
Ma, L.4
Hirata-Fukae, C.5
Li, H.F.6
Feng, L.7
Lecanu, L.8
Walker, B.R.9
Planel, E.10
Arancio, O.11
Gozes, I.12
Aisen, P.S.13
-
64
-
-
34447503455
-
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
-
M.P. Mazanetz and P.M. Fischer, Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases, Nat Rev Drug Discov 6 (2007), 464-479.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 464-479
-
-
Mazanetz, M.P.1
Fischer, P.M.2
-
66
-
-
33745591369
-
Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice
-
M.L. Michaelis, Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice, Curr Alzheimer Res 3 (2006), 215-219.
-
(2006)
Curr Alzheimer Res
, vol.3
, pp. 215-219
-
-
Michaelis, M.L.1
-
67
-
-
28844481487
-
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies
-
H. Nakashima, T. Ishihara, P. Suguimoto, O. Yokota, E. Oshima, A. Kugo, S. Terada, T. Hamamura, J.Q. Trojanowski, V.M. Lee and S. Kuroda, Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies, Acta Neuropathol 110 (2005), 547-556.
-
(2005)
Acta Neuropathol
, vol.110
, pp. 547-556
-
-
Nakashima, H.1
Ishihara, T.2
Suguimoto, P.3
Yokota, O.4
Oshima, E.5
Kugo, A.6
Terada, S.7
Hamamura, T.8
Trojanowski, J.Q.9
Lee, V.M.10
Kuroda, S.11
-
68
-
-
23044439880
-
Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: Implications for the treatment of tauopathic neurodegenerative diseases
-
M. Necula, C.N. Chirita and J. Kuret, Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases, Biochemistry 44 (2005), 10227-10237.
-
(2005)
Biochemistry
, vol.44
, pp. 10227-10237
-
-
Necula, M.1
Chirita, C.N.2
Kuret, J.3
-
69
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
W. Noble, E. Planel, C. Zehr, V. Olm, J. Meyerson, F. Suleman, K. Gaynor, L. Wang, J. LaFrancois, B. Feinstein, M. Burns, P. Krishnamurthy, Y. Wen, R. Bhat, J. Lewis, D. Dickson and K. Duff, Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo, Proc Natl Acad Sci USA 102 (2005), 6990-6995.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
Gaynor, K.7
Wang, L.8
LaFrancois, J.9
Feinstein, B.10
Burns, M.11
Krishnamurthy, P.12
Wen, Y.13
Bhat, R.14
Lewis, J.15
Dickson, D.16
Duff, K.17
-
70
-
-
0026053022
-
Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51
-
M. Novak, R. Jakes, P.C. Edwards, C. Milstein and C.M. Wischik, Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51, Proc Natl Acad Sci USA 88 (1991), 5837-5841.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 5837-5841
-
-
Novak, M.1
Jakes, R.2
Edwards, P.C.3
Milstein, C.4
Wischik, C.M.5
-
71
-
-
0027398169
-
Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament
-
M. Novak, J. Kabat and C.M. Wischik, Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament, EMBO J 12 (1993), 365-370.
-
(1993)
EMBO J
, vol.12
, pp. 365-370
-
-
Novak, M.1
Kabat, J.2
Wischik, C.M.3
-
72
-
-
0031157814
-
Neuroimmunology of Alzheimer's disease
-
M. Novak, Neuroimmunology of Alzheimer's disease, Bratisl Lek Listy 98 (1994), 303-314.
-
(1994)
Bratisl Lek Listy
, vol.98
, pp. 303-314
-
-
Novak, M.1
-
73
-
-
0242720372
-
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
-
M. Pérez, F. Hernández, F. Lim, J. Díaz-Nido and J. Avila, Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model, J Alzheimers Dis 5 (2003), 301-308.
-
(2003)
J Alzheimers Dis
, vol.5
, pp. 301-308
-
-
Pérez, M.1
Hernández, F.2
Lim, F.3
Díaz-Nido, J.4
Avila, J.5
-
74
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
M. Pickhardt, Z. Gazova, M. von Bergen, I. Khlistunova, Y. Wang, A. Hascher, E.M. Mandelkow, J. Biernat and E. Mandelkow, Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells, J Biol Chem 280 (2005), 3628-3635.
