Chemistry of covalent inhibition of the gastric (H+, K +)-ATPase by proton pump inhibitors

Journal of the American Chemical Society

Volumn 126, Issue 25, 2004, Pages 7800-7811

  Shin, Jai Moo ^a   Cho, Young Moon ^a   Sachs, George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DISEASES; DRUG PRODUCTS; PH EFFECTS; ULTRAVIOLET SPECTROSCOPY;

COVALENT INHIBITION; PROTON PUMP INHIBITORS (PPI);

ENZYMES;

BENATOPRAZOLE; BENZIMIDAZOLE DERIVATIVE; CYSTEINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; IMIDAZOLE DERIVATIVE; IMIDAZOPYRIDINE DERIVATIVE; LANSOPRAZOLE; N1 METHYLLANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PRODRUG; PROTON PUMP INHIBITOR; PYRIDINE DERIVATIVE; PYRIDYLMETHYLSULFINYL BENZIMIDAZOLE; RABEPRAZOLE; SULFENAMIDE DERIVATIVE; SULFENIC ACID DERIVATIVE; THIOPHENE DERIVATIVE; TIMOPRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; COVALENT BOND; DISULFIDE BOND; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; PH; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; REACTION ANALYSIS; STOMACH ACID SECRETION; STOMACH PARIETAL CELL; SURFACE PROPERTY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTI-ULCER AGENTS; BENZIMIDAZOLES; DRUG STABILITY; ENZYME INHIBITORS; GASTRIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HALF-LIFE; HETEROCYCLIC COMPOUNDS, 2-RING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PROTON PUMPS; SPECTROPHOTOMETRY, ULTRAVIOLET; STOMACH;

EID: 3042544378     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja049607w     Document Type: Article

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