Successful virtual screening for novel inhibitors of human carbonic anhydrase: Strategy and experimental confirmation

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3588-3602

  Grüneberg, Sven ^a,b   Stubbs, Milton T ^a   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; BRINZOLAMIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; DICLOFENAMIDE; DORZOLAMIDE; METHAZOLAMIDE; SEZOLAMIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG SCREENING; ENZYME INHIBITION; HUMAN; PHARMACOPHORE; PROTEIN BINDING; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; HUMANS; ISOENZYMES; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037103119     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011112j     Document Type: Article

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