Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2210-2215

  Temperini, Claudia ^a   Innocenti, Alessio ^a   Guerri, Annalisa ^a   Scozzafava, Andrea ^a   Rusconi, Stefano ^b   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Carbonic anhydrase; Enzyme activator; Enzyme inhibitor; Foscarnet; Isozymes; X ray crystallography; Zinc binding group

Indexed keywords

ANTIVIRUS AGENT; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; ENZYME INHIBITOR; FOSCARNET; ISOENZYME; PHOSPHONIC ACID DERIVATIVE; ZINC;

ARTICLE; CRYSTAL STRUCTURE; DRUG INTERACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; KINETICS; MOLECULAR RECOGNITION; MOLECULE; X RAY;

BINDING SITES; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE INHIBITORS; FOSCARNET; HUMANS; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

HERPESVIRIDAE;

EID: 33947690287     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.113     Document Type: Article

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