-
(2005)
J Biol Chem
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
Hascher, A.6
Mandelkow, E.M.7
Biernat, J.8
Mandelkow, E.9
-
75
-
-
34548502687
-
Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells
-
M. Pickhardt, G. Larbig, I. Khlistunova, A. Coksezen, B. Meyer, E.M. Mandelkow, B. Schmidt and E. Mandelkow, Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells, Biochemistry 46 (2007), 10016-10023.
-
(2007)
Biochemistry
, vol.46
, pp. 10016-10023
-
-
Pickhardt, M.1
Larbig, G.2
Khlistunova, I.3
Coksezen, A.4
Meyer, B.5
Mandelkow, E.M.6
Schmidt, B.7
Mandelkow, E.8
-
76
-
-
33845699846
-
An update on pharmacological approaches to neurodegenerative diseases
-
R. Scatena, G.E. Martorana, P. Bottoni, G. Botta, P. Pastore and B. Giardina, An update on pharmacological approaches to neurodegenerative diseases, Expert Opin Investig Drugs 16 (2007), 59-72.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 59-72
-
-
Scatena, R.1
Martorana, G.E.2
Bottoni, P.3
Botta, G.4
Pastore, P.5
Giardina, B.6
-
77
-
-
10944223484
-
Tau protein as a differential biomarker of tauopathies
-
N. Sergeant, A. Delacourte and L. Buée, Tau protein as a differential biomarker of tauopathies, Biochim Biophys Acta 1739 (2005), 179-197.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 179-197
-
-
Sergeant, N.1
Delacourte, A.2
Buée, L.3
-
78
-
-
33947497523
-
Intrinsically disordered tau protein in Alzheimer's tangles: A coincidence or a rule?
-
R. Skrabana, M. Skrabanova, N. Csokova, J. Sevcik and M. Novak, Intrinsically disordered tau protein in Alzheimer's tangles: a coincidence or a rule? Bratisl Lek Listy 107 (2006), 354-358.
-
(2006)
Bratisl Lek Listy
, vol.107
, pp. 354-358
-
-
Skrabana, R.1
Skrabanova, M.2
Csokova, N.3
Sevcik, J.4
Novak, M.5
-
79
-
-
33845524844
-
Intrinsically disordered proteins in the neurodegenerative processes: Formation of tau protein paired helical filaments and their analysis
-
R. Skrabana, J. Sevcik and M. Novak, Intrinsically disordered proteins in the neurodegenerative processes: Formation of tau protein paired helical filaments and their analysis, Cell Mol Neurobiol 26 (2006), 1083-1095.
-
(2006)
Cell Mol Neurobiol
, vol.26
, pp. 1083-1095
-
-
Skrabana, R.1
Sevcik, J.2
Novak, M.3
-
80
-
-
37649024109
-
Development and application of Hsp90 inhibitors
-
D.B. Solit amd G. Chiosis, Development and application of Hsp90 inhibitors, Drug Discov Today 13 (2008), 38-43.
-
(2008)
Drug Discov Today
, vol.13
, pp. 38-43
-
-
Solit, D.B.1
Chiosis, G.2
-
81
-
-
0029201345
-
Chaperone-like effect of monoclonal antibodies on refolding of heat-denatured carboxypeptidase A
-
B. Solomon and F. Schwartz, Chaperone-like effect of monoclonal antibodies on refolding of heat-denatured carboxypeptidase A, J Mol Recognit 8 (1995), 72-76.
-
(1995)
J Mol Recognit
, vol.8
, pp. 72-76
-
-
Solomon, B.1
Schwartz, F.2
-
82
-
-
0030058382
-
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
-
B. Solomon, R. Koppel, E. Hanan and T. Katzav, Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide, Proc Natl Acad Sci USA 93 (1996), 452-455.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 452-455
-
-
Solomon, B.1
Koppel, R.2
Hanan, E.3
Katzav, T.4
-
83
-
-
0030971789
-
Disaggregation of Alzheimer beta-amyloid by site-directed mAb
-
B. Solomon, R. Koppel, D. Frankel and E. Hanan-Aharon, Disaggregation of Alzheimer beta-amyloid by site-directed mAb, Proc Natl Acad Sci USA 94 (1997), 4109-4112.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4109-4112
