Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming

Journal of Experimental Medicine

Volumn 198, Issue 4, 2003, Pages 615-621

  Martín Fontecha, Alfonso ^a   Sebastiani, Silvia ^a   Höpken, Uta E ^b   Uguccioni, Mariagrazia ^a   Lipp, Martin ^b   Lanzavecchia, Antonio ^a   Sallusto, Federica ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

CCL21; Dendritic cell; Dendritic cell based vaccination; Migration; T cell priming

Indexed keywords

CANCER VACCINE; CHEMOKINE RECEPTOR CCR7; CYTOKINE; DRUG VEHICLE; TUMOR NECROSIS FACTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CELL COUNT; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE CELL; LYMPH VESSEL ENDOTHELIUM; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; UPREGULATION; VACCINATION;

ANIMALS; CELL MOVEMENT; CELL TRANSPLANTATION; DENDRITIC CELLS; FLUORESCENT DYES; HUMANS; INTERLEUKIN-1; LYMPH NODES; MICE; MICE, INBRED BALB C; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0042922810     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030448     Document Type: Article

References (29)

1. Banchereau, J., and R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
2. Dieu, M.C., B. Vanbervliet, A. Vicari, J.M. Bridon, E. Oldham, S. Ait-Yahia, F. Briere, A. Zlotnik, S. Lebecque, and C. Caux. 1998. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188:373-386.
3. Sallusto, F., P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C.R. Mackay, S. Qin, and A. Lanzavecchia. 1998. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28:2760-2769.
4. Ngo, V.N., H.L. Tang, and J.G. Cyster. 1998. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J. Exp. Med. 188:181-191.
5. Gunn, M.D., K. Tangemann, C. Tam, J.G. Cyster, S.D. Rosen, and L.T. Williams. 1998. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA. 95:258-263.
6. Kriehuber, E., S. Breiteneder-Geleff, M. Groeger, A. Soleiman, S.F. Schoppmann, G. Stingl, D. Kerjaschki, and D. Maurer. 2001. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J. Exp. Med. 194:797-808.
7. Willimann, K., D.F. Legler, M. Loetscher, R.S. Roos, M.B. Delgado, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1998. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur. J. Immunol. 28:2025-2034.
8. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 99:23-33.
9. Gunn, M.D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L.T. Williams, and H. Nakano. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:451-460.
10. Nakano, H., and M.D. Gunn. 2001. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strainspecific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J. Immunol. 166:361-369.
11. Mori, S., H. Nakano, K. Aritomi, C.R. Wang, M.D. Gunn, and T. Kakiuchi. 2001. Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J. Exp. Med. 193:207-218.
12. Junt, T., H. Nakano, T. Dumrese, T. Kakiuchi, B. Odermatt, R.M. Zinkernagel, H. Hengartner, and B. Ludewig. 2002. Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice. J. Immunol. 168:6032-6040.
13. Robbiani, D.F., R.A. Finch, D. Jager, W.A. Muller, A.C. Sartorelli, and G.J. Randolph. 2000. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell. 103:757-768.
14. Scandella, E., Y. Men, S. Gillessen, R. Forster, and M. Groettrup. 2002. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood. 100:1354-1361.
15. Luft, T., M. Jefford, P. Luetjens, T. Toy, H. Hochrein, K.A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky. 2002. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood. 100:1362-1372.
16. Mandala, S., R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G.J. Shei, D. Card, C. Keohane, et al. 2002. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 296:346-349.
17. Banchereau, J., B. Schuler-Thurner, A.K. Palucka, and G. Schuler. 2001. Dendritic cells as vectors for therapy. Cell. 106:271-274.
18. Kedl, R.M., J.W. Kappler, and P. Marrack. 2003. Epitope dominance, competition and T cell affinicy maturation. Curr. Opin. Immunol. 15:120-127.
19. Smith, A.L., M.E. Wikstrom, and B. Fazekas de St Groth. 2000. Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity. 13:783-794.
20. + T cells. J. Exp. Med. 186:239-245.
21. + T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194:707-717.
22. + T cell tolerance. J. Exp. Med. 196:1627-1638.
23. Mazzucchelli, L., A. Blaser, A. Kappeler, P. Scharli, J.A. Laissue, M. Bagiolini, and M. Uguccioni. 1999. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J. Clin. Invest. 104:R49-R54.
24. Cahill, R.N., H. Frost, and Z. Trnka. 1976. The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes. J. Exp. Med. 143:870-888.
25. Hall, J.G., and B. Morris. 1965. The immediate effect of antigens on the cell output of a lymph node. Br. J. Exp. Pathol. 46:450-454.
26. Stein, J.V., A. Rot, Y. Luo, M. Narasimhaswamy, H. Nakano, M.D. Gunn, A. Matsuzawa, E.J. Quackenbush, M.E. Dorf, and U.H. von Andrian. 2000. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 191:61-76.
27. Rossi, D., and A. Zlotnik. 2000. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:217-242.
28. Hermans, I.F., D.S. Ritchie, J. Yang, J.M. Roberts, and F. Ronchese. 2000. CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity. J. Immunol. 164:3095-3101.
29. Schrama, D., L.O. Pedersen, P. Keikavoussi, M.H. Andersen, P. Straten Pt, E.B. Brocker, E. Kampgen, and J.C. Becker. 2002. Aggregation of antigen-specific T cells at the inoculation site of mature dendritic cells. J. Invest. Dermatol. 119:1443-1448.