A potentially simpler approach to measure aqueous pKa of insoluble basic drugs containing amino groups

Journal of Pharmaceutical Sciences

Volumn 92, Issue 7, 2003, Pages 1473-1481

  Ruiz, Rebeca ^a   Ràfols, Clara ^a   Rosés, Martí ^a   Bosch, Elisabeth ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Antidepressant drugs; Aqueous pK; Potentiometry

Indexed keywords

1 AMINO 3 METHYLBUTANE; 2 OCTYLAMINE; AMINE; ANTIDEPRESSANT AGENT; BUTYLAMINE; ETHYLAMINE; HEXYLAMINE; IMIPRAMINE; ISOBUTYLAMINE; ISOPROPYLAMINE; MAPROTILINE; METHANOL; METHYLAMINE; NORTRIPTYLINE; PENTYLAMINE; PROPYLAMINE; TRAZODONE; TRIMIPRAMINE MALEATE; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; DISSOCIATION CONSTANT; DRUG SOLUBILITY; DRUG STRUCTURE; MATHEMATICAL MODEL; PH MEASUREMENT; PKA; POTENTIOMETRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TITRIMETRY; YASUDA SHEDLOVSKY EQUATION;

EID: 0037745015     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10415     Document Type: Article

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