Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers

Journal of Pharmaceutical Sciences

Volumn 97, Issue 7, 2008, Pages 2581-2606

  Shalaeva, Marina ^a   Kenseth, Jeremy ^b   Lombardo, Franco ^a,c   Bastin, Andrea ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Advanced Analytical TechnologiesInc   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Aqueous buffers; Dissociation constants of drug molecules; Low solubility compounds; Mixed cosolvent buffers; Multiplexed capillary electrophoresis

Indexed keywords

METHANOL; ORGANIC COMPOUND; WATER;

ARTICLE; CAPILLARY ELECTROPHORESIS; DISSOCIATION CONSTANT; PH; PHYSICAL CHEMISTRY; PKA;

EID: 52449106452     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21287     Document Type: Article

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