Carbonic anhydrase inhibitors: Synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9113-9120

  Güzel, Özlen ^a,b   Innocenti, Alessio ^b   Scozzafava, Andrea ^b   Salman, Aydin ^a   Parkkila, Seppo ^c   Hilvo, Mika ^c   Supuran, Claudiu T ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF TAMPERE   (Finland)

Author keywords

CA XIV selective inhibitor; Carbonic anhydrase; Indole 5 sulfonamide; Isoforms CA I CA XV; Sulfonamide

Indexed keywords

CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE XII; ISOENZYME; PHENYL 1H INDOLE 5 SULFONAMIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; HUMANS; HYDRAZINES; INDOLES; ISOENZYMES; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

MAMMALIA; MURINAE;

EID: 53249121381     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.032     Document Type: Article

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