The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment

Journal of Experimental Medicine

Volumn 193, Issue 9, 2001, Pages 1105-1111

  Baekkevold, Espen S ^a,d   Yamanaka, Takeshi ^a   Palframan, Roger T ^c   Carlsen, Hege S ^a   Reinholt, Finn P ^b   Von Andrian, Ulrich H ^c   Brandtzaeg, Per ^a   Haraldsen, Guttorm ^a  

^a Lab Immunohistochemistry I   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c HARVARD MEDICAL SCHOOL   (United States)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Chemokines; Lymphocyte trafficking; Lymphoid tissue; Plt plt mice; Vascular endothelium

Indexed keywords

BETA CHEMOKINE; CHEMOKINE; EPSTEIN BARR VIRUS INDUCED MOLECULE 1 LIGAND CHEMOKINE; MESSENGER RNA; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ENDOTHELIUM; FOOT PAD; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TONSIL; TRANSCYTOSIS; VENULE;

ANIMALS; CHEMOKINES, CC; CYTOPLASMIC VESICLES; HUMANS; INJECTIONS; LIGANDS; LYMPH NODES; MICE; RECEPTORS, CHEMOKINE; RNA, MESSENGER; T-LYMPHOCYTES; TONSIL; VENULES;

EID: 0035821218     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.9.1105     Document Type: Article

References (29)

1. von Andrian, U.H., and C.R. Mackay. 2000. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343:1020-1034.
2. Butcher, E.C., and L.J. Picker. 1996. Lymphocyte homing and homeostasis. Science. 272:60-66.
3. Girard, J.P., and T.A. Springer. 1995. High endotlielial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol. Today. 16:449-457.
4. Campbell, J.J., J. Hedrick, A. Zlotnik, M.A. Siani, D.A. Thompson, and E.C. Butcher. 1998. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science. 279:381-384.
5. Cyster, J.G. 1999. Chemokines and cell migration in secondary lymphoid organs. Science. 286:2098-2102.
6. Zlotnik, A., and O. Yoshie. 2000. Chemokines: a new classification system and their role in immunity. Immunity. 12: 121-127.
7. Campbell, J.J., and E.C. Butcher. 2000. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12:336-341.
8. Gunn, M.D., K. Tangemann, C. Tam, J.G. Cyster, S.D. Rosen, and L.T. Williams. 1998. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA. 95:258-263.
9. Stein, J.V., A. Rot, Y. Luo, M. Narasimhaswamy, H. Nakano, M.D. Gunn, A. Matsuzawa, E.J. Quackenbush, M.E. Dorf, and U.H. von Andrian. 2000. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen I-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 191:61-75.
10. Warnock, K.A., J.J. Campbell, M.E. Dorf, A. Matsuzawa, L.M. McEvoy, and E.C. Butcher. 2000. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules. J. Exp. Med. 191:77-88.
11. Nakano, H., T. Tamura, T. Yoshimoto, H. Yagita, M. Miyasaka, E.C. Butcher, H. Nariuchi, T. Kakiuchi, and A. Matsuzawa. 1997. Genetic detect in T lymphocyte-specific homing into peripheral lymph nodes. Eur. J. Immunol. 27:215-221.
12. Gunn, M.D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L.T. Williams, and H. Nakano. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:451-460.
13. Vassileva, G., H. Soto, A. Zlotnik, H. Nakano, T. Kakiuchi, J.A. Hedrick, and S.A. Lira. 1999. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. J. Exp. Med. 190:1183-1188.
14. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 99:23-33.
15. Yoshida, R., T. Imai, K. Hieshima, J. Kusuda, M. Baba, M. Kitaura, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie. 1997. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272:13803-13809.
16. Campbell, J.J., E.P. Bowman, K. Murphy, K.K. Youngman, M.A. Siani, D.A. Thompson, L.J. Wu, A. Zlotnik, and E.C. Butcher. 1998. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3 beta receptor CCR7. J. Cell Biol. 141: 1053-1059.
17. Luther, S.A., H.L. Tang, P.L. Hyman, A.C. Farr, and J.G. Cyster. 2000. Coexpression of the chemokines ELC. and SLC by T zone stromal cells and deletion ot the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA. 97:12694-12699.
18. Nakano, H., and M.D. Gunn. 2001. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J. Immunol. 166:361-369.
19. Ngo, V.N., H.L. Tang, and J.G. Cyster. 1998. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J. Exp. Med. 188:181-191.
20. Dieu, M.C., B. Vanbervliet, A. Vicari, J.M. Bridon, E. Oldham, S. Ait-Yahia, F. Briere, A. Zlotnik, S. Lebecque, and C. Caux. 1998. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188:373-386.
21. Middleton, J., S. Neil, J. Wintle, I. Clark-Lewis:, H. Moore, C. Lam, M. Auer, E. Hub, and A. Rot. 1997. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell. 91:385-395.
22. Girard, J.P., E.S. Baekkevold, T. Yamanaka, G. Haraldsen, P. Brandtzaeg, and F. Amalric. 1999. Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization. Am. J. Pathol. 155:2043-2055.
23. Manjunath, N., P. Shankar, B. Stockton, P.D. Dubey, J. Lieberman, and U.H. von Andrian. 1999. A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo. Proc. Natl. Acad. Sci. USA. 96:13932-13937.
24. Breitfeld, D., L. Ohl, E. Kremmer, J. Ellwart, F. Sallusto, M. Lipp, and R. Forster. 2000. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192: 1545-1551.
25. Warnock, R.A., S. Askari, E.C. Butcher, and U.H. von Andrian. 1998. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J. Exp. Med. 187:205-216.
26. Anderson, A.O., and S. Shaw. 1993. T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node. Semin. Immunol. 5:271-282.
27. Tedla, N., H.W. Wang, H.P. McNeil, N. Di Girolamo, T. Hampartzoumian, D. Wakefield, and A. Lloyd. 1998. Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta. J. Immunol. 161:5663-5672.
28. Gretz, J.E., C.C. Norbury, A.O. Anderson, A.E. Proudfoot, and S. Shaw. 2000. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192:1425-1439.
29. Gretz, J.E., E.P. Kaldjian, A.O. Anderson, and S. Shaw. 1996. Sophisticated strategies for information encounter in the lymph node. The reticular network as a conduit of soluble information and a highway for cell traffic. J. Immunol. 157:495-499.