Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1469-1477

  Bi, Xiaoning ^a,d   Haque, Tasir S ^b   Zhou, Jun ^a   Skillman, A Geoffrey ^c   Lin, Bin ^a   Lee, Christine E ^b   Kuntz, Irwin D ^c   Ellman, Jonathan A ^b   Lynch, Gary ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Cathepsin D; Hippocampus; Inhibitor; Lysosome; Tau

Indexed keywords

CATHEPSIN D; CATHEPSIN D INHIBITOR; PEPTIDE HYDROLASE INHIBITOR; PROTEINASE; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME INHIBITOR COMPLEX; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ALZHEIMER DISEASE; ANIMALS; CATHEPSIN D; DIAZOMETHANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LYSOSOMES; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0034030039     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741469.x     Document Type: Article

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