A rapid method for pKa determination of drugs using pressure-assisted capillary electrophoresis with photodiode array detection in drug discovery

Journal of Pharmaceutical Sciences

Volumn 91, Issue 4, 2002, Pages 933-942

  Ishihama, Yasushi ^a   Nakamura, Masahiro ^a   Miwa, Toshinobu ^a   Kajima, Takashi ^a   Asakawa, Naoki ^a  

^a EISAI CO LTD   (Japan)

Author keywords

HTS; Photodiode array detection; pKa; Pressure assisted capillary electrophoresis

Indexed keywords

ACETYLSALICYLIC ACID; ALPRENOLOL; ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIOVASCULAR AGENT; CHOLINESTERASE INHIBITOR; DICLOFENAC; DONEPEZIL; ENALAPRIL; FLUFENAMIC ACID; FLUINDOSTATIN; FLURBIPROFEN; FUROSEMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDOMETACIN; KETOPROFEN; METOPROLOL; NADOLOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE; PIPERAZINE DERIVATIVE; PIROXICAM; PRAVASTATIN; PROPRANOLOL; PROTON PUMP INHIBITOR; RABEPRAZOLE; SULINDAC; UNINDEXED DRUG; INDAN DERIVATIVE; PIPERIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL STRUCTURE; COMPUTER PROGRAM; DIODE; DRUG DETERMINATION; ELECTROPHORESIS; MEASUREMENT; PHOTODIODE ARRAY DETECTION; PKA; PRESSURE ASSISTED CAPILLARY ELECTROPHORESIS; REGRESSION ANALYSIS; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; DRUG DESIGN; METHODOLOGY; PH; PHARMACEUTICS; PRESSURE; STATISTICS;

DRUG DESIGN; ELECTROPHORESIS, CAPILLARY; HYDROGEN-ION CONCENTRATION; INDANS; PIPERIDINES; PRESSURE; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036017359     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10087     Document Type: Article

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