-
-
Solomon, B.1
Koppel, R.2
Frankel, D.3
Hanan-Aharon, E.4
-
84
-
-
0036592954
-
Immunological concept in the treatment of Alzheimer's disease
-
B. Solomon, Immunological concept in the treatment of Alzheimer's disease, Drug Dev Res 56 (2002), 163-167.
-
(2002)
Drug Dev Res
, vol.56
, pp. 163-167
-
-
Solomon, B.1
-
85
-
-
34250004883
-
Clinical immunologic approaches for the treatment of Alzheimer's disease
-
B. Solomon, Clinical immunologic approaches for the treatment of Alzheimer's disease, Expert Opin Investig Drugs 16 (2007), 819-828.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 819-828
-
-
Solomon, B.1
-
86
-
-
34548260005
-
Looking for novel ways to treat the hallmarks of Alzheimer's disease
-
A.J. Stewart, A. Fox, B.H. Morimoto and I. Gozes, Looking for novel ways to treat the hallmarks of Alzheimer's disease, Expert Opin Investig Drugs 16 (2007), 1183-196.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 1183-1196
-
-
Stewart, A.J.1
Fox, A.2
Morimoto, B.H.3
Gozes, I.4
-
87
-
-
14844303721
-
Inhibition of heparininduced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
S. Taniguchi, N. Suzuki, M. Masuda, S. Hisanaga, T. Iwatsubo, M. Goedert and M. Hasegawa, Inhibition of heparininduced tau filament formation by phenothiazines, polyphenols, and porphyrins, J Biol Chem 280 (2005), 7614-7623.
-
(2005)
J Biol Chem
, vol.280
, pp. 7614-7623
-
-
Taniguchi, S.1
Suzuki, N.2
Masuda, M.3
Hisanaga, S.4
Iwatsubo, T.5
Goedert, M.6
Hasegawa, M.7
-
88
-
-
20044388897
-
Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation
-
T. Taniguchi, M. Sumida, S. Hiraoka, K. Tomoo, T. Kakehi, K. Minoura, S. Sugiyama, K. Inaka, T. Ishida, N. Saito and C. Tanaka, Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation, FEBS Lett 579 (2005), 1399-1404.
-
(2005)
FEBS Lett
, vol.579
, pp. 1399-1404
-
-
Taniguchi, T.1
Sumida, M.2
Hiraoka, S.3
Tomoo, K.4
Kakehi, T.5
Minoura, K.6
Sugiyama, S.7
Inaka, K.8
Ishida, T.9
Saito, N.10
Tanaka, C.11
-
89
-
-
0032744527
-
Tau is modified by tissue transglutaminase in situ: Possible functional and metabolic effects of polyamination
-
J. Tucholski, J. Kuret and G.V. Johnson, Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination, J Neurochem 73 (1999), 1871-1880.
-
(1999)
J Neurochem
, vol.73
, pp. 1871-1880
-
-
Tucholski, J.1
Kuret, J.2
Johnson, G.V.3
-
90
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
-
M. von Bergen, P. Friedhoff, J. Biernat, J. Heberle, E.M. Mandelkow and E. Mandelkow, Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure, Proc Natl Acad Sci USA 97 (2000), 5129-5134.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5129-5134
-
-
von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
91
-
-
16244390510
-
Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: Evidence for sparing of the entorhinal cortex and CA1 field
-
A. von Gunten, E. Kövari, C.B. Rivara, C. Bouras, P.R. Hof and P. Giannakopoulos, Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field, Exp Neurol 193 (2005), 198-206.
-
(2005)
Exp Neurol
, vol.193
, pp. 198-206
-
-
von Gunten, A.1
Kövari, E.2
Rivara, C.B.3
Bouras, C.4
Hof, P.R.5
Giannakopoulos, P.6
-
92
-
-
0029815467
-
Glycosylation of microtubule-associated protein tau: An abnormal posttranslational modification in Alzheimer's disease
-
J.Z. Wang, I. Grundke-Iqbal and K. Iqbal, Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease, Nat Med 2 (1996), 871-875.
-
(1996)
Nat Med
, vol.2
, pp. 871-875
-
-
Wang, J.Z.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
93
-
-
0019935804
-
Plaques, tangles and dementia. A quantitative study
-
G.K. Wilcock and M.M. Esiri, Plaques, tangles and dementia. A quantitative study, J Neurol Sci 56 (1982), 343-356.
-
(1982)
J Neurol Sci
, vol.56
, pp. 343-356
-
-
Wilcock, G.K.1
Esiri, M.M.2
-
94
-
-
0024044195
-
Structural characterization of the core of the paired helical filament of Alzheimer disease
-
C.M. Wischik, M. Novak, P.C. Edwards, A. Klug, W. Tichelaar and R.A. Crowther, Structural characterization of the core of the paired helical filament of Alzheimer disease, Proc Natl Acad Sci USA 85 (1988), 4884-4888.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4884-4888
-
-
Wischik, C.M.1
Novak, M.2
Edwards, P.C.3
Klug, A.4
Tichelaar, W.5
Crowther, R.A.6
-
95
-
-
0003986552
-
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
-
C.M. Wischik, M. Novak, H.C. Thøgersen, P.C. Edwards, M.J. Runswick, R. Jakes, J.E. Walker, C. Milstein, M. Roth and A. Klug, Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease, Proc Natl Acad Sci USA 85 (1988), 4506-4510.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4506-4510
-
-
Wischik, C.M.1
Novak, M.2
Thøgersen, H.C.3
Edwards, P.C.4
Runswick, M.J.5
Jakes, R.6
Walker, J.E.7
Milstein, C.8
Roth, M.9
Klug, A.10
-
96
-
-
0029742937
-
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
-
C.M. Wischik, P.C. Edwards, R.Y. Lai, M. Roth and C.R. Harrington, Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines, Proc Natl Acad Sci USA 93 (1996), 11213-11218.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11213-11218
-
-
Wischik, C.M.1
Edwards, P.C.2
Lai, R.Y.3
Roth, M.4
Harrington, C.R.5
-
97
-
-
0028023944
-
Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
-
S.D. Yan, X. Chen, A.M. Schmidt, J. Brett, G. Godman, Y.S. Zou, C.W. Scott, C. Caputo, T. Frappier, M.A. Smith et al., Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress, Proc Natl Acad Sci USA 91 (1994), 7787-7791.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7787-7791
-
-
Yan, S.D.1
Chen, X.2
Schmidt, A.M.3
Brett, J.4
Godman, G.5
Zou, Y.S.6
Scott, C.W.7
Caputo, C.8
Frappier, T.9
Smith, M.A.10
-
98
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Y. Yoshiyama, M. Higuchi, B. Zhang, S.M. Huang, N. Iwata, T.C. Saido, J. Maeda, T. Suhara, J.Q. Trojanowski and V.M. Lee, Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model, Neuron 53 (2007), 337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.10
-
99
-
-
33745152289
-
Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo
-
N. Zilka, P. Filipcik, P. Koson, L. Fialova, R. Skrabana, M. Zilkova, G. Rolkova, E. Kontsekova and M. Novak, Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo, FEBS Lett 580 (2006), 3582-3588.
-
(2006)
FEBS Lett
, vol.580
, pp. 3582-3588
-
-
Zilka, N.1
Filipcik, P.2
Koson, P.3
Fialova, L.4
Skrabana, R.5
Zilkova, M.6
Rolkova, G.7
Kontsekova, E.8
Novak, M.9
-
100
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
B. Zhang, A. Maiti, S. Shively, F. Lakhani, G. McDonald-Jones, J. Bruce, E.B. Lee, S.X. Xie, S. Joyce, C. Li, P.M. Toleikis, V.M. Lee and J.Q. Trojanowski, Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model, Proc Natl Acad Sci USA 102 (2005), 227-231.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 227-231
-
-
Zhang, B.1
Maiti, A.2
Shively, S.3
Lakhani, F.4
McDonald-Jones, G.5
Bruce, J.6
Lee, E.B.7
Xie, S.X.8
Joyce, S.9
Li, C.10
Toleikis, P.M.11
Lee, V.M.12
Trojanowski, J.Q.13
|