메뉴 건너뛰기




Volumn 47, Issue 1, 2008, Pages 113-126

Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD3 PROTEIN; TRANSFERASE;

EID: 38649097826     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21956     Document Type: Article
Times cited : (27)

References (48)
  • 1
    • 0012781968 scopus 로고    scopus 로고
    • Transforming growth factor β1
    • Mire-Sluis AR, Thorpe R, eds, San Diego, CA: Academic Press;
    • Ruscetti FW, Birchenall-Roberts MC, McPherson JM, Wiltrout RH. Transforming growth factor β1. In: Mire-Sluis AR, Thorpe R, eds. Cytokines. San Diego, CA: Academic Press;2006:415-432.
    • (2006) Cytokines , pp. 415-432
    • Ruscetti, F.W.1    Birchenall-Roberts, M.C.2    McPherson, J.M.3    Wiltrout, R.H.4
  • 2
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998;16:137-161.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 3
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000;12:171-181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 4
    • 24644441010 scopus 로고    scopus 로고
    • TGF-beta signaling in T cells: Roles in lymphoid and epithelial neoplasia
    • Letterio JJ. TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia. Oncogene 2005;24:5701-5712.
    • (2005) Oncogene , vol.24 , pp. 5701-5712
    • Letterio, J.J.1
  • 5
    • 0033953109 scopus 로고    scopus 로고
    • The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases
    • Prud'homme GJ, Piccirillo CA. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. J Autoimmun 2000;14:23-42.
    • (2000) J Autoimmun , vol.14 , pp. 23-42
    • Prud'homme, G.J.1    Piccirillo, C.A.2
  • 6
    • 0036595050 scopus 로고    scopus 로고
    • T-cell signalling and autoimmunity: Molecular mechanisms of disease
    • Ohashi PS. T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat Rev Immunol 2002;2:427-438.
    • (2002) Nat Rev Immunol , vol.2 , pp. 427-438
    • Ohashi, P.S.1
  • 7
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005;201:737-746.
    • (2005) J Exp Med , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3    Hurst, S.D.4    Coffman, R.L.5    Flavell, R.A.6
  • 8
    • 0141796312 scopus 로고    scopus 로고
    • TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003;9:1202-1208.
    • (2003) Nat Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3    Megret, J.4    Bach, J.F.5    Chatenoud, L.6
  • 9
    • 0026656850 scopus 로고
    • Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice
    • Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA. Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc Natl Acad Sci U S A 1992;89:7375-7379.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 7375-7379
    • Thorbecke, G.J.1    Shah, R.2    Leu, C.H.3    Kuruvilla, A.P.4    Hardison, A.M.5    Palladino, M.A.6
  • 11
    • 33646929213 scopus 로고    scopus 로고
    • A phosphatase controls the fate of receptor-regulated Smads
    • Schilling SH, Datto MB, Wang XF. A phosphatase controls the fate of receptor-regulated Smads. Cell 2006;125:838-840.
    • (2006) Cell , vol.125 , pp. 838-840
    • Schilling, S.H.1    Datto, M.B.2    Wang, X.F.3
  • 12
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • Nomura M, Li E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 1998;393:786-790.
    • (1998) Nature , vol.393 , pp. 786-790
    • Nomura, M.1    Li, E.2
  • 14
    • 0034906821 scopus 로고    scopus 로고
    • TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
    • Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 2001;3:708-714.
    • (2001) Nat Cell Biol , vol.3 , pp. 708-714
    • Perlman, R.1    Schiemann, W.P.2    Brooks, M.W.3    Lodish, H.F.4    Weinberg, R.A.5
  • 15
    • 0033573825 scopus 로고    scopus 로고
    • G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation
    • Dai JL, Bansal RK, Kern SE. G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation. Proc Natl Acad Sci U S A 1999;96:1427-1432.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 1427-1432
    • Dai, J.L.1    Bansal, R.K.2    Kern, S.E.3
  • 16
    • 33744801153 scopus 로고    scopus 로고
    • Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
    • Yang YA, Zhang GM, Feigenbaum L, Zhang YE. Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2. Cancer Cell 2006;9:445-457.
