Cytoskeletal integrity as a drug target

Current Alzheimer Research

Volumn 2, Issue 2, 2005, Pages 227-229

  Michaelis, M L ^a   Seyb, K I ^a   Ansar, S ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CALPAIN; PACLITAXEL;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CONFERENCE PAPER; CYTOSKELETON; DRUG TARGETING; NERVE CELL LESION; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CYTOSKELETON; DRUG DELIVERY SYSTEMS; HUMANS; NEUROPROTECTIVE AGENTS;

EID: 20844451897     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/1567205053585837     Document Type: Conference Paper

References (23)

1. Goedert M, Crowther RA and Spillantini MG. Tau mutations cause frontotemporal dementias. Neuron 21: 955-8 (1998).
2. Busciglio J, Lorenzo A, Yeh J and Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14: 879-88 (1995).
3. Grace EA, Rabiner CA and Busciglio J. Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease. Neuroscience 114: 265-73 (2002).
4. Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, et al. Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. J Neurochem 84: 347-62 (2003).
5. Sigurdsson EM, Lee JM, Dong XW, Hejna MJ and Lorens SA. Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects. Neurobiol Aging 18: 591-608 (1997).
6. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M and Yankner B. A. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 4: 827-31 (1998).
7. Lee VM, Daughenbaugh R and Trojanowski JQ. Microrubule stabilizing drugs for the treatment of Alzheimer's disease. Neurobiol Aging 15 Suppl 2: 887-9 (1994).
8. Michaelis ML, Ranciat N, Chen Y, Bechtel M, Ragan R, Hepperle M, et al. Protection against beta-amyloid toxicity in primary neurons by paclitaxel (Taxol). J Neurochem 70: 1623-7 (1998).
9. Michaelis ML, Ansar S, Chen Y, Reiff ER, Seyb KI, Himes RH, et al. {beta}-Amyloid-Induced Neurodegeneration and Protection by Structurally Diverse Microtubule-Stabilizing Agents. J Pharmacol Exp Ther (2004).
10. Michaelis ML, Dobrowsky RT and Li G. Tau neurofibrillary pathology and microtubule stability. J Mol Neurosci 19: 289-93 (2002).
11. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P and Tsai LH. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402: 615-22 (1999).
12. Dhavan R and Tsai LH. A decade of CDK5. Nat Rev Mol Cell Biol 2: 749-59 (2001).
13. Mattson MP and Chan SL. Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits. J Mol Neurosci 17: 205-24 (2001).
14. Sherman MY and Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29: 15-32 (2001).
15. Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS and Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101: 249-58 (2000).
16. Chapman R, Sidrauski C and Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus. Annu Rev Cell Dev Biol 14: 459-85 (1998).
17. Morishima N, Nakanishi K, Takenouchi H, Shibata T and Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277: 34287-94 (2002).
18. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett 514: 122-8 (2002).
19. Burke WJ, Raghu G and Strong R. Taxol protects against calcium-mediated death of differentiated rat pheocliromocytoma cells. Life Sci 55: 313-9 (1994).
20. Furukawa K, and Mattson MP. Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity. Brain Res 689: 141-6 (1995).
21. Sponne J, Fifre A, Drouet B, Klein C, Koziel V, Pincon-Raymond M, et al. Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation. J Biol Chem 278: 3437-45 (2003).
22. Furukawa K, Wang Y, Yao PJ, Fu W, Mattson MP, Itoyama Y, et al. Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation. J Neurochem 87: 427-36 (2003).
23. Trushina E, Heldebrant MP, Perez-Terzic CM, Bortolon R, Kovtun IV, Badger JD 2nd, et al. Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease. Proc Natl Acad Sci USA 100: 12171-6 (2003).