    • (2006) Cancer Cell , vol.9 , pp. 445-457
    • Yang, Y.A.1    Zhang, G.M.2    Feigenbaum, L.3    Zhang, Y.E.4
  • 17
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    • Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF, Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999;19:2495-2504.
    • (1999) Mol Cell Biol , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.F.6
  • 18
    • 33745911148 scopus 로고    scopus 로고
    • Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis
    • Kremer M, Hines IN, Milton RJ, Wheeler MD. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. HEPATOLOGY 2006;44:216-227.
    • (2006) HEPATOLOGY , vol.44 , pp. 216-227
    • Kremer, M.1    Hines, I.N.2    Milton, R.J.3    Wheeler, M.D.4
  • 20
    • 0034598156 scopus 로고    scopus 로고
    • Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
    • Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejyo F, et al. Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 2000;191:105-114.
    • (2000) J Exp Med , vol.191 , pp. 105-114
    • Kaneko, Y.1    Harada, M.2    Kawano, T.3    Yamashita, M.4    Shibata, Y.5    Gejyo, F.6
  • 23
    • 0029894529 scopus 로고    scopus 로고
    • ICE/CED-3 proteases in apoptosis
    • Whyte M. ICE/CED-3 proteases in apoptosis. Trends Cell Biol 1996;6:245-248.
    • (1996) Trends Cell Biol , vol.6 , pp. 245-248
    • Whyte, M.1
  • 24
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
    • Remy I, Montmarquette A, Michnick SW. PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol 2004;6:358-365.
    • (2004) Nat Cell Biol , vol.6 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 25
    • 0032531423 scopus 로고    scopus 로고
    • TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
    • Piccirillo CA, Chang Y, Prud'homme GJ. TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol 1998;161:3950-3956.
    • (1998) J Immunol , vol.161 , pp. 3950-3956
    • Piccirillo, C.A.1    Chang, Y.2    Prud'homme, G.J.3
  • 28
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 30
    • 0142180066 scopus 로고    scopus 로고
    • Activated Kupffer cells play an important role in intra-hepatic Th1-associated necro-inflammation in concanavalin A-induced hepatic injury in mice
    • Morita A, Itoh Y, Toyama T, Fujii H, Nishioji K, Kirishima T, et al. Activated Kupffer cells play an important role in intra-hepatic Th1-associated necro-inflammation in concanavalin A-induced hepatic injury in mice. Hepatol Res 2003;27:143-150.
    • (2003) Hepatol Res , vol.27 , pp. 143-150
    • Morita, A.1    Itoh, Y.2    Toyama, T.3    Fujii, H.4    Nishioji, K.5    Kirishima, T.6
  • 31
    • 7444272649 scopus 로고    scopus 로고
    • Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis
    • Li AG, Lu SL, Zhang MX, Deng C, Wang XJ. Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis. Cancer Res 2004;64:7836-7845.
    • (2004) Cancer Res , vol.64 , pp. 7836-7845
    • Li, A.G.1    Lu, S.L.2    Zhang, M.X.3    Deng, C.4    Wang, X.J.5
  • 32
    • 0036088872 scopus 로고    scopus 로고
    • Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice
    • Louis H, Le MA, Flamand V, Nagy N, Quertinmont E, Paulart F, et al. Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice. Gastroenterology 2002;122:2001-2010.
    • (2002) Gastroenterology , vol.122 , pp. 2001-2010
    • Louis, H.1    Le, M.A.2    Flamand, V.3    Nagy, N.4    Quertinmont, E.5    Paulart, F.6
  • 33
    • 33745537971 scopus 로고    scopus 로고
    • Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism
    • Li B, Sun R, Wei H, Gao B, Tian Z. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. HEPATOLOGY 2006;43:1211-1219.
    • (2006) HEPATOLOGY , vol.43 , pp. 1211-1219
    • Li, B.1    Sun, R.2    Wei, H.3    Gao, B.4    Tian, Z.5
  • 34
    • 33947259765 scopus 로고    scopus 로고
    • Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-beta target gene expression
    • Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, et al. Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-beta target gene expression. Int Atch Allergy Immunol 2007;142:309-317.
    • (2007) Int Atch Allergy Immunol , vol.142 , pp. 309-317
    • Kanzaki, M.1    Shibagaki, N.2    Hatsushika, K.3    Mitsui, H.4    Inozume, T.5    Okamoto, A.6
  • 36
    • 0034680863 scopus 로고    scopus 로고
    • Critical role of Smads and AP-1 complex in transforming growth factor-beta-dependent apoptosis
    • Yamamura Y, Hua X, Bergelson S, Lodish HF. Critical role of Smads and AP-1 complex in transforming growth factor-beta-dependent apoptosis. J Biol Chem 2000;275:36295-36302.
    • (2000) J Biol Chem , vol.275 , pp. 36295-36302
    • Yamamura, Y.1    Hua, X.2    Bergelson, S.3    Lodish, H.F.4
  • 37
    • 33846183551 scopus 로고    scopus 로고
    • Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach
    • Cao Y, Chen L, Zhang W, Liu Y, Papaconstantinou HT, Bush CR, et al. Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach. Am J Physiol Gastrointest Liver Physiol 2007;292:G28-G38.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Cao, Y.1    Chen, L.2    Zhang, W.3    Liu, Y.4    Papaconstantinou, H.T.5    Bush, C.R.6
  • 38
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A. TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005;16:1987-2002.
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 39
    • 20144379460 scopus 로고    scopus 로고
    • Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21 (WAF1/Cip1)
    • Pardali K, Kowanetz M, Heldin CH, Moustakas A. Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21 (WAF1/Cip1). J Cell Physiol 2005;204:260-272.
    • (2005) J Cell Physiol , vol.204 , pp. 260-272
    • Pardali, K.1    Kowanetz, M.2    Heldin, C.H.3    Moustakas, A.4
  • 40
    • 0242322012 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
    • Yoo J, Ghiassi M, Jirmanova L, Balliet AG, Hoffman B, Fornace AJ Jr, et al. Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem 2003;278:43001-43007.
    • (2003) J Biol Chem , vol.278 , pp. 43001-43007
    • Yoo, J.1    Ghiassi, M.2    Jirmanova, L.3    Balliet, A.G.4    Hoffman, B.5    Fornace Jr, A.J.6
  • 41
    • 0033973631 scopus 로고    scopus 로고
    • NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines
    • Fiorucci S, Santucci L, Antonelli E, Distrutti E, Del SG, Morelli O, et al. NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology 2000;118:404-421.
    • (2000) Gastroenterology , vol.118 , pp. 404-421
    • Fiorucci, S.1    Santucci, L.2    Antonelli, E.3    Distrutti, E.4    Del, S.G.5    Morelli, O.6
  • 42
    • 0033551802 scopus 로고    scopus 로고
    • Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
    • Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 1999;274:23013-23019.
    • (1999) J Biol Chem , vol.274 , pp. 23013-23019
    • Chen, R.H.1    Chang, M.C.2    Su, Y.H.3    Tsai, Y.T.4    Kuo, M.L.5
  • 43
    • 34547435358 scopus 로고    scopus 로고
    • Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis
    • Hines IN, Kremer M, Isayama F, Perry AW, Milton RJ, Black AL, et al. Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis. HEPATOLOGY 2007;46:229-241.
    • (2007) HEPATOLOGY , vol.46 , pp. 229-241
    • Hines, I.N.1    Kremer, M.2    Isayama, F.3    Perry, A.W.4    Milton, R.J.5    Black, A.L.6
  • 44
    • 0037099745 scopus 로고    scopus 로고
    • TGF-beta receptor-acrivated p38 MAP kinase mediates Smad-independent TGF-beta responses
    • Yu L, Hebert MC, Zhang YE. TGF-beta receptor-acrivated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 2002;21:3749-3759.
    • (2002) EMBO J , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 45
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-869.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 46
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 48
    • 0038730615 scopus 로고    scopus 로고
    • Protection against liver damage by cardiotrophin-1: A hepatocyte survival factor up-regulated in the regenerating liver in rats
    • Bustos M, Beraza N, Lasarte JJ, Baixeras E, Alzuguren P, Bordet T, et al. Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats. Gastroenterology 2003;125:192-201.
    • (2003) Gastroenterology , vol.125 , pp. 192-201
    • Bustos, M.1    Beraza, N.2    Lasarte, J.J.3    Baixeras, E.4    Alzuguren, P.5    Bordet